Section of Neonatology, Perinatal and Pulmonary Biology

Division Details

Division Data Summary

Research and Training Details

Number of Faculty51
Number of Joint Appointment Faculty1
Number of Research Fellows8
Number of Research Students16
Number of Support Personnel114
Direct Annual Grant Support$9,428,773
Direct Annual Industry Support$659,536
Peer Reviewed Publications110

Clinical Activities and Training

Number of Clinical Staff22
Number of Clinical Fellows12

Division Photo

Group photo of the Division of Section of Neonatology, Perinatal and Pulmonary Biology-450

Row 1: C Hill, J Dritz, Y Xu, L Nommsen-Rivers, B Kamath-Rayne, B Haberman, S Bhattacharrya, A Perl, S Wert, J Greenberg, L Muglia, J Whitsett, V Narendran, A Nathan, T Weaver, N Goyal, C Valentine, K Melton

Row 2: T Cahill, D Premer, K Sparling, L Bookman, B Johnson, K Schibler, K Wikenheiser-Brokamp, S Glasser, M Ikegami, T Korfhagen, P Kingma, N Hillman, D Sinner, J Rone

Row 3: A Morrow, S Wexelblatt, T Suzuki, E Hall, J Shannon, B Trapnell, J Bridges, W Rice

Significant Accomplishments

Significant Accomplishments

The Center for Prevention of Preterm Birth

This endeavor is unique among children’s hospitals in developing a platform to circumvent the leading causing of infant mortality, preterm birth. To accomplish this goal, Cincinnati Children’s has dedicated substantial institutional resources to maintaining the current areas of accomplishment in lung development and complications of prematurity. Additionally, this year we recruited Louis Muglia, MD.

Number One Neonatology Program
Our work in helping prevent prematurity and improving outcomes for infants born prematurely has made us a leader in the field.  Our efforts were recognized this year by US News and World Report, who named us the number one neonatology program in the nation in their 2012 issue of “Best Children’s Hospitals.”

First MRI in a neonatal intensive care unit.

We were first in the world to establish an MRI scanner in a newborn intensive care unit, which we did this year. Previously, infants most in need of this imaging modality were prevented from study because of the risks of transporting them out of the NICU. The novel, safe implementation of this imaging system within the Cincinnati Children’s NICU will be transformative in newborn care.

Expansion of Cincinnati Children’s newborn care services to Dayton

In October of 2012, the Perinatal Institute will offer clinical services for newborns in the Kettering Health Network hospitals in Dayton, Ohio. This will add 5,000 deliveries per year to our service area and enhance opportunities for patient-focused research and quality improvement.

Leading pulmonary research

Jeffrey Whitsett, MD, and colleagues received a National Institutes of Health award to study “Airway Progenitor Cell Proliferation and Differentiation During Lung Repair” as part of a consortium for the study of lung repair and regeneration. This effort focuses on transcriptional mechanisms controlling proliferation and differentiation of airway epithelial cell progenitors. The investigative team plans to generate new antibodies, gene expression data and transgenic models with broad application to the field of pulmonary biology and medicine.

Division Highlights

Airway Progenitor Cell Proliferation and Differentiation during Lung Repair

Dr. Jeffrey Whitsett and colleagues were award a NIH U01 entitled “Airway Progenitor Cell Proliferation and Differentiation during Lung Repair” as part of a Consortium for the study of "Lung Repair and Regeneration." The goal of this effort focuses on transcriptional mechanisms controlling proliferation and differentiation of Airway Epithelial Cell progenitors. The investigative team plans to also generate and provide new antibodies, gene expression data and transgenic models of broad application to the field of Pulmonary Biology and Medicine.

Preterm Respiratory Outcomes Program (PROP)

We initiated patient enrollment in the Preterm Respiratory Outcomes Program (PROP) this year. This NHLBI-sponsored program supports a novel multicenter initiative to enhance understanding and predict one year respiratory outcomes in extremely preterm infants; those born 12 or more weeks before term. The PROP includes multicenter and CCHMC-specific projects. Dr. Alan Jobe is the Principal Investigator for the PROP, with Dr. Jim Greenberg serving as Co-Investigator. When enrollment is completed in 2014, the PROP cohort will include high-resolution data from over 750 subjects and promises to offer new insight and strategies for the treatment of neonatal chronic lung disease.

Chorioamnionitis in late preterm infants study

Drs. Alan Jobe, Suhas Kallapur are completing enrollment for their study of chorioamnionitis in late preterm infants. Many births between 32-36 weeks gestation occur in association with maternal chorioamnionitis. Often this infection is mild or asymptomatic, and the infants seem to do well after delivery. However, there are important questions about how this complication affects longer-term outcomes during infancy and beyond. This study will add important new information regarding the relationship between infection, inflammation and respiratory outcomes in this patient population.

Eunice Kennedy Shriver NICHD Neonatal Research Network

Dr. Kurt Schibler serves as Cincinnati Children’s Principal Investigator for the Eunice Kennedy Shriver NICHD Neonatal Research Network The 18 centers comprising the network are charged with conducting multicenter clinical trials to inform clinical practice and improve the outcome of newborn infants. Two recent high profile manuscripts, listed below, have prompted a change in practice among Maternal Fetal Medicine specialists regarding administration of antenatal steroid to mothers at high risk for delivery at the limits of viability and have confirmed long-term benefit, at school age, of hypothermia for treatment of neonatal hypoxic ischemic encephalopathy. Ongoing Network trials focus on optimizing neuroprotection strategies and improving survival of premature infants and reducing complications associated with prematurity. Postdoctoral fellows in the Perinatal Institute have used the Cincinnati-specific NICHD Neonatal Research Network Database for outcomes research.

Nation-leading program in prevention of prematurity

The Perinatal Institute has developed a nation-leading program in prevention of prematurity. This endeavor has resulted in the genesis of a unique transdisciplinary research endeavor that encompasses faculty for Cincinnati Children’s, UC College of Medicine, the McMicken College of Arts and Sciences and partner institutions around the state of Ohio and Midwest. This unique collaborative environment brings together basic biological, social and medical sciences to improve health outcomes for mothers and infants in the region and nation.

A new approach to investigation newborn brain insults

The greatest morbidity of children born prematurely stems from complications in brain development. To better understand and treat complications from neurological injury form being born early, the Perinatal Institute has implemented a new approach to investigation newborn brain insults – building a novel, prematurity compatible brain MRI imaging system in our NICU. This advance has already led to better care of preterm infants and holds the promise for new discoveries to prevent the greatest complications of early birth.

Expansion of newborn care in the Dayton region

Cincinnati Children’s neonatologists have long been recognized as the leaders in newborn care in the greater Cincinnati/Northern Kentucky region. To expand our sphere of influence in improving pregnancy outcomes, Cincinnati Children’s faculty will now deliver exceptional newborn care in the nurseries in the Dayton region. This expansion not only enhances infant outcomes, but provides an unparalleled opportunity for population-based research to further improve outcomes for preterm birth.

