Rheumatology & Center for Autoimmune Genomics and Etiology
Division Details
Division Data Summary
Research and Training Details
| Number of Faculty | 15 |
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| Number of Research Fellows | 3 |
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| Number of Support Personnel | 11 |
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| Direct Annual Grant Support | $4,880,993 |
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| Direct Annual Industry Support | $831,340 |
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| Peer Reviewed Publications | 62 |
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Clinical Activities and Training
| Number of Clinical Staff | 6 |
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| Number of Clinical Fellows | 5 |
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| Number of Other Students | 9 |
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| Inpatient Encounters | 520 |
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| Outpatient Encounters | 3,888 |
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Division Photo
Row 1: M Weirauch, E Giannini, H Brunner, R Mina
Row 2: J Harley, T Ting, E Morgan-DeWitt
Row 3: K Kaufman, A Grom
Significant Accomplishments
Significant Accomplishments
The Division of Rheumatology Maintains International Stature
Rheumatology has had a successful fiscal year with a number of important accomplishments and publications, including: Collaborating with Seattle Children’s, Edward Giannini, MSc, DrPH, has shown that aggressive treatment early in the disease course leads to better therapeutic responses and outcomes in juvenile idiopathic arthritis. Michael Henrickson, MD, MPH, published a comprehensive evaluation of the pediatric rheumatology workforce. An institution-wide initiative led by Michael Barnes, PhD, created a biobank for tissues and DNA that is expected to have 750,000 samples before the end of the year; the samples will be useful to research. The continuing efforts of Susan Thompson, PhD, and colleagues led to discovery of a gene important for juvenile idiopathic arthritis.
Work with Micro-RNA’s Leads to Important Findings
Nan Shen, MD, has revealed many of the details of how small RNA’s, called micro-RNA’s, control the production of particular inflammatory mediators known as cytokines. Shen’s research has important clinical implications for treating autoimmune diseases such as systemic lupus erythematosus, allergy and asthma.
Center for Autoimmune Genomic Etiology Joins eMERGE Consortium
As a result of the work of John Harley, MD, Cincinnati Children’s is now an NIH-funded member of the eMERGE (electronic MEdical Records and GEnomics) Network. This network is a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. We are helping lead the national initiative to use genetic data with electronic medical records to deepen our understanding of childhood diseases and usher in the coming era of personalized medicine.
Significant Publications
- Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N, Qian Y. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med. Jun 3 2012.
- IL-17 is an important cytokine in many inflammatory disorders. This study reveals an important role for micro-RNA 236 in the control of IL-17 expression.
- Wallace, C. A., Giannini, E. H., Spalding, S. J., Hashkes, P. J., O'Neil, K. M., Zeft, A. S., Szer, I. S., Ringold, S., Brunner, H. I., Schanberg, L. E., Sundel, R. P., Milojevic, D., Punaro, M. G., Chira, P., Gottlieb, B. S., Higgins, G. C., Ilowite, N. T., Kimura, Y., Hamilton, S., Johnson, A., Huang, B., & Lovell, D. J. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum, 64(6), 2012-2021. 2012.
- The paradigm of treatment whereby children with juvenile idiopathic arthritis are started on a relatively non-aggressive therapeutic regimen has been overturned by this work. This study showed that a high proportion of children treated very aggressively early in their disease course can be brought into a state of inactive disease after only 6 months of therapy initiation.
Henrickson M. Three-Part Series: Policy Challenges for the Pediatric Rheumatology Workforce
Part I. Education and Economics.Pediatr Rheumatol Online J. 9:23. 2011.
Part II. Health Care System Delivery and Workforce Supply. Pediatr Rheumatol Online J. 9:24. 2011.
Part III. The International Situation. Pediatr Rheumatol Online J. 9:26. 2011.
- This three-part analysis of current challenges to pediatric rheumatologists regarding barriers to access to care for children with rheumatic disease and to achieving optimal clinical outcomes addresses 1) education and economics, 2) health care system delivery and workforce supply, and 3) the international situation. Dr. Henrickson presents possible solutions to each identified challenge. Per an accompanying editorial (Lindsley CB: Policy challenges for the pediatric rheumatology workforce. Pediatr Rheumatol Online J 2012 10:5), Dr. Henrickson “has initiated an important conversation that has the potential to impact the future of our discipline… Dr. Henrickson has carefully analyzed workforce issues both in the US and internationally and made suggestions that should be seriously considered by the pediatric rheumatology community and implemented where feasible.”
