Maternal Influenza Immunization
The Mother’s Gift influenza immunization trial is a Bill & Melinda Gates Foundation-funded prospective trial of influenza immunization during pregnancy, which is carried out with collaborators in Nepal. The study follows an earlier Gates Foundation-funded maternal immunization project in Bangladesh, and the purpose is to evaluate the effects seen in the Bangladesh trial in greater detail. We will recruit 1,600 pregnant women, randomize them to receive influenza vaccine, or a placebo, and assess maternal, newborn and infant outcomes in the two groups. The study is done in collaboration with the Institute of Medicine in Kathmandu, Nepal, Johns Hopkins University and the University of Washington. Recruitment of subjects in the Terai region of Nepal began in May. By the end of June, 300 mothers had been recruited and immunized, and recruitment will continue. All mothers and infants are followed until the infants reach 6 months of age. Part of the project is developing PCR capability within Nepal to diagnose and characterize influenza viruses.
Vitamin D Research
A study by Adekunle Dawodu, MBBS, evaluating prenatal vitamin D supplementation in women in the United Arab Emirates, funded by the Thrasher Research Fund, has completed enrollment and follow-up of patients. The data are being analyzed. The findings indicate that 98 percent of subjects upon enrollment are vitamin D deficient. This extraordinarily high prevalence of vitamin D deficiency during pregnancy could have significant adverse effect on the mother and the growing fetus. This study will provide the first data to determine the efficacy of high-dose vitamin D to prevent deficiency in mothers and their newborns in a high-risk population.
In FY2011, the International Visitors’ Office within the Global Health Center facilitated more than 150 visitors from 39 countries to come to Cincinnati Children’s to learn from our world-renowned faculty. Visitors went to more than 30 divisions throughout the medical center. Through these visits, we are able to change the outcome for more children around the world through education and research.