Significant Publications

Besnard V, Wert SE, Ikegami M, Xu Y, Murray SA, Donahue LR, Whitsett JA. Maternal synchronization of gestation length and lung maturation. PLoS ONE. 6: e26682. 2011.
This important study found that fetal lung maturation is determined by both fetal and maternal genomic information in mice. Further, experiments demonstrated that maternal genotype determines the timing of birth and can influence fetal lung growth and maturation to ensure perinatal survival.
Kallapur SG, Kramer BW, Knox CL, Berry CA, Collins JJ, Kemp MW, Nitsos I, Polglase GR, Robinson J, Hillman NH, Newnham JP, Chougnet C, Jobe AH. Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheep. J Immunol. 187(5):2688-95. Sep 2011.
Chorioamnionitis associated with preterm delivery is often polymicrobial with ureaplasma being the most common isolate. In this paper, Kallapur et al. find that ureaplasma reprogram innate immune responses in a manner that depends upon the duration of exposure during pregnancy.
Kamath-Rayne BD, DeFranco EA, Marcotte MP.Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomesObstet Gynecol. 119(5):909-16. May 2012.
Kamath-Rayne et al. evaluate whether antenatal corticosteroids given after fetal lung immaturity in pregnancies at 34 weeks of gestation or more would improve neonatal outcomes and, in particular, respiratory outcomes. They found that administration of antenatal corticosteroids after immature fetal lung indices did not reduce respiratory morbidity in neonates born at 34 weeks of gestation or more, a result that will influence significantly influence future therapy.
South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JMSpatial analysis of preterm birth demonstrates opportunities for targeted intervention. Matern Child Health J. 16(2):470-8. Feb 2012.
This study targeted intervention strategies for reducing preterm birth through use of geographic analysis of Hamilton County vital records. It demonstrated that the heterogeneous distribution of preterm birth proportion within an urban county is complex and requires location specific analysis to develop appropriate interventions.
Kuppala VS, Meinzen-Derr J, Morrow AL,Schibler KR. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr. 159(5):720-5. Nov 2011.
This study found that prolonged administration of empirical antibiotics to premature infants with sterile cultures in the first week of life was associated with subsequent severe outcomes. These results suggest that judicious restriction of antibiotic use should be investigated as a strategy to reduce severe outcomes for premature infants.

