2013 Research Annual Report

Bone Marrow Transplantation and Immune Deficiency

Division Details

Division Data Summary

Research and Training Details

Number of Faculty14
Number of Joint Appointment Faculty3
Number of Research Fellows2
Number of Support Personnel26
Direct Annual Grant Support$915,563
Direct Annual Industry Support$181,230
Peer Reviewed Publications36

Clinical Activities and Training

Number of Clinical Staff10
Number of Clinical Fellows6
Number of Other Students2
Inpatient Encounters9,102
Outpatient Encounters5,532

Division Photo

Bone Marrow Transplant and Immune Deficiency

Row 1: J Sumegi, K Myers, S Davies, A Kumar

Row 2: J El-Bietar, S Jodele, R Marsh

Row 3: J Bleesing, M Grimley, S Chandra



Division Publications

Bone Marrow Transplant and Immune Deficiency Publications

  1. Al Hawas R, Ren Q, Ye S, Karim ZA, Filipovich AH, Whiteheart SW. Munc18b/STXBP2 is required for platelet secretion. Blood. 2012; 120:2493-500.
  2. Ayas M, Saber W, Davies SM, Harris RE, Hale GA, Socie G, LeRademacher J, Thakar M, Deeg HJ, Al-Seraihy A, Battiwalla M, Camitta BM, Olsson R, Bajwa RS, Bonfim CM, Pasquini R, Macmillan ML, George B, Copelan EA, Wirk B, Al Jefri A, Fasth AL, Guinan EC, Horn BN, Lewis VA, Slavin S, Stepensky P, Bierings M, Gale RP. Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. J Clin Oncol. 2013; 31:1669-76.
  3. Borges M, Barreira-Silva P, Flórido M, Jordan MB, Correia-Neves M, Appelberg R. Molecular and Cellular Mechanisms of Mycobacterium avium-Induced Thymic Atrophy. J Immunol. 2012; 189:3600-8.
  4. Buchbinder D, Nugent DJ, Brazauskas R, Wang Z, Aljurf MD, Cairo MS, Chow R, Duncan C, Eldjerou LK, Gupta V, Hale GA, Halter J, Hayes-Lattin BM, Hsu JW, Jacobsohn DA, Kamble RT, Kasow KA, Lazarus HM, Mehta P, Myers KC, Parsons SK, Passweg JR, Pidala J, Reddy V, Sales-Bonfim CM, Savani BN, Seber A, Sorror ML, Steinberg A, Wood WA, Wall DA, Winiarski JH, Yu LC, Majhail NS. Late effects in hematopoietic cell transplant recipients with acquired severe aplastic anemia: a report from the late effects working committee of the center for international blood and marrow transplant research. Biol Blood Marrow Transplant. 2012; 18:1776-84.
  5. Bucuvalas J, Filipovich L, Yazigi N, Narkewicz MR, Ng V, Belle SH, Zhang S, Squires RH. Immunophenotype Predicts Outcome in Pediatric Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2013; 56:311-315.
  6. Chima RS, Abulebda K, Jodele S. Advances in critical care of the pediatric hematopoietic stem cell transplant patient. Pediatr Clin North Am. 2013; 60:689-707.
  7. Chima RS, Daniels RC, Kim MO, Li D, Wheeler DS, Davies SM, Jodele S. Improved outcomes for stem cell transplant recipients requiring pediatric intensive care. Pediatr Crit Care Med. 2012; 13:e336-42.
  8. Eapen M, Ahn KW, Orchard PJ, Cowan MJ, Davies SM, Fasth A, Hassebroek A, Ayas M, Bonfim C, O'Brien TA, Gross TG, Horwitz M, Horwitz E, Kapoor N, Kurtzberg J, Majhail N, Ringden O, Szabolcs P, Veys P, Baker KS. Long-term survival and late deaths after hematopoietic cell transplantation for primary immunodeficiency diseases and inborn errors of metabolism. Biol Blood Marrow Transplant. 2012; 18:1438-45.
