Division Data Summary
Research and Training Details
|Number of Faculty||14|
|Number of Research Students||1|
|Number of Support Personnel||29|
|Direct Annual Grant Support||$1,220,631|
|Direct Annual Industry Support||$149,455|
|Peer Reviewed Publications||29|
Clinical Activities and Training
|Number of Clinical Staff||50|
|Number of Clinical Fellows||10|
Row 1: S Rose, A Shah, D Elder
Row 2: P Stenger, N Yayah-Jones, B Freedman, N Crimmins, S Lawson, J Katz
Row 3: P Backeljauw, D Klein, S Handwerger, L Dolan, M Rutter
Etiologic Approach to the Classification of Diabetes
In 1997 the American Diabetes Association presented a framework for the classification of the types of diabetes based on etiology. To date, no one has attempted to operationalize these definitions. To achieve this goal, the SEARCH for Diabetes in Youth Study assessed clinical and biochemical data from 2,291 participants attempting to define diabetes type by etiology. Four main categories were established: autoimmune plus insulin sensitive; autoimmune plus insulin resistant; non-autoimmune insulin sensitive; non-autoimmune insulin resistant. This classification offers researchers and clinicians a practical application of the ADA diagnostic criteria and identifies groups of youth in whom further research studies are required to define their type of diabetes.
Racial Differences in Arterial Stiffness among Youth with Diabetes
Adult studies demonstrate African-Americans with type 2 diabetes (T2D) have an increased risk to develop stroke and myocardial infarction compared to Caucasians. Whether similar racial disparities exist in adolescents to suggest African-American youth with T2D are at increased risk to develop early cardiovascular (CV) complications from T2D is not known. To answer this question, a team led by Amy Shah, MD, recruited 215 youth with T2D (55 percent African-American, 65 percent female) in a cross-sectional study and measured arterial stiffness, a known precursor atherosclerosis. They found compared to age and BMI matched Caucasians, African-Americans adolescents with T2D had increased arterial stiffness. Additionally, the investigators demonstrated the CV risk factors that were associated with arterial stiffness differed among the two race groups. In Caucasians, blood pressure appeared to be the largest risk factor contributing to arterial stiffness while in African-Americans age was the largest contributor. Other important risk factors that differed among groups were lipids and T2D duration. These findings suggest that race-specific risk factor modification approaches should be considered to limit future CV complications associated with T2D.
Regulation of Human Placental Development
Little is known about the transcription factors (TFs) and signaling molecules that are critical for the differentiation of placenta stem cells (cytotrophoblast cells (CTB)) to mature syncytiotrophoblast cells (STB). These cells, which form of the outer layer of placenta villi, are responsible for most functions of the mature placenta, including the synthesis and secretion of hormones and growth factors that modulate fetal growth and development and the transport of nutrients and gases between the maternal and fetal circulations. Recent studies by Stuart Handwerger, MD, and colleagues have demonstrated that the TFs TFAP2A, NR2F2 and FOXF1 are critical for the differentiation of human CTB to a STB phenotype. Binding sites for the TFs were detected on the promoter regions of many genes induced during CTB differentiation; and overexpression of the TFs induced the expression of many of the up-regulated genes. Moreover, silencing of the genes for the three TFs with lentiviruses expressing shRNAs for the factors attenuated CTB differentiation. Immunohistochemical analysis of human placenta sections from normal and pathologic pregnancies have so far demonstrated that AP-2α expression is suppressed in mild preeclampsia (PE), diabetes, hypertension and fetal growth retardation and increased in severe PE. Studies with NR2F2 and FOXF1 are in progress. Taken together, these studies provide important new insights into the pathophysiology of abnormal placenta development.
- The insulin-like growth factors and growth disorders of childhood. Endocrinol Metab Clin North Am. 2012; 41:265-82., .
- Bariatric surgery in hypothalamic obesity. Front Endocrinol (Lausanne). 2012; 3:23., , .
- Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study. Diabetes Care. 2011; 34:1628-33., , , , , , , , , , , .
- Physical activity is independently associated with multiple measures of arterial stiffness in adolescents and young adults. Metabolism. 2012; 61:869-72., , , , , , .
