2011 Research Annual Report

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Section of Neonatology, Perinatal and Pulmonary Biology

 

Division Data Summary

Research and Training Details

Number of Faculty49
Number of Joint Appointment Faculty1
Number of Research Fellows13
Number of Research Students12
Number of Support Personnel95
Direct Annual Grant Support$8,710,340
Direct Annual Industry Support$187,905
Peer Reviewed Publications97

Clinical Activities and Training

Number of Clinical Staff15
Number of Clinical Fellows14
Inpatient Encounters86,977
Outpatient Encounters2,168

Division Photo

Section of Neonatology, Perinatal and Pulmonary Biology

Row 1: S Wert, L Nommsen-Rivers, N Goyal, J Greenberg, J Whitsett, Y Xu, A Nathan

Row 2: H Kaplan, D Premer, S Kallapur, T Weaver, A Perl, T Kalin, S Glasser, A Kenny, B Johnson, J Bridges, M Ikegami, E Hall, V Narendran, S Merhar, K Melton C Valentine

Row 3: K Wikenheiser-Brokamp, T Suzuki, D Sinner, L Ward, K Schibler, A Jobe, N Hillman, V Kalinichenko, J Shannon, J Reuter, W Rice, S Hoath

Significant Publications

Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW deliveries at subspecialty perinatal centers via perinatal outreach. Pediatrics. 2011 Mar;127(3):487-93. Mar, 2011.
This work utilizes regional data from the greater Cincinnati area to demonstrate the importance of referral of “high risk” mothers to tertiary obstetrical centers for the care and delivery of their preterm infants.  Maternal, rather than infant transfer, reduces perinatal morbidity and mortality related to preterm birth. This publication highlights the benefits of our regionalized clinical program.
McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC; National Institutes of Health Rare Lung Diseases Consortium; MILES Trial Group. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 364(17):1595-606. Apr 28, 2011.
This is a landmark publication, demonstrating the first effective treatment for the life-threatening pulmonary complications of lymphangioleiomyomatosis (LAM).  It is a carefully controlled, double blind, multicenter study, led by Dr. McCormack (UC) and Dr. Trapnell (CCHMC-UC), began as a part of the “Rare Lung Disease Consortium” here at CCHMC.
Kamath BD, Marcotte MP, Defranco EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. Am J Obstet Gynecol. 204 (6):518.e1-518.e8. Jun, 2011.
It is increasingly clear that late preterm delivery poses significant risks to the newborn.  This work demonstrates increased pulmonary morbidity, admission to special care units for multiple complications of prematurity, in spite of documented pulmonary maturation, a finding of national significance in reducing the rate of preterm birth and associated complications that occur even in late “preterms.” This work demonstrates that pulmonary maturity is not sufficient to ensure neonatal outcomes comparable to infants born at term.
Kaplan HC, Lannon C, Walsh MC, Donovan EF; Ohio Perinatal Quality Collaborative. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 127(3):427-35. Mar, 2011.
Cooperation among Ohio delivery hospitals and the use of centralized databases, provide the infrastructure to document and reduce late onset sepsis in very preterm infants.  This work demonstrates the value of a multi-center improvement collaborative to improve neonatal outcomes and reduce health care costs.
Morrow AL, Meinzen-Derr J, Huang P, Schibler KR,  , Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants. J Pediatr. 158(5):745-51. May, 2011.
This work identifies secretor and nonsecretor status of the mother/infant dyad as an important risk factor for the necrotizing enterocolitis (NEC) and death of low birth weight/preterm infants.  It is the first genetic test that indicates the risk for severe outcomes for preterm infants, and provides support for the importance of the innate immune system and its likely interaction with the microbiome in the pathogenesis of NEC and neonatal sepsis.

Division Highlights

Beena Kamath, MD, MPH

Dr. Kamath, along with colleagues Emily DeFranco, DO, (Dept. of OB/GYN University of Cincinnati) and Michael Marcotte, MD (Dept. of OB/GYN Good Samaritan Hospital), reported important findings regarding previously unappreciated limitations of fetal lung maturity testing to predict readiness for postnatal life.

Noah Hillman, MD, Alan Jobe, MD, PhD, Machiko Ikegami, PhD, and Suhas Kallapur, MD Neonatal MRI Imaging

These investigators led a pre-clinical study of MRI imaging using a novel prototype MRI developed by Dr. Chuck Dumoulin and his colleagues in the CCHMC Imaging Research Center. Preterm lambs were delivered by Cesarean section, treated with pulmonary surfactant, stabilized on mechanical ventilation and subjected to sequential MRI imaging. Successful studies of brain, lung, and gastrointestinal structures were conducted. Findings are being applied toward development of a clinical MRI device scheduled for installation in the CCHMC NICU by January 2012.

James Greenberg, MD, Eric Hall, PhD, and Jareen Meinzen-Derr, PhD Infant Mortality Reduction

This group is working with the Anderson Center to support the CCHMC Community Health Strategic goal to reduce infant mortality in Hamilton County to the national average of 6.9/1000 live birth by 2015. They continue work on geographic analytic method to identify key “hot spots” for targeted interventions to reduce preterm birth through coordination of care.

Heather Kaplan, MD, Edward Donovan, MD, and Carole Lannon, PhD Multi-Institutional Quality Improvement to Reduce Late-Onset Sepsis

These investigators demonstrated the efficacy of a state-wide quality collaborative (Ohio Perinatal Quality Collaborative) to reduce infections in the NICU.

Division Collaboration

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Divisional faculty have close collaborations with faculty in multiple divisions within CCHMC, the University of Cincinnati, and with investigators throughout the world.

