2013 Research Annual Report

Critical Care Medicine

Division Details

Division Data Summary

Research and Training Details

Number of Faculty11
Number of Support Personnel20
Direct Annual Grant Support$844,327
Direct Annual Industry Support$15,490
Peer Reviewed Publications22

Clinical Activities and Training

Number of Clinical Staff10
Number of Clinical Fellows14
Number of Other Students1
Inpatient Encounters8,521

Division Photo

Critical Care Medicine

Row 1: H Wong, B Zingarelli, E Stalets, B Varisco

Row 2: S Poynter Wong, R Chima, D Wheeler, K Tegtmeyer, L Doughty



Significant Accomplishments

Significant Accomplishments

LifeCenter’s Champions for Life Award

Sue Poynter Wong, MD, was awarded the LifeCenter’s Champions for Life award on November 13, 2012. She was nominated in particular for her collaboration and work with one of our donor families. Her kind and empathetic care for her patient and this family was recognized, as was her tireless effort to preserve all options for donation. With the compassionate care provided in our PICU and the support and commitment from Sue, four lives were saved through the gift of organ donation from this patient and her family.

Trustee Award & Procter Scholar (TAPS) Program

Brian Varisco, MD, was awarded the Procter Scholar Program Award on December 12, 2012. The goal of the Procter Scholar Program is to support highly skilled pediatricians with a strong commitment to pursuing a career in academic research. Funds will support MD or MD/PhD pediatric fellows who are transitioning to a faculty appointment, with the goal of transitioning to a National Institutes of Health K-level award or K-level equivalent awards from foundations. Varisco has shown a strong commitment to pursuing a career in academic research, a record of accomplishment in research, along with a well-defined scientific research plan.

Leadership Changes in Critical Care Medicine

Congratulations to Derek Wheeler, MD, on his appointment this year to Associate Chief of Staff and to Erika Stalets, MD, on her appointment to Medical Director of the Division of Critical Care Medicine.


Division Publications

Critical Care Medicine Publications

  1. Basu RK. End-of-Life Care in Pediatrics: Ethics, Controversies, and Optimizing the Quality of Death. Pediatr Clin North Am. 2013; 60:725-39.
  2. Basu RK, Andrews A, Krawczeski C, Manning P, Wheeler DS, Goldstein SL. Acute Kidney Injury Based on Corrected Serum Creatinine Is Associated With Increased Morbidity in Children Following the Arterial Switch Operation. Pediatr Crit Care Med. 2013; 14:e218–e224.
  3. Basu RK, Chawla LS, Wheeler DS, Goldstein SL. Renal angina: An emerging paradigm to identify children at risk for acute kidney injury. Pediatric Nephrology. 2012; 27:1067-1078.
  4. Brady PW, Muething S, Kotagal U, Ashby M, Gallagher R, Hall D, Goodfriend M, White C, Bracke TM, DeCastro V, Geiser M, Simon J, Tucker KM, Olivea J, Conway PH, Wheeler DS. Improving situation awareness to reduce unrecognized clinical deterioration and serious safety events. Pediatrics. 2013; 131:e298-308.
  5. Chima RS, Abulebda K, Jodele S. Advances in critical care of the pediatric hematopoietic stem cell transplant patient. Pediatr Clin North Am. 2013; 60:689-707.
  6. Chima RS, Daniels RC, Kim MO, Li D, Wheeler DS, Davies SM, Jodele S. Improved outcomes for stem cell transplant recipients requiring pediatric intensive care. Pediatr Crit Care Med. 2012; 13:e336-42.
  7. Hanna W, Wong HR. Pediatric sepsis: challenges and adjunctive therapies. Crit Care Clin. 2013; 29:203-22.
  8. Jodele S, Hirsch R, Laskin B, Davies S, Witte D, Chima R. Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2013; 19:202-7.
  9. Kaplan JM, Nowell M, Lahni P, O'Connor MP, Hake PW, Zingarelli B. Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis. Obesity (Silver Spring). 2012; 20:1995-2002.
  10. Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H. Toll-like receptor-induced inflammatory cytokines are suppressed by gain of function or overexpression of Galpha(i2) protein. Inflammation. 2012; 35:1611-7.
  11. Menon K, McNally JD, Choong K, Ward RE, Lawson ML, Ramsay T, Wong HR. A Survey of Stated Physician Practices and Beliefs on the Use of Steroids in Pediatric Fluid and/or Vasoactive Infusion-Dependent Shock. Pediatr Crit Care Med. 2013; 14:462–466.
  12. Mickiewicz B, Vogel HJ, Wong HR, Winston BW. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med. 2013; 187:967-76.
  13. Muething SE, Goudie A, Schoettker PJ, Donnelly LF, Goodfriend MA, Bracke TM, Brady PW, Wheeler DS, Anderson JM, Kotagal UR. Quality improvement initiative to reduce serious safety events and improve patient safety culture. Pediatrics. 2012; 130:e423-31.
  14. Nowak JE, Harmon K, Caldwell CC, Wong HR. Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis. Pediatr Crit Care Med. 2012; 13:e323-9.
  15. Riley C, Basu RK, Kissoon N, Wheeler DS. Pediatric sepsis: preparing for the future against a global scourge. Curr Infect Dis Rep. 2012; 14:503-11.
  16. Riley C, Poss WB, Wheeler DS. The evolving model of pediatric critical care delivery in North America. Pediatr Clin North Am. 2013; 60:545-62.
  17. Wheeler DS. Care of the critically ill pediatric patient. Pediatr Clin North Am. 2013; 60:xv-xvi.
  18. Wheeler DS. An after action report of drotrecogin alpha (activated) and lessons for the future*. Pediatr Crit Care Med. 2012; 13:692-4.
  19. Wheeler DS, Geis G, Mack EH, Lemaster T, Patterson MD. High-reliability emergency response teams in the hospital: improving quality and safety using in situ simulation training. BMJ Qual Saf. 2013; 22:507-14.
  20. Wong HR. Genome-wide expression profiling in pediatric septic shock. Pediatr Res. 2013; 73:564-9.
  21. Wong HR, Cvijanovich NZ, Hall M, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Bigham MT, Sen A, Nowak J, Quasney M, Henricksen JW, Chopra A, Banschbach S, Beckman E, Harmon K, Lahni P, Shanley TP. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care. 2012; 16:R213.
  22. Wong HR, Salisbury S, Xiao Q, Cvijanovich NZ, Hall M, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Sen A, Nowak J, Quasney M, Henricksen JW, Chopra A, Banschbach S, Beckman E, Harmon K, Lahni P, Lindsell CJ. The pediatric sepsis biomarker risk model. Crit Care. 2012; 16:R174.