  9. Filipovich AH. Gene therapy targets XLP. Blood. 2013; 121:1066-7.
  10. Gazda HT, Preti M, Sheen MR, O'Donohue MF, Vlachos A, Davies SM, Kattamis A, Doherty L, Landowski M, Buros C, Ghazvinian R, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum Mutat. 2012; 33:1037-44.
  11. Hassan A, Booth C, Brightwell A, Allwood Z, Veys P, Rao K, Hönig M, Friedrich W, Gennery A, Slatter M, Bredius R, Finocchi A, Cancrini C, Aiuti A, Porta F, Lanfranchi A, Ridella M, Steward C, Filipovich A, Marsh R, Bordon V, Al-Muhsen S, Al-Mousa H, Alsum Z, Al-Dhekri H, Al Ghonaium A, Speckmann C, Fischer A, Mahlaoui N, Nichols KE, Grunebaum E, Al Zahrani D, Roifman CM, Boelens J, Davies EG, Cavazzana-Calvo M, Notarangelo L, Gaspar HB. Outcome of hematopoietic stem cell transplantation for adenosine deaminase-deficient severe combined immunodeficiency. Blood. 2012; 120:3615-24; quiz 3626.
  12. Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI. The fanconi anemia pathway limits human papillomavirus replication. J Virol. 2012; 86:8131-8.
  13. Jodele S, Hirsch R, Laskin B, Davies S, Witte D, Chima R. Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2013; 19:202-7.
  14. Jodele S, Laskin BL, Goebel J, Khoury JC, Pinkard SL, Carey PM, Davies SM. Does early initiation of therapeutic plasma exchange improve outcome in pediatric stem cell transplant-associated thrombotic microangiopathy?. Transfusion. 2012; 53:661-7.
  15. Kamani NR, Walters MC, Carter S, Aquino V, Brochstein JA, Chaudhury S, Eapen M, Freed BM, Grimley M, Levine JE, Logan B, Moore T, Panepinto J, Parikh S, Pulsipher MA, Sande J, Schultz KR, Spellman S, Shenoy S. Unrelated donor cord blood transplantation for children with severe sickle cell disease: results of one cohort from the phase II study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). Biol Blood Marrow Transplant. 2012; 18:1265-72.
  16. Laskin BL, Nehus E, Goebel J, Khoury JC, Davies SM, Jodele S. Cystatin C-estimated glomerular filtration rate in pediatric autologous hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012; 18:1745-52.
  17. Li J, Sipple J, Maynard S, Mehta PA, Rose SR, Davies SM, Pang Q. Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Antioxid Redox Signal. 2012; 17:1083-98.
  18. Marsh RA, Allen CE, McClain KL, Weinstein JL, Kanter J, Skiles J, Lee ND, Khan SP, Lawrence J, Mo JQ, Bleesing JJ, Filipovich AH, Jordan MB. Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab. Pediatr Blood Cancer. 2013; 60:101-9.
  19. Marsh RA, Bleesing JJ, Filipovich AH. Flow cytometric measurement of SLAM-associated protein and X-linked inhibitor of apoptosis. Methods Mol Biol. 2013; 979:189-97.
  20. Marsh RA, Rao K, Satwani P, Lehmberg K, Muller I, Li D, Kim MO, Fischer A, Latour S, Sedlacek P, Barlogis V, Hamamoto K, Kanegane H, Milanovich S, Margolis DA, Dimmock D, Casper J, Douglas DN, Amrolia PJ, Veys P, Kumar AR, Jordan MB, Bleesing JJ, Filipovich AH. Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes. Blood. 2013; 121:877-83.
