2012 Research Annual Report

Heart Institute

Division Details

Division Data Summary

Research and Training Details

Number of Faculty50
Number of Research Fellows31
Number of Research Students12
Number of Support Personnel232
Direct Annual Grant Support$6,639,040
Direct Annual Industry Support$59,351
Peer Reviewed Publications189

Clinical Activities and Training

Number of Clinical Staff5
Number of Clinical Fellows13
Inpatient Encounters1,652
Outpatient Encounters16,074

Division Photo

Group photo of the Hear tInstitute

Row 1: R Siegel, P Goldenberg, A Lorts, C Castleberry, S Rajan, W Zheng, K Hor, J Towbin, J Robbins, E Purevjav

Row 2: M Maillet, S Kirk, K Yutzey, B Blaxall, J van Berlo, A Phillips, S Goldstein, H Ippisch, J Cnota, E Urbina, A Divanovic, J Anderson, D Spar

Row 3: J Gulick, J Waxman, Z Khuchua, S Ware, J Molkentin, C Chin, I Iliopoulos, D Cooper, B Marino, E Michelfelder, B Goldstein C Liu

Row 4: D Nelson, N Madsen, R Hinton, C Learn, R Czosek, T Knilans, G Webb, M Taylor



Significant Accomplishments

Significant Accomplishments

Advanced Cardiomyopathy and Heart Failure Diagnosis and Treatments

The Heart Institute has become an international leader in heart muscle disease (cardiomyopathies) and its associated treatments. We have developed the largest Advanced Pediatric and Young Adult Cardiomyopathy and Heart Failure Program in the US, directed by John Lynn Jefferies, MD, MPH, and Jeffrey Towbin, MD. Our Heart Transplant Program, under the medical direction of Clifford Chin, MD, is one of the largest and most successful in the US. We performed 14 transplants in the past year and 10 the previous year, with 100 percent survival. More recently, the Heart Institute has become a leader in mechanical circulatory support with the addition of David Morales, MD, a world-renowned pediatric cardiothoracic surgeon and new chief of cardiothoracic surgery. Eight children with end-stage heart failure received mechanical circulatory support this year; six of whom were successfully transplanted and are doing well. Members of the Heart Institute also published more than 170 manuscripts this year.

Heart Institute Leads an International Research Consortium

Under the leadership of Jeffrey Robbins, PhD, the Heart Institute was awarded one of four grants given worldwide by the Fondation Leducq to study how proteotoxicity – cell malfunctions caused by misfolded proteins – can lead to heart disease and failure. The consortium for this study is led by Cincinnati Children’s and includes laboratories at the University of Texas-Southwest, University of North Carolina at Chapel Hill and premier academic medical centers in Germany, Great Britain and Italy. These proteotoxicity studies were recognized by the Leducq Foundation as having the potential to lead to novel treatments for a variety of heart diseases, with new therapeutic targets being identified in our pediatric population.

Pediatric Heart Network Consortium

The Heart Institute successfully competed for a renewal grant to continue serving as one of nine “core” sites in the Pediatric Heart Network (PHN) through 2016. This national competition was open to academic centers across North America. The National Heart, Lung and Blood Institute created this collaborative network to conduct clinical studies in children with congenital or acquired heart disease. Since its inception, the PHN has completed more than 10 multi-center studies that have had significant impact on the field of pediatric cardiovascular disease. The most recent study, evaluating the use of therapies for individuals with Marfan syndrome, began in 2007 and will have a major impact on how we treat these patients. These complex, randomized trials are the only way of carrying out high quality clinical research in rare diseases. Cincinnati Children’s has been a core site in the PHN since 2006. James Cnota, MD and Catherine Krawczeski, MD, serve as principal investigators.