Faculty, Staff, and Trainees

Faculty Members

Hector Wong, MD, Professor
Leadership Director
Research Interests Septic shock, Genomics, Biomarkers
Ranjit Chima, MD, Assistant Professor
Research Interests Bone Marrow Transplantation-Associated Critical Illness ECLS Glucose Homeostasis
Lesley Doughty, MD, Associate Professor
Leadership Fellowship Director
Research Interests Sepsis, viral infections & mechanical ventilation
Jennifer Kaplan, MD, MS, Associate Professor
Research Interests Sepsis, obesity and inflammation
Sue E. Poynter, MD, Assistant Professor
Leadership Medical Director Division of Respiratory Care; Associate Director Pediatric Residency Training Program
Research Interests Medical education, residency & fellowship training
Erika Stalets, MD, Instructor
Leadership Medical Director
Research Interests Quality improvement, patient safety and sepsis
Ken Tegtmeyer, MD, Professor
Leadership Chair Code Committee
Research Interests Multimedia Medical Education
Rajit Basu, MD, Assistant Professor
Research Interests Phenotype and recognition of kidney injury, end of life care
Derek S. Wheeler, MD, Associate Professor
Leadership Associate Chief of Staff
Research Interests Patient safety, healthcare administration
Basilia Zingarelli, MD, Ph.D., Associate Professor
Research Interests Sepsis, hemorrhage and ischemia and reperfusion injury
Brian Varisco, MD, Instructor
Research Interests Mechanisms of lung development, repair and regeneration

Joint Appointment Faculty Members

Bradley Marino, MD, Associate Professor (Cardiology)
Research Interests Long-term outcomes in children and adolescents with CHD, Resuscitation of children with CHD

Trainees

  • Kamal Abulebda, MD, PL-6, University of Aleppo, Syrian Republic
  • Aaron Gardner, MD, PL-7, St. George's University
  • William Hanna, MD, PL-7, University of Kentucky College of Medicine
  • Shilpa Shah, MD, PL-7, The University of Texas Medical Branch
  • Danielle Webster, MD, PL-6, University of Missouri - Kansas City
  • Matthew Alder, MD, PL-5, University of Alabama School of Medicine
  • Theodore DeMartini, MD, PL-5, University of Texas Medical Branch
  • Hammad Ganatra, MD, PL-4, Aga Khan Medical College
  • Katja Gist, MD, PL-8, University of New England College of Osteopathic Medicine
  • Yu Inata, MD, PL-4, Osaka City University
  • Laura Kitzmiller, MD, PL-4, Wayne State University School of Medicine
  • Travis Langner, MD, PL-5, University of Kansas School of Medicine
  • Mary Sandquist, MD, PL-4, Ohio State University College of Medicine
  • Claire Stewart, MD, PL-4, Ohio State University College of Medicine

Grants, Contracts, and Industry Agreements

Critical Care Medicine Grants

Grant and Contract AwardsAnnual Direct

Kaplan, J

PPAR gamma in Pediatric Sepsis and the Inflammatory Response in Obesity
K08 GM 09313506/01/10-05/31/14$115,250

Wheeler, D

Therapeutic Hypothermia after Pediatric Cardiac Arrest
U01 HL 09434509/01/09-02/28/14$6,002

Wong, H

MMP-8 as a Novel Therapeutic Target in Sepsis
R01 GM 09699404/01/11-03/31/15$183,350
Stratification of Pediatric Septic Shock
R01 GM 09977308/07/12-06/30/16$243,861

Zingarelli, B

PPARgamma and PPARgamma Agonists in Septic Shock
R01 GM 06720209/14/12-06/30/16$254,894
Role of Eicosanoids in Shock
R01 GM 02767307/01/12-03/31/16$22,128

Poynter, S

Multi-Center Trial of Limiting PGY 2&3 Resident Work Hours in the PICU
U01 HL 1114789/15/12-5/31/17$18,842
Current Year Direct$844,327
Industry Contracts

Barr, R

$11,640

Chima, R

$3,850
Current Year Direct Receipts$15,490
Total$859,817