  21. Mehta PA, Faulkner LB. Hematopoietic cell transplantation for thalassemia: a global perspective BMT tandem meeting 2013. Biol Blood Marrow Transplant. 2013; 19:S70-3.
  22. Mehta PA, Svahn J, Davies SM, Pang Q, Harris R, Ghezzi P, Lanza T, Ferretti E, Barabino P, Mueller R, Dufour C. Etanercept treatment in Fanconi anaemia; combined US and Italian experience. Br J Haematol. 2012; 158:809-11.
  23. Mellor-Heineke S, Villanueva J, Jordan MB, Marsh R, Zhang K, Bleesing JJ, Filipovich AH, Risma KA. Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis. Front Immunol. 2013; 4:72.
  24. Myers KC, Davies SM, Shimamura A. Clinical and molecular pathophysiology of Shwachman-Diamond syndrome: an update. Hematol Oncol Clin North Am. 2013; 27:117-28, ix.
  25. Myers KC, Lawrence J, Marsh RA, Davies SM, Jodele S. High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant. 2013; 19:500-3.
  26. Pearce KF, Lee SJ, Haagenson M, Petersdorf EW, Norden J, Collin MP, Klein JP, Spellman SR, Lowerson SA, Davies S, Dickinson AM. Analysis of non-HLA genomic risk factors in HLA-matched unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia. Haematologica. 2012; 97:1014-9.
  27. Phillips CL, Davies SM, McMasters R, Absalon M, O'Brien M, Mo J, Broun R, Moscow JA, Smolarek T, Garzon R, Blum W, Schwind S, Marcucci G, Perentesis JP. Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults. Br J Haematol. 2013; 161:406-10.
  28. Rose SR, Myers KC, Rutter MM, Mueller R, Khoury JC, Mehta PA, Harris RE, Davies SM. Endocrine phenotype of children and adults with Fanconi anemia. Pediatr Blood Cancer. 2012; 59:690-6.
  29. Ross JA, Linabery AM, Blommer CN, Langer EK, Spector LG, Hilden JM, Heerema NA, Radloff GA, Tower RL, Davies SM. Genetic variants modify susceptibility to leukemia in infants: a Children's Oncology Group report. Pediatr Blood Cancer. 2013; 60:31-4.
  30. Shin CR, Kim MO, Li D, Bleesing JJ, Harris R, Mehta P, Jodele S, Jordan MB, Marsh RA, Davies SM, Filipovich AH. Outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome. Bone Marrow Transplant. 2012; 47:1428-35.
  31. Small TN, Qasim W, Friedrich W, Chiesa R, Bleesing JJ, Scurlock A, Veys P, Sparber-Sauer M. Alternative donor SCT for the treatment of MHC class II deficiency. Bone Marrow Transplant. 2013; 48:226-32.
  32. Sumegi J, Nestheide SV, Barnes MG, Villanueva J, Zhang K, Grom AA, Filipovich AH. Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis. Blood. 2013; 121:e14-24.
  33. Terrell CE, Jordan MB. Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8+ T cells and dendritic cells. Blood. 2013; 121:5184-91.
  34. Unnisa Z, Clark JP, Roychoudhury J, Thomas E, Tessarollo L, Copeland NG, Jenkins NA, Grimes HL, Kumar AR. Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. Blood. 2012; 120:4973-81.
  35. Ye S, Karim ZA, Al Hawas R, Pessin JE, Filipovich AH, Whiteheart SW. Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. Blood. 2012; 120:2484-92.
  36. Zhang MJ, Davies SM, Camitta BM, Logan B, Tiedemann K, Eapen M, Thiel EL. Comparison of outcomes after HLA-matched sibling and unrelated donor transplantation for children with high-risk acute lymphoblastic leukemia. Biol Blood Marrow Transplant. 2012; 18:1204-10.