Division Publications

  1. Accornero F, van Berlo JH, Benard MJ, Lorenz JN, Carmeliet P, Molkentin JD. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism. Circulation research. 2011; 109:272-80.
  2. Acharya A, Hans CP, Koenig SN, Nichols HA, Galindo CL, Garner HR, Merrill WH, Hinton RB, Garg V. Inhibitory role of Notch1 in calcific aortic valve disease. PloS one. 2011; 6:e27743.
  3. Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, Calkins H, Camm AJ, Ellinor PT, Gollob M, Hamilton R, Hershberger RE, Judge DP, Le Marec H, McKenna WJ, Schulze-Bahr E, Semsarian C, Towbin JA, Watkins H, Wilde A, Wolpert C, Zipes DP. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart rhythm : the official journal of the Heart Rhythm Society. 2011; 8:1308-39.
  4. Ackerman MJ, Priori SG, Willems S, Berul C, Brugada R, Calkins H, Camm AJ, Ellinor PT, Gollob M, Hamilton R, Hershberger RE, Judge DP, Le Marec H, McKenna WJ, Schulze-Bahr E, Semsarian C, Towbin JA, Watkins H, Wilde A, Wolpert C, Zipes DP. HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2011; 13:1077-109.
  5. Adachi I, Krishnamurthy R, Morales DL. A double aortic arch mimicking a right aortic arch with an aberrant subclavian artery. J Vasc Surg. 2011; 54:1151-3.
  6. Alvarez JA, Orav EJ, Wilkinson JD, Fleming LE, Lee DJ, Sleeper LA, Rusconi PG, Colan SD, Hsu DT, Canter CE, Webber SA, Cox GF, Jefferies JL, Towbin JA, Lipshultz SE. Competing risks for death and cardiac transplantation in children with dilated cardiomyopathy: results from the pediatric cardiomyopathy registry. Circulation. 2011; 124:814-23.
  7. Anderson JB, Iyer SB, Beekman RH, 3rd, Jenkins KJ, Klitzner TS, Kugler JD, Martin GR, Neish SR, Rosenthal GL, Lannon CM. National pediatric cardiology quality improvement collaborative: Lessons from development and early years. Progress in Pediatric Cardiology. 2011; 32:103-109.
  8. Anderson JB, Knilans TK. Syncope. Schwartz's Clinical Handbook of Pediatrics. Baltimore: Lippincott Williams & Wilkins; 2012:793-798.
  9. Anderson JB, Marino BS, Irving SY, Garcia-Espana JF, Ravishankar C, Stallings VA, Medoff-Cooper B. Poor post-operative growth in infants with two-ventricle physiology. Cardiology in the young. 2011; 21:421-9.
  10. Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott DA, Stevens MV, Camenisch TD, Conway SJ, Doetschman T. Transforming growth factor Beta2 is required for valve remodeling during heart development. Developmental dynamics : an official publication of the American Association of Anatomists. 2011; 240:2127-41.
  11. Bainbridge MN, Wang M, Wu Y, Newsham I, Muzny DM, Jefferies JL, Albert TJ, Burgess DL, Gibbs RA. Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities. Genome biology. 2011; 12:R68.
  12. Barsheshet A, Goldenberg I, J OU, Moss AJ, Jons C, Shimizu W, Wilde AA, McNitt S, Peterson DR, Zareba W, Robinson JL, Ackerman MJ, Cypress M, Gray DA, Hofman N, Kanters JK, Kaufman ES, Platonov PG, Qi M, Towbin JA, Vincent GM, Lopes CM. Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to beta-blocker therapy in type 1 long-QT syndrome. Circulation. 2012; 125:1988-96.
  13. Barsheshet A, Moss AJ, McNitt S, Polonsky S, Lopes CM, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Kaufman ES, Towbin JA, Vincent GM, Qi M, Goldenberg I. Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation. Circulation. Cardiovascular genetics. 2011; 4:491-9.
  14. Barsheshet A, Peterson DR, Moss AJ, Schwartz PJ, Kaufman ES, McNitt S, Polonsky S, Buber J, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Towbin JA, Vincent GM, Zhang L, Goldenberg I. Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome. Heart rhythm : the official journal of the Heart Rhythm Society. 2011; 8:1207-13.
  15. Bassett AS, McDonald-McGinn DM, Devriendt K, Digilio MC, Goldenberg P, Habel A, Marino B, Oskarsdottir S, Philip N, Sullivan K, Swillen A, Vorstman J. Practical guidelines for managing patients with 22q11.2 deletion syndrome. The Journal of pediatrics. 2011; 159:332-9 e1.
  16. Bedard JE, Haaning AM, Ware SM. Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease. PloS one. 2011; 6:e23755.
  17. Beebe DW, Miller N, Kirk S, Daniels SR, Amin R. The association between obstructive sleep apnea and dietary choices among obese individuals during middle to late childhood. Sleep medicine. 2011; 12:797-9.
  18. Bennett BL, Mahabee-Gittens M, Chua MS, Hirsch R. Elevated cardiac troponin I level in cases of thoracic nonaccidental trauma. Pediatric emergency care. 2011; 27:941-4.
  19. Bergersen L, Gauvreau K, Foerster SR, Marshall AC, McElhinney DB, Beekman RH, 3rd, Hirsch R, Kreutzer J, Balzer D, Vincent J, Hellenbrand WE, Holzer R, Cheatham JP, Moore JW, Burch G, Armsby L, Lock JE, Jenkins KJ. Catheterization for Congenital Heart Disease Adjustment for Risk Method (CHARM). JACC. Cardiovascular interventions. 2011; 4:1037-46.
  20. Blinder JJ, Goldstein SL, Lee VV, Baycroft A, Fraser CD, Nelson D, Jefferies JL. Congenital heart surgery in infants: effects of acute kidney injury on outcomes. J Thorac Cardiovasc Surg. 2012; 143:368-74.
  21. Blinder JJ, Martinez HR, Craigen WJ, Belmont J, Pignatelli RH, Jefferies JL. Noncompaction of the left ventricular myocardium in a boy with a novel chromosome 8p23.1 deletion. American journal of medical genetics. Part A. 2011; 155A:2215-20.
  22. Bryant R, 3rd, Aboutalebi A, Kim JJ, Kertesz N, Morales DL. Epicardial implantable cardioverter-defibrillator system placed in a 4.9-kg infant. Tex Heart Inst J. 2011; 38:421-3.
  23. Burnside J, Gomez D, Preston TJ, Olshove VF, Jr., Phillips A. In-vitro quantification of gaseous microemboli in two extracorporeal life support circuits. The Journal of extra-corporeal technology. 2011; 43:123-9.
  24. Carlo WF, Carberry KE, Heinle JS, Morales DL, McKenzie ED, Fraser CD, Jr., Nelson DP. Interstage attrition between bidirectional Glenn and Fontan palliation in children with hypoplastic left heart syndrome. The Journal of thoracic and cardiovascular surgery. 2011; 142:511-6.
  25. Casadonte JR, Kim JM, Dadlani GH, Jacobs JP, Cooper DS, Stapleton GE. Blalock-Taussig Shunt Thrombosis Prophylaxis in a Patient With Jacobsen Syndrome and Thrombocytopenia. World Journal for Pediatric and Congenital Heart Surgery. 2011; 2:641-643.
  26. Cast AE, Gao C, Amack JD, Ware SM. An essential and highly conserved role for Zic3 in left-right patterning, gastrulation and convergent extension morphogenesis. Developmental biology. 2012; 364:22-31.
  27. Chai PJ, Jacobs JP, Dalton HJ, Costello JM, Cooper DS, Kirsch R, Rosenthal T, Graziano JN, Quintessenza JA. Extracorporeal cardiopulmonary resuscitation for post-operative cardiac arrest: indications, techniques, controversies, and early results—what is known (and unknown). Cardiol Young. 2011; 21 Suppl 2:109-17.
  28. Chakraborty S, Yutzey KE. Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo. Developmental biology. 2012; 363:234-46.
  29. Cheek JD, Wirrig EE, Alfieri CM, James JF, Yutzey KE. Differential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease. Journal of molecular and cellular cardiology. 2012; 52:689-700.
  30. Cnota JF, Gupta R, Michelfelder EC, Ittenbach RF. Congenital heart disease infant death rates decrease as gestational age advances from 34 to 40 weeks. The Journal of pediatrics. 2011; 159:761-5.
  31. Cooper DS, Charpie JR, Flores FX, Gaynor JW, Salvin JW, Devarajan P, Krawczeski CD. Acute Kidney Injury and Critical Cardiac Disease. World Journal for Pediatric and Congenital Heart Surgery. 2011; 2:411-423.
  32. Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome. Heart Rhythm. 2012; 9:892-8.
  33. Costello JM, Cooper DS, Jacobs JP, Chai PJ, Kirsch R, Rosenthal T, Dalton HJ, Graziano JN, Quintessenza JA. Intermediate-term outcomes after paediatric cardiac extracorporeal membrane oxygenation--what is known (and unknown). Cardiol Young. 2011; 21 Suppl 2:118-23.
  34. Cua CL, Phillips A, Ackley T, Ro PS, Kertesz N. Optimization of biventricular pacing via strain dyssynchrony measurements in a paediatric patient. Acta Cardiol. 2011; 66:527-30.
  35. Czosek RJ, Goldenberg P, Miller EM, Spicer R, Towbin JA, Ware SM. Cardiac electrical system involvement in Alstrom syndrome: uncommon causes of dilated cardiomyopathies. Cardiogenetics. 2012; 2:e2.