Division Publications

  1. Becker PM, Tran TS, Delannoy MJ, He C, Shannon JM, McGrath-Morrow S. Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. PLoS One. 2011; 6:e27449.
  2. Bell SM, Zhang L, Mendell A, Xu Y, Haitchi HM, Lessard JL, Whitsett JA. Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium. Dev Biol. 2011; 358:79-90.
  3. Berry CA, Nitsos I, Hillman NH, Pillow JJ, Polglase GR, Kramer BW, Kemp MW, Newnham JP, Jobe AH, Kallapur SG. Interleukin-1 in lipopolysaccharide induced chorioamnionitis in the fetal sheep. Reprod Sci. 2011; 18:1092-102.
  4. Besnard V, Wert SE, Ikegami M, Xu Y, Heffner C, Murray SA, Donahue LR, Whitsett JA. Maternal synchronization of gestational length and lung maturation. PLoS One. 2011; 6:e26682.
  5. Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV. Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. PLoS One. 2011; 6:e22217.
  6. Bookman LB, Melton KR, Pan BS, Bender PL, Chini BA, Greenberg JM, Saal HM, Taylor JA, Elluru RG. Neonates with tongue-based airway obstruction: a systematic review. Otolaryngol Head Neck Surg. 2012; 146:8-18.
  7. Bridges JP, Lin S, Ikegami M, Shannon JM. Conditional hypoxia inducible factor-1alpha induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol. 2012; 362:24-41.
  8. Carlo WA, McDonald SA, Fanaroff AA, Vohr BR, Stoll BJ, Ehrenkranz RA, Andrews WW, Wallace D, Das A, Bell EF, Walsh MC, Laptook AR, Shankaran S, Poindexter BB, Hale EC, Newman NS, Davis AS, Schibler K, Kennedy KA, Sanchez PJ, Van Meurs KP, Goldberg RN, Watterberg KL, Faix RG, Frantz ID, 3rd, Higgins RD, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation. JAMA. 2011; 306:2348-58.
  9. Carlo WA, McDonald SA, Tyson JE, Stoll BJ, Ehrenkranz RA, Shankaran S, Goldberg RN, Das A, Schendel D, Thorsen P, Skogstrand K, Hougaard DM, Oh W, Laptook AR, Duara S, Fanaroff AA, Donovan EF, Korones SB, Stevenson DK, Papile LA, Finer NN, O'Shea TM, Poindexter BB, Wright LL, Ambalavanan N, Higgins RD, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N, Collaborators:, Jobe AH, Narendran V. Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. J Pediatr. 2011; 159:919-25 e3.
  10. Chapman DJ, Nommsen-Rivers L. Impact of maternal nutritional status on human milk quality and infant outcomes: an update on key nutrients. Adv Nutr. 2012; 3:351-2.
  11. Cole CR, Hansen NI, Higgins RD, Bell EF, Shankaran S, Laptook AR, Walsh MC, Hale EC, Newman NS, Das A, Stoll BJ, Eunice Kennedy Shriver National Institute of Child H, Human Development's Neonatal Research N, Collaborator: Schibler K. Bloodstream infections in very low birth weight infants with intestinal failure. J Pediatr. 2012; 160:54-9 e2.
  12. Cummings KJ, Nakano M, Omae K, Takeuchi K, Chonan T, Xiao YL, Harley RA, Roggli VL, Hebisawa A, Tallaksen RJ, Trapnell BC, Day GA, Saito R, Stanton ML, Suarthana E, Kreiss K. Indium lung disease. Chest. 2012; 141:1512-21.
  13. Daikoku T, Jackson L, Besnard V, Whitsett J, Ellenson LH, Dey SK. Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes. Gynecol Oncol. 2011; 122:424-429.
  14. Dando SJ, Nitsos I, Kallapur SG, Newnham JP, Polglase GR, Pillow JJ, Jobe AH, Timms P, Knox CL. The role of the multiple banded antigen of Ureaplasma parvum in intra-amniotic infection: major virulence factor or decoy?. PLoS One. 2012; 7:e29856.
  15. D'Mello S, Trauernicht A, Ryan A, Bonkowski E, Willson T, Trapnell BC, Frank SJ, Kugasathan S, Denson LA. Innate dysfunction promotes linear growth failure in pediatric Crohn's disease and growth hormone resistance in murine ileitis. Inflamm Bowel Dis. 2012; 18:236-245.
  16. Feinstein JA, Benson DW, Dubin AM, Cohen MS, Maxey DM, Mahle WT, Pahl E, Villafane J, Bhatt AB, Peng LF, Johnson BA, Marsden AL, Daniels CJ, Rudd NA, Caldarone CA, Mussatto KA, Morales DL, Ivy DD, Gaynor JW, Tweddell JS, Deal BJ, Furck AK, Rosenthal GL, Ohye RG, Ghanayem NS, Cheatham JP, Tworetzky W, Martin GR. Hypoplastic left heart syndrome: current considerations and expectations. J Am Coll Cardiol. 2012; 59:S1-42.
  17. Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, Campbell-Thompson M, Yachnis AT, Sandhaus RA, McElvaney NG, Mueller C, Messina LM, Wilson JM, Brantly M, Knop DR, Ye GJ, Chulay JD. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing alpha1-antitrypsin: interim results. Hum Gene Ther. 2011; 22:1239-47.
  18. Geraghty S, Davidson B, Tabangin M, Morrow A. Predictors of breastmilk expression by 1 month postpartum and influence on breastmilk feeding duration. Breastfeed Med. 2012; 7:112-7.
  19. Glasser SW, Senft AP. Use of transgenic mouse models to understand the origins of familial pulmonary fibrosis. Curr Pharm Biotechnol. 2011; 12:1447-54.
  20. Goldenberg RL, McClure EM, Kamath BD. Intrapartum perinatal mortality. Indian Pediatr. 2012; 49:187-8.
  21. Goyal NK, Fager C, Lorch SA. Adherence to discharge guidelines for late-preterm newborns. Pediatrics. 2011; 128:62-71.
  22. Goyal NK, Fiks AG, Lorch SA. Persistence of underweight status among late preterm infants. Arch Pediatr Adolesc Med. 2012; 166:424-30.
  23. Goyal NK, Fiks AG, Lorch SA. Association of late-preterm birth with asthma in young children: practice-based study. Pediatrics. 2011; 128:e830-8.
  24. Hillman NH, Nitsos I, Berry C, Pillow JJ, Kallapur SG, Jobe AH. Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011; 301:L712-20.
  25. Huang F-F, Barnes PF, Feng Y, Donis R, Chroneos ZC, Idell S, Allen T, Perez DR, Whitsett JA, Dunussi-Joannopoulos K, Shams H. GM-CSF in the Lung Protects Against Lethal Influenza Infection. Am J Respir Crit Care Med. 2011; 184:259-268.
  26. Huang P, Xia M, Tan M, Zhong W, Wei C, Wang L, Morrow A, Jiang X. Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner. J Virol. 2012; 86:4833-43.
  27. Jobe AH. What is BPD in 2012 and what will BPD become?. Early Hum Dev. 2012; 88 Suppl 2:S27-8.
  28. Jobe AH. What is RDS in 2012?. Early Hum Dev. 2012; 88 Suppl 2:S42-4.
  29. Jobe AH, Kallapur SG, Kramer BW. Perinatal events and their influence on lung development and function.. The Newborn Lung: Neonatology questions and controversies series. Philadelphia: Elsevier/Saunders; 2012:57-90.
  30. Kallapur SG, Kramer BW, Knox CL, Berry CA, Collins JJ, Kemp MW, Nitsos I, Polglase GR, Robinson J, Hillman NH, Newnham JP, Chougnet C, Jobe AH. Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheep. J Immunol. 2011; 187:2688-95.
  31. Kallapur SG, Kramer BW, Nitsos I, Pillow JJ, Collins JJP, Polglase GR, Newnham JP, Jobe AH. Pulmonary and systemic inflammatory responses to intra-amniotic IL-1α in fetal sheep.. Am J Physiol Lung Cell Mol Physiol. 2011; 301:L285-L295.
  32. Kamath BD. Neonatal Sepsis. Berman's Pediatric Decision Making. Philadelphia, PA: Elsevier/Mosby; 2011:300-305.
  33. Kamath BD, Donovan EF, Christopher R, Brodbeck J, Slone C, Marcotte MP. Using improvement science to increase accuracy and reliability of gestational age documentation. Am J Perinatol. 2012; 29:217-24.
  34. Kamath-Rayne BD, DeFranco EA, Marcotte MP. Antenatal steroids for treatment of fetal lung immaturity after 34 weeks of gestation: an evaluation of neonatal outcomes. Obstet Gynecol. 2012; 119:909-16.
  35. Kamath-Rayne BD, MacGuire ER, McClure EM, Goldenberg RL, Jobe AH. Clinical algorithms for the identification of sick newborns in community-based settings. Acta Paediatr. 2012; 101:344-51.
  36. Kaplan HC, Ballard J. Changing practice to improve patient safety and quality of care in perinatal medicine. Am J Perinatol. 2012; 29:35-42.
  37. Kaplan HC, Provost LP, Froehle CM, Margolis PA. The Model for Understanding Success in Quality (MUSIQ): building a theory of context in healthcare quality improvement. BMJ Qual Saf. 2012; 21:13-20.
  38. Kemp MW, Kallapur SG, Jobe AH, Newnham JP. Obesity and the developmental origins of health and disease. J Paediatr Child Health. 2012; 48:86-90.