Faculty, Staff, and Trainees

Faculty Members

Stella Davies, MBBS, PhD, MRCP, Professor
Leadership Jacob G. Schmidlapp Endowed Chair; Director, Bone Marrow Transplantation and Immune Deficiency; Executive Co-Director, Cancer and Blood Diseases Institute; Director, Division of Bone Marrow Transplantation and Immune Deficiency
Research Interests Blood and Marrow Transplant, Fanconi anemia and other marrow failure disorders, Pharmacogenetics and Pharmacokinetics, Survivorship Research, and BMT for Children with Leukemia.
Jacob Bleesing, MD, PhD, Associate Professor
Research Interests Clinical Investigation of Primary Immunodeficiency Disorders, with emphasis on disorders of immunodysregulation and B-cell disorders
Sharat Chandra, MD, Instructor
Research Interests Bone marrow transplantation for children with malignant and primary immune deficiency disorders.
Alexandra Filipovich, MD, Professor
Leadership Ralph J. Stolle Chair in Clinical Immunology; Director, Immunodeficiency and; Medical Director, Diagnostic Laboratory
Research Interests Histiocytic disorders, primary immune deficiency disorders and Immunoreconstitution Following Pediatric Stem Cell Transplantation
Michael Grimley, MD, Associate Professor
Research Interests Bone marrow transplantation for children with malignant and non-malignant disorders and treatment of chronic GVHD.
Richard Harris, MD, Professor
Research Interests Transplantation for children with bone marrow failure syndromes and aplastic anemia
Sonata Jodele, MD, Associate Professor
Research Interests Phase I clinical trials; stem cell transplantation; high risk pediatric malignancies; childhood neuroblastoma, Ewingís sarcoma, renal complications of transplantation.
Ashish Kumar, MD, PhD, Assistant Professor
Research Interests Etiology of childhood leukemia, transplantation of children with malignancy and primary immune deficiencies.
Rebecca Marsh, MD, Assistant Professor
Research Interests Pathogenesis of HLH with XIAP deficiency, diagnostic laboratory assays, improving outcomes of allogeneic BMT in primary immune deficiencies, use of reduced intensity conditioning regimens.
Parinda Mehta, MD, Associate Professor
Research Interests Blood and Marrow Transplant, Fanconi anemia and other failure disorders, Pharmacogenetics and Pharmacokinetics
Kasiani Myers, MD, Assistant Professor
Research Interests Blood and Marrow Transplant, Fanconi anemia and other marrow failure disorders, longitudinal studies of hematopoiesis
Janos Sumegi, MD, PhD, Professor
Research Interests Lymphoproliferative disease, Hemophagocytic Lymphohistiocytosis, Usher syndrome, etiology of childhood sarcomas.

Joint Appointment Faculty Members

Mark Johnson, MD, Assistant Professor (Child Psychiatry)
Research Interests Psychiatric support of bone marrow transplant patients
Michael Jordan, MD, Associate Professor (Immunobiology)
Research Interests Regulation of the immune response; immunotherapy of cancer, animal models of hemophagocytic disorders.
Ahna Pai, PhD, Associate Professor (Adherence Psychology in children receiving bone marrow transplantation)

Clinical Staff Members

  • Michael Huang, MD
  • Ernest Lawhorn, MD
  • Sunil Raikar, MD
  • Kristen Stefanski, MD
  • Gregory Wallace, DO
  • Paula Cuthrell, RN, MSN, CFNP
  • Jennifer Detzel, RN, MSN, CFNP
  • Laura Diggs, RN, MSN, CNP
  • Emily Herman, RN, CNP
  • Mary Ann Michael, RN, MSN, CPNP
  • Katie Scholle, RN, CNP
  • Gretchen Vaughn, RN, MSN, CNP

Trainees

  • Pooja Khandelwal, MD, PL-VI, University of Arizona College of Medicine
  • Zeynep (Yesim) Kucuk, MD, PL-VII, North Shore University-Long Island Jewish Medical Center, New Hyde Park, NY
  • Samantha Michaels, MD, PL-IV, University of Kentucky Children's Hospital
  • Omar Niss, MD, PL-VI, University of Nebraska Medical Center/Creighton University
  • Ahmad Rayes, MD, PL-IV, SUNY Upstate Medical University
  • Jordan Wright, MD, PL-VI, University of Alabama at Birmingham, Birmingham, AL