  36. Czosek RJ, Knilans TK. Tachycardia. Schwartz's Clinical Handbook of Pediatrics. Baltimore: Lippincott Williams & Wilkins; 2012:799-808.
  37. Czosek RJ, Meganathan K, Anderson JB, Knilans TK, Marino BS, Heaton PC. Cardiac rhythm devices in the pediatric population: utilization and complications. Heart rhythm : the official journal of the Heart Rhythm Society. 2012; 9:199-208.
  38. Divanovic A, Cnota J, Ittenbach R, Tan X, Border W, Crombleholme T, Michelfelder E. Characterization of diastolic dysfunction in twin-twin transfusion syndrome: association between Doppler findings and ventricular hypertrophy. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2011; 24:834-40.
  39. Dohn TE, Waxman JS. Distinct phases of Wnt/beta-catenin signaling direct cardiomyocyte formation in zebrafish. Developmental biology. 2012; 361:364-76.
  40. Echo A, Kelley BP, Bullocks JM, Morales DL. The treatment of an unusual complication associated with a HeartMate II LVAD in an adolescent. Pediatr Transplant. 2012; 16:E130-3.
  41. Edwards NM, Daniels SR, Claytor RP, Khoury PR, Dolan LM, Kimball TR, Urbina EM. Physical activity is independently associated with multiple measures of arterial stiffness in adolescents and young adults. Metabolism. 2012; 61:869-72.
  42. Fan Y, Weng YG, Huebler M, Cowger J, Morales D, Franz N, Xiao YB, Potapov E, Hetzer R. Predictors of in-hospital mortality in children after long-term ventricular assist device insertion. J Am Coll Cardiol. 2011; 58:1183-90.
  43. Feinstein JA, Benson DW, Dubin AM, Cohen MS, Maxey DM, Mahle WT, Pahl E, Villafane J, Bhatt AB, Peng LF, Johnson BA, Marsden AL, Daniels CJ, Rudd NA, Caldarone CA, Mussatto KA, Morales DL, Ivy DD, Gaynor JW, Tweddell JS, Deal BJ, Furck AK, Rosenthal GL, Ohye RG, Ghanayem NS, Cheatham JP, Tworetzky W, Martin GR. Hypoplastic left heart syndrome: current considerations and expectations. J Am Coll Cardiol. 2012; 59:S1-42.
  44. Flynn JT, Urbina EM. Pediatric ambulatory blood pressure monitoring: indications and interpretations. J Clin Hypertens (Greenwich). 2012; 14:372-82.
  45. Frommelt PC, Guey LT, Minich LL, Bhat M, Bradley TJ, Colan SD, Ensing G, Gorentz J, Heydarian H, John JB, Lai WW, Levine JC, Mahle WT, Miller SG, Ohye RG, Pearson GD, Shirali GS, Wong PC, Cohen MS. Does Initial Shunt Type for the Norwood Procedure Affect Echocardiographic Measures of Cardiac Size and Function During Infancy?: The Single Ventricle Reconstruction Trial. Circulation. 2012; 125:2630-2638.
  46. Gazit AZ, Cooper DS. Emerging technologies. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2011; 12:S55-61.
  47. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. The Journal of thoracic and cardiovascular surgery. 2011; 142:e153-203.
  48. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. The Journal of thoracic and cardiovascular surgery. 2011; 142:1303-38.
  49. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Journal of the American College of Cardiology. 2011; 58:e212-60.
  50. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011; 124:e783-831.
  51. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Executive Summary A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Journal of the American College of Cardiology. 2011; 58:2703-38.
  52. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011; 124:2761-96.
  53. Goldberg DJ, French B, Szwast AL, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SM, Rychik J. Impact of sildenafil on echocardiographic indices of myocardial performance after the fontan operation. Pediatr Cardiol. 2012; 33:689-96.
  54. Goldenberg I, Thottathil P, Lopes CM, Moss AJ, McNitt S, J OU, Robinson JL, Zareba W, Ackerman MJ, Kaufman ES, Towbin JA, Vincent M, Barsheshet A. Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome. Heart rhythm : the official journal of the Heart Rhythm Society. 2012; 9:49-56.
  55. Goldenberg PC, Calkins ME, Richard J, McDonald-McGinn D, Zackai E, Mitra N, Emanuel B, Devoto M, Borgmann-Winter K, Kohler C, Conroy CG, Gur RC, Gur RE. Computerized neurocognitive profile in young people with 22q11.2 deletion syndrome compared to youths with schizophrenia and At-Risk for psychosis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2012; 159B:87-93.
  56. Goldstein BH, Aiyagari R, Bocks ML, Armstrong AK. Hydrogel expandable coils for vascular occlusion in congenital cardiovascular disease: a single center experience. Congenit Heart Dis. 2012; 7:212-8.
  57. Goldstein BH, Fifer CG, Armstrong AK, Gelehrter SK, Treadwell MC, van de Ven C, Rocchini AP. Use of a pressure guidewire in fetal cardiac intervention for critical aortic stenosis. Pediatrics. 2011; 128:e716-9.
  58. Goldstein BH, Golbus JR, Sandelin AM, Warnke N, Gooding L, King KK, Donohue JE, Gurney JG, Goldberg CS, Rocchini AP, Charpie JR. Usefulness of peripheral vascular function to predict functional health status in patients with Fontan circulation. The American journal of cardiology. 2011; 108:428-34.
  59. Goldstein BH, Sandelin AM, Golbus JR, Warnke N, Gooding L, King KK, Donohue JE, Yu S, Gurney JG, Goldberg CS, Rocchini AP, Charpie JR. Impact of vitamin C on endothelial function and exercise capacity in patients with a fontan circulation. Congenit Heart Dis. 2012; 7:226-34.
  60. Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers DM, Molkentin JD. Decreased cardiac L-type Ca(2) channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation. 2012; 122:280-90.
  61. Goonasekera SA, Molkentin JD. Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte. J Mol Cell Cardiol. 2012; 52:317-22.
  62. Habli M, Michelfelder E, Cnota J, Wall D, Polzin W, Lewis D, Lim FY, Crombleholme TM. Prevalence and progression of recipient-twin cardiomyopathy in early-stage twin-twin transfusion syndrome. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2012; 39:63-8.
  63. Haghighi K, Pritchard T, Bossuyt J, Waggoner JR, Yuan Q, Fan GC, Osinska H, Anjak A, Rubinstein J, Robbins J, Bers DM, Kranias EG. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of molecular and cellular cardiology. 2012; 52:773-82.
  64. Hehir DA, Cooper DS, Walters EM, Ghanayem NS. Feeding, growth, nutrition, and optimal interstage surveillance for infants with hypoplastic left heart syndrome. Cardiol Young. 2011; 21 Suppl 2:59-64.
  65. Hershenson JA, Ro PS, Miao Y, Tobias JD, Olshove V, Naguib AN. Changes in hemodynamic parameters and cerebral saturation during supraventricular tachycardia. Pediatric cardiology. 2012; 33:286-9.
  66. Hickey EJ, Veldtman G, Bradley TJ, Gengsakul A, Webb G, Williams WG, Manlhiot C, McCrindle BW. Functional health status in adult survivors of operative repair of tetralogy of Fallot. The American journal of cardiology. 2012; 109:873-80.
  67. Hinton RB, Benson DW. Hypoplastic Left Heart Syndrome. Pediatric cardiovascular medicine. Chichester, West Sussex, UK: Wiley-Blackwell; 2012:523-533.
  68. Hollander SA, Reinhartz O, Chin C, Yeh J, Maeda K, Mallidi H, Bernstein D, Rosenthal D. Use of the Impella 5.0 as a bridge from ECMO to implantation of the HeartMate II left ventricular assist device in a pediatric patient. Pediatric transplantation. 2012; 16:205-6.
  69. Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA, Jr.. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Developmental cell. 2011; 21:469-78.
  70. Hom KA, Hirsch R, Elluru RG. Antihypertensive drug-induced angioedema causing upper airway obstruction in children. International journal of pediatric otorhinolaryngology. 2012; 76:14-9.
  71. Hor KH, Marino B. Chest Pain. Schwartz's Clinical Handbook of Pediatrics. Baltimore: Lippincott Williams & Wilkins; 2012:209-216.
  72. Hor KN, Mazur W, Taylor MD, Al-Khalidi HR, Cripe LH, Jefferies JL, Raman SV, Chung ES, Kinnett KJ, Williams K, Gottliebson WM, Benson DW. Effects of steroids and angiotensin converting enzyme inhibition on circumferential strain in boys with Duchenne muscular dystrophy: a cross-sectional and longitudinal study utilizing cardiovascular magnetic resonance. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 2011; 13:60.
  73. Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ. Animal Models of Heart Failure: A Scientific Statement From the American Heart Association. Circ Res. 2012; 111:131-150.