  39. Kemp MW, Saito M, Kallapur SG, Jobe AH, Keelan JA, Li S, Kramer B, Zhang L, Knox C, Yaegashi N, Newnham JP. Inflammation of the fetal ovine skin following in utero exposure to Ureaplasma parvum. Reprod Sci. 2011; 18:1128-37.
  40. Kenchegowda D, Swamynathan S, Gupta D, Wan H, Whitsett J, Swamynathan SK. Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Dev Biol. 2011; 356:5-18.
  41. King BA, Boyd JT, Kingma PS. Pulmonary maturational arrest and death in a patient with pulmonary interstitial glycogenosis. Pediatr Pulmonol. 2011; 46:1142-1145.
  42. Kingma P, Jobe AH. The Surfactant System. Kendig and Chernick's Disorders of the Respiratory Tract in Children. Philadelphia: Elsevier/Saunders; 2012:29-34.
  43. Kingma PS. Is premedication for intubation of preterm infants the right choice?. J Pediatr. 2011; 159:883-4.
  44. Kramer EL, Hardie WD, Mushaben EM, Acciani TH, Pastura PA, Korfhagen TR, Hershey GK, Whitsett JA, Le Cras TD. Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease. J Appl Physiol. 2011; 111:1760-7.
  45. Kunzmann S, Collins JJP, Yang Y, Uhlig S, Kallapur SG, Speer CP, Jobe AH, Kramer BW. Antenatal Inflammation Reduces Expression of Caveolin-1 and Influences Multiple Signaling Pathways in Preterm Fetal Lungs. Am J Respir Cell Mol Biol. 2011; 45:969-976.
  46. Kupert E, Anderson M, Liu Y, Succop P, Levin L, Wang J, Wikenheiser-brokamp K, Chen P, Pinney SM, Macdonald T, Dong Z, Starnes S, Lu S. Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BMC Cancer. 2011; 11:513.
  47. Kuppala VS, Meinzen-Derr J, Morrow AL, Schibler KR. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr. 2011; 159:720-5.
  48. Kuppala VS, Tabangin M, Haberman B, Steichen J, Yolton K. Current state of high-risk infant follow-up care in the United States: results of a national survey of academic follow-up programs. J Perinatol. 2012; 32:293-8.
  49. Kuypers E, Collins JJ, Jellema RK, Wolfs TG, Kemp MW, Nitsos I, Pillow JJ, Polglase GR, Newnham JP, Germeraad WT, Kallapur SG, Jobe AH, Kramer BW. Ovine fetal thymus response to lipopolysaccharide-induced chorioamnionitis and antenatal corticosteroids. PLoS One. 2012; 7:e38257.
  50. Kuypers E, Collins JJ, Kramer BW, Ofman G, Nitsos I, Pillow JJ, Polglase GR, Kemp MW, Newnham JP, Gavilanes AW, Nowacki R, Ikegami M, Jobe AH, Kallapur SG. Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs. Am J Physiol Lung Cell Mol Physiol. 2012; 302:L380-9.
  51. LaDow K, Schumann BL, Luse N, Warshawsky D, Pickens WL, Hoath SB, Talaska G. Acute treatment with kerosene damages the dermal barrier and alters the distribution of topically applied benzo(a)pyrene in mice. J Occup Environ Hyg. 2011; 8:701-8.
  52. Le LD, Keswani SG, Biesiada J, Lim FY, Kingma PS, Haberman BE, Frischer J, Habli M, Crombleholme TM. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. J Pediatr Surg. 2012; 47:57-62.
  53. Liu Y, Sadikot RT, Adami GR, Kalinichenko VV, Pendyala S, Natarajan V, Zhao YY, Malik AB. FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med. 2011; 208:1473-1484.
  54. Luisetti M, Balfour-Lynn IM, Johnson SR, Miravitlles M, Strange C, Trapnell BC, van Bronswijk H, Vogelmeier C. Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe. Respir Med. 2012; 106:759-68.
  55. Luisetti M, Bruno P, Kadija Z, Suzuki T, Raffa S, Torrisi MR, Campo I, Mariani F, Pozzi E, Trapnell BC, Mariotta S. Relationship among diffuse pulmonary fibrosis, alveolar proteinosis and granulocyte-macrophage colony stimulating factor autoantibodies.. Respir Care. 2011; 56:1608-1610.
  56. Madala SK, Schmidt S, Davidson C, Ikegami M, Wert S, Hardie WD. MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation. Am J Respir Cell Mol Biol. 2012; 46:380-8.
  57. Maeda Y, Chen G, Xu Y, Haitchi HM, Du L, Keiser AR, Howarth PH, Davies DE, Holgate ST, Whitsett JA. Airway Epithelial Transcription Factor NK2 Homeobox 1 Inhibits Mucous Cell Metaplasia and Th2 Inflammation.. Am J Respir Crit Care Med. 2011; 184:421-429.
  58. Matias SL, Nommsen-Rivers LA, Dewey KG. Determinants of exclusive breastfeeding in a cohort of primiparous periurban peruvian mothers. J Hum Lact. 2012; 28:45-54.
  59. McClure EM, de Graft-Johnson J, Jobe AH, Wall S, Koblinsky M, Moran A, Wright LL, Mwebesa W, Koso-Thomas M, Goldenberg RL, Maternal, Child Health Integrated Project Antenatal Corticosteroid Conference Working G. A conference report on prenatal corticosteroid use in low- and middle-income countries. Int J Gynaecol Obstet. 2011; 115:215-9.
  60. McClure EM, Pasha O, Goudar SS, Chomba E, Garces A, Tshefu A, Althabe F, Esamai F, Patel A, Wright LL, Moore J, Kodkany BS, Belizan JM, Saleem S, Derman RJ, Carlo WA, Hambidge KM, Buekens P, Liechty EA, Bose C, Koso-Thomas M, Jobe AH, Goldenberg RL, Global Network I. Epidemiology of stillbirth in low-middle income countries: a Global Network Study. Acta Obstet Gynecol Scand. 2011; 90:1379-85.
  61. McDowell SA, Ma Y, Kusano R, Akinbi HT. Simvastatin is Protective During Staphylococcus aureus Pneumonia. Curr Pharm Biotechnol. 2011; 12:1455-1462.
  62. Merhar S. Biomarkers in neonatal posthemorrhagic hydrocephalus. Neonatology. 2012; 101:1-7.
  63. Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, Vinks AA. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatr. 2011; 159:152-154 e3.
  64. Merhar SL, Tabangin ME, Meinzen-Derr J, Schibler KR. Grade and laterality of intraventricular haemorrhage to predict 18-22 month neurodevelopmental outcomes in extremely low birthweight infants. Acta Paediatr. 2012; 101:414-8.
  65. Murphy KE, Hannah ME, Willan AR, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Tomat L, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, Group MC, Wedig K. Maternal side-effects after multiple courses of antenatal corticosteroids (MACS): the three-month follow-up of women in the randomized controlled trial of MACS for preterm birth study. J Obstet Gynaecol Can. 2011; 33:909-21.
  66. Murphy KE, Willan AR, Hannah ME, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative G, Collaborator: Wedig K. Effect of antenatal corticosteroids on fetal growth and gestational age at birth. Obstet Gynecol. 2012; 119:917-23.
  67. Mushaben EM, Hershey GK, Pauciulo MW, Nichols WC, Le Cras TD. Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice. PLoS One. 2012; 7:e32468.
  68. Mushaben EM, Kramer EL, Brandt EB, Khurana Hershey GK, Le Cras TD. Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma. J Immunol. 2011; 187:5756-63.
  69. Namaky D, Herzberg J, Dehoop T, Jones E, Wedig K, Marcotte M. Long-term maternal depression after expectant management of early preterm birth. J Reprod Med. 2011; 56:479-84.
  70. Nogee LM, Trapnell BC. Lung diseases associated with disruption of pulmonary homeostasis.. Kendig and Chernick's disorders of the respiratory tract in children. Philadelphia, PA: Elsevier/Saunders; 2012:810-821.
  71. Nommsen-Rivers LA, Dolan LM, Huang B. Timing of Stage II Lactogenesis Is Predicted by Antenatal Metabolic Health in a Cohort of Primiparas. Breastfeed Med. 2012; 7:43-49.
  72. Onyango AW, Nommsen-Rivers L, Siyam A, Borghi E, de Onis M, Garza C, Lartey A, Baerug A, Bhandari N, Dewey KG, Araujo CL, Mohamed AJ, Van den Broeck J. Post-partum weight change patterns in the WHO Multicentre Growth Reference Study. Matern Child Nutr. 2011; 7:228-240.
  73. Paller AS, Hawk JL, Honig P, Giam YC, Hoath S, Mack MC, Stamatas GN. New insights about infant and toddler skin: implications for sun protection. Pediatrics. 2011; 128:92-102.
  74. Pillow JJ, Musk GC, McLean CM, Polglase GR, Dalton RGB, Jobe AH, Suki B. Variable ventilation improves ventilation and lung compliance in preterm lambs. Intensive Care Med. 2011; 37:1352-1359.
  75. Plantier L, Besnard V, Xu Y, Ikegami M, Wert SE, Hunt AN, Postle AD, Whitsett JA. Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity. J Biol Chem. 2012; 287:10099-114.
  76. Rawlins EL, Perl AK. The a"MAZE"ing world of lung-specific transgenic mice. Am J Respir Cell Mol Biol. 2012; 46:269-82.