- Niewold TB, Kelly JA, Kariuki SN, Franek BS, Kumar AA, Kaufman KM, Thomas K, Walker D, Kamp S, Frost JM, Wong AK, Merrill JT, Alarcón-Riquelme ME, Tikly M, Ramsey-Goldman R, Reveille JD, Petri MA, Edberg JC, Kimberly RP, Alarcón GS, Kamen DL, Gilkeson GS, Vyse TJ, James JA, Gaffney PM, Moser KL, Crow MK, Harley JB. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.Ann Rheum Dis. Mar 2012. 71(3):463-8. Epub. Nov 16 2011.
- We show that the gene variants at IRF5 influences the differences between patients.
- Thompson, S. D., Marion, M. C., Sudman, M., Ryan, M., Tsoras, M., Howard, T. D., Barnes, M. G., Ramos, P. S., Thomson, W., Hinks, A., Haas, J. P., Prahalad, S., Bohnsack, J. F., Wise, C. A., Punaro, M., Rose, C. D., Pajewski, N. M., Spigarelli, M., Keddache, M., Wagner, M., Langefeld, C. D., & Glass, D. N. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13.Arthritis Rheum. 2012.
- This work represents, to our knowledge, the largest genome-wide association study of JIA cases to date and focuses on the 2 most common subtypes, oligoarticular and RF-negative polyarticular JIA. We report novel JIA-associated loci and supporting eQTL results that extend the JIA associations beyond those previously reported (PTPN2, PTPN22, IL2RA, ADAD1-IL2-IL21, ANGPT1, COG6, C12orf30, and STAT4). The strongest replicated evidence for association with JIA was found at the chromosome 3q13 region, which includes CD80, a co-stimulatory molecule necessary for T cell activation. A novel association was also found near at 10q21 and includes JMJD1C, a gene that encodes a hormone-dependent transcription factor that functions by removing methyl marks on histones. It is noteworthy that a gene expression signature (defined by 50 expression probe sets) for JIA patients with chronically active arthritis also included JMJD1C. The overlap of genetic and gene expression findings cannot be explained by chance and suggests a functional relationship to disease pathogenesis.
Division Publications
Division Publications
- Anaya JM, Kim-Howard X, Prahalad S, Chernavsky A, Canas C, Rojas-Villarraga A, Bohnsack J, Jonsson R, Bolstad AI, Brun JG, Cobb B, Moser KL, James JA, Harley JB, Nath SK. Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. Autoimmun Rev. 2012; 11:276-80.
- Bronson PG, Goldstein BA, Ramsay PP, Beckman KB, Noble JA, Lane JA, Seldin MF, Kelly JA, Harley JB, Moser KL, Gaffney PM, Behrens TW, Criswell LA, Barcellos LF. The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus. Genes Immun. 2011; 12:667-71.
- Brunner HI, Mina R, Pilkington C, Beresford MW, Reiff A, Levy DM, Tucker LB, Eberhard BA, Ravelli A, Schanberg LE, Saad-Magalhaes C, Higgins GC, Onel K, Singer NG, von Scheven E, Itert L, Klein-Gitelman MS, Punaro M, Ying J, Giannini EH. Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2011; 63:1213-23.
- Carle AC, Dewitt EM, Seid M. Measures of health status and quality of life in juvenile rheumatoid arthritis: Pediatric Quality of Life Inventory (PedsQL) Rheumatology Module 3.0, Juvenile Arthritis Quality of Life Questionnaire (JAQQ), Paediatric Rheumatology Quality of Life Scale (PRQL), and Childhood Arthritis Health Profile (CAHP). Arthritis Care Res (Hoboken). 2011; 63 Suppl 11:S438-45.