  74. Hunt SA, Burch MB, Bhat G, Canter CE, Chinnock RE, Crespo-Leiro M, Delgado RM, Dobbels F, Grady KL, Kao WG, Lamour JM, Parry G, Patel JK, Pini D, Towbin JA, Wolfel EE. Long-term Care of Heart Transplant Recipients. ISHLT Guidelines for the Care of Heart Transplant Recipients. Birmingham: University of Alabama Printing; 2012.
  75. Iyer SB, Anderson JB, Slicker J, Beekman RH, 3rd, Lannon CM. Using Statistical Process Control to Identify Early Growth Failure Among Infants With Hypoplastic Left Heart Syndrome. World Journal for Pediatric and Congenital Heart Surgery. 2011; 2:576-585.
  76. Jacobs JP, Edwards FH, Shahian DM, Prager RL, Wright CD, Puskas JD, Morales DL, Gammie JS, Sanchez JA, Haan CK, Badhwar V, George KM, O'Brien SM, Dokholyan RS, Sheng S, Peterson ED, Shewan CM, Feehan KM, Han JM, Jacobs ML, Williams WG, Mayer JE, Jr., Chitwood WR, Jr., Murray GF, Grover FL. Successful linking of the Society of Thoracic Surgeons database to social security data to examine survival after cardiac operations. Ann Thorac Surg. 2011; 92:32-7; discussion 38-9.
  77. Jacobs JP, Jacobs ML, Austin EHI, Mavroudis C, Pasquali SK, Lacour-Gayet FG, Tchervenkov CI, Walters HI, Bacha EA, del Nido PJ, Fraser CD, Gaynor JW, Hirsch JC, Morales DLS, Pourmoghadam KK, Tweddell JS, Prager RL, Mayer JE. Quality Measures for Congenital and Pediatric Cardiac Surgery. World Journal for Pediatric and Congenital Heart Surgery. 2012; 3:32-47.
  78. Jacobs JP, Morales DLS. Strategies for longitudinal follow-up of patients with pediatric and congenital cardiac disease. Progress in Pediatric Cardiology. 2011; 32:97-102.
  79. Jacobs JP, Pasquali SK, Jeffries H, Barnett-Jones S, Cooper DS, Vincent R. Outcomes Analysis and Quality Improvement for the Treatment of Patients With Pediatric and Congenital Cardiac Disease. World Journal for Pediatric and Congenital Heart Surgery. 2011; 2:620-633.
  80. Jacobs ML, Daniel M, Mavroudis C, Morales DL, Jacobs JP, Fraser CD, Jr., Turek JW, Mayer JE, Tchervenkov C, Conte J. Report of the 2010 society of thoracic surgeons congenital heart surgery practice and manpower survey. Ann Thorac Surg. 2011; 92:762-8; discussion 768-9.
  81. James J, Kinnett K, Wang Y, Ittenbach RF, Benson DW, Cripe L. Electrocardiographic abnormalities in very young Duchenne muscular dystrophy patients precede the onset of cardiac dysfunction. Neuromuscular disorders : NMD. 2011; 21:462-7.
  82. Jefferies JL, Pignatelli RH, Martinez HR, Robbins-Furman PJ, Liu P, Gu W, Lupski JR, Potocki L. Cardiovascular findings in duplication 17p11.2 syndrome. Genetics in medicine : official journal of the American College of Medical Genetics. 2012; 14:90-4.
  83. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012; 483:96-9.
  84. Johnson BA, Marino B. Cyanosis. Schwartz's Clinical Handbook of Pediatrics. Baltimore: Lippincott Williams & Wilkins; 2012:266-273.
  85. Kanetzke EE, Lynch J, Prows CA, Siegel RM, Myers MF. Perceived utility of parent-generated family health history as a health promotion tool in pediatric practice. Clinical pediatrics. 2011; 50:720-8.
  86. Kindel SJ, Miller EM, Gupta R, Cripe LH, Hinton RB, Spicer RL, Towbin JA, Ware SM. Pediatric cardiomyopathy: importance of genetic and metabolic evaluation. J Card Fail. 2012; 18:396-403.
  87. Krawczeski CD, Goldstein SL, Woo JG, Wang Y, Piyaphanee N, Ma Q, Bennett M, Devarajan P. Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass. Journal of the American College of Cardiology. 2011; 58:2301-9.
  88. Krishnamurthy VK, Opoka AM, Kern CB, Guilak F, Narmoneva DA, Hinton RB. Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease. Matrix biology : journal of the International Society for Matrix Biology. 2012; 31:197-205.
  89. Kwiatkowski D, Wang Y, Cnota J. The utility of outpatient echocardiography for evaluation of asymptomatic murmurs in children. Congenit Heart Dis. 2012; 7:283-8.
  90. Kwiatkowski DM, Goldstein SL, Krawczeski CD. Biomarkers of acute kidney injury in pediatric cardiac patients. Biomark Med. 2012; 6:273-82.
  91. Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ. Inhibition of PKCalpha/beta With Ruboxistaurin Antagonizes Heart Failure in Pigs After Myocardial Infarction Injury. Circulation research. 2011; 109:1396-400.
  92. Laksman ZW, Silversides CK, Sedlak T, Samman AM, Williams WG, Webb GD, Liu PP. Valvular aortic stenosis as a major sequelae in patients with pre-existing subaortic stenosis changing spectrum of outcomes. Journal of the American College of Cardiology. 2011; 58:962-5.
  93. Larsen RL, Canter CE, Naftel DC, Tressler M, Rosenthal DN, Blume ED, Mahle WT, Yung D, Morrow WR, Orav EJ, Wilkinson JD, Towbin JA, Lipshultz SE. The impact of heart failure severity at time of listing for cardiac transplantation on survival in pediatric cardiomyopathy. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2011; 30:755-60.
  94. Law SP, Kim JJ, Decker JA, Price JF, Cabrera AG, Graves DE, Morales DL, Heinle JS, Denfield SW, Dreyer WJ, Rossano JW. Hospital charges for pediatric heart transplant hospitalizations in the United States from 1997 to 2006. J Heart Lung Transplant. 2012; 31:485-91.
  95. Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL. Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Developmental dynamics : an official publication of the American Association of Anatomists. 2012; 241:493-504.
  96. Learn C, Phillips A, Chisolm J, Hill S, Cheatham J, Winch P, Galantowicz M, Holzer R. Pulmonary atresia with ventricular septal defect and multifocal pulmonary blood supply: does an intensive interventional approach improve the outcome?. Congenital heart disease. 2012; 7:111-21.
  97. Lee MP, Yutzey KE. Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. PloS one. 2011; 6:e29758.
  98. Li J, Horak KM, Su H, Sanbe A, Robbins J, Wang X. Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice. The Journal of clinical investigation. 2011; 121:3689-700.
  99. Li X, Chan TO, Myers V, Chowdhury I, Zhang XQ, Song J, Zhang J, Andrel J, Funakoshi H, Robbins J, Koch WJ, Hyslop T, Cheung JY, Feldman AM. Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Galphaq-mediated cell signaling. Circulation. 2011; 124:572-81.
  100. Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J, Tabas I. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell metabolism. 2012; 15:545-53.
  101. Liu Q, Chen Y, Auger-Messier M, Molkentin JD. Interaction Between NFkappaB and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling. Circulation research. 2012; 110:1077-86.
  102. Liu Q, Molkentin JD. Protein kinase Calpha as a heart failure therapeutic target. J Mol Cell Cardiol. 2011; 51:474-8.
  103. Lorts A. Pleural Effusions. Schwartz's Clinical Handbook of Pediatrics. Baltimore: Lippincott Williams & Wilkins; 2012:633-638.
  104. Lorts A, Krawczeski CD. Perioperative care of a child with transposition of the great arteries. Current treatment options in cardiovascular medicine. 2011; 13:456-63.
  105. Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, Prywes R, Lorenz JN, Mori K, Lawler J, Robbins J, Molkentin JD. A Thrombospondin-Dependent Pathway for a Protective ER Stress Response. Cell. 2012; 149:1257-68.
  106. Mack EH, Wheeler DS, Hirsch R. Endovascular treatment of near-fatal neonatal superior vena cava syndrome. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2011; 12:e410-2.
  107. Mahle WT, Martin GR, Beekman RH, 3rd, Morrow WR. Endorsement of Health and Human Services recommendation for pulse oximetry screening for critical congenital heart disease. Pediatrics. 2012; 129:190-2.
  108. Makarewich CA, Correll RN, Gao H, Zhang H, Yang B, Berretta RM, Rizzo V, Molkentin JD, Houser SR. A caveolae-targeted L-type Ca(2) channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility. Circulation research. 2012; 110:669-74.
  109. Marino BS. Transposition of the Great Arteries. The 5 Minute Pediatric Consult. Philadelphia: Lippincott Williams & Wilkins; 2012:898-899.
  110. Marino BS, Jefferies JL. Myocarditis. The 5 Minute Pediatric Consult. Philadelphia: Lippincott Williams & Wilkins; 2012:568-569.
  111. Martin GR, Mitchell S, Beekman RH, 3rd, Feinstein JA, Jenkins KJ, Landzberg M, Webb G. The Adult Congenital and Pediatric Cardiology Section: increasing the opportunities for the congenital heart disease community within the American College of Cardiology. Journal of the American College of Cardiology. 2012; 59:84-7.