Faculty Members

Jeffrey A. Whitsett, MD, Professor
Co-Director, Perinatal Institute; Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Research Interests Lung Development; Surfactant
Henry T. Akinbi, MD, Associate Professor
Research Interests Neonatal Infections and Blood Transfusions
Laurel Bookman, MD, Assistant Professor
Research Interests Implementation Science, International Health
James Bridges, PhD, Instructor
Research Interests Hypoxia Inducible Factors and Downstream Target Genes in Chronic Lung Disease
Tanya E. Cahill, MD, Assistant Professor
Director, High Risk Infant Follow-Up Program
Research Interests Neonatal Abstinence Syndrome and High Risk Infant Follow-Up
Michael W. Crossman, MD, PhD, Assistant Professor
Research Interests Bioethics
Horacio Falciglia, MD, Professor Emeritus
Research Interests Seleniun Status and Neonatal Sepsis; Neonatal Mortality
Stephan W. Glasser, PhD, Associate Professor
Research Interests Gene Regulation in the Lung
James M. Greenberg, MD, Professor
Co-Director, Perinatal Institute; Director, Division of Neonatology
Research Interests Preterm Birth, Community Health, Pulmonary Vascular Development
Beth E. Haberman, MD, Assistant Professor
Medical Director, Cincinnati Children's NICU & Co-Medical Director, Mercy Anderson Hospital Nurseries
Research Interests Infant Follow-up
Eric Hall, PhD, Assistant Professor
Research Interests Biomedical Informatics
Noah H. Hillman, MD, Assistant Professor
Research Interests Pulmonary Physiology, Neonatal Resustitation, Lung Injury/Repair
Steven B. Hoath, MD, Professor
Medical Director, Skin Sciences Program
Research Interests Skin Development & Environmental Interactions
Machiko Ikegami, MD, PhD, Professor
Director, Surfactant and Metabolic Function Core
Research Interests Surfactant Metabolism; Lung Injury
Alan H. Jobe, MD, PhD, Professor
Director, Division of Perinatal Biology
Research Interests Injury and Repair of the Preterm Lung
Tanya V. Kalin, MD, PhD, Assistant Professor
Research Interests Transcriptional Regulation of Carcinogenesis and Radiation-Induced Lung Fibrosis
Vladimir V. Kalinichenko, MD, PhD, Associate Professor
Research Interests Fox Proteins in Lung Development
Suhas G. Kallapur, MD, Associate Professor
Director, Neonatology CME
Research Interests Fetal Inflammation/Physiology, Lung Development/Inflammation, BPD, Developmental Immunology
Beena Kamath, MD, MPH, Assistant Professor
Research Interests Neonatal Outcomes and Public Health; Fetal Lung Maturity; Global Health
Heather Kaplan, MD, MSCE, Assistant Professor
Research Interests Health Services Research; Improvement Science
Alan P. Kenny, MD, PhD, Instructor
Research Interests Molecular Development of the Foregut Organs
Paul S. Kingma, MD, PhD, Assistant Professor
Research Interests Innate Immune Systems; Cystic Fibrosis; Neonatal Infection
Thomas R. Korfhagen, MD, PhD, Professor
Research Interests Lung Defense
Timothy Le Cras, PhD, Associate Professor
Director of Admissions, Molecular & Developmental Biology Graduate Program
Research Interests Chronic Lung Diseases; Lung Development, Pulmonary Hypertension
Kristin R. Melton, MD, Associate Professor
Associate Director, Neonatal Fellowship Training Program
Research Interests Developmental Biology, Neural Crest Biology
Ardythe L. Morrow, PhD, Professor
Director, Center for Interdisciplinary Research in Human Milk and Lactation
Research Interests Molecular Epidemiology of Human Milk, Epidemiologic Methods, Prevention of Infectious Disease, Predictive Biomarkers of Neonatal Outcomes
Vivek Narendran, MD, MBA, Associate Professor
Medical Director, Univ. Hosp. NICU & Newborn Nursery; Medical Director, The Christ Hospital Nursery; Chair, Department of Pediatrics, the University Hospital
Research Interests C-PAP; Business Case for Quality Improvements; Preterm Infant Skin
Amy T. Nathan, MD, Assistant Professor
Medical Director, TriHealth Nurseries
Research Interests Immunobiology
Laurie A. Nommsen-Rivers, PhD, RD, IBCLC, Assistant Professor
Co-Chair, Seminar Series in Human Milk and Lactation
Research Interests Human Lactation and Breastfeeding
Anne-Karina Perl, PhD, Assistant Professor
Research Interests Alveolar Regneration and Bronchiolar Injury/Repair
John H. Reuter, MD, PhD, Associate Professor
Co-Medical Director, Bethesda North Hospital Nurseries
Research Interests
Ward R. Rice, MD, PhD, Professor
Director, Neonatal Fellowship Training Program; Director, Newborn Services, St. Elizabeth Medical Center
Research Interests Lung Development, Surfactant Biology
Kurt R. Schibler, MD, Associate Professor
Principal Investigator, NICHD Neonatal Research Network
Research Interests Neonatal Immunology, Necrotizing Enterocolitis
John M. Shannon, PhD, Professor
Director of Graduate Studies, Program in Molecular and Developmental Biology
Research Interests Lung Development, Foregut Embryology
Debora I. Sinner, PhD, Instructor
Research Interests Wnt Signaling and Sox Transcription Factors in Lung Development and Disease
Andrew P. South, MD, MPH, Assistant Professor
Research Interests Outcomes and Etiology of Gastroschisis, Epidemiology of Late-Preterm Birth
Jean J. Steichen, MD, Professor Emeritus
Research Interests Infant Follow-up
Takuji Suzuki, MD, PhD., Instructor
Research Interests Lung Immunology
Bruce C. Trapnell, MD, MS, Professor
Director, Rare Lung Diseases Network; Scientific Director, PAP Foundation; Co-Director, Cystic Fibrosis TDN Center
Research Interests Rare Lung Diseases; GM-CSF, Gene Therapy
Laura Ward, MD, Assistant Professor
Co-Medical Director, Mercy Anderson Hospital Nurseries
Research Interests Use of Human Milk in the NICU
Timothy E. Weaver, MS, PhD, Professor
Associate Director, Division of Pulmonary Biology; Co-Director, Molecular and Developmental Biology Program
Research Interests Pathogenesis of Interstitial Lung Diseases
Kathryn E. Wedig, MD, Associate Professor
Director, High Risk Clinic @ GSH; Medical Director, Mercy Hospital Fairfield
Research Interests Infant Follow-up, Neonatal Abstinence Syndrome
Susan E. Wert, PhD, Associate Professor
Director, Molecular Morphology Core, Division of Pulmonary Biology
Research Interests Lung Development, Molecular Morphology of the Lung, Ultrastructural Analysis of the Lung, Genetic Surfactant Disorders
Scott Wexelblatt, MD, Assistant Professor
Medical Director Regional Newborn Services; Co-Medical Director Bethesda North Hospital Nurseries
Research Interests Late Preterm Infant, Quality Improvement
Yan Xu, PhD, Associate Professor
Director, Microarray-Bioinformatics Core, Division of Pulmonary Biology
Research Interests Bioinformatics, Systems Biology, Transcriptional Network