- Castillejo-Lopez C, Delgado-Vega AM, Wojcik J, Kozyrev SV, Thavathiru E, Wu YY, Sanchez E, Pollmann D, Lopez-Egido JR, Fineschi S, Dominguez N, Lu R, James JA, Merrill JT, Kelly JA, Kaufman KM, Moser KL, Gilkeson G, Frostegard J, Pons-Estel BA, D'Alfonso S, Witte T, Callejas JL, Harley JB, Gaffney PM, Martin J, Guthridge JM, Alarcon-Riquelme ME. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis. 2012; 71:136-42.
- Dewitt EM, Grussemeyer CA, Friedman JY, Dinan MA, Lin L, Schulman KA, Reed SD. Resource use, costs, and utility estimates for patients with cystic fibrosis with mild impairment in lung function: analysis of data collected alongside a 48-week multicenter clinical trial. Value Health. 2012; 15:277-83.
- Dillon SP, Kurien BT, Li S, Bruner GR, Kaufman KM, Harley JB, Gaffney PM, Wallace DJ, Weisman MH, Scofield RH. Sex chromosome aneuploidies among men with systemic lupus erythematosus. J Autoimmun. 2012; 38:J129-34.
- Du F, Lu LJ, Teng JL, Shen N, Ye P, Bao CD. T-614 alters the production of matrix metalloproteinases (MMP-1 andMMP-3) and inhibits the migratory expansion of rheumatoid synovial fibroblasts, in vitro. Int Immunopharmacol. 2012; 13:54-60.
- Fukuda T, Brunner HI, Sagcal-Gironella AC, Vinks AA. Nonsteroidal anti-inflammatory drugs may reduce enterohepatic recirculation of mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. Ther Drug Monit. 2011; 33:658-62.
- Guo Q, Shen N, Yuan K, Li J, Wu H, Zeng Y, Fox J, 3rd, Bansal AK, Singh BB, Gao H, Wu M. Caveolin-1 plays a critical role in host immunity against Klebsiella pneumoniae by regulating STAT5 and Akt activity. Eur J Immunol. 2012; 42:1500-11.
- Guthridge JM, Clark DN, Templeton A, Dominguez N, Lu R, Vidal GS, Kelly JA, Kauffman KM, Harley JB, Gaffney PM, James JA, Poole BD. Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions. J Biomed Biotechnol. 2012; 2012:594056.
- Henrickson M. Policy challenges for the pediatric rheumatology workforce: Part II. Health care system delivery and workforce supply. Pediatr Rheumatol Online J. 2011; 9:23.
- Huang X, Guo Y, Bao C, Shen N. Multidimensional single cell based STAT phosphorylation profiling identifies a novel biosignature for evaluation of systemic lupus erythematosus activity. PLoS One. 2011; 6:e21671.
- Hughes T, Adler A, Kelly JA, Kaufman KM, Williams AH, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martin J, Niewold TB, Vila LM, Scofield RH, Gilkeson GS, Gaffney PM, Criswell LA, Moser KL, Merrill JT, Jacob CO, Tsao BP, James JA, Vyse TJ, Alarcon-Riquelme ME, Harley JB, Richardson BC, Sawalha AH. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum. 2012; 64:485-92.
- Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Boackle SA, Stevens AM, Alarcon GS, Niewold TB, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Criswell LA, Vila LM, Jacob CO, Gaffney PM, Moser KL, Vyse TJ, Alarcon-Riquelme ME, James JA, Tsao BP, Scofield RH, Harley JB, Richardson BC, Sawalha AH. Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis. 2012; 71:694-9.
- Irwin DE, Gross HE, Stucky BD, Thissen D, DeWitt EM, Lai JS, Amtmann D, Khastou L, Varni JW, DeWalt DA. Development of six PROMIS pediatrics proxy-report item banks. Health Qual Life Outcomes. 2012; 10:22.
- Irwin DE, Stucky BD, Langer MM, Thissen D, DeWitt EM, Lai JS, Yeatts KB, Varni JW, DeWalt DA. PROMIS Pediatric Anger Scale: an item response theory analysis. Qual Life Res. 2012; 21:697-706.
- Isackson PJ, Ochs-Balcom HM, Ma C, Harley JB, Peltier W, Tarnopolsky M, Sripathi N, Wortmann RL, Simmons Z, Wilson JD, Smith SA, Barboi A, Fine E, Baer A, Baker S, Kaufman K, Cobb B, Kilpatrick JR, Vladutiu GD. Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS. Muscle Nerve. 2011; 44:531-8.
- Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP, Jr., Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Moser KL, Klein-Gitelman M, Wagner-Weiner L, Langefeld CD, Armstrong DL, Zidovetzki R. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A. 2012; 109:E59-67.
- Kashikar-Zuck S, Ting TV, Arnold LM, Bean J, Powers SW, Graham TB, Passo MH, Schikler KN, Hashkes PJ, Spalding S, Lynch-Jordan AM, Banez G, Richards MM, Lovell DJ. Cognitive behavioral therapy for the treatment of juvenile fibromyalgia: a multisite, single-blind, randomized, controlled clinical trial. Arthritis Rheum. 2012; 64:297-305.
- Khanna D, Krishnan E, Dewitt EM, Khanna PP, Spiegel B, Hays RD. The future of measuring patient-reported outcomes in rheumatology: Patient-Reported Outcomes Measurement Information System (PROMIS). Arthritis Care Res (Hoboken). 2011; 63 Suppl 11:S486-90.
- Khanna D, Krishnan E, Dewitt EM, Khanna PP, Spiegel B, Hays RD. Patient-Reported Outcomes Measurement Information System (PROMIS(R)) -- The future of measuring patient reported outcomes in rheumatology. Arthritis Care Res (Hoboken). 2011; 63:S486-S490.
- Ko K, Franek BS, Marion M, Kaufman KM, Langefeld CD, Harley JB, Niewold TB. Genetic Ancestry, Serum Interferon-alpha Activity, and Autoantibodies in Systemic Lupus Erythematosus. J Rheumatol. 2012; 39:1238-40.
- Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, Alarcon-Riquelme ME, Alarcon GS, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Cho SK, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Kim JH, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Scofield RH, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Kaufman KM, Harley JB, Wakeland EK, Langefeld CD, Gaffney PM, Montgomery CG, Moser KL. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet. 2012; 90:648-60.
- Li R, Yang W, Zhang J, Hirankarn N, Pan HF, Mok CC, Chan TM, Wong RW, Mok MY, Lee KW, Wong SN, Leung AM, Li XP, Avihingsanon Y, Lee TL, Ho MH, Lee PP, Wong WH, Wong CM, Ng IO, Yang J, Li PH, Zhang Y, Zhang L, Li W, Baum L, Kwan P, Rianthavorn P, Deekajorndej T, Suphapeetiporn K, Shotelersuk V, Garcia-Barcelo MM, Cherny SS, Tam PK, Sham PC, Lau CS, Shen N, Lau Y, Ye DQ. Association of CD247 with systemic lupus erythematosus in Asian populations. Lupus. 2012; 21:75-83.
- Li Y, Tang Y, Zhou R, Sun D, Duan Y, Wang N, Chen Z, Shen N. Genetic polymorphism in the 3'-untranslated region of the E-cadherin gene is associated with risk of different cancers. Mol Carcinog. 2011; 50:857-62.
- Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM, Freedman BI, Anaya JM, Alarcon-Riquelme ME, Pons-Estel BA, Martin J, Glenn S, Adler A, Bae SC, Park SY, Bang SY, Song YW, Boackle SA, Brown EE, Edberg JC, Alarcon GS, Petri MA, Criswell LA, Ramsey-Goldman R, Reveille JD, Vila LM, Gilkeson GS, Kamen DL, Ziegler J, Jacob CO, Rasmussen A, James JA, Kimberly RP, Merrill JT, Niewold TB, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Moser KL, Harley JB, Gaffney PM, Montgomery CG. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun. 2012; 13:232-8.
- Mina R, Klein-Gitelman MS, Ravelli A, Beresford MW, Avcin T, Espada G, Eberhard BA, Schanberg LE, O'Neil KM, Silva CA, Higgins GC, Onel K, Singer NG, von Scheven E, Imundo LF, Nelson S, Giannini EH, Brunner HI. Inactive disease and remission in childhood-onset systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012; 64:683-93.
- Mina R, Melson P, Powell S, Rao M, Hinze C, Passo M, Graham TB, Brunner HI. Effectiveness of dexamethasone iontophoresis for temporomandibular joint involvement in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2011; 63:1511-6.
- Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chedeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quintero-del Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012; 64:375-83.
- Morishita K, Li SC, Muscal E, Spalding S, Guzman J, Uribe A, Abramson L, Baszis K, Benseler S, Bowyer S, Campillo S, Chira P, Hersh AO, Higgins G, Eberhard A, Ede K, Imundo L, Jung L, Kim S, Kingsbury DJ, Klein-Gitelman M, Lawson EF, Lovell DJ, Mason T, McCurdy D, Nanda K, Nassi L, O'Neil KM, Rabinovich E, Ramsey SE, Reiff A, Rosenkranz M, Schikler K, Stevens A, Wahezi D, Cabral DA. Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe). J Rheumatol. 2012; 39:1088-94.
- Namjou B, Choi CB, Harley IT, Alarcon-Riquelme ME, Kelly JA, Glenn SB, Ojwang JO, Adler A, Kim K, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown EE, Edberg J, Alarcon GS, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Kim EM, Park SY, Sung YK, Guthridge JM, Merrill JT, Petri M, Ramsey-Goldman R, Vila LM, Niewold TB, Martin J, Pons-Estel BA, Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams AH, Comeau ME, Reveille JD, Kang C, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Bae SC. Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheum. 2012; 64:1960-9.
- Niewold TB, Kelly JA, Kariuki SN, Franek BS, Kumar AA, Kaufman KM, Thomas K, Walker D, Kamp S, Frost JM, Wong AK, Merrill JT, Alarcon-Riquelme ME, Tikly M, Ramsey-Goldman R, Reveille JD, Petri MA, Edberg JC, Kimberly RP, Alarcon GS, Kamen DL, Gilkeson GS, Vyse TJ, James JA, Gaffney PM, Moser KL, Crow MK, Harley JB. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis. 2012; 71:463-8.
- Ochs SM, Thumann S, Richau R, Weirauch MT, Lowe TM, Thomm M, Hausner W. Activation of archaeal transcription mediated by recruitment of transcription factor B. J Biol Chem. 2012; 287:18863-71.
- Prahalad S, Thompson SD, Conneely KN, Jiang Y, Leong T, Prozonic J, Brown MR, Ponder LA, Angeles-Han ST, Vogler LB, Kennedy C, Wallace CA, Wise CA, Punaro M, Reed A, Park JL, Mellins ED, Zeft AS, Bohnsack JF, Glass DN. Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope. Arthritis Rheum. 2012; 64:925-30.
- Qi X, Flick MJ, Frederick M, Chu Z, Mason R, DeLay M, Thornton S. Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity. PLoS One. 2012; 7:e33966.
- Ramos PS, Criswell LA, Moser KL, Comeau ME, Williams AH, Pajewski NM, Chung SA, Graham RR, Zidovetzki R, Kelly JA, Kaufman KM, Jacob CO, Vyse TJ, Tsao BP, Kimberly RP, Gaffney PM, Alarcon-Riquelme ME, Harley JB, Langefeld CD. A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet. 2011; 7:e1002406.
- Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, Lessard CJ, Li H, Edberg JC, Zidovetzki R, Criswell LA, Gaffney PM, Graham DC, Graham RR, Kelly JA, Kaufman KM, Brown EE, Alarcon GS, Petri MA, Reveille JD, McGwin G, Vila LM, Ramsey-Goldman R, Jacob CO, Vyse TJ, Tsao BP, Harley JB, Kimberly RP, Alarcon-Riquelme ME, Langefeld CD, Moser KL. Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum. 2011; 63:2049-57.
- Ravelli A, Grom AA, Behrens EM, Cron RQ. Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment. Genes Immun. 2012; 13:289-98.
- Ritterhouse LL, Crowe SR, Niewold TB, Kamen DL, Macwana SR, Roberts VC, Dedeke AB, Harley JB, Scofield RH, Guthridge JM, James JA. Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis. 2011; 70:1569-74.
- Romick-Rosendale LE, Brunner HI, Bennett MR, Mina R, Nelson S, Petri M, Kiani A, Devarajan P, Kennedy MA. Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis. Arthritis Res Ther. 2011; 13:R199.
- Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vila LM, Merrill JT, Tsao BP, Kamen DL, Gilkeson GS, James JA, Vyse TJ, Gaffney PM, Jacob CO, Niewold TB, Richardson BC, Harley JB, Alarcon-Riquelme ME, Sawalha AH. Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum. 2011; 63:3493-501.
- Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman KM, Kelly JA, Niewold TB, Kamen DL, Gilkeson GS, Ziegler JT, Langefeld CD, Alarcon GS, Edberg JC, Ramsey-Goldman R, Petri M, Brown EE, Kimberly RP, Reveille JD, Vila LM, Merrill JT, Anaya JM, James JA, Pons-Estel BA, Martin J, Park SY, Bang SY, Bae SC, Moser KL, Vyse TJ, Criswell LA, Gaffney PM, Tsao BP, Jacob CO, Harley JB, Alarcon-Riquelme ME, Sawalha AH. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis. 2011; 70:1752-7.
- Schanberg LE, Sandborg C, Barnhart HX, Ardoin SP, Yow E, Evans GW, Mieszkalski KL, Ilowite NT, Eberhard A, Imundo LF, Kimura Y, von Scheven E, Silverman E, Bowyer SL, Punaro M, Singer NG, Sherry DD, McCurdy D, Klein-Gitelman M, Wallace C, Silver R, Wagner-Weiner L, Higgins GC, Brunner HI, Jung L, Soep JB, Reed AM, Provenzale J, Thompson SD. Use of atorvastatin in systemic lupus erythematosus in children and adolescents. Arthritis Rheum. 2012; 64:285-96.
- Schauberger EM, Ewart SL, Arshad SH, Huebner M, Karmaus W, Holloway JW, Friderici KH, Ziegler JT, Zhang H, Rose-Zerilli MJ, Barton SJ, Holgate ST, Kilpatrick JR, Harley JB, Lajoie-Kadoch S, Harley IT, Hamid Q, Kurukulaaratchy RJ, Seibold MA, Avila PC, Rodriguez-Cintron W, Rodriguez-Santana JR, Hu D, Gignoux C, Romieu I, London SJ, Burchard EG, Langefeld CD, Wills-Karp M. Identification of ATPAF1 as a novel candidate gene for asthma in children. J Allergy Clin Immunol. 2011; 128:753-760 e11.
- Sherwin CM, Sagcal-Gironella AC, Fukuda T, Brunner HI, Vinks AA. Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. Br J Clin Pharmacol. 2012; 73:727-40.
- Sikora KA, Grom AA. Update on the pathogenesis and treatment of systemic idiopathic arthritis. Curr Opin Pediatr. 2011; 23:640-6.
- Sreih A, Ezzeddine R, Leng L, LaChance A, Yu G, Mizue Y, Subrahmanyan L, Pons-Estel BA, Abelson AK, Gunnarsson I, Svenungsson E, Cavett J, Glenn S, Zhang L, Montgomery R, Perl A, Salmon J, Alarcon-Riquelme ME, Harley JB, Bucala R. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis Rheum. 2011; 63:3942-51.
- Tan W, Sunahori K, Zhao J, Deng Y, Kaufman KM, Kelly JA, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Bae SC, Lee JH, Lee JS, Chang DM, Song YW, Yu CY, Kimberly RP, Edberg JC, Brown EE, Petri MA, Ramsey-Goldman R, Vila LM, Reveille JD, Alarcon-Riquelme ME, Harley JB, Boackle SA, Stevens AM, Scofield RH, Merrill JT, Freedman BI, Anaya JM, Criswell LA, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Gilkeson GS, Kamen DL, James JA, Grossman JM, Hahn BH, Tsokos GC, Tsao BP, Alarcon GS. Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis Rheum. 2011; 63:2755-63.
- Thanou-Stavraki A, Aberle T, Aksentijevich I, Bane BL, Harley JB. Clarithromycin in adult-onset still's disease: a potentially useful therapeutic. J Clin Rheumatol. 2011; 17:373-6.
- Ting TV, Hashkes PJ, Schikler K, Desai AM, Spalding S, Kashikar-Zuck S. The role of benign joint hypermobility in the pain experience in Juvenile Fibromyalgia: an observational study. Pediatr Rheumatol Online J. 2012; 10:16.