  112. Martin LJ, Hinton RB, Benson DW. Genetics of Cardiovascular Disease in the Young. Pediatric cardiovascular medicine. Chichester, West Sussex, UK: Wiley-Blackwell; 2012:23-32.
  113. Martin LJ, Hinton RB, Zhang X, Cripe LH, Benson DW. Aorta Measurements are Heritable and Influenced by Bicuspid Aortic Valve. Front Genet. 2011; 2:61.
  114. Martinez HR, Niu MC, Sutton VR, Pignatelli R, Vatta M, Jefferies JL. Coffin-Lowry syndrome and left ventricular noncompaction cardiomyopathy with a restrictive pattern. American journal of medical genetics. Part A. 2011; 155A:3030-4.
  115. Martinez HR, Pignatelli R, Belmont JW, Craigen WJ, Jefferies JL. Childhood onset of left ventricular dysfunction in a female manifesting carrier of muscular dystrophy. American journal of medical genetics. Part A. 2011; 155A:3025-9.
  116. Maskatia SA, Decker JA, Spinner JA, Kim JJ, Price JF, Jefferies JL, Dreyer WJ, Smith EO, Rossano JW, Denfield SW. Restrictive Physiology is Associated With Poor Outcomes in Children With Hypertrophic Cardiomyopathy. Pediatric cardiology. 2012; 33:141-9.
  117. Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, Chung ES, Taylor MD, Jefferies JL, Woodrow Benson D, Gottliebson WM. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2012; 28:99-107.
  118. McBride KL, Ware SM. Modifying Mendel: approaches for identification of susceptibility alleles for human cardiovascular malformations. Circ Cardiovasc Genet. 2012; 5:274-6.
  119. McLendon PM, Robbins J. Desmin-related cardiomyopathy: an unfolding story. American journal of physiology. Heart and circulatory physiology. 2011; 301:H1220-8.
  120. Mead TJ, Yutzey KE. Notch signaling and the developing skeleton. Advances in experimental medicine and biology. 2012; 727:114-30.
  121. Mead TJ, Yutzey KE. Notch pathway regulation of neural crest cell development in vivo. Developmental dynamics : an official publication of the American Association of Anatomists. 2012; 241:376-89.
  122. Metzger A, Matsuura T, McKnite S, Marino BS, Nadkarni VM, Yannopoulos D. Intrathoracic pressure regulation improves 24-hour survival in a pediatric porcine model of hemorrhagic shock. Pediatric research. 2011; 70:267-71.
  123. Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome. Heart rhythm : the official journal of the Heart Rhythm Society. 2011; 8:1537-43.
  124. Miller EM, Hopkin R, Bao L, Ware SM. Implications for genotype-phenotype predictions in Townes-Brocks syndrome: case report of a novel SALL1 deletion and review of the literature. American journal of medical genetics. Part A. 2012; 158A:533-40.
  125. Moffett BS, McDade E, Rossano JW, Dickerson HA, Nelson DP. Enteral potassium supplementation in a pediatric cardiac intensive care unit: evaluation of a practice change. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2011; 12:552-4.
  126. Morales DL, Adachi I, Heinle JS, Fraser CD, Jr.. A new era: use of an intracorporeal systemic ventricular assist device to support a patient with a failing Fontan circulation. J Thorac Cardiovasc Surg. 2011; 142:e138-40.
  127. Muili KA, Ahmad M, Orabi AI, Mahmood SM, Shah AU, Molkentin JD, Husain SZ. Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury. American journal of physiology. Gastrointestinal and liver physiology. 2012; 302:G898-905.
  128. Mun JY, Gulick J, Robbins J, Woodhead J, Lehman W, Craig R. Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C). Journal of molecular biology. 2011; 410:214-25.
  129. Murphy LL, Moon-Grady AJ, Cuneo BF, Wakai RT, Yu S, Kunic JD, Benson DW, George AL, Jr.. Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmia. Heart Rhythm. 2012; 9:590-7.
  130. Naguib A, McKee C, Phillips A, Tobias JD. Dexmedetomidine as the primary anesthetic agent during cardiac surgery in an infant with a family history of malignant hyperthermia. Saudi journal of anaesthesia. 2011; 5:426-9.
  131. Nehus E, Goebel J, Mitsnefes M, Lorts A, Laskin B. Intensive hemodialysis for cardiomyopathy associated with end-stage renal disease. Pediatric nephrology. 2011; 26:1909-12.
  132. Newburger JW, Sleeper LA, Bellinger DC, Goldberg CS, Tabbutt S, Lu M, Mussatto KA, Williams IA, Gustafson KE, Mital S, Pike N, Sood E, Mahle WT, Cooper DS, Dunbar-Masterson C, Krawczeski CD, Lewis A, Menon SC, Pemberton VL, Ravishankar C, Atz TW, Ohye RG, Gaynor JW. Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial. Circulation. 2012; 125:2081-91.
  133. Opotowsky AR, Siddiqi OK, D'Souza B, Webb GD, Fernandes SM, Landzberg MJ. Maternal cardiovascular events during childbirth among women with congenital heart disease. Heart. 2012; 98:145-51.
  134. Pahl E, Sleeper LA, Canter CE, Hsu DT, Lu M, Webber SA, Colan SD, Kantor PF, Everitt MD, Towbin JA, Jefferies JL, Kaufman BD, Wilkinson JD, Lipshultz SE. Incidence of and risk factors for sudden cardiac death in children with dilated cardiomyopathy: a report from the Pediatric Cardiomyopathy Registry. Journal of the American College of Cardiology. 2012; 59:607-15.
  135. Palmer BM, Sadayappan S, Wang Y, Weith AE, Previs MJ, Bekyarova T, Irving TC, Robbins J, Maughan DW. Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophysical journal. 2011; 101:1661-9.
  136. Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX. Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol. 2011; 22:1748-57.
  137. Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD. Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. Journal of the American Society of Nephrology : JASN. 2011; 22:1737-47.
  138. Pattison JS, Osinska H, Robbins J. Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circulation research. 2011; 109:151-60.
  139. Pattison JS, Robbins J. Autophagy and proteotoxicity in cardiomyocytes. Autophagy. 2011; 7:1259-60.
  140. Perry J, Lanzberg M, Franklin W, Webb GD, Chang AC. Cardiac Intensive Care of the Adult With Congenital Heart Disease: Basic Principles in the Management of Common Problems. World Journal for Pediatric and Congenital Heart Surgery. 2011; :3.
  141. Petrucci O, O'Brien SM, Jacobs ML, Jacobs JP, Manning PB, Eghtesady P. Risk factors for mortality and morbidity after the neonatal Blalock-Taussig shunt procedure. The Annals of thoracic surgery. 2011; 92:642-51; discussion 651-2.
  142. Pignatelli R, Law MA, Martinez H, Altman C, Ayres N, Jefferies JL, Ganame J. Two-dimensional speckle strain imaging: in the management of paraganglioma, acute junctional tachycardia, and myocardial dysfunction in a child. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. 2012; 39:119-21.
  143. Preston TJ, Olshove VF, Jr., Chase M. Bloodless extracorporeal membrane oxygenation in the Jehovah's Witness patient. J Extra Corpor Technol. 2012; 44:39-42.
  144. Purevjav E, Arimura T, Augustin S, Huby AC, Takagi K, Nunoda S, Kearney DL, Taylor MD, Terasaki F, Bos JM, Ommen SR, Shibata H, Takahashi M, Itoh-Satoh M, McKenna WJ, Murphy RT, Labeit S, Yamanaka Y, Machida N, Park JE, Alexander PM, Weintraub RG, Kitaura Y, Ackerman MJ, Kimura A, Towbin JA. Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Human molecular genetics. 2012; 21:2039-53.
  145. Quinn ME, Haaning A, Ware SM. Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice. Human molecular genetics. 2012; 21:1888-96.
  146. Raake J, Johnson B, Seger B, Manning PB, Eghtesady P, Boesch P, Rutter M, Woodard A, Chima RS. Extracorporeal membrane oxygenation, extubation, and lung-recruitment maneuvers as rescue therapy in a patient with tracheal dehiscence following slide tracheoplasty. Respiratory care. 2011; 56:1198-202.
  147. Robbins J. Twenty years of gene targeting: what we don't know. Circulation research. 2011; 109:722-3.
  148. Rocchini AP, Goldstein BH. Common Arterial Trunk (Truncus Arteriosus). Pediatric cardiovascular medicine. Chichester, West Sussex, UK: Wiley-Blackwell; 2012:651-659.
  149. Rodriguez FH, 3rd, Moodie DS, Parekh DR, Franklin WJ, Morales DL, Zafar F, Graves DE, Friedman RA, Rossano JW. Outcomes of hospitalization in adults in the United States with atrial septal defect, ventricular septal defect, and atrioventricular septal defect. Am J Cardiol. 2011; 108:290-3.
  150. Rossano JW, Kim JJ, Decker JA, Price JF, Zafar F, Graves DE, Morales DL, Heinle JS, Bozkurt B, Towbin JA, Denfield SW, Dreyer WJ, Jefferies JL. Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail. 2012; 18:459-70.