Joint Appointment Faculty Members

Kathryn Wikenheiser-Brokamp, MD/PhD, Associate Professor
Pathology
Research Interests Pulmonary Pathology, Pediatric and Adult Lung Diseases

Clinical Staff Members

  • Stephen Bird, MD
  • Mary Burwinkel, MD
  • Thomas Catalanotto, MD
  • Christine Chappell, MD
  • Diane Donley, MD
  • Michelle French, MD
  • Pamela Holmes, MD
  • Katie Loudermilk, MD
  • Alisa McGill, MD
  • Miriam Peri, MD
  • Ajay Ponkshe, MD
  • Danna Premer, MD
  • John Robinson, MD
  • Deborah Rufner, MD
  • Kira Zimmerly, MD

Trainees

  • Thomas Acciani, BS, University of Illinois Urbana
  • Ceyda Acun, MD, PL6, George Washington University Hospital, Washington, DC
  • David Balli, BA, DePauw University, Greencastle, IN
  • Clare Berry, PhD, University of Western Australia
  • Valerie Besnard, PhD, Universite Rene Descartes - Paris V
  • Craig Bolte, PhD, University of Cincinnati
  • Gang Chen, MS , PhD, Yangzhou University, China
  • Elizabeth Davies, BSc, University of Southampton, UK
  • David Dewar, MD, PL4, Michigan State University, East Lansing, MI
  • Jill Fritz, BS, Miami University, Oxford, OH
  • Tate Gisslen, MD, PL4, University of Minnesota Medical School, Minneapolis, MN
  • Corryn Greenwood, MD, PL5, Mayo Clinic School of Graduate Medical Education, Rochester, NY
  • David Hahn, BS, Northern Kentucky University
  • Hans Michael Haitchi, MD, PhD, University of Southampton, UK
  • Jamie Havrilak, BS, Susquehanna University, Selinsgrove, PA
  • Prakruti Jambula, MD, PL6, Univ. of Oklahoma HSC, Oklahoma City, OK
  • Venkata Kuppala, MD, PL6, The Cleveland Clinic, Cleveland, OH
  • Ryosuke Kusano, MD, Kyoto Prefectural University of Medicine, Japan
  • Audrone LaForgia, MD, PL5, EVMS/Children's Hospital of the King's Daughters, Norfolk, VA
  • Alexander Lange, PhD, University of Cincinnati
  • Karunyakanth Mandapaka, MS, University of Cincinnati
  • Rafael Mena, MD, PL6, Cincinnati Children's Hospital Medical Center - UCMC, Cincinnati, OH
  • Stephanie Merhar, MD, PL6, Cincinnati Children's Hospital Medical Center - UCMC, Cincinnati, OH
  • Anne Minter, BA, Miami University, Oxford, OH
  • Nagendra Monangi, MD, PL5, Osmania Medical College, Hyderabad, India; University of South Alabama, Mobile, AL
  • Elizabeth Mushaben, BS, College of Mount St. Joseph
  • Gaston Ofman, MD, Favaloro University School of Medicine, Buenos Aires, Argentina
  • Laurent Plantier, MD, PhD, Universite of Paris, France
  • Malia Ray, MD, University of Louisville, Kentucky
  • Xiaomeng Ren, MD, PhD, Chinese Academy of Medical Sciences and Peking Union Medical College
  • Christine Sarlone, MD, PL6, Univ. of Tennessee HSC, Memphis, TN
  • Atsuyasu Sato, MD, PhD, Kyoto University, Japan
  • Jennifer Smith, MD, PL4, University of Louisville School of Medicine, Louisville, KY
  • Kevin Stutey, MD, PL4, Eastern Virginia Medical School, Norfolk, VA
  • Diana Taft, BA, Cornell University, Ithaca, NY
  • David Tompkins, MS, University of Texas
  • Elizabeth Wetzel, MD, MSc, PL6, Indiana Univ. SOM, Indianapolis, IN
  • Tim Wolfs, PhD, Royal Netherlands Academy of Arts and Sciences, The Netherlands
  • Qing Yan Xie, BA, MS, Beijing University of Technology, Wuhan, China
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Significant Accomplishments

Diagnosis and Treatment of Pulmonary Alveolar Proteinosis 

National Institutes of Health funding was approved for Bruce Trapnell, MD, MS, and coworkers who have developed lung markers for the diagnosis of hereditary and acquired disorders of surfactant metabolism.  They have found that pulmonary alveolar proteinosis (PAP) is a heterogeneous disorder caused, in part, by autoimmunity against GM-CSF and by mutations in GM-CSF receptors, enabling correct diagnosis and treatment of these life-threatening disorders.  New treatment modalities, including gene therapy, are being tested in the clinics.

Pathogenesis of Interstitial Lung Disease and Emphysema

New NIH funding was approved for studies, led by Timothy Weaver, PhD, to identify the mechanisms causing lung remodeling in idiopathic pulmonary fibrosis associated with mutations in the surfactant protein-C gene, a cause of life-threatening pulmonary disease in children and adults.  Anne Karina Perl, PhD, leads the work identifying the role of growth factors to enhance lung growth in children and adults with emphysema.