Division Collaboration

Immunobiology » L. Grimes
MEIS1 and MLL-fusion leukemia: Research project investigating the role of MEIS1 in MLL-fusion leukemia using transgenic mice. (A. Kumar)
Experimental Hematology and Cancer Biology » J. Mulloy
Animal models of human leukemia: Research project aimed at developing xenograft mouse models of human leukemia using primary patient derived material. (A. Kumar)
Experimental Hematology and Cancer Biology » J. Mulloy and J. Cancelas
The molecular origin of monosomy 7 in very young children. Translational research project exploring the causes of monosomy 7. (P. Mehta, SM Davies)
Experimental Hematology and Cancer Biology » N. Ratner
MEIS1 and MPNSTs: Research project aimed at understanding the role of MEIS1 in malignant peripheral nerve sheath tumors (MPNST). (A. Kumar)
Critical Care; Radiology; Nephrology » H. Wong, S. Poynter, W. Ball, J. Leach, J. Goebel, and M. Mitsnefes PRES working group
To identify patients at risk for PRES, outline uniform evaluation and therapy guidelines. (S. Jodele, SM Davies)
Nephrology » J. Goebel
Blood, and Not Urine, BK Viral Load Predicts Renal Outcome in Children with Hemorrhagic Cystitis following Hematopoietic Stem Cell Transplantation.Biol Blood Marrow Transplant. 2011 (Jodele S Davies SM, Mehta PA, Bleesing JJ, Filipovich AH, Marsh RA).
Nephrology » J. Goebel
Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy. (S Jodele, SM Davies).
Critical Care » R. Chima and D. Wheeler
BMT-PICU risk score index working group: To determine outcome predictors for BMT patients that are treated in PICU. To validate BMT-PICU risk score at Cincinnati Children’s and later at collaborating institutions. (S Jodele, SM Davies)
Critical Care » R. Chima and D. Wheeler
Paper describing excellent outcomes for children admitted to PICU post-transplant admitted to PICU. (S Jodele, SM Davies)
Surgery ; Gastroenterology » J. Nathan, G. Tiao, M. Alonzo, N. Yazigi , and S. Kocoschis
Incidence of acute and chronic graft versus host disease and donor T-cell chimerism after small bowel or combined organ transplantation. In press in the Journal of Pediatric Surgery. (S. Jodele, S. Davies)
Surgery ; Dermatology » R. Azizkhan and A. Lucky
Preparation of a stem cell transplant protocol for children with epidermolysis bullosa. (S Jodele and SM Davies)
Genetics ; Pathology » T. Smoralek, S. Zimmerman , and R. McMasters
The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations.Pediatr Blood Cancer. 2011 (Myers K, Davies SM, Harris RE, Mehta PA)
Oncology » J. Perentesis
Novel therapeutic approaches for EVI1+ leukemias(Kumar A)
Genetics » K. Zhang
Genotyping for PID and HLH (Filipovich, Bleesing)
Experimental Hematology and Cancer Biology » S. Wells
The Fanconi Anemia Pathway Limits Human Papillomavirus Replication. (P. Mehta, Davies, S.)
Experimental Hematology and Cancer Biology » Q. Pang
Fanconi Anemia Links Reactive Oxygen Species to Insulin Resistance and Obesity. (P. Mehta, Davies, S.)
Experimental Hematology and Cancer Biology » Q. Pang
The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters. (P. Mehta, Davies, S., Myers, K.)
Experimental Hematology and Cancer Biology » Q. Pang
Etanercept Treatment in Fanconi Anaemia; Combined US and Italian Experience.(P. Mehta, Davies, S., Harris, R)
Experimental Hematology and Cancer Biology » Q. Pang
Ongoing collaboration on a translational study: Quercetin in patients with Fanconi anemia, a Pilot study (P. Mehta)
Experimental Hematology and Cancer Biology » J. Mulloy and J. Cancelas
Identify the cell of origin of the monosomy 7 clone in children with MDS arising in children with and without known genetic predisposition syndromes, and establish timing of onset in very young children (in utero vs. ex utero). (P. Mehta)
Endocrinology » S. Rose and D. Elder
Endocrine phenotype of children and adults with Fanconi anemia. (P. Mehta, S. Davies, Myers, K.,Harris, R.)
Asthma Research » M. Butsch-Kovacic
HPV and Immune Function in Fanconi anemia: Research project investigating the epidemiology of HPV infection and the role of immune function in Fanconi Anemia. (P. Mehta)
Asthma Research » M. Butsch-Kovacic
Determination of antibody responses to natural infection with HPV and HPV vaccination in individuals with Fanconi anemia and to evaluate the predictors of effective or ineffective immune responses to HPV in individuals with FA. (P. Mehta)
Pharmacology » S. Vinks
Therapeutic Drug Monitoring of Voriconazole in pediatric BMT patients. (P. Mehta)
Pharmacology » S. Vinks
Pharmacokinetics of every 4th day Micafungin in high risk pediatric BMT patients. (P. Mehta)
Pharmacology » S. Vinks
The Impact of Alemtuzumab Levels on Donor Chimerism and Graft Versus Host Disease Following Allogeneic Hematopoietic Cell Transplantation: A Prospective Study. (P. Mehta)
Immunobiology » L. Grimes
Severe Congenital Neutropenia: Research project investigating novel genetic etiologies and molecular and cellular phenotypes of severe congenital neutropenia (K. Myers)
Asthma Research » M. Butsch Kovacic
HPV and Immune Function in Fanconi anemia: Research project investigating the epidemiology of HPV infection and the role of immune function in Fanconi Anemia. (K. Myers, P. Mehta)
Endocrinology » S. Rose
Endocrine function after RIC: Research project investigating endocrine function in pediatric patients after reduced intensity bone marrow transplantation. (K. Myers)
Ophthalmology » T. Schwartz
Ophthalmic GHVD: Research project investigating the incidence, severity and treatment of ophthalmic graft versus host disease in patients with systemic GVHD after bone marrow transplant. (K. Myers)
Experimental Hematology and Cancer Biology » P. Malik
Gene therapy for Hemophagocytic Lymphohistiocytosis(M. Jordan)
Experimental Hematology and Cancer Biology » P. Malik
Novel methods to promote stem cell engraftment (M. Jordan)
Allergy and Immunology » K. Risma
Gene therapy for Hemophagocytic Lymphohistiocytosis (M. Jordan)
Allergy and Immunology » K. Risma
The biology of cytotoxicity: Genotype/phenotype correlations(M. Jordan)
Cellular and Molecular Immunology » D. Hildeman
Selective ablation of undesirable T cell responses (M. Jordan)
Allergy and Immunology » M. Jordan
Immune profiling in Hemophagocytic Lymphohistiocytosis
Nephrology; Biostatistics & Epidemiology; Experimental Hematology and Cancer Biology » Dr. Prasad, Devarajan, J. Goebel, J. Khoury, and A. Lane