  151. Sadayappan S, Gulick J, Osinska H, Barefield D, Cuello F, Avkiran M, Lasko VM, Lorenz JN, Maillet M, Martin JL, Brown JH, Bers DM, Molkentin JD, James J, Robbins J. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation research. 2011; 109:141-50.
  152. Samayoa AX, Mallory GB, Jr., Morales DL. Pneumonectomy acutely after pediatric bilateral lung transplantation: management of communicating thoracic spaces. J Heart Lung Transplant. 2012; 31:438-9.
  153. Sawdy JM, Kempton TM, Olshove V, Gocha M, Chisolm JL, Hill SL, Kirk A, Cheatham JP, Holzer RJ. Use of a dose-dependent follow-up protocol and mechanisms to reduce patients and staff radiation exposure in congenital and structural interventions. Catheter Cardiovasc Interv. 2011; 78:136-42.
  154. Schumacher KR, Cools M, Goldstein BH, Ioffe-Dahan V, King K, Gaffney D, Russell MW. Oral budesonide treatment for protein-losing enteropathy in Fontan-palliated patients. Pediatric cardiology. 2011; 32:966-71.
  155. Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G, Sadoshima J. Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012; 125:1134-46.
  156. Sengupta A, Chakraborty S, Paik J, Yutzey KE, Evans-Anderson HJ. FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Developmental dynamics : an official publication of the American Association of Anatomists. 2012; 241:803-13.
  157. Shah AS, Dolan LM, D'Agostino RB, Jr., Standiford D, Davis C, Testaverde L, Pihoker C, Daniels SR, Urbina EM. Comparison of mercury and aneroid blood pressure measurements in youth. Pediatrics. 2012; 129:e1205-10.
  158. Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Pediatric diabetes. 2012; 13:170-5.
  159. Shamszad P, Slesnick TC, Smith EO, Taylor MD, Feig DI. Association between left ventricular mass index and cardiac function in pediatric dialysis patients. Pediatr Nephrol. 2012; 27:835-41.
  160. Shen J, Benson DW. Aortopulmonary Shunts: Patent Ductus Arteriosus, Aortopulmonary Window, Aortic Orgin of a Pulmonary Artery. Pediatric cardiovascular medicine. Chichester, West Sussex, UK: Wiley-Blackwell; 2012:343-353.
  161. Sheridan RM, Michelfelder EC, Choe KA, Divanovic A, Liu C, Ware S, Stanek J. Ductus arteriosus aneurysm with massive thrombosis of pulmonary artery and fetal hydrops. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 2012; 15:79-85.
  162. Siegel RM, Rich W, Khoury J. An office-based low-carbohydrate intervention in teens: one-year follow-up of a six-month intervention. Clinical pediatrics. 2011; 50:1062-3.
  163. Sorrell MR, Waxman JS. Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation. Developmental biology. 2011; 358:44-55.
  164. Srivatsa SS, Taylor MD, Hor K, Collins DA, King-Strunk M, Pelberg RA, Mazur W. Liquefaction necrosis of mitral annular calcification (LNMAC): review of pathology, prevalence, imaging and management: proposed diagnostic imaging criteria with detailed multi-modality and MRI image characterization. Int J Cardiovasc Imaging. 2012; 28:1161-71.
  165. Sung V, Beebe DW, Vandyke R, Fenchel MC, Crimmins NA, Kirk S, Hiscock H, Amin R, Wake M. Does sleep duration predict metabolic risk in obese adolescents attending tertiary services? A cross-sectional study. Sleep. 2011; 34:891-8.
  166. Tariq M, Belmont JW, Lalani S, Smolarek T, Ware SM. SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing. Genome Biol. 2011; 12:R91.
  167. Tariq M, Le TT, Putnam P, Kindel SJ, Keddache M, Ware SM. Targeted capture and massively parallel sequencing in pediatric cardiomyopathy: development of novel diagnostics. Cardiogenetics. 2012; 2:e7.
  168. Thiagarajan RR, Almond CS, Cooper DS, Morales DLS. Ventricular Assist Devices for Mechanical Circulatory Support in Children. World Journal for Pediatric and Congenital Heart Surgery. 2012; 3:104-109.
  169. Tisma-Dupanovic S, Gowdamarajan R, Goldenberg I, Huang DT, Knilans T, Towbin JA. Prolonged QT in a 13-year-old patient with Down syndrome and complete atrioventricular canal defect. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2011; 16:403-6.
  170. Towbin JA. Cardiomyopathies. Pediatric cardiovascular medicine. Chichester, West Sussex, UK: Wiley-Blackwell; 2012:826-854.
  171. Towbin JA, Vatta M, Li H, Bowles NE. Genetics and Cardiac Arrhythmia Syndromes. Electrophysiological Disorders of the Heart. Philadelphia: Elsevier Saunders; 2011:795-808.
  172. Tranter M, Liu Y, He S, Gulick J, Ren X, Robbins J, Jones WK, Reineke TM. In vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. Molecular therapy : the journal of the American Society of Gene Therapy. 2012; 20:601-8.
  173. Tuzun E, Bick R, Kadipasaoglu C, Conger JL, Poindexter BJ, Gregoric ID, Frazier OH, Towbin JA, Radovancevic B. Modification of a volume-overload heart failure model to track myocardial remodeling and device-related reverse remodeling. ISRN cardiology. 2011; 2011:831062.
  174. Urbina EM, Gao Z, Khoury PR, Martin LJ, Dolan LM. Insulin resistance and arterial stiffness in healthy adolescents and young adults. Diabetologia. 2012; 55:625-31.
  175. van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108:12331-6.
  176. Varma N, Helms R, Benson DW, Sanagala T. Congenital sick sinus syndrome with atrial inexcitability and coronary sinus flutter. Circulation. Arrhythmia and electrophysiology. 2011; 4:e52-8.
  177. Walsh MA, Grenier MA, Jefferies JL, Towbin JA, Lorts A, Czosek RJ. Conduction abnormalities in pediatric patients with restrictive cardiomyopathy. Circulation. Heart failure. 2012; 5:267-73.
  178. Ware SM, Aygun MG, Hildebrandt F. Spectrum of clinical diseases caused by disorders of primary cilia. Proceedings of the American Thoracic Society. 2011; 8:444-50.
  179. Weith A, Sadayappan S, Gulick J, Previs MJ, Vanburen P, Robbins J, Warshaw DM. Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. Journal of molecular and cellular cardiology. 2012; 52:219-27.
  180. Williams RV, Zak V, Ravishankar C, Altmann K, Anderson J, Atz AM, Dunbar-Masterson C, Ghanayem N, Lambert L, Lurito K, Medoff-Cooper B, Margossian R, Pemberton VL, Russell J, Stylianou M, Hsu D. Factors affecting growth in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial. J Pediatr. 2011; 159:1017-22 e2.
  181. Woodward GA, Kirsch R, Trautman MS, Kleinman ME, Wernovsky G, Marino BS. Stabilization and Transport of the High-Risk Infant. Avery's Diseases of the Newborn: Expert Consult. Philadelphia: Saunders Elsevier; 2011:341-356.
  182. Wray J, Brown K, Marino BS, Franklin R. Medical Test Results Do Not Tell the Whole Story: Health-Related Quality of Life Offers a Patient Perspective on Outcomes. World Journal for Pediatric and Congenital Heart Surgery. 2011; 2:566-575.
  183. Wray J, Franklin R, Brown K, Blyth J, Marino BS. Linguistic validation of a disease-specific quality of life measure for children and teenagers with cardiac disease. Cardiol Young. 2012; 22:13-7.
  184. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, 2nd, Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. The Journal of clinical investigation. 2011; 121:3269-76.
  185. Yetman AT, Webb GD. Adults with Congenital Heart Disease. Pediatric cardiovascular medicine. Chichester, West Sussex, UK: Wiley-Blackwell; 2012:762-772.
  186. Zafar F, Khan MS, Heinle JS, Adachi I, McKenzie ED, Schecter MG, Mallory GB, Morales DL. Does donor arterial partial pressure of oxygen affect outcomes after lung transplantation? A review of more than 12,000 lung transplants. J Thorac Cardiovasc Surg. 2012; 143:919-25.
  187. Zaoutis TE, Webber S, Naftel DC, Chrisant MA, Kaufman B, Pearce FB, Spicer R, Dipchand AI. Invasive fungal infections in pediatric heart transplant recipients: incidence, risk factors, and outcomes. Pediatric transplantation. 2011; 15:465-9.
  188. Zappitelli M, Krawczeski CD, Devarajan P, Wang Z, Sint K, Thiessen-Philbrook H, Li S, Bennett MR, Ma Q, Shlipak MG, Garg AX, Parikh CR. Early postoperative serum cystatin C predicts severe acute kidney injury following pediatric cardiac surgery. Kidney international. 2011; 80:655-62.
  189. Zussman ME, Bagby M, Benson DW, Gupta R, Hirsch R. Pulmonary vascular resistance in repaired congenital diaphragmatic hernia vs. age-matched controls. Pediatr Res. 2012; 71:697-700.