Genetic Networks Linking Mucus Metaplasia and Inflammation

NIH funding was approved for the study of a new genetic network regulating airway epithelial cell differentiation and mucus production related to cystic fibrosis, asthma and COPD in work led by Thomas Korfhagen, MD, PhD, and Jeffrey Whitsett, MD.  A master regulator of mucus production and its impact on lung structure and inflammation are being studied as a target for therapy for chronic lung diseases in children and adults.

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Division Publications

  1. Akeson A, Herman A, Wiginton D, Greenberg J. Endothelial cell activation in a VEGF-A gradient: relevance to cell fate decisions. Microvasc Res. 2010; 80:65-74.
  2. Akinbi H, Meinzen-Derr J, Auer C, Ma Y, Pullum D, Kusano R, Reszka KJ, Zimmerly K. Alterations in the host defense properties of human milk following prolonged storage or pasteurization. J. Pediatr. Gastroenterol. Nutr.. 2010; 51:347-52.
  3. Ambalavanan N, Walsh M, Bobashev G, Das A, Levine B, Carlo WA, Higgins RD, Collaborators:, Jobe AH, Schibler K. Intercenter differences in bronchopulmonary dysplasia or death among very low birth weight infants. Pediatrics. 2011; 127:e106-16.
  4. Balli D, Zhang Y, Snyder J, Kalinichenko VV, Kalin TV. Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer Res. 2011; 71:40-50.
  5. Bell EF, Hansen NI, Morriss FH, Jr., Stoll BJ, Ambalavanan N, Gould JB, Laptook AR, Walsh MC, Carlo WA, Shankaran S, Das A, Higgins RD, Collaborators:, Jobe AH. Impact of timing of birth and resident duty-hour restrictions on outcomes for small preterm infants. Pediatrics. 2010; 126:222-31.
  6. Benjamin DK, Jr., Stoll BJ, Gantz MG, Walsh MC, Sanchez PJ, Das A, Shankaran S, Higgins RD, Auten KJ, Miller NA, Walsh TJ, Laptook AR, Carlo WA, Kennedy KA, Finer NN, Duara S, Schibler K, Chapman RL, Van Meurs KP, Frantz ID, 3rd, Phelps DL, Poindexter BB, Bell EF, O'Shea TM, Watterberg KL, Goldberg RN, Collaborator:, Jobe AH. Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics. 2010; 126:e865-73.
  7. Binder S, Hill K, Meinzen-Derr J, Greenberg JM, Narendran V. Increasing VLBW deliveries at subspecialty perinatal centers via perinatal outreach. Pediatrics. 2011; 127:487-93.
  8. Boghossian NS, Hansen NI, Bell EF, Stoll BJ, Murray JC, Laptook AR, Shankaran S, Walsh MC, Das A, Higgins RD, Collaborators:, Jobe AH, Schibler K. Survival and morbidity outcomes for very low birth weight infants with Down syndrome. Pediatrics. 2010; 126:1132-40.
  9. Bookman L, Engmann C, Srofenyoh E, Enweronu-Laryea C, Owen M, Randolph G, Price W, Barker P. Educational impact of a hospital-based neonatal resuscitation program in Ghana. Resuscitation. 2010; 81:1180-2.
  10. Bookman L, Troy R, McCaffrey M, Randolph G. Using quality-improvement methods to reduce variation in surfactant administration. Qual Saf Health Care. 2010; 19:e23.
  11. Boppana SB, Ross SA, Shimamura M, Palmer AL, Ahmed A, Michaels MG, Sanchez PJ, Bernstein DI, Tolan RW, Jr., Novak Z, Chowdhury N, Britt WJ, Fowler KB, Collaborator:, Schibler K. Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med. 2011; 364:2111-8.
  12. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA. Cell Plasticity in Lung Injury and Repair: Report from an NHLBI Workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011; 8:215-22.
  13. Chantry CJ, Nommsen-Rivers LA, Peerson JM, Cohen RJ, Dewey KG. Excess weight loss in first-born breastfed newborns relates to maternal intrapartum fluid balance. Pediatrics. 2011; 127:e171-9.
  14. Chavez Valdez R, Ahlawat R, Wills-Karp M, Nathan A, Ezell T, Gauda EB. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Pediatr. 2011; 158:57-64, 64 e1.
  15. Chen S, Rong M, Platteau A, Hehre D, Smith H, Ruiz P, Whitsett J, Bancalari E, Wu S. CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2011; 300:L330-40.
  16. Collins JJ, Kallapur SG, Knox CL, Nitsos I, Polglase GR, Pillow JJ, Kuypers E, Newnham JP, Jobe AH, Kramer BW. Inflammation in fetal sheep from intra-amniotic injection of Ureaplasma parvum. Am J Physiol Lung Cell Mol Physiol. 2010; 299:L852-60.
  17. Dando SJ, Nitsos I, Newnham JP, Jobe AH, Moss TJ, Knox CL. Maternal administration of erythromycin fails to eradicate intrauterine ureaplasma infection in an ovine model. Biol Reprod. 2010; 83:616-22.
  18. D'Angio CT, Heyne RJ, O'Shea TM, Schelonka RL, Shankaran S, Duara S, Goldberg RN, Stoll BJ, Van Meurs KP, Vohr BR, Das A, Li L, Burton RL, Hastings B, Phelps DL, Sanchez PJ, Carlo WA, Stevenson DK, Higgins RD, Collaborator:, Jobe AH. Heptavalent pneumococcal conjugate vaccine immunogenicity in very-low-birth-weight, premature infants. Pediatr Infect Dis J. 2010; 29:600-6.
  19. Davis AS, Hintz SR, Van Meurs KP, Li L, Das A, Stoll BJ, Walsh MC, Pappas A, Bell EF, Laptook AR, Higgins RD, Collaborator:, Schibler K. Seizures in extremely low birth weight infants are associated with adverse outcome. J Pediatr. 2010; 157:720-5 e1-2.
  20. Davis JA, Visscher MO, Wickett RR, Hoath SB. Role of TNF-alpha polymorphism -308 in neurosensory irritation. Int J Cosmet Sci. 2011; 33:105-12.