Project: “A Prospective Analysis of Clinical and Biochemical Markers for Pediatric Stem Cell Transplant-Associated Thrombotic Microangiopathy (TA-TMA)” Clinical and biomarker data analysis is ongoing. Project support: 

  1. P50 Application in response to RFA-DK-11-009 – Pediatric Centers of Excellence in Nephrology
  2. Center for Clinical and Translational Science and Training (CCTST), University of Cincinnati Academic Health Center, T1 Pilot Grant (All BMT Faculty)
Human Genetics ; Hematology » K. Zhang and R. Gruppo
Project: “Complement gene testing in patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy”
Project support: The Investigator Initiated Trial Grant from Alexion Therapeutics (S. Jodele, S. Davies)
Human Genetics; Nephrology » K. Zhang, J. Goebel, and B. Dixon
Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Manuscript is published in Blood journal (Jodele, et al, 2013. Jun 27. [epub ahead of print] (S. Jodele, S. Davies)
Cardiology ; Critical Care ; Pathology » R. Hirsch, R. Chima, H. Wong, and D. Witte
Project: “Pulmonary Hypertension in Patients with Hematopoietic Stem Cell Transplant -Associated Thrombotic Microangiopathy”
Manuscript is published in Biology of Bone Marrow Transplantation journal (Jodele, et al, Biol Blood Marrow Transplant. 2013, Feb)(S. Jodele, S. Davies)
Cardiology; Critical Care; Pathology » R. Hirsch, R. Chima, H. Wong, and D. Witte
Invited Pulmonary Hypertension in HSCT patient's manuscript is published in Biology of Bone Marrow Transplantation journal. First author, C. Dandoy, Hematology/Oncology Fellow and mentee to S. Jodele for this project. (Dandoy, et al, Bio. Blood Marrow Transplant 2013, Jul 23) (S. Jodele)
Cardiology; Critical Care; Pathology » R. Hirsch, R. Chima, H. Wong, and D. Witte
"Echocardiographic screening for pulmonary hypertension in HSCT patients." S. Jodele is mentoring C. Dandoy for this project. This project was completed, data analyzed and manuscript is in preparation. This project was awarded oral presentation at ASBMT 2013, and plenary session at ASPHO 2013 meetings. (S. Jodele, S. Davies)
Cardiology; Critical Care; Pathology » R. Hirsch, R. Chima, H. Wong, and D. Witte
Pulmonary Hypertension in HSCT patients: biomarkers pilot study." S. Jodele is mentoring C. Dandoy for this project. The study has been completed and data is being analyzed. (S. Jodele, S. Davies)
Nephrology » J. Goebel
Project: “Retrospective analysis of BK virus infections in an existing cohort of pediatric hematopoietic cell transplant recipients at Cincinnati Children’s Hospital Medical Center” Manuscript published in Biology of Bone Marrow Transplantation journal. (Laskin, et al, Biol Blood Marrow Transplant. 2013 Aug;19(8):1175-82) (S. Jodele, S. Davies)
Nephrology ; Pathology » J. Goebel , H. Yin, and J. Khoury
Project: “Cystatin C to Estimate Renal Function in Bone Marrow Transplant and Oncology Patients”
Publication: Biol Blood Marrow Transplantation (Laskin, et al, Biol Blood Marrow Transplant 2012 Nov; 18(11):1745-52)(S. Jodele, S. Davies)
Nephrology; Pathology; Biostatistics and Epidemiology » J. Goebel, H. Yin, and J. Khoury