  77. Rich W, Finer NN, Gantz MG, Newman NS, Hensman AM, Hale EC, Auten KJ, Schibler K, Faix RG, Laptook AR, Yoder BA, Das A, Shankaran S, Support, Generic Database Subcommittees of the Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Enrollment of extremely low birth weight infants in a clinical research study may not be representative. Pediatrics. 2012; 129:480-4.
  78. Ridsdale R, Lewis DF, Weaver TE, Akinbi HT. Proteomic analysis of lamellar bodies isolated from amniotic fluid: implications for function. Am J Perinatol. 2012; 29:419-28.
  79. Samson CM, Jurickova I, Molden E, Schreiner W, Colliver J, Bonkowski E, Han X, Trapnell BC, Denson LA. Granulocyte-macrophage colony stimulating factor blockade promotes CCR9+ lymphocyte expansion in Nod2 deficient mice.. Inflamm Bowel Dis. 2011; 17:2443-2455.
  80. Sant'Anna G, Laptook AR, Shankaran S, Bara R, McDonald SA, Higgins RD, Tyson JE, Ehrenkranz RA, Das A, Goldberg RN, Walsh MC, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N, Collaborator: Schibler K. Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy. J Child Neurol. 2012; 27:451-7.
  81. Schroer KT, Gibson AM, Sivaprasad U, Bass SA, Ericksen MB, Wills-Karp M, Lecras T, Fitzpatrick AM, Brown LA, Stringer KF, Hershey GK. Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress. J Allergy Clin Immunol. 2011; 128:539-48.
  82. Schwartz HP, Haberman BE, Ruddy RM. Hyperbilirubinemia: current guidelines and emerging therapies. Pediatr Emerg Care. 2011; 27:884-9.
  83. Sever-Chroneos Z, Murthy A, Davis J, Florence JM, Kurdowska A, Krupa A, Tichelaar JW, White MR, Hartshorn KL, Kobzik L, Whitsett JA, Chroneos ZC. GM-CSF modulates pulmonary resistance to influenza A infection. Antiviral Res. 2011; 92:319-28.
  84. Shane AL, Hansen NI, Stoll BJ, Bell EF, Sanchez PJ, Shankaran S, Laptook AR, Das A, Walsh MC, Hale EC, Newman NS, Schrag SJ, Higgins RD, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N, Collaborator: Schibler K. Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infants. Pediatrics. 2012; 129:e914-22.
  85. Shankaran S, Pappas A, McDonald SA, Laptook AR, Bara R, Ehrenkranz RA, Tyson JE, Goldberg R, Donovan EF, Fanaroff AA, Das A, Poole WK, Walsh M, Higgins RD, Welsh C, Salhab W, Carlo WA, Poindexter B, Stoll BJ, Guillet R, Finer NN, Stevenson DK, Bauer CR, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N, Collaborators:, Jobe AH, Schibler K, Steichen J. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. 2011; 128:e112-20.
  86. Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, Gustafson KE, Leach TM, Green C, Bara R, Petrie Huitema CM, Ehrenkranz RA, Tyson JE, Das A, Hammond J, Peralta-Carcelen M, Evans PW, Heyne RJ, Wilson-Costello DE, Vaucher YE, Bauer CR, Dusick AM, Adams-Chapman I, Goldstein RF, Guillet R, Papile LA, Higgins RD, Eunice Kennedy Shriver NNRN, Collaborator: Schibler K. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012; 366:2085-92.
  87. Sinner DI, Kim GJ, Henderson GC, Igal RA. Stearoyl CoA Desaturase-5: A Novel Regulator of Neuronal Cell Proliferation and Differentiation. PLoS One. 2012; 7:e39787.
  88. Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic detection of pulmonary hypertension in extremely low birth weight infants with bronchopulmonary dysplasia requiring prolonged positive pressure ventilation. J Perinatol. 2011; 31:635-640.
  89. Smith PB, Ambalavanan N, Li L, Cotten CM, Laughon M, Walsh MC, Das A, Bell EF, Carlo WA, Stoll BJ, Shankaran S, Laptook AR, Higgins RD, Goldberg RN, the Generic Database S, for the Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N, Collaborator: Schibler K. Approach to Infants Born at 22 to 24 Weeks' Gestation: Relationship to Outcomes of More-Mature Infants. Pediatrics. 2012; 129:e1508-e1516.
  90. South AP, Jones DE, Hall ES, Huo S, Meinzen-Derr J, Liu L, Greenberg JM. Spatial Analysis of Preterm Birth Demonstrates Opportunities for Targeted Intervention.. Matern Child Health J. 2012; 16:470-478.
  91. South AP, Wessel JJ, Sberna A, Patel M, Morrow AL. Hospital readmission among infants with gastroschisis. J Perinatol. 2011; 31:546-550.
  92. Srofenyoh E, Ivester T, Engmann C, Olufolabi A, Bookman L, Owen M. Advancing obstetric and neonatal care in a regional hospital in Ghana via continuous quality improvement. Int J Gynaecol Obstet. 2012; 116:17-21.
  93. Starnes SL, Pathrose P, Wang J, Succop P, Morris JC, Bridges J, Kupert EY, Anderson M. Clinical and molecular predictors of recurrence in stage I non-small cell lung cancer. Ann Thorac Surg. 2012; 93:1606-12.
  94. Sun X, Zhang L, Xie H, Wan H, Magella B, Whitsett JA, Dey SK. Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation. Proc Natl Acad Sci U S A. 2012; 109:1145-50.
  95. Thomas CW, Meinzen-Derr J, Hoath SB, Narendran V. Neurodevelopmental outcomes of extremely low birth weight infants ventilated with continuous positive airway pressure vs. mechanical ventilation. Indian J Pediatr. 2012; 79:218-23.
  96. Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA. Sox2 Activates Cell Proliferation and Differentiation in the Respiratory Epithelium. Am J Respir Cell Mol Biol. 2011; 45:101-110.
  97. Trapnell BC, McColley SA, Kissner DG, Rolfe MW, Rosen JM, McKevitt M, Moorehead L, Montgomery AB, Geller DE, Phase FTISG. Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection. Am J Respir Crit Care Med. 2012; 185:171-8.
  98. Trapnell BC, Strausbaugh SD, Woo MS, Tong SY, Silber SA, Mulberg AE, Leitz G. Efficacy and safety of PANCREAZE(R) for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2011; 10:350-6.
  99. Valentine CJ. Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. Adv Nutr. 2012; 3:370-6.
  100. Vanek VW, Seidner DL, Allen P, Bistrian B, Collier S, Gura K, Miles JM, Valentine CJ, Kochevar M, Novel Nutrient Task Force IFEW, American Society for P, Enteral Nutrition Board of D. A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. Nutr Clin Pract. 2012; 27:150-92.
  101. Varisco BM, Ambalavanan N, Whitsett JA, Hagood JS. Thy-1 Signals through PPARgamma to Promote Lipofibroblast Differentiation in the Developing Lung. Am J Respir Cell Mol Biol. 2012; 46:765-72.
  102. Visscher MO, Barai N, LaRuffa AA, Pickens WL, Narendran V, Hoath SB. Epidermal barrier treatments based on vernix caseosa. Skin Pharmacol Physiol. 2011; 24:322-9.
  103. Wapner R, Jobe AH. Controversy: antenatal steroids. Clin Perinatol. 2011; 38:529-45.
  104. Wetzel EA, Kingma PS. Subgaleal hemorrhage in a neonate with factor X deficiency following a non-traumatic cesarean section. J Perinatol. 2012; 32:304-5.
  105. Whitsett JA, Haitchi HM, Maeda Y. Intersections between pulmonary development and disease. Am J Respir Crit Care Med. 2011; 184:401-6.
  106. Whitsett JA, Kalinichenko VV. Integrin alpha6beta4 defines a novel lung epithelial progenitor cell: a step forward for cell-based therapies for pulmonary disease. J Clin Invest. 2011; 121:2543-5.
  107. Woo JG, Guerrero ML, Guo F, Martin LJ, Davidson BS, Ortega H, Ruiz-Palacios GM, Morrow AL. Human milk adiponectin affects infant weight trajectory during the second year of life. J Pediatr Gastroenterol Nutr. 2012; 54:532-9.
  108. Wortham BW, Eppert BL, Motz GT, Flury JL, Orozco-Levi M, Hoebe K, Panos RJ, Maxfield M, Glasser SW, Senft AP, Raulet DH, Borchers MT. NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol. 2012; 188:4468-75.
  109. Wyckoff MH, Salhab WA, Heyne RJ, Kendrick DE, Stoll BJ, Laptook AR, National Institute of Child H, Human Development Neonatal Research N, Collaborators:, Jobe A, Schibler K. Outcome of extremely low birth weight infants who received delivery room cardiopulmonary resuscitation. J Pediatr. 2012; 160:239-244 e2.
  110. Wynn JL, Tan S, Gantz MG, Das A, Goldberg RN, Adams-Chapman I, Stoll BJ, Shankaran S, Walsh MC, Auten KJ, Miller NA, Sanchez PJ, Higgins RD, Cotten CM, Smith PB, Benjamin DK, Jr., Network NNR, Collaborator: Schibler K. Outcomes following candiduria in extremely low birth weight infants. Clin Infect Dis. 2012; 54:331-9.