- beta-Cell Dysfunction in Adolescents and Adults with Newly Diagnosed Type 2 Diabetes Mellitus. J Pediatr. 2012; 160:904-10., , , , , .
- Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up. Diabetes Care. 2011; 34:2347-52., , , , , , , , , , , .
- Blood glucose monitoring and glycemic control in adolescents with type 1 diabetes: meter downloads versus self-report. Pediatr Diabetes. 2011; 12:560-6., , .
- Explaining the family conflict-glycemic control link through psychological variables in adolescents with type 1 diabetes. J Behav Med. 2011; 34:268-74., , , , .
- Prediction of adolescents' glycemic control 1 year after diabetes-specific family conflict: the mediating role of blood glucose monitoring adherence. Arch Pediatr Adolesc Med. 2011; 165:624-9., , , .
- Psychological screening in adolescents with type 1 diabetes predicts outcomes one year later. Diabetes Res Clin Pract. 2011; 94:39-44., , , .
- Depressive symptoms predict change in glycemic control in adolescents with type 1 diabetes: rates, magnitude, and moderators of change. Pediatr Diabetes. 2011; 12:718-23., , .
- Breaking T cell tolerance to beta cell antigens by merocytic dendritic cells. Cell Mol Life Sci. 2011; 68:2873-83., .
- Fetal development in women with diabetes: imprinting for a life-time?. J Matern Fetal Neonatal Med. 2012; 25:11-4., , , , , .
- Growth hormone secretion after conformal radiation therapy in pediatric patients with localized brain tumors. J Clin Oncol. 2011; 29:4776-80., , , , , .
- Timing of stage II lactogenesis is predicted by antenatal metabolic health in a cohort of primiparas. Breastfeed Med. 2012; 7:43-9., , .
- Pediatric parenting stress and its relation to depressive symptoms and fear of hypoglycemia in parents of young children with type 1 diabetes mellitus. J Clin Psychol Med Settings. 2011; 18:345-52., , , , .
- A comparison of average daily risk range scores for young children with type 1 diabetes mellitus using continuous glucose monitoring and self-monitoring data. Diabetes Technol Ther. 2012; 14:239-43., , , .
- Changes in treatment adherence and glycemic control during the transition to adolescence in type 1 diabetes. Diabetes Care. 2012; 35:1219-24., , , , , , , .
- Identification of self-management patterns in pediatric type 1 diabetes using cluster analysis. Pediatr Diabetes. 2011; 12:611-8., , , , , .
- Bone mineral density is normal in children with Fanconi anemia. Pediatr Blood Cancer. 2011; 57:1034-8., , , , , , .
- Critical role for TWIST1 in the induction of human uterine decidualization. Endocrinology. 2011; 152:4368-76., , .
- Comparison of mercury and aneroid blood pressure measurements in youth. Pediatrics. 2012; 129:e1205-10., , , , , , , , .
- Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Pediatr Diabetes. 2012; 13:170-5., , , , .
- Executive functioning, cortisol reactivity, and symptoms of psychopathology in girls with premature adrenarche. Dev Psychopathol. 2012; 24:211-23., , , , , .
- Does sleep duration predict metabolic risk in obese adolescents attending tertiary services? A cross-sectional study. Sleep. 2011; 34:891-8., , , , , , , , .
- Neuropsychological functioning in girls with premature adrenarche. J Int Neuropsychol Soc. 2012; 18:151-6., , , , , , , , , .
- Absence of mutation in coding regions of CYP2R1 gene in apparent autosomal dominant vitamin D 25-hydroxylase deficiency rickets. J Clin Endocrinol Metab. 2012; 97:E796-801., .
- Description of children with 45,X/46,XY karyotype. Eur J Pediatr. 2012; 171:521-9., , .
- Insulin resistance and arterial stiffness in healthy adolescents and young adults. Diabetologia. 2012; 55:625-31., , , , .