Project: " Complement C4d staining in tissue samples of patients with stem cell transplant associated thrombotic microangiopathy (SCT-TMA)" Manuscript is published in Transplantation journal (Laskin, et al, Transplantation. 2013 Jul 27;96(2):217-223)(S. Jodele, S. Davies)
Critical Care » R. Chima, D. Wheeler, H. Wong, and T. Shanley
Book Chapter: "Pediatric intensive care for patients undergoing hematopoetic stem cell transplantation." Chapter Authors: Shilpa Sha, Sonata Jodele, Stella Davies and Ranjit Chima. Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, 2nd Edition, Volume 1: "Care of the Critically Ill or Injured Child." Editor(s) name(s): Derek S. Wheeler, Hector R. Wong, Thomas P. Shanley (S. Jodele, S. Davies)
Critical Care » R. Chima
Book Chapter: "Advances in critical care of the pediatric hematopoietic stem cell transplant patient." Chima RS, Abulebda K, Jodele S. Pediatr Clin North Am. 2013 Jun;60(3):689-707 .doi: 10.1016/j.pcl.2013.02.007. Epub 2013 Mar 12
Nephrology; Hoxworth Cell Therapy Team; Biostatistics & Epidemiology » J. Goebel, J. Khoury, and P. Carey
Project: “Does early initiation of therapeutic plasma exchange improve outcome in pediatric stem cell transplant-associated thrombotic microangiopathy?”Publication: Transfusion. 2012 Jul 15. d (S. Jodele, S. Davies)
Critical Care; Biostatistics Epidemiology; Experimental Hematology and Cancer Biology » R. Chima, D. Wheeler, and A. Lane
BMT-PICU risk score index working group. Research is ongoing (S. Jodele, S, Davies)
Critical Care » R. Chima and D. Wheeler
Publication: Improved outcomes for stem cell transplant recipients requiring pediatric intensive care. Pediatr Crit Care Med. 2012 Jul 11 (S. Jodele, S. Davies)
Rheumatology; Human Genetics; Allergy » A. Grom, Barnes, K. Zhang, and K. Risma
Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis. (J. Sumegi, A. Filipovich)
Oncology; Human Genetics » L. Wagner and T. Smolarek
Assessment of minimal residual disease in ewing sarcoma. (J. Sumegi)
Gastroenterology, Hepatology and Nutrition » L. Denson
Novel immune-dysregulatory diseases presenting as IBD (A. Kumar)
Gastroenterology, Hepatology and Nutrition » A. Miethke
Discovering biomarkers and pathogenesis of hepatitis associated aplastic anemia (A. Kumar)
Neonatology and Pulmonary Biology » J. Bridges
Investigating the connection between HIF-1 and MEIS1 (A. Kumar)
Pediatrics » K. Setchell
Pharmacokinetics of Quercetin in patients with Fanconi anemia (P. Mehta, S. Davies)
Human Genetics » K. Zhang
Role of Pharmacogenetics and Therapeutic Drug Monitoring in BMT Patients (P. Mehta, S. Davies)
Infectious Diseases » B. Connelly
Incidence and Outcomes of Fungal Infections in Children after Bone Marrow Transplant: CCHMC Experience. (P. Mehta, S. Davies)
Immunobiology » D. Hildeman and J. Katz
Exploiting the DNA damage response for selective immunomodulation (M. Jordan)
Allergy and Immunology » K. Risma
The biology of cytotoxicity: Genotype/phenotype correlations (M. Jordan)
Experimental Hematology and Cancer Biology; Allergy and Immunology » P. Malik and K. Risma
Gene correction strategies for Hemophagocytic lymphohistiocytosis (M. Jordan)
Experimental Hematology and Cancer Biology » P. Malik
Novel methods to promote stem cell engraftment (M. Jordan)
Human Genetics » K. Zhang
Discovery and characterization of new primary immune deficiencies. (M. Jordan, R. Marsh)