- Ting TV, Kudalkar D, Nelson S, Cortina S, Pendl J, Budhani S, Neville J, Taylor J, Huggins J, Drotar D, Brunner HI. Usefulness of cellular text messaging for improving adherence among adolescents and young adults with systemic lupus erythematosus. J Rheumatol. 2012; 39:174-9.
- Vladutiu GD, Isackson PJ, Kaufman K, Harley JB, Cobb B, Christopher-Stine L, Wortmann RL. Genetic risk for malignant hyperthermia in non-anesthesia-induced myopathies. Mol Genet Metab. 2011; 104:167-73.
- Wallace CA, Giannini EH, Huang B, Itert L, Ruperto N. American College of Rheumatology provisional criteria for defining clinical inactive disease in select categories of juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2011; 63:929-36.
- Wallace CA, Giannini EH, Spalding SJ, Hashkes PJ, O'Neil KM, Zeft AS, Szer IS, Ringold S, Brunner HI, Schanberg LE, Sundel RP, Milojevic D, Punaro MG, Chira P, Gottlieb BS, Higgins GC, Ilowite NT, Kimura Y, Hamilton S, Johnson A, Huang B, Lovell DJ. Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum. 2012; 64:2012-2021.
- Wang FF, Zhu LA, Zou YQ, Zheng H, Wilson A, Yang CD, Shen N, Wallace DJ, Weisman MH, Chen SL, Lu LJ. New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus. Arthritis Res Ther. 2012; 14:R103.
- Wang J, Cao N, Yuan M, Cui H, Tang Y, Qin L, Huang X, Shen N, Yang HT. MicroRNA-125b/Lin28 Pathway Contributes to the Mesendodermal Fate Decision of Embryonic Stem Cells. Stem Cells Dev. 2012; 21:1524-37.
- Wang JL, Lin YW, Chen HM, Kong X, Xiong H, Shen N, Hong J, Fang JY. Calcium prevents tumorigenesis in a mouse model of colorectal cancer. PLoS One. 2011; 6:e22566.
- Wang N, Shen N, Vyse TJ, Anand V, Gunnarson I, Sturfelt G, Rantapaa-Dahlqvist S, Elvin K, Truedsson L, Andersson BA, Dahle C, Ortqvist E, Gregersen PK, Behrens TW, Hammarstrom L. Selective IgA deficiency in autoimmune diseases. Mol Med. 2011; 17:1383-96.
- Weirauch MT, Hughes TR. A Catalogue of Eukaryotic Transcription Factor Types, Their Evolutionary Origin, and Species Distribution. A Handbook of Transcription Factors. Dordrecht ; London: Springer; 2011:25-73.
- Yang D, Li T, Wang Y, Tang Y, Cui H, Zhang X, Chen D, Shen N, Le W. miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression. J Cell Sci. 2012; 125:1673-82.
- Zhou XJ, Lu XL, Nath SK, Lv JC, Zhu SN, Yang HZ, Qin LX, Zhao MH, Su Y, Shen N, Li ZG, Zhang H. Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum. 2012; 64:222-31.