Faculty, Staff, and Trainees

Faculty Members

Jeffrey A. Whitsett, MD, Professor
Leadership Co-Director, Perinatal Institute; Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Research Interests Lung Development; Surfactant
Henry T. Akinbi, MD, Associate Professor
Research Interests Neonatal Infections and Blood Transfusions
Sandip Bhattacharyya, MSc, PhD, Assistant Professor
Research Interests Inflammation Immunology, Signal Transduction
Laurel Bookman, MD, Assistant Professor
Research Interests Implementation Science, International Health
James Bridges, PhD, Instructor
Research Interests Hypoxia Inducible Factors and Downstream Target Genes in Chronic Lung Disease
Tanya E. Cahill, MD, Assistant Professor
Leadership Director, High Risk Infant Follow-Up Program
Research Interests Neonatal Abstinence Syndrome and High Risk Infant Follow-Up
Michael W. Crossman, MD, PhD, Assistant Professor
Research Interests Bioethics
Jay Dritz, MD, Assistant Professor
Research Interests Neonatal resuscitation, quality improvement
Stephan W. Glasser, PhD, Associate Professor
Research Interests Gene Regulation in the Lung
Neera Goyal, MD, MSHP, Assistant Professor
James M. Greenberg, MD, Professor
Leadership Co-Director, Perinatal Institute; Director, Division of Neonatology
Research Interests Preterm Birth, Community Health, Pulmonary Vascular Development
Beth E. Haberman, MD, Assistant Professor
Leadership Medical Director, Cincinnati Children's NICU & Co-Medical Director, Mercy Anderson Hospital Nurseries
Research Interests Infant Follow-up
Eric Hall, PhD, Assistant Professor
Research Interests Biomedical Informatics
Noah H. Hillman, MD, Assistant Professor
Research Interests Pulmonary Physiology, Neonatal Resuscitation, Lung Injury/Repair
Steven B. Hoath, MD, Professor
Leadership Medical Director, Skin Sciences Program
Research Interests Skin Development & Environmental Interactions
Machiko Ikegami, MD, PhD, Professor
Leadership Director, Surfactant and Metabolic Function Core
Research Interests Surfactant Metabolism; Lung Injury
Alan H. Jobe, MD, PhD, Professor
Leadership Director, Division of Perinatal Biology
Research Interests Injury and Repair of the Preterm Lung
Beth Ann Johnson, MD, Assistant Professor
Tanya V. Kalin, MD, PhD, Assistant Professor
Research Interests Transcriptional Regulation of Carcinogenesis and Radiation-Induced Lung Fibrosis
Vladimir V. Kalinichenko, MD, PhD, Associate Professor
Research Interests Fox Proteins in Lung Development
Suhas G. Kallapur, MD, Associate Professor
Leadership Director, Neonatology CME
Research Interests Fetal Inflammation/Physiology, Lung Development/Inflammation, BPD, Developmental Immunology
Beena Kamath, MD, MPH, Assistant Professor
Research Interests Neonatal Outcomes and Public Health; Fetal Lung Maturity; Global Health
Heather Kaplan, MD, MSCE, Assistant Professor
Research Interests Health Services Research; Improvement Science
Alan P. Kenny, MD, PhD, Instructor
Research Interests Molecular Development of the Foregut Organs
Paul S. Kingma, MD, PhD, Assistant Professor
Research Interests Innate Immune Systems; Cystic Fibrosis; Neonatal Infection
Thomas R. Korfhagen, MD, PhD, Professor
Research Interests Lung Defense
Timothy Le Cras, PhD, Associate Professor
Leadership Director of Admissions, Molecular & Developmental Biology Graduate Program
Research Interests Chronic Lung Diseases; Lung Development, Pulmonary Hypertension
Kristin R. Melton, MD, Associate Professor
Leadership Associate Director, Neonatal Fellowship Training Program
Research Interests Developmental Biology, Neural Crest Biology
Stephanie Merhar, MD, MS, Assistant Professor
Research Interests Neonatal neuroimaging, infant follow up
Ardythe L. Morrow, PhD, Professor
Leadership Director, Center for Interdisciplinary Research in Human Milk and Lactation
Research Interests Molecular Epidemiology of Human Milk, Epidemiologic Methods, Prevention of Infectious Disease, Predictive Biomarkers of Neonatal Outcomes
Louis Muglia, MD, PhD, Professor
Leadership Co-Director, Perinatal Institute; Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Research Interests Genetics of Birth Timing; Neurobiology of the Stress Response
Vivek Narendran, MD, MBA, Associate Professor
Leadership Medical Director, Univ. Hosp. NICU & Newborn Nursery; Medical Director, The Christ Hospital Nursery; Chair, Department of Pediatrics, the University Hospital
Research Interests C-PAP; Business Case for Quality Improvements; Preterm Infant Skin
Amy T. Nathan, MD, Assistant Professor
Leadership Medical Director, TriHealth Nurseries
Research Interests Immunobiology
Laurie A. Nommsen-Rivers, PhD, RD, IBCLC, Assistant Professor
Leadership Co-Chair, Seminar Series in Human Milk and Lactation
Research Interests Human Lactation and Breastfeeding
Anne-Karina Perl, PhD, Assistant Professor
Research Interests Alveolar Regeneration and Bronchiolar Injury/Repair
John H. Reuter, MD, PhD, Associate Professor
Leadership Co-Medical Director, Bethesda North Hospital Nurseries
Ward R. Rice, MD, PhD, Professor
Leadership Director, Neonatal Fellowship Training Program; Director, Newborn Services, St. Elizabeth Medical Center
Research Interests Lung Development, Surfactant Biology
Jerod Rone, MD, Associate Professor
Kurt R. Schibler, MD, Associate Professor
Leadership Principal Investigator, NICHD Neonatal Research Network
Research Interests Neonatal Immunology, Necrotizing Enterocolitis
John M. Shannon, PhD, Professor
Leadership Director of Graduate Studies, Program in Molecular and Developmental Biology
Research Interests Lung Development, Foregut Embryology
Debora I. Sinner, PhD, Instructor
Research Interests Wnt Signaling and Sox Transcription Factors in Lung Development and Disease
Andrew P. South, MD, MPH, Assistant Professor
Research Interests Outcomes and Etiology of Gastroschisis, Epidemiology of Late-Preterm Birth
Jean J. Steichen, MD, Professor Emeritus
Research Interests Infant Follow-up
Takuji Suzuki, MD, PhD., Instructor
Research Interests Lung Immunology
Bruce C. Trapnell, MD, MS, Professor
Leadership Director, Rare Lung Diseases Network; Scientific Director, PAP Foundation; Co-Director, Cystic Fibrosis TDN Center
Research Interests Rare Lung Diseases; GM-CSF, Gene Therapy
Christina Valentine, MD, Assistant Professor
Research Interests Maternal and Infant Nutrition to improve perinatal health
Laura Ward, MD, Assistant Professor
Leadership Co-Medical Director, Mercy Anderson Hospital Nurseries
Research Interests Use of Human Milk in the NICU
Timothy E. Weaver, MS, PhD, Professor
Leadership Associate Director, Division of Pulmonary Biology; Co-Director, Molecular and Developmental Biology Program
Research Interests Pathogenesis of Interstitial Lung Diseases
Kathryn E. Wedig, MD, Associate Professor
Leadership Director, High Risk Clinic @ GSH; Medical Director, Mercy Hospital Fairfield
Research Interests Infant Follow-up, Neonatal Abstinence Syndrome
Susan E. Wert, PhD, Associate Professor
Leadership Director, Molecular Morphology Core, Division of Pulmonary Biology
Research Interests Lung Development, Molecular Morphology of the Lung, Ultrastructural Analysis of the Lung, Genetic Surfactant Disorders
Scott Wexelblatt, MD, Assistant Professor
Leadership Medical Director Regional Newborn Services; Co-Medical Director Bethesda North Hospital Nurseries
Research Interests Late Preterm Infant, Quality Improvement
Yan Xu, PhD, Associate Professor
Leadership Director, Microarray-Bioinformatics Core, Division of Pulmonary Biology
Research Interests Bioinformatics, Systems Biology, Transcriptional Network