Grants, Contracts, and Industry Agreements

Division Grants

Heart Institute

Grant and Contract AwardsAnnual Direct

Accornero, F

PGF Role in Regulating Cardiac Remodeling
11POST753003507/01/11-06/30/13$43,000

Anderson, J

Nutritional Deficiencies in Infants with Single Ventricle
10/01/10-09/30/12$12,500

Bhuiyan, S

Functional Significance and Regulation of cMyBP-C Binding to Actin
11POST759018107/01/11-06/30/13$43,000

Cole, C

Myocardial Protection during Fetal Bypass: Role of Calcium Cycling
F32 HL 10305407/01/10-06/30/12$53,042

Cooper, D

Outcomes in Patients Requiring More Than a Single Course of ECMO Therapy
04/01/12-03/31/13$5,000

Correll, R

Regulation of Cardiac Gene Expression by the L-type Calcium Channel, CaV1.2
F32 HL 09755109/07/09-01/06/12$18,989

Cnota, J

Pediatric Heart Network Prairieland Consortium
U01 HL 10967309/01/11-06/30/16$367,500

Gupta, M

Role of Myosin Binding Protein-C Phosphorylation in Cardiac Function
11POST759002607/01/11-06/30/13$43,000

Hor, K

Early Treatment with Aldosterone Antagonism Attenuates Cardiomyopathy in Duchenne Muscular Dystrophy
06/01/12-05/31/14$29,811
Early Treatment with Aldosterone Antagonism Attenuates Cardiomyopathy in Duchenne Muscular Dystrophy - Supplement Funds
06/01/12-05/31/14$10,000

Horn, M

Differential Twist1 Dimer Function and Gene Regulation in Valve Progenitor Cells
11PRE724002307/01/11-06/30/13$23,000

Ippisch, H

Cardiovascular Effects of Dietary Fat and Exercise Challenges in Obese Children
K23 HL 09117409/01/08-07/31/13$126,135

Karch, J

The Role of Bax and Bak in Necrotic Cell Death
07/01/10-06/30/12$23,000

Khuchua, Z

A Mouse Model of Barth Syndrome, a Mitochondrial Cardiolipin Disorder
R01 HL 10886707/07/11-03/31/15$250,000

Kimball, T

Chronic Kidney Disease in Children
U01 DK 06614308/01/08-07/31/13$55,222

Krishnamurthy, V

Aortic Root Structure-Function Relationships in a Mouse Model of Aortic Valve Disease and Aortopathy
11PRE721004407/01/11-06/30/12$23,000

Lattin, B

Weight Management Program for Pre-school Children: A Feasibility Study for Group Treatment
06/01/12-05/31/13$10,000

Marino, B

Do Biochemical, Hematopoietic, and Stool Biomarkers Predict Low Cardiac Index in Patients with Fontan Physiology
01/01/12-12/31/13$100,000
Understanding Mechanisms of Fontan Failure and Key Predictors for Patient Outcome
R01 HL 09825202/01/10-01/31/14$16,667

McLendon, P

The Role of Impaired Protein Degradation Pathways in CryABR120G-Mediated Desmin-R
F32 HL 11255801/11/12-01/10/14$51,326

Michelfelder, E

Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
05/15/11-12/31/14$33,848

Molkentin, J

Calcium as a Molecular Signal in the Heart
R01 HL 08931208/15/07-06/30/12$239,303
Cardiac Hypertrophic Intracellular Signaling Pathways
R01 HL 06292702/01/09-12/31/13$222,750
Molecular Pathways Controlling Cardiac Gene Expression
R37 HL 06056207/01/08-06/30/13$250,000
Mechanisms of TGF Regulated Fibrosis in Muscular Dystrophy: Project 3
P01 NS 07202707/01/11-06/30/16$225,000
Thrombospondin 4 Regulates Adaptive ER Stress Response
R01 HL 10592401/01/11-12/31/11$315,000
Ca Signaling Domains Programming Cardiac Hypertrophy
2P01 HL 08010108/01/11-05/31/16$274,517

Rajan, S

Translational and Post-translational Regulation of Tropomyosin in Normal and Cardiomyopathic Hearts
11SDG498002908/01/11-12/31/14$102,083

Robbins, J

Cardiac Myosin Binding Protein-C: Structure, Function and Regulation
P01 HL 05940802/01/10-01/31/15$349,278
Proteotoxicity: An Unappreciated Mechanism of Heart Disease
10/01/11-09/30/16$168,182
Signaling Processes Underlying Cardiovascular Function
P01 HL 06977901/11/08-12/31/12$1,219,260

Sengupta, A

FOXO Function in Cardiomyocytes During Development and Disease
11POST721002607/01/11-06/30/13$43,000

Siegel, R

Collaborative Community Based Initiative to Improve the Health of Overweight and Obese Children in Cincinnati
01/01/11-12/31/12$76,223

Urbina, E

Accelerated CV Aging in Youth Related to CV Risk Factor Clusters
R01 HL 10559101/01/11-12/31/15$379,410
Modifying Dietary Behavior in Adolescents with Elevated Blood Pressure
R01 HL 08856702/01/08-01/31/13$38,672

van Berlo, J

Functional Relevance and Extent of Endogenous Cardiac Regeneration by C-Kit Positive Stem Cells
K99 HL 11285206/04/12-06/03/17$121,660
GATA-6 Function is Crucial for Cardiac Hypertrophy to Prevent Heart Failure
07/01/10-06/30/12$45,000