Faculty, Staff, and Trainees
- Stuart Handwerger, MD, Professor
- Leadership Professor of Cancer and Cell Biology
- Research Interests Growth and thyroid disorders; perinatal endocrinology
- Philippe Backeljauw, MD, Professor
- Leadership Director, Cincinnati Turner Syndrome Center
- Research Interests Growth disorders; disorders of bone and calcium metabolism; Turner Syndrome
- Nancy Crimmins, MD, Assistant Professor
- Research Interests Diabetes; obesity
- Lawrence M Dolan, MD, Professor
- Leadership Division Director, Robert and Mary Shoemaker Professor of Pediatrics
- Research Interests Diabetes mellitus; non-insulin dependent diabetes; sexual development disorders; growth disorders; disorders of the thyroid; goiters; hypoglycemia
- Deborah Elder, MD, Assistant Professor
- Research Interests Diabetes; growth disorders; precocious puberty; calcium disorders
- Jonathan Katz, PhD, Associate Professor
- Leadership Director, Diabetes Research Center
- David J Klein, MD, PhD, Associate Professor
- Research Interests Diabetes mellitus; intensive diabetes management programs; early detection of renal disease; effects of diabetes mellitus on renal proteogycan synthesis
- Susan Rose, MD, Professor
- Research Interests Hypothalamic pituitary function; thyroid disorders; disorders of growth or puberty; endocrine function in cancer survivors; endocrine function after head injury
- Meilan Rutter, MD, Assistant Professor
- Research Interests Calcium disorders; endocrine function in childhood cancer survivors; endocrine function in muscular dystrophy
- Peggy Stenger, DO, Assistant Professor
- Research Interests Growth disorders; disorders of sexual development; pubertal disorders; disorders of the thyroid; goiter
- Nana-Hawa Yayah Jones, MD, Assistant Professor
- Research Interests Adherence/compliance in type 1 diabetes
- Iris Gutmark-Little, MD, Assistant Professor
- Research Interests Airway and great vessel disorders in Turner syndrome
- Sarah Lawson, MD, Assistant Professor
- Research Interests Turner syndrome; Septo-optic dysplasia; endocrine abnormalities related to oncology and its treatments
- Amy Shah, MD, Assistant Professor
- Research Interests Type 2 diabetes; pre-diabetes; insulin resistance; obesity; lipid disorders
Joint Appointment Faculty Members
- Jessica Woo, PhD, Assistant Professor (Epidemiology)
- Reproductive Sciences » S.K. Dey, MD and Sanjoy Das, PhD
- Neonatology & Pulmonary Biology » Cindy Bachurski, PhD, Jeffrey Whitsett, MD, and Alexander Lange, PhD
- Biomedical Informatics » Bruce Aronow, PhD and Anil Jegga, MS, DVM
- Pathology » Jerzy Stanek, MD, PhD and Rachel Sheridan, PhD
- Molecular and Developmental Biology » James Wells, PhD
- Healthworks; Preventive Cardiology; Gastroenterology » Holly Ippisch, MD, Robert Siegel, MD, and Stavra Xanthakos, MD, MS
- Center for Better Health and Nutrition clinical collaboration
- Center for Adherance in Psychiatry » Denny Drotar, PhD and Korey Hood, PhD
- Pulmonary » Gary McPhail, MD
Impaired Fasting Glucose and Indeterminant Glucose Tolerance in a Cystic Fibrosis Population (Two and Four Year Clinical Outcomes)
Blood Glucose Monitoring in the hospitalized patient with Cystic Fibrosis - Validation of the expert opinion using Continuous Glucose Monitoring
- Solid Organ Transplantation » John Bucuvalas, MD
- Screening and Management of Diabetes in youths with solid organ transplantation
- Adolescent Medicine » Jennifer Hillman, MD, MS
- Diagnosis, screening for comorbidities and management of Polycystic Ovarian Syndrome across three disciplines within an academic hospital
- General Pediatrics » Maria Britto, MD, MPH
- ICU » Derek Wheeler, MD
- Pharmacy » Anne Lesko, PharmD and Shannon Saldana, PharmD, MS, BCPP
- Adolescent Gyn, Urology, Genetics » Lesley Breech, MD, Curtis Sheldon, MD, Shumyle Alam, MD, Pramod Reddy, MD, and Howard Saal, MD
Clinical collaboration - Disorders of Sexual Development Clinic
(Cincinnati Disorders of Sex Development Center)