  21. Davis JA, Visscher MO, Wickett RR, Hoath SB. Influence of tumour necrosis factor-alpha polymorphism-308 and atopy on irritant contact dermatitis in healthcare workers. Contact Dermatitis. 2010; 63:320-32.
  22. Donovan EF, Besl J, Paulson J, Rose B, Iams J. Infant death among Ohio resident infants born at 32 to 41 weeks of gestation. Am J Obstet Gynecol. 2010; 203:58 e1-5.
  23. Duvoix A, Miranda E, Perez J, Sorensen GL, Holmskov U, Trapnell BC, Madsen J, Clark HW, Edwards LD, Miller BE, Tal-Singer RM, Lomas DA. Evaluation of full-length, cleaved and nitrosylated serum surfactant protein D as biomarkers for COPD. COPD. 2011; 8:79-95.
  24. Ehrenkranz RA, Das A, Wrage LA, Poindexter BB, Higgins RD, Stoll BJ, Oh W, Collaborators:, Jobe AH, Schibler K. Early nutrition mediates the influence of severity of illness on extremely LBW infants. Pediatr Res. 2011; 69:522-9.
  25. Farkas T, Cross RW, Hargitt E, 3rd, Lerche NW, Morrow AL, Sestak K. Genetic diversity and histo-blood group antigen interactions of rhesus enteric caliciviruses. J Virol. 2010; 84:8617-25.
  26. Fuller KK, Richie DL, Feng X, Krishnan K, Stephens TJ, Wikenheiser-Brokamp KA, Askew DS, Rhodes JC. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus. Mol Microbiol. 2011; 79:1045-62.
  27. Galambos C, Levy H, Cannon CL, Vargas SO, Reid LM, Cleveland R, Lindeman R, deMello DE, Wert SE, Whitsett JA, Perez-Atayde AR, Kozakewich H. Pulmonary pathology in thyroid transcription factor-1 deficiency syndrome. Am J Respir Crit Care Med. 2010; 182:549-54.
  28. Goldenberg RL, McClure EM, Macguire ER, Kamath BD, Jobe AH. Lessons for low-income regions following the reduction in hypertension-related maternal mortality in high-income countries. Int J Gynaecol Obstet. 2011; 113:91-5.
  29. Gower WA, Wert SE, Ginsberg JS, Golan A, Whitsett JA, Nogee LM. Fatal familial lung disease caused by ABCA3 deficiency without identified ABCA3 mutations. J Pediatr. 2010; 157:62-8.
  30. Hagaman JT, Panos RJ, McCormack FX, Thakar CV, Wikenheiser-Brokamp KA, Shipley RT, Kinder BW. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases. Chest. 2011; 139:353-60.
  31. Han X, Gilbert S, Groschwitz K, Hogan S, Jurickova I, Trapnell B, Samson C, Gully J. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010; 59:1066-78.
  32. Hardie WD, Hagood JS, Dave V, Perl AK, Whitsett JA, Korfhagen TR, Glasser S. Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle. 2010; 9:2769-76.
  33. Hillman NH, Kallapur SG, Pillow JJ, Nitsos I, Polglase GR, Ikegami M, Jobe AH. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res. 2010; 11:151.
  34. Hillman NH, Polglase GR, Pillow JJ, Saito M, Kallapur SG, Jobe AH. Inflammation and lung maturation from stretch injury in preterm fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011; 300:L232-41.
  35. Hintz SR, Kendrick DE, Wilson-Costello DE, Das A, Bell EF, Vohr BR, Higgins RD, Collaborator:, Jobe AH. Early-childhood neurodevelopmental outcomes are not improving for infants born at ‹ 25 weeks' gestational age. Pediatrics. 2011; 127:62-70.
  36. Isemann B, Meinzen-Derr J, Akinbi H. Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. J Perinatol. 2011; 31:25-9.
  37. Jobe AH, Kallapur SG. Long term consequences of oxygen therapy in the neonatal period. Semin Fetal Neonatal Med. 2010; 15:230-5.
  38. Kalin TV, Ustiyan V, Kalinichenko VV. Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models. Cell Cycle. 2011; 10:396-405.
  39. Kamath BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Neonatal Mortality From Respiratory Distress Syndrome: Lessons for Low-Resource Countries. Pediatrics. 2011; 127:1139-1146.
  40. Kamath BD, Marcotte MP, DeFranco EA. Neonatal morbidity after documented fetal lung maturity in late preterm and early term infants. American Journal of Obstetrics and Gynecology. 2011; 204:518.e1-8.
  41. Kaplan HC, Brady PW, Dritz MC, Hooper DK, Linam WM, Froehle CM, Margolis P. The influence of context on quality improvement success in health care: a systematic review of the literature. Milbank Q. 2010; 88:500-59.
  42. Kaplan HC, Lannon C, Walsh MC, Donovan EF. Ohio statewide quality-improvement collaborative to reduce late-onset sepsis in preterm infants. Pediatrics. 2011; 127:427-35.
  43. Kaplan HC, Lorch SA, Pinto-Martin J, Putt M, Silber JH. Assessment of surfactant use in preterm infants as a marker of neonatal intensive care unit quality. BMC Health Serv Res. 2011; 11:22.
  44. Kaplan HC, Tabangin ME, McClendon D, Meinzen-Derr J, Margolis PA, Donovan EF. Understanding variation in vitamin A supplementation among NICUs. Pediatrics. 2010; 126:e367-73.
  45. Kemp MW, Saito M, Newnham JP, Nitsos I, Okamura K, Kallapur SG. Preterm birth, infection, and inflammation advances from the study of animal models. Reprod Sci. 2010; 17:619-28.
  46. Kemp MW, Saito M, Nitsos I, Jobe AH, Kallapur SG, Newnham JP. Exposure to in utero lipopolysaccharide induces inflammation in the fetal ovine skin. Reprod Sci. 2011; 18:88-98.