Ware, S

Genetic causes of congenital heart defects
06/01/10-05/31/13$79,590
Role of the Embryonic Node in Cardiac Development and Congenital Heart Disease
R01 HL 08863904/01/07-03/31/12$250,000
Uncovering Novel Genetic Causes and Risk in Congenital Heart Disease Patients
BWF #100849607/01/09-06/30/15$150,000

Waxman, J

Elucidation of Molecular Networks Required to Limit Cardiac Cell Number
R00 HL 09112607/15/10-05/31/13$162,745
Illumination of Mechanisms Controlling Atrial Cell Formation
02/01/11-01/31/13$69,327

Yutzey, K

Student Undergraduate Research Fellowship
12UFEL999000002/01/12-01/31/14$20,000
Twist 1 Regulation of Valve Progenitors
R01 HL 08271607/01/10-05/31/15$250,000
Wnt Signaling in Heart Valve Development and Disease
R01 HL 09431904/15/12-02/28/16$250,000
Current Year Direct$6,639,040
Industry Contracts

Beekman

$2,229

Chin

$10,372

Hirsch

$22,372

Krawczeski

$24,378
Current Year Direct Receipts$59,351
Total$6,698,391

Division Grants

Cardiology

Grant and Contract AwardsAnnual Direct

Anderson, J

Nutritional Deficiencies in Infants with Single Ventricle
10/01/10-09/30/12$12,500

Cnota, J / Krawczeski, C

Pediatric Heart Network Prairieland Consortium
U01 HL 10967309/01/11-06/30/16$367,500

Cooper, D

Outcomes in Patients Requiring More Than a Single Course of ECMO Therapy
04/01/12-03/31/13$5,000

Hor, K

Early Treatment with Aldosterone Antagonism Attenuates Cardiomyopathy in Duchenne Muscular Dystrophy
06/01/12-05/31/14$29,811
Early Treatment with Aldosterone Antagonism Attenuates Cardiomyopathy in Duchenne Muscular Dystrophy - Supplement Funds
06/01/12-05/31/14$10,000

Ippisch, H

Cardiovascular Effects of Dietary Fat and Exercise Challenges in Obese Children
K23 HL 09117409/01/08-07/31/13$126,135

Kimball, T

Chronic Kidney Disease in Children
U01 DK 06614308/01/08-07/31/13$55,222

Lattin, B

Weight Management Program for Pre-school Children: A Feasibility Study for Group Treatment
06/01/12-05/31/13$10,000

Marino, B

Do Biochemical, Hematopoietic, and Stool Biomarkers Predict Low Cardiac Index in Patients with Fontan Physiology
01/01/12-12/31/13$100,000
Understanding Mechanisms of Fontan Failure and Key Predictors for Patient Outcome
R01 HL 09825202/01/10-01/31/14$16,667

Michelfelder, E

Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
05/15/11-12/31/14$33,848

Urbina, E

Accelerated CV Aging in Youth Related to CV Risk Factor Clusters
R01 HL 10559101/01/11-12/31/15$379,410
Modifying Dietary Behavior in Adolescents with Elevated Blood Pressure
R01 HL 08856702/01/08-01/31/13$38,672
Current Year Direct$1,184,765
Industry Contracts

Beekman, R

$2,229

Chin, C

$10,372

Hirsch, R

$22,372

Krawczeski, C

$24,378
Current Year Direct Receipts$59,351
Total$1,244,116

Division Grants

Cardiothoracic Surgery

Grant and Contract AwardsAnnual Direct

Cole, C

Myocardial Protection during Fetal Bypass: Role of Calcium Cycling
F32 HL 10305407/01/10-06/30/12$53,042
Current Year Direct$53,042
Total$53,042

Division Grants

Molecular Cardiovascular Biology

Grant and Contract AwardsAnnual Direct

Accornero, F

PGF Role in Regulating Cardiac Remodeling
11POST753003507/01/11-06/30/13$43,000

Bhuiyan, S

Functional Significance and Regulation of cMyBP-C Binding to Actin
11POST759018107/01/11-06/30/13$43,000

Correll, R

Regulation of Cardiac Gene Expression by the L-type Calcium Channel, CaV1.2
F32 HL 09755109/07/09-01/06/12$18,989

Gupta, M

Role of Myosin Binding Protein-C Phosphorylation in Cardiac Function
11POST759002607/01/11-06/30/13$43,000

Horn, M

Differential Twist1 Dimer Function and Gene Regulation in Valve Progenitor Cells
11PRE724002307/01/11-06/30/13$23,000

Karch, J

The Role of Bax and Bak in Necrotic Cell Death
07/01/10-06/30/12$23,000

Khuchua, Z

A Mouse Model of Barth Syndrome, a Mitochondrial Cardiolipin Disorder
R01 HL 10886707/07/11-03/31/15$250,000

Krishnamurthy, V

Aortic Root Structure-Function Relationships in a Mouse Model of Aortic Valve Disease and Aortopathy
11PRE721004407/01/11-06/30/12$23,000

McLendon, P

The Role of Impaired Protein Degradation Pathways in CryABR120G-Mediated Desmin-R
F32 HL 11255801/11/12-01/10/14$51,326

Molkentin, J

Calcium as a Molecular Signal in the Heart
R01 HL 08931208/15/07-06/30/12$239,303
Cardiac Hypertrophic Intracellular Signaling Pathways
R01 HL 06292702/01/09-12/31/13$222,750
Molecular Pathways Controlling Cardiac Gene Expression
R37 HL 06056207/01/08-06/30/13$250,000
Mechanisms of TGF Regulated Fibrosis in Muscular Dystrophy
P01 NS 07202707/01/11-06/30/16$225,000
Thrombospondin 4 Regulates Adaptive ER Stress Response
R01 HL 10592401/01/11-12/31/11$315,000
Ca Signaling Domains Programming Cardiac Hypertrophy
PO1 HL 08010108/01/11-05/31/16$271,987

Rajan, S

Translational and Post-Translational Regulation of Tropomyosin in Normal and Cardiomyopathic Hearts
11SDG498002908/01/11-12/31/14$76,370

Robbins , J

Cardiac Myosin Binding Protein-C: Structure, Function and Regulation
P01 HL 05940802/01/10-01/31/15$349,278
Proteotoxicity: An Unappreciated Mechanism of Heart Disease
10/01/11-09/30/16$168,182
Signaling Processes Underlying Cardiovascular Function
P01 HL 06977901/11/08-12/31/12$1,219,260

Sengupta, A

FOXO Function in Cardiomyocytes During Development and Disease
11POST721002607/01/11-06/30/13$43,000

van Berlo, J

Functional Relevance and Extent of Endogenous Cardiac Regeneration by C-Kit Positive Stem Cells
K99 HL 11285206/04/12-06/03/17$121,660
GATA-6 Function is Crucial for Cardiac Hypertrophy to Prevent Heart Failure
07/01/10-06/30/12$45,000

Ware, S

Genetic Causes of Congenital Heart Defects
06/01/10-05/31/13$79,590
Role of the Embryonic Node in Cardiac Development and Congenital Heart Disease
R01 HL 08863904/01/07-03/31/12$250,000
Uncovering Novel Genetic Causes and Risk in Congenital Heart Disease Patients
BWF #100849607/01/09-06/30/15$150,000

Waxman, J

Elucidation of Molecular Networks Required to Limit Cardiac Cell Number
R00 HL 09112607/15/10-05/31/13$162,745
Illumination of Mechanisms Controlling Atrial Cell Formation
02/01/11-01/31/13$69,327

Yutzey, K

Student Undergraduate Research Fellowship
12UFEL999000002/01/12-01/31/14$20,000
Twist 1 Regulation of Valve Progenitors
R01 HL 08271607/01/10-05/31/15$250,000
Wnt Signaling in Heart Valve Development and Disease
R01 HL 09431904/15/12-02/28/16$250,000
Current Year Direct$5,296,767
Total$5,296,767