- Gastroenterology » Lee Denson, MD
- Study of the effects of growth hormone on patients with Crohn's disease
- Emergency Medicine » Mike Gittelman, MD and Wendy Pomerantz, MD
- Injury prevention project (RWJ sponsored) in an obesity prevention project in an area experiencing health disparities
- Psychiatry » Michael Sorter, MD and Mary Matias-Akhtar, MD
- Project to see if Metformin given at the initiation of anti-psychotic treatment can prevent weight accretion, which occurs commonly in children on these agents
- Rheumatology » Hermine Brunner, MD
- NIH funded grant of Triptorelin therapy in lupus patients
- Hematology Oncology » Richard Harris, MD, Stella Davies, MD, Parinda Mehta, MD, and Karen Burns, MD
Funded study of oxadrolone therapy in children with Fanconi Anemia
Research, database, and multicenter care of patients with Fanconi Anemia and other bone marrow failure syndromes
- Mayerson Center » Kathi Makoroff, MD
- Pfizer funded study shaken infants
- Physical Medicine and Rehabilitation » Linda Michaud, MD
- Pfizer funded study of endocrine function after traumatic brain injury
- Neurology » Brenda Wong, MD and James Collins, MD
IGF-I therapy and muscle function in Duchenne Muscular Dystrophy research study
Research, database and interdisciplinary team care of patients with Duchenne Muscular Dystrophy
- Cardiology » Elaine Urbina, MD, Thomas Kimball, MD, and John Morrison, PhD
Clinical management protocol for cardiac disease in Turner syndrome
The epidemiology of peripheral cardiovascular disease in youth with a specific emphasis on the role of obesity, insulin resistance and diabetes
The epidemiology of central (heart) cardiovascular disease in youth with a specific emphasis on the role of obesity, insulin resistance and diabetes
The ability of pre-teen variables to predict the development of obesity, insulin resistance, diabetes and cardiovascular disease
- Epidemiology and Biostatistics » Lisa Martin, PhD, Jane Khoury, PhD, Jessica Woo, PhD, and Heidi Sucharew, PhD
Contribution of genetics to obesity in adolescents
The effect of maternal type 1 diabetes on adolescents and young adult offspring with a focus on obesity and carbohydrate metabolism
Creation of clinical database for the Comprehensive Weight Management Center
Contribution to collaborative research in Duchenne Muscular Dystrophy
- Psychology and Behavioral Medicine » Scott Powers, PhD
- Eating behaviors in individuals 16 years of age with type 1 diabetes
- Surgery » Thomas Inge, MD, PhD
Bariatric surgery in youth: safety, efficacy, and effect on carbohydrate and cardiovascular outcomes
International Hypothalamic Obesity Registry
Grants, Contracts, and Industry Agreements
|Grant and Contract Awards||Annual Direct|
|Effect of High Fat Diet on Hypothalamic Microglia|
|Type 1 Diabetes TrialNet|
|Air Pollution, Subclinical CVD and Inflammatory Markers in the SEARCH Cohort|
|R01 ES 019168||09/27/11-06/30/15||$16,137|
|SEARCH for Diabetes in Youth, Phase 3: Registry Study |
|U18 DP 002709||09/30/10-09/29/15||$409,298|
|T1D Exchange Registry|
|Transcriptional Control of Human Placental Differentiation|
|R01 HD 065339||02/01/11-01/31/16||$216,358|
|Incretin Expression and Regional Pattering in Human Pluripotent Stem Cell Derived Intestine|
|Dissecting Dendritic Cell Function in Autoimmune Diabetes|
|R01 DK 078179||08/01/09-07/31/14||$213,172|
Katz, J / Hildeman, D
|Control of Diabetes by Manipulation of Bc12 Family Members|
|R01 DK 081175||07/01/11-06/30/15||$125,000|
Katz, J / Janssen, E
|Dendritic Cells in the Breaking of Peripheral Tolerance in Type 1 Diabetes|
|R01 CA 138617||09/10/10-08/31/13||$$115,121|
|DMD Insulin Growth Factor-1|
|IGF Drug Only|
|Center for Environmental Genetics New Investigator Scholar|
|P30 ES 006096||04/01/11-02/28/12||$4,500|
|CNS NFkappaB Regulation of Glucose Homeostasis|
|F32 DK 091077||07/01/11-06/30/13||$59,582|
|Current Year Direct||$1,220,631|
|Current Year Direct Receipts||$149,455|