Grants, Contracts, and Industry Agreements

Bone Marrow Transplant and Immune Deficiency Grants

Grant and Contract AwardsAnnual Direct

Davies, S

Childhood Cancer Survivor Study
U24 CA 05572712/01/11-11/30/16$175,985
Children's Oncology Chair Award - Scientific Leadership
U10 CA 09854303/01/11-02/28/14$11,546
Children's Oncology Chair Award
U10 CA 09854304/13/12-02/28/14$5,775
Molecular Epidemiology of Pediatric Germ Cell Tumors
R01 CA 15128408/10/11-05/31/16$11,039

Filipovich, A

Gene Therapy for SCID-X1 Using Self-Inactivating (SIN) Gammaretroviral Vector
U01 AI 08762809/01/10-08/31/15$270,783
Rare Diseases Clinical Consortia for the Rare Diseases
U54 AI 08297309/12/09-08/31/14$3,696

Kumar, A

A New Leukemia Treatment using an Old Drug
06/01/13-05/31/14$25,000
The Role of MEIS1 in Hematopoiesis and Hematopoietic Transformation
R01 HL 11119207/15/15-04/30/17$238,000

Mehta, P

Quercetin in Patients with Fanconi Anemia, a Pilot Study
07/01/11-06/30/13$27,273
Serology as a Biomarker for Immune Response to HPV Vaccination and Exposure in Fanconi Anemia
07/01/12-06/30/13$40,000

Myers, K

Chemoprevention of Leukemia in a Genetically Susceptible Population
07/01/12-06/30/15$62,466

Sumegi, J

PAX3-NCOA1 and PAX3-NCOA2, Downstream Target Genes in Rhabdomyosarcoma
01/01/13-12/31/13$20,000
Identification of PAX3-NCOA1 and PAX3-NCOA2 Target Genes
07/01/12-06/30/13$24,000
Current Year Direct$915,563
Industry Contracts

Grimley, M

$66,400

Harris, R

$1,001

Jodele, S

$113,829
Current Year Direct Receipts$181,230
Total$1,096,793