Joint Appointment Faculty Members

Kathryn Wikenheiser-Brokamp, MD/PhD, Associate Professor (Pathology)
Research Interests Pulmonary Pathology, Pediatric and Adult Lung Diseases

Clinical Staff Members

  • Stephen Bird, MD
  • Mary Burwinkel, MD
  • Thomas Catalanotto, MD
  • Christine Chappell, MD
  • Diane Donley, MD
  • Dena Elkeeb, MD
  • Horacio Falciglia, MD
  • Michelle French, MD
  • Angelique Gloster, MD
  • Pamela Holmes, MD
  • Clinton Joiner, MD
  • Jill Klein, MD
  • Katie Loudermilk, MD
  • Alisa McGill, MD
  • Miriam Peri, MD
  • Ajay Ponkshe, MD
  • Danna Premer, MD
  • John Robinson, MD
  • Deborah Rufner, MD
  • Kelley Shultz,
  • Jean Steichen,
  • Kira Zimmerly, MD


  • Thomas Acciani, BS, University of Illinois Urbana
  • Ceyda Acun, MD, PL7, George Washington University Hospital, Washington, DC
  • Melinda Arnett, PhD, University of Kansas Medical Center, Kansas City, Kansas
  • Aria Attia, MS, Georgetown University, Washington, DC
  • David Balli, BA, DePauw University, Greencastle, IN
  • Craig Bolte, PhD, University of Cincinnati, Cincinnati, OH
  • Katherine Brown, , University of the West of England, Bristol, England
  • Yuqi Cai, PhD, Zhejiang University School of Medicine, Hangzhou, China
  • Gang Chen, MS , PhD, Yangzhou University, China
  • Rebecca Currier, BS, Louisiana Tech University, Ruston, LA
  • David Dewar, MD, PL5, Michigan State University, East Lansing, MI
  • Jill Fritz, BS, Miami University, Oxford, OH
  • Chen Gao, BS, Beijing Normal University, Beijing, China
  • Tate Gisslen, MD, PL5, University of Minnesota Medical School, Minneapolis, MN
  • Jennifer Goetz, MD, PL5, University of Louisville School of Medicine, Louisville, KY
  • Corryn Greenwood, MD, PL6, Mayo Clinic School of Graduate Medical Education, Rochester, NY
  • David Hahn, BS, Northern Kentucky University
  • Hans Michael Haitchi, MD, PhD, University of Southampton, UK
  • Jamie Havrilak, BS, Susquehanna University, Selinsgrove, PA
  • Sandra Hernandez, , Univeristy of Cincinnati
  • Audrone LaForgia, MD, PL6, EVMS/Children's Hospital of the King's Daughters, Norfolk, VA
  • Melissa Landis, MD, PL4, Columbia University School of Medicine, New York, New York
  • Gloria Laryea, BS, University of Maryland Eastern Shore, Princess Anne, Maryland
  • Anne Minter, BA, Miami University, Oxford, OH
  • Nagendra Monangi, MD, PL6, Osmania Medical College, Hyderabad, India; University of South Alabama, Mobile, AL
  • Elizabeth Mushaben, BS, College of Mount St. Joseph
  • Gaston Ofman, MD, Favaloro University School of Medicine, Buenos Aires, Argentina
  • Kriti Puri, MBBS, All India Institute of Medical Sciences, New Delhi, India
  • Malia Ray, MD, University of Louisville, Kentucky
  • Melissa Rice, MD, PL4, Indiana University School of Medicine, Indianapolis, Indiana
  • Tony Sallese, BS, University of St. Francis, Joliet, IL
  • Atsuyasu Sato, MD, PhD, Kyoto University, Japan
  • Heather Smith, MD, PL4, Miller School of Medicine, Miami, Florida
  • Kevin Stutey, MD, PL5, Eastern Virginia Medical School, Norfolk, VA
  • Diana Taft, BA, Cornell University, Ithaca, NY
  • Chelsea Tolentino, BS, Grambling State University
  • Jason Wiles, MD, PL4, University of Louisville School of Medicine, Louisville, Kentucky
  • Tim Wolfs, PhD, Royal Netherlands Academy of Arts and Sciences, The Netherlands
  • Qing Yan Xie, BA, MS, Beijing University of Technology, Wuhan, China

Division Collaboration

Reproductive Sciences; Developmental Biology; Pulmonary Medicine; Biomedical Informatics; Safety - The James A. Anderson Center; Infectious Disease; Human Genetics; Biostatistics and Epidemiology » SK Dey, Takiko Daikoku, Christopher Wylie, James Wells, Noah Schroyer, Aaron Zorn, Richard Lang, William Hardie, Imre Solti, Steven Muething, Margaret Hostetter, Ge Zhang, and Maurizio Macaluso

Division’s faculty have close collaborations with faculty in multiple divisions within Cincinnati Children’s, the University of Cincinnati, and with investigators across the United States and throughout the world.