Faculty, Staff, and Trainees
Faculty Members
- John Harley, MD, PhD, Professor
- Leadership Division Director
- Hermine Brunner, MD, MSc, Professor
- Edward H. Giannini, MSc, DrPH, Professor
- David N. Glass, MD, Professor
- Alexei A. Grom, MD, Associate Professor
- Michael Henrickson, MD, MPH, Associate Professor
- Leadership Clinical Director
- Jennifer Huggins, MD, Associate Professor
- Leadership Fellowship Director
- Kenneth Kaufman, PhD, Professor
- Daniel Joe Lovell, MD, MPH, Professor
- Leadership Joseph E. Levinson Endowed Chair in Pediatric Rheumatology
- Esi Morgan DeWitt, MD, MSCE, Assistant Professor
- Nan Shen, MD, Associate Professor
- Susan Thompson, PhD, Professor
- Leadership Associate Director
- Sherry Thornton, PhD, Assistant Professor
- Tracy Ting, MD, Assistant Professor
- Matthew Weirauch, PhD, Assistant Professor
Clinical Staff Members
- Janalee Taylor, MSN, RN, CNP
Trainees
- Moussa El-Hallak, MD, PL-5, Memorial University Medical Center
- Pai-Yue Lu, MD, PGY-, Cincinnati Children's Hospital Medical Center
- David Moser, DO, PL-6, United States Army, Pediatrics
- Keith Sikora, MD, PL-6, Johns Hopkins Hospital
- Patricia Vega-Fernandez, MD, PL-5, University of Texas Health Science Center at San Antonio, Texas
Grants, Contracts, and Industry Agreements
Division Grants
| Grant and Contract Awards | Annual Direct |
|---|
Barnes, M
| Expansion of Family Aspects of a DNA Biorepository |
|
| UL1 RR 026314 | 09/01/11-03/31/12 | $108,944 |
Brunner, H
| Towards Measures of Lupus Nephritis Activity & Damage in Children |
|
| U01 AR 059509 | 08/08/10-05/31/13 | $129,719 |
Flick, M
| Mechanisms Linking the Hemostatic Protease Thrombin to Arthritic Disease |
|
| R01 AR 056990 | 08/10/09-07/31/14 | $171,072 |
Grom, A
| MUNC13-4 Gene Polymorphisms in Macrophage Activation Syndrome and Systemic Juvenile Idiopathic Arthritis |
|
| R01 AR 059049 | 08/08/11-07/31/16 | $225,000 |
Harley, J
| Better Outcomes for Children: GWAS & PheWAS in eMERGEII. |
|
| U01 HG 006828 | 05/15/12-04/30/15 | $616,656 |
| Genetic Linkage in Lupus |
|
| R37 AI 024717 | 09/07/10-02/28/15 | $277,494 |
| Genome-Wide Association Study in African-Americans with Systemic Lupus Erythematosus |
|
| W81XWH-10-1-0675 | 09/01/10-08/31/13 | $269,095 |
| Program Project in the Genetics of SLE-Project 2: Genomics of Lupus Associations in the Hispanic 12q24 Linkage |
|
| P01 AR 049084 | 04/01/11-03/31/13 | $90,695 |
| Genomics of Lupus: Administratve Core A |
|
| P01 AI 083194 | 08/15/09-07/31/14 | $58,204 |
| Genomics of Lupus: Project 2 |
|
| P01 AI 083194 | 08/15/09-07/31/14 | $105,933 |
Kaufman, K
| Reverse Genomics of Anti-Protective Antigen Response |
|
| U19 AI 062629 | 09/01/11-08/31/14 | $77,582 |
Lovell, D
| Multidisciplinary Clinical Research Center |
|
| P60 AR 047784 | 08/18/08-07/31/13 | $847,448 |
| Lovell, D | Administrative Core | $73,066 |
|
| Giannini, E | Methods Core | $115,723 |
|
| Brunner, H | Project 1 | $165,115 |
|
| Lovell, D | Project 2 | $180,077 |
|
|
|
Morgan DeWitt, E
| Enhancing PROMIS in Pediatric Pain, Rheumatology, and Rehabilitation Research |
|
| U01 AR 057940 | 09/30/09-07/31/13 | $412,506 |
| Juvenile Arthritis Improvement Network for Clinical Excellence & Safety |
|
| 07/01/10-06/30/12 | $93,015 |
Thompson, S
| Cincinnati Rheumatic Disease Core Center |
|
| P30 AR 047363 | 08/25/11-06/30/16 | $400,000 |
| Thompson, S | Administrative Core | $137,490 |
|
|
|
|
|
| Gene Expression In Pediatric Arthritis |
|
| P01 AR 048929 | 09/01/11-08/31/16 | $997,630 |
| Thompson, S | Administrative Core | $163,910 |
|
| Thompson, S | Core A | $133,310 |
|
|
| Harley, J | Project 1 | $58,303 |
|
| Lovell, D | Project 2 | $38,399 |
|
| Thompson, S | Project 3 | $255,120 |
|
|
| Current Year Direct | $4,880,993 |
|---|
Brunner
| $19,892 |
| $101,974 |
| $9,500 |
| $20,611 |
| $9,000 |
Lovell
| $202,733 |
| $5,974 |
| $170,268 |
| $77,405 |
| $213,983 |
| Current Year Direct Receipts | $831,340, |
|---|
