Joshua Waxman, PhD
The Waxman lab’s recent work has focused on factors that affect cardiac progenitor specification and indicates that cardiac and forelimb progenitors interact, helping to direct each ones’ development. Specifically, we have found that retinoic acid signaling acting on forelimb progenitors impacts fibroblast growth factor signaling, which acts on cardiac progenitors. Together, these interactions allow proper specification of these different fields. We think elucidating these interactions will allow us to understand developmental syndromes that result in both heart and forelimb defects.