The Perinatal Institute at Cincinnati Children’s provided a new home for efforts to both improve outcomes for infants born prematurely and prevent prematurity to synergistically reduce infant mortality in our region. To accomplish these daunting goals, we have assembled faculty from across Cincinnati Children’s, the college of medicine, the arts and sciences and institutions around Ohio in an integrative, transdisciplinary endeavor unique in pediatrics and women’s health. Perinatal Institute investigators maintain collaborative relationships with colleagues in Japan, Germany, Mexico, Argentina, Finland, and Australia.

Grants, Contracts, and Industry Agreements

Division Grants

Grant and Contract AwardsAnnual Direct

Bridges, J

The Role of HIF2a in Airway Smooth Muscle Remodeling
Cystic Fibrosis Foundation Research Development Program - Project 4

Chen, G

University Research Council Postdoctoral Fellow Research

Glasser, S

Role of Surfactant Protein-C and Innate Lung Defense
R01 HL 05004608/01/09-07/31/13$250,000

Goyal, N

Dosage Effect of Home Visitation on Neonatal Outcomes
K12 HD 05195304/01/12-03/31/14$100,000

Hall, E

Neonatal Research Networks Terminology Harmonization

Hillman, N

Lung Injury with Resuscitation in the Preterm
K08 HL 09708508/01/09-07/31/14$121,750

Ikegami, M

Role of C/EBPalpha in Cytoprotection and Recovery from Lung Injury
R01 HL 09546404/01/09-03/31/13$247,500

Jobe, A / Chougnet C

Biomarkers of Immunologic Function and Preterm Respiratory Outcomes
U01 HL 10180005/01/10-04/30/15$381,253
Jobe, ACore$153,901
Chougnet, CProject$93,788
Chougnet, CProject$31,922
Kingma, PProject$20,448
Hardie, WProject$49,983
Morrow, AProject$31,211
Biomarkers of Immunologic Function and Preterm Respiratory Outcomes
U01 HL 10179409/20/10-04/30/15$25,562

Jobe, A / Kallapur, S

Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease
R01 HL 09706409/24/09-07/31/13$348,802

Kalin, T

Role of Foxm1 in Lung Cancer Microenvironment
R01 CA 14272407/01/10-06/30/15$201,275
Role of Foxm1 in the Pathogenesis of Prostate Cancer

Kalinichenko, V

Foxf1 Transcription Factor in Development of Pulmonary Capillaries
R01 HL 08415105/01/11-04/30/15$250,000

Kallapur, S

Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis
R01 HD 05786902/03/09-01/31/14$242,830

Kamath-Rayne, B

Novel Amniotic Fluid Biomarkers to Predict Fetal Lung Maturity
K12 HD5195307/01/11-06/30/13$100,000

Kenny, A

Secreted BMP Antagonists in Foregut Organ Development
K08 HL10566112/08/2010-11/30/2015$121,300

Kingma, P

Surfactant Protein D in Pulmonary and Systemic Host Defense
K08 HL 08950507/01/08-06/30/13$121,600

LeCras, T

Impact of Early Life Diesel Exposure on Immune Patterning
R01 HL 09713505/01/10-04/30/15$343,734
LeCras, T$134,837
Hershey, G$208,897

Merhar, S

Protein Supplementation in Infants with Brain Injury

Morrow, A

Novel Genetic and Salivary Glycan Biomarkers for Risk of NEC in ELBW Infants
R01 HD 05914001/15/09-12/31/13$573,036
The Role of Human Milk in Infant Nutrition and Health
P01 HD 01302108/01/09-07/31/14$959,816
Jiang, XiCore D$84,803
Jiang, XiProject 2$110,955

Muglia, L

Genetic Analysis of Human Preterm Birth
Amygdala Glucocorticoid Receptor Function in Stress
R01 MH07901001/01/12-12/31/13$261,822
Alcohol Action on Extended Amygdala Glutamate Synapses
R01 AA1945505/01/12-04/30/13$9,802
Research Consortium on Pre-Term Birth (Strauss, A - PI)

Perl, A

FGF and PDGF Regulate Myofibroblast Differentiation in Alveolar Regeneration
R01 HL 10400307/01/10-06/30/14$250,000


NICHD Cooperative Multicenter Neonatal Research Network Capitation
U10 HD 06304804/01/11-03/31/16$125,827
NICHD Cooperative Multicenter Neonatal Research Network
U10 HD 02785304/01/11-03/31/16$197,000

Shannon, J

LPCAT1 is Essential for Perinatal Lung Function and Survival
R01 HL 09831907/01/10-06/30/14$314,281

Sinner, D

Molecular Mechanisms Underlying Lung Growth and Hypoplasia: Role of Wntless

Trapnell, B

Macrophage-based Human Gene Therapy for Hereditary PAP
R21 HL 10613412/15/10-11/30/12$150,000
Role of GM-CSF in Myeloid Cell Function and Innate Immunity
R01 HL 08545304/01/11-03/31/16$250,000
Cincinnati Center for Clinical/Translational Sciences & Training
UL1 RR 02631404/01/12-03/31/14$23,181

Weaver, T

Role of SFTPC in Pathogenesis of Interstitial Lung Disease
R01 HL 08649212/01/08-11/30/13$326,260
The Role of Autophagy in the Pathogenesis of interstitial Lung Disease
R01 HL 10392308/01/11-06/30/15$335,127

Whitsett, J

Airway Progenitor Cell Proliferation and Differentiation During Lung Repair
U01 HL 11096401/01/12-12/31/16$555,300
Pulmonary and Cardiovascular Development Training Grant
T32 HL 00775207/01/09-06/30/14$254,539
Transcriptional Control of Submucosal Gland Formation and Function
R01 HL 10890707/01/11-04/30/15$257,958
Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelial Cells
R01 HL 09558005/24/69-04/01/09$342,888
Cystic Fibrosis Foundation Research Development Program (Core 1)

Xu, Y

Role of SREBP Network in Surfactant Lipid Homeostasis and Lung Maturation
R01 HL 10543307/01/11-06/30/15$311,281
Cystic Fibrosis Foundation Research Development Program - Project 3
Current Year Direct$9,428,773
Industry Contracts

Kingma, P


Morrow, A


Trapnell, B


Valentine, C

Current Year Direct Receipts$659,536