Pediatric Asthma Repository Begins Studying Hospital Stays
In 2012, Gurjit Khurana Hershey, MD, PhD and the Division of
Asthma Research, working in conjunction with Governor Kasich’s office, were
awarded a grant from the Ohio Children’s
Hospital Association (OCHA) and the Ohio Department of Job and
Family Services (ODJFS) to develop and lead an asthma research study in
conjunction with the five other free-standing children’s hospitals in Ohio.
Utilizing a new central IRB infrastructure available to research institutions in
Ohio, the Ohio Pediatric Asthma Repository (OPAR) began enrollment in December
2012 and now has 905 participants. The six-hospital group will analyze
phenotypic, demographic, treatment, and outcome data to look for differences
between patients, treatments and site pathways to see what factors impact
reutilization and length of hospital stay.
Cincinnati Children’s Joins Three
Clinical Trials Through Inner City Asthma Consortium
Cincinnati Children’s is one of 10 research centers to
join the Inner City Asthma Consortium, the nation’s largest effort to study asthma in the
inner city. Gurjit Khurana Hershey, MD, PhD, is the principal investigator for
the Cincinnati site. Thus far, Cincinnati Children's has been involved in three
clinical trial studies:
- Preventative Omalizumab or Step-up Therapy
for Severe Fall Exacerbations, which examines whether the drug therapy decreases
autumn-season asthma exacerbations.
- Asthma Phenotypes in the Inner
City, which seeks to differentiate easy vs. difficult-to-treat asthma.
- Biomarker-Based Cockroach Sublingual Immunotherapy, which evaluates
immunotherapy against exposure to German cockroach, the most common species
infesting apartments and other urban buildings.
Cooperative Research Center Studies
Epithelial Cell Genes in Allergic Response
Gurjit Khurana Hershey, MD, PhD, is the principal
investigator of an NIH-funded Asthma
and Allergic Diseases Cooperative Research Center (AADCRC) and serves on the
AADCRC steering committee. This Center focuses on characterizing epithelial
genes in allergic diseases and delineating the mechanisms by which they
contribute to allergic response. The overarching hypothesis is that epithelial
cell genes play a central role in the pathogenesis of allergic disorders. The
Center provides important insights about genes and pathways that may be
important in epithelial-driven allergic inflammation and provides a basis for
the design of new therapies aimed at epithelial surfaces, such as the lung in
asthma cases, the skin in atopic dermatitis, or the gut in food allergy or