2011 Research Annual Report

Division Collaboration

Gastroenterology, Hepatology, and Nutrition » N. Yazigi, MD

Clinical care of children with liver disease and hematologic disorders (T. Kalfa, MD, PhD.)

Radiology » R. Fleck, Jr., MD

Evaluation of children with transfusional hemosiderosis (iron overload) by liver MRI.  (T. Kalfa, MD, PhD.)

Clinical Pharmacology » A. Vinks, PharmD, PhD, FCP

Pharmacokinetics in sickle cell disease. (C. Joiner, MD, PhD, K. Kalinyak, MD)

Anesthesia » N. Weidner, MD

Pain management in sickle cell patients. (K. Kalinyak, MD, C. Quinn, MD, MS)

Human Genetics » K. Zhang, MD, MBA

Genetic diagnostic services for hematology patients. (C. Joiner, MD, PhD, T. Kalfa, MD, PhD)

Experimental Hematology and Cancer Biology » P. Malik, MD

Comprehensive Sickle Cell Center; Gene transfer into hematopoietic stem cells. (A. Perumbeti, MD, C. Joiner, MD, PhD)

University of Cincinnati Division of Hematology/Oncology » R. Franco, PhD; G. Atweh, MD

Comprehensive Sickle Cell Center; Sickle cell pathophysiology, fetal hemoglobin induction. (C. Joiner, MD, PhD)

University of Cincinnati Division of Endocrinology » R. Cohen, PhD

Comprehensive Sickle Cell Center; Red blood cell survival and hemoglobin glycosylation. (C. Joiner, MD, PhD)

Experimental Hematology and Cancer Biology; Bone Marrow Transplantation and Immune Deficiency » P. Malik, MD; S. Davies, MBBS, PhD, MRCP

Comprehensive Sickle Cell Center; Gene transfer therapy in sickle cell diseases. (A. Perumbeti, MD, K. Kalinyak, MD, C. Joiner, MD, PhD)

Developmental Biology » J. Degen, PhD

Hemophilia and Thrombophilia Program; Role of coagulation programs in cancer metastasis. (J. Palumbo, MD)

Behavioral Medicine and Clinical Psychology » M. Mitchell, PhD

Comprehensive Sickle Cell Center; Adherence to hydroxyurea therapy. (K. Kalinyak, MD, C. Joiner, MD, PhD)

Experimental Hematology and Cancer Biology » J. Degen, PhD

Hemophilia and Thrombophilia Program (E. Mullins, MD)

Clinical Pharmacology; Experimental Hematology and Cancer Biology » A. Vinks, PharmD, PhD, FCP ; P. Malik, MD

Comprehensive Sickle Cell Center; Zileuton therapy for sickle cell disease. (K. Kalinyak, MD, C. Joiner, MD, PhD)

Experimental Hematology and Cancer Biology; Pulmonary Medicine » P. Malik, MD; W. Hardie, MD ; M. Ednick, DO

Comprehensive Sickle Cell Center; Multidisciplinary clinic for sickle cell patients, inflammation in sickle cell disease. (K. Kalinyak, MD, C. Joiner, MD, PhD)

Experimental Hematology and Cancer Biology; Cardiology; Radiology; Pulmonary Medicine » P. Malik, MD; R. Fleck, MD; W. Gottleibson, MD; A. Towbin, MD ; C. Kerschmar, MD

Comprehensive Sickle Cell Center; Cardiovascular complications of sickle cell disease. (K. Kalinyak, MD, C Joiner, MD, PhD)

Experimental Hematology and Cancer Biology » Y. Zheng, PhD

Comprehensive Sickle Cell Center; signaling pathways in red blood cells. (T. Kalfa, MD, PhD)

Anesthesia » C. Kurth, MD

Hematology Program; Clinical evaluation of transcutaneous hemoglobin analysis. (K. Kalinyak, MD, C. Joiner, MD, PhD)

Radiology » A. Towbin, MD

Hematology Program; Clinical evaluation of sickle cell patients. (K. Kalinyak, MD, C. Joiner, MD, PhD)

Sports Medicine » J. Divine, MD, MS

Comprehensive Sickle Cell Center; Evaluation and counseling of athletes for sickle cell trait (C. Joiner, MD, PhD)

University of Cincinnati Division of General Internal Medicine » T. Diers, MD

Comprehensive Sickle Cell Center; Transition of sickle cell patients to adult care. (K. Kalinyak, MD, C. Joiner, MD, PhD)

Pulmonary Medicine » M. Ednick, DO; W. Hardie, MD

Clinical Care and research in sickle cell patients. (K. Kalinyak, MD, Quinn, MD, MS)

Adolescent Medicine » L. Ayensu-Coker, MD

Clinical care for bleeding disorders in adolescent girls. (E. Mullins, MD, C. Tarango, MD)

Cardiology » D. Nelson, MD, PhD; J. Jeffries, MD, MPH, FAAP, FACC ; A. Lorts, MD; J. Towbin, MD, FAAP, FACC, FAHA

Clinical management of anti-coagulation of cardiac patients. (C. Tarango, MD)

Experimental Hematology and Cancer Biology » Y. Zheng, PhD

NIDDK Center of Excellence in Molecular Hematology. (C. Joiner, MD, PhD)

Neurology » M. Kabbouche, MD

Clinic for children with sickle cell disease and stroke. (C. Quinn, MD, MS)

Cardiology » T. Kimball, MD

PFAST Study. (C. Quinn, MD, MS)

Experimental Hematology and Cancer Biology » Y. Zheng, PhD

Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PLoS One. Feb 2011;6(2):e16951. (J. Palumbo, MD)

Experimental Hematology and Cancer Biology; Rheumatology » M. Flick, PhD; J. Degen, PhD; S. Thornton, PhD

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A1E217A. Blood. Jun 2011;117(23):6326-6337. (E. Mullins, MD, J. Palumbo, MD)

Human Genetics; Oncology » M. Keddache, MS; A. Hammill, MD, PhD

Compound heterozygosity for two novel mutations in the erythrocyte protein 4.2 gene causing spherocytosis in a Caucasian patient. Br J Haematol. Mar 2011;152(6):780-783. (C. Joiner, MD, PhD, T. Kalfa, MD, PhD)

Oncology; Gastroenterology, Hepatology and Nutrition » B. Mizukawa, MD; J. Heubi, MD

Cooperating G6PD mutations associated with severe neonatal hyperbilirubinemia and cholestasis. Pediatr Blood Cancer. May 2011 ;56(5):840-842. (K. Kalinyak, MD, T. Kalfa, MD, PhD)

Experimental Hematology and Cancer Biology » P. Malik, MD

Therapy for beta-globinopathies: a brief review and determinants for successful and safe correction. Ann N Y Acad Sci. Aug 2010; 1202:36-44. (A. Perumbeti, MD)