  47. King BA, Kingma PS. Surfactant protein D deficiency increases lung injury during endotoxemia. Am J Respir Cell Mol Biol. 2011; 44:709-15.
  48. Knox CL, Dando SJ, Nitsos I, Kallapur SG, Jobe AH, Payton D, Moss TJ, Newnham JP. The severity of chorioamnionitis in pregnant sheep is associated with in vivo variation of the surface-exposed multiple-banded antigen/gene of Ureaplasma parvum. Biol Reprod. 2010; 83:415-26.
  49. Kuang Z, Hao Y, Hwang S, Zhang S, Kim E, Akinbi HT, Schurr MJ, Irvin RT, Hassett DJ, Lau GW. The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol. 2011; 79:1220-35.
  50. Kulkarni RM, Herman A, Ikegami M, Greenberg JM, Akeson AL. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev. 2011; 128:29-40.
  51. Kwon JM, Guillet R, Shankaran S, Laptook AR, McDonald SA, Ehrenkranz RA, Tyson JE, O'Shea TM, Goldberg RN, Donovan EF, Fanaroff AA, Poole WK, Higgins RD, Walsh MC. Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial. J Child Neurol. 2011; 26:322-8.
  52. Laughon MM, Langer JC, Bose CL, Smith PB, Ambalavanan N, Kennedy KA, Stoll BJ, Buchter S, Laptook AR, Ehrenkranz RA, Cotten CM, Wilson-Costello DE, Shankaran S, Meurs KP, Davis AS, Gantz MG, Finer NN, Yoder BA, Faix RG, Carlo WA, Schibler KR, Newman NS, Rich W, Das A, Higgins RD, Walsh MC, Collaborator:, Narendran V. Prediction of Bronchopulmonary Dysplasia by Postnatal Age in Extremely Premature Infants. Am J Respir Crit Care Med. 2011; 183:1715-1722.
  53. Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol. 2011; 300:L414-21.
  54. Lee AJ, Lambermont VA, Pillow JJ, Polglase GR, Nitsos I, Newnham JP, Beilharz MW, Kallapur SG, Jobe AH, Kramer BW. Fetal responses to lipopolysaccharide-induced chorioamnionitis alter immune and airway responses in 7-week-old sheep. Am J Obstet Gynecol. 2011; 204:364 e17-24.
  55. Lee TC, Lim FY, Keswani SG, Frischer JS, Haberman B, Kingma PS, Habli M, Jaekle RK, Sharp G, Kline-Fath B, Rubio EI, Calvo M, Guimaraes C, Crombleholme TM. Late gestation fetal magnetic resonance imaging-derived total lung volume predicts postnatal survival and need for extracorporeal membrane oxygenation support in isolated congenital diaphragmatic hernia. J Pediatr Surg. 2011; 46:1165-71.
  56. Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. 2010; 137:3953-63.
  57. Luisetti M, Kadija Z, Mariani F, Rodi G, Campo I, Trapnell BC. Therapy options in pulmonary alveolar proteinosis. Ther Adv Respir Dis. 2010; 4:239-48.
  58. Luisetti M, Kroneberg P, Suzuki T, Kadija Z, Muellinger B, Campo I, Gleske J, Rodi G, Zimlich WC, Mariani F, Ferrari F, Frey M, Trapnell BC. Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer. Pulm Pharmacol Ther. 2011; 24:123-7.
  59. Madala SK, Maxfield MD, Davidson CR, Schmidt SM, Garry D, Ikegami M, Hardie WD, Glasser SW. Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice. Pulm Med. 2011; 2011:653524.
  60. McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP, 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 2011; 364:1595-606.
  61. Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol. 2010; 177:1503-13.
  62. Morrow AL, Meinzen-Derr J, Huang P, Schibler KR, Cahill T, Keddache M, Kallapur SG, Newburg DS, Tabangin M, Warner BB, Jiang X. Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants. J Pediatr. 2011; 158:745-51.
  63. Nommsen-Rivers LA, Chantry CJ, Peerson JM, Cohen RJ, Dewey KG. Delayed onset of lactogenesis among first-time mothers is related to maternal obesity and factors associated with ineffective breastfeeding. Am J Clin Nutr. 2010; 92:574-84.
  64. Nommsen-Rivers LA, Cohen RJ, Chantry CJ, Dewey KG. The Infant Feeding Intentions scale demonstrates construct validity and comparability in quantifying maternal breastfeeding intentions across multiple ethnic groups. Matern Child Nutr. 2010; 6:220-7.
  65. Nylund CM, D'Mello S, Kim MO, Bonkowski E, Dabritz J, Foell D, Meddings J, Trapnell BC, Denson LA. Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease. J Pediatr Gastroenterol Nutr. 2011; 52:542-8.
  66. Oh W, Fanaroff AA, Carlo WA, Donovan EF, McDonald SA, Poole WK. Effects of delayed cord clamping in very-low-birth-weight infants. J Perinatol. 2011; 31 Suppl 1:S68-71.
  67. Pappas A, Shankaran S, Laptook AR, Langer JC, Bara R, Ehrenkranz RA, Goldberg RN, Das A, Higgins RD, Tyson JE, Walsh MC, Collaborators:, Jobe AH, Schibler K. Hypocarbia and adverse outcome in neonatal hypoxic-ischemic encephalopathy. J Pediatr. 2011; 158:752-758 e1.
  68. Pasha O, Goldenberg RL, McClure EM, Saleem S, Goudar SS, Althabe F, Patel A, Esamai F, Garces A, Chomba E, Mazariegos M, Kodkany B, Belizan JM, Derman RJ, Hibberd PL, Carlo WA, Liechty EA, Hambidge KM, Buekens P, Wallace D, Howard-Grabman L, Stalls S, Koso-Thomas M, Jobe AH, Wright LL. Communities, birth attendants and health facilities: a continuum of emergency maternal and newborn care (the Global Network's EmONC trial). BMC Pregnancy Childbirth. 2010; 10:82.
  69. Pastva AM, Walker JK, Maddox LA, Mukherjee S, Giamberardino C, Hsia B, Potts E, Zhu H, Degan S, Sunday ME, Lawson BL, Korfhagen TR, Schwartz DA, Eu JP, Foster WM, McMahon TJ, Que L, Wright JR. Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. Am J Respir Cell Mol Biol. 2011; 44:175-84.
  70. Perl AK, Riethmacher D, Whitsett JA. Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis. Am J Respir Crit Care Med. 2011; 183:511-21.
  71. Polglase GR, Dalton RG, Nitsos I, Knox CL, Pillow JJ, Jobe AH, Moss TJ, Newnham JP, Kallapur SG. Pulmonary vascular and alveolar development in preterm lambs chronically colonized with Ureaplasma parvum. Am J Physiol Lung Cell Mol Physiol. 2010; 299:L232-41.
  72. Privette Vinnedge LM, McClaine R, Wagh PK, Wikenheiser-Brokamp KA, Waltz SE, Wells SI. The human DEK oncogene stimulates beta-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene. 2011; 30:2741-52.
  73. Ren X, Zhang Y, Snyder J, Cross ER, Shah TA, Kalin TV, Kalinichenko VV. Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair. Mol Cell Biol. 2010; 30:5381-93.
  74. Rich WD, Auten KJ, Gantz MG, Hale EC, Hensman AM, Newman NS, Finer NN, Collaborators:, Jobe AH, Schibler K, Narendran V. Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollment. Pediatrics. 2010; 126:e215-21.
  75. Ridsdale R, Na CL, Xu Y, Greis KD, Weaver T. Comparative proteomic analysis of lung lamellar bodies and lysosome-related organelles. PLoS One. 2011; 6:e16482.
  76. Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Kohler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med. 2010; 16:1141-6.
  77. Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. Am J Respir Crit Care Med. 2010; 182:49-61.
  78. Sandell LL, Iulianella A, Melton KR, Lynn M, Walker M, Inman KE, Bhatt S, Leroux-Berger M, Crawford M, Jones NC, Dennis JF, Trainor PA. A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis. 2011; 49:342-59.
  79. Sato A, Schehr A, Ikegami M. Leptin does not influence surfactant synthesis in fetal sheep and mice lungs. Am J Physiol Lung Cell Mol Physiol. 2011; 300:L498-505.
  80. Schelonka RL, Maheshwari A, Carlo WA, Taylor S, Hansen NI, Schendel DE, Thorsen P, Skogstrand K, Hougaard DM, Higgins RD, Collaborators:, Jobe AH, Narendran V. T cell cytokines and the risk of blood stream infection in extremely low birth weight infants. Cytokine. 2011; 53:249-55.
  81. Shah TA, Hillman NH, Nitsos I, Polglase GR, Pillow JJ, Newnham JP, Jobe AH, Kallapur SG. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr Res. 2010; 68:210-5.
  82. Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011; 127:254-61, 261 e1-6.
  83. Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010; 126:910-6.
  84. Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011; 470:105-9.
  85. Srikiatkhachorn A, Chintapalli J, Liu J, Jamaluddin M, Harrod KS, Whitsett JA, Enelow RI, Ramana CV. Interference with intraepithelial TNF-alpha signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection. Viral Immunol. 2010; 23:639-45.
  86. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, Hale EC, Newman NS, Schibler K, Carlo WA, Kennedy KA, Poindexter BB, Finer NN, Ehrenkranz RA, Duara S, Sanchez PJ, O'Shea TM, Goldberg RN, Van Meurs KP, Faix RG, Phelps DL, Frantz ID, 3rd, Watterberg KL, Saha S, Das A, Higgins RD, Collaborator:, Jobe AH. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010; 126:443-56.
  87. Stoll BJ, Hansen NI, Sanchez PJ, Faix RG, Poindexter BB, Van Meurs KP, Bizzarro MJ, Goldberg RN, Frantz ID, 3rd, Hale EC, Shankaran S, Kennedy K, Carlo WA, Watterberg KL, Bell EF, Walsh MC, Schibler K, Laptook AR, Shane AL, Schrag SJ, Das A, Higgins RD. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics. 2011; 127:817-26.
  88. Suzuki T, Sakagami T, Young LR, Carey BC, Wood RE, Luisetti M, Wert SE, Rubin BK, Kevill K, Chalk C, Whitsett JA, Stevens C, Nogee LM, Campo I, Trapnell BC. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010; 182:1292-304.
  89. Valentine CJ, Morrow G, Fernandez S, Gulati P, Bartholomew D, Long D, Welty SE, Morrow AL, Rogers LK. Docosahexaenoic Acid and Amino Acid Contents in Pasteurized Donor Milk are Low for Preterm Infants. J Pediatr. 2010; 157:906-10.
  90. Visscher MO, Robinson M, Fugit B, Rosenberg RJ, Hoath SB, Randall Wickett R. Amputee skin condition: occlusion, stratum corneum hydration and free amino acid levels. Arch Dermatol Res. 2011; 303:117-24.
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  92. Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol. 2010; 347:301-14.
  93. Watanabe M, Uchida K, Nakagaki K, Trapnell BC, Nakata K. High avidity cytokine autoantibodies in health and disease: pathogenesis and mechanisms. Cytokine Growth Factor Rev. 2010; 21:263-73.
  94. Wolfs TG, Kallapur SG, Polglase GR, Pillow JJ, Nitsos I, Newnham JP, Chougnet CA, Kroon E, Spierings J, Willems CH, Jobe AH, Kramer BW. IL-1alpha mediated chorioamnionitis induces depletion of FoxP3+ cells and ileal inflammation in the ovine fetal gut. PLoS One. 2011; 6:e18355.
  95. Wu H, Suzuki T, Carey B, Trapnell BC, McCormack FX. Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages. J Biol Chem. 2011; 286:14932-40.
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Grants, Contracts, and Industry Agreements

Grant and Contract AwardsAnnual Direct / Project Period Direct

Bridges, J

Cystic Fibrosis Foundation Research Development Program (Project 4)
07/01/071-06/30/11$40,000

Glasser, S

Role of Surfactant Protein-C and Innate Lung Defense
R01 HL 05004608/01/09-07/31/13$250,000

Hillman, N

Lung Injury with Resuscitation of the Preterm
K08 HL 09708508/01/09-07/31/14$121,000

Ikegami, M

Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
R01 HL 09546404/01/09-03/31/13$250,000
Efficacy of SP-D Containing Surfactant for Treatment of Premature Newborns
06/01/09-05/31/12$94,764

Jobe, A

Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease (Jobe/Kallapur)
R01 HL 09706409/24/09-07/31/13$350,495
Biomarkers of Immunologic Function and Preterm Respiratory Outcomes (Jobe/Chougnet)
U01 HL 10180005/01/10-04/30/15$346,019
Jobe, ACore$152,329
Chougnet, CProject$92,592
Kingma, PProject$20,266
Young, LProject$49,538
Morrow, AProject$30,933
Biomarkers of Immunologic Function and Preterm Respiratory Outcomes
U01 HL 10179412/01/10-04/30/12$25,574

Kalin, T

Role of Foxm1 in Lung Cancer Microenvironment
R01 CA 14272407/01/10-06/30/15$207,500
Role of Foxm1 in the Pathogenesis of Prostate Cancer
W81XWH091038907/01/09-06/30/12$74,888

Kalinichenko, V

Foxf1 Transcription Factor in Development of Pulmonary Capillaries
R01 HL 08415105/01/11-04/30/15$250,000

Kallapur, S

Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis
R01 HD 05786902/03/09-01/31/14$241,397

Kenny, A

Secreted BMP Antagonists in Foregut Organ Development
K08 HL 10566112/08/10-11/30/15$121,300

Kingma, P

Surfactant Protein D in Pulmonary and Systemic Host Defense
K08 HL 08950507/01/08-06/30/13$120,850

Korfhagen, T

RELM Peptides Alter Lung Defense
R21 HL 08359909/01/09-08/31/11$150,000

LeCras, T.

Impact of Early Life Diesel Exposure on Immune Patterning and Lung Structure/Function (LeCras/Hershey)
R01 HL 09713509/01/09-07/31/14$347,205
LeCras, T$127,047
Hershey, G$220,158
Pathogenesis of Neonatal Lung Disease
01/01/07-12/31/11$90,909

Morrow, A

Novel Genetic and Salivary Glycan Biomarkers for Risk of NEC in ELBW Infants
R01 HD 05914001/15/09-12/31/13$513,785
The Role of Human Milk in Infant Nutrition and Health
P01 HD 01302108/01/09-07/31/14$972,187
Jiang, XiCore D$85,727
Jiang, XiProject 2$111,904
Cincinnati Center for Clinical and Translational Sciences and Training (Design, Biostatistics & Ethics)
UL1 RR 02631404/03/09-03/31/14$87,392

Nommsen-Rivers, L

Antidepressant Therapy in Breastfeeding Mothers
07/01/10-06/30/11$90,000
Maternal Metabolic Health and Delayed Lactogenesis
01/15/11-06/30/11$49,986
Mediating Factors in the Relationship between Obesity and Poor Lactation Outcomes
R21 HD 06327509/07/10-08/31/12$238,074

Perl, A

FGF and PDGF Regulate Myofibroblast Differentiation in Alveolar Regeneration
R01 HL 10400307/01/10-06/30/14$250,000
Role of EGF Recptor Regerating Airway Epithelium and Airway Wall Thickening
07/01/09-06/30/11$40,000

Schibler, K

NICHD Cooperative Multicenter Neonatal Research Network
U10 HD 02785304/01/11-03/31/16$200,000
NICHD Cooperative Multicenter Neonatal Research Network Capitation
U10 HL 02785304/01/11-03/31/16$57,870

Shannon, J

LPCAT1 is Essential for Perinatal Lung Function and Survival
R01 HL 09831907/01/10-06/30/14$317,457
Role of HIF-1alpha in Fetal Lung Epithelial Differentiation
R01 HL 08437602/01/07-01/31/12$358,040

Trapnell, B

Macrophage-based Human Gene Therapy for Hereditary PAP
R21 HL 10613412/15/10-11/30/12$125,000
QUANTitative Chest Computed Tomography Unmasking Emphysema Progression in Alpha-1 Antitrypsin Deficiency (QUANTUM-1)
07/01/10-06/30/11$14,577
Role of Anti-GM-CSF Antibodies in Myeloid Cell Function and Innate Immunity
R01 HL 08545304/01/11-03/31/16$250,000

Weaver, T

Role of SFTPC in Pathogenesis of Interstitial Lung Disease
R01 HL 08649212/01/08-11/30/13$290,155

Whitsett, J

Pulmonary and Cardiovascular Development Training Grant
T32 HL 00775207/01/09-06/30/14$250,879
Reagents for Detection and Isolation of Pulmonary Progenitor Cell Populations
RC1 HL10037109/30/09-08/31/11$107,229
Transcriptional Control of Respiratory Epithelial Progenitor Cells
R01 HL 09015609/28/07-06/30/11$381,790
Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelial Cells
R01 HL 09558004/01/09-03/31/13$319,763
Unbiased Genome-Wide Screen to Identify Genes Regulating Mucous Cell Hyperplasia
RC1 HL 10031509/01/09-08/31/11$270,508
ABCA3 and Alveolar Homeostasis
R01 HL 08561007/10/06-06/30/11$313,747
Cystic Fibrosis Foundation Research Development Program (Core 1)
07/01/07-06/30/11$50,000

Xu, Y

Cystic Fibrosis Foundation Research Development Program (Project 3)
07/01/07-06/30/11$80,000
Current Year Direct$8,710,340
Industry Contracts

Ikegami, M

$133,447

Trapnell, B

$54,458
Current Year Direct Receipts$187,905
Total$8,898,245
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