Developmental Biology

Division Details

Division Data Summary

Research and Training Details

Number of Faculty24
Number of Joint Appointment Faculty22
Number of Research Fellows61
Number of Research Students43
Number of Support Personnel48
Direct Annual Grant Support$5,409,866
Direct Annual Industry Support$115,500
Peer Reviewed Publications41

Clinical Activities and Training

Number of Clinical Fellows3
Number of Other Students24

Division Photo

Developmental Biology-450

Row 1: R Hegde, J Park, K Campbell, R Kopan, Y Ogawa

Row 2: Y Lan, Y Yoshida, R Jiang, G Guasch, T DeFalco, C Yin, S Brugmann

Row 3: S Sumanas, T Nakamura, M Nakafuku, J Wells, S Namekawa, R Waclaw, S Huppert

Row 4: C Mayhew, S Crone, S Cha

Row 5: V Cleghon, B Gebelein, V Kalinichenko, R Stottmann, A Zorn, J Lessard, S. Potter, D Wiginton, J Ma

Significant Accomplishments

Significant Accomplishments

Long-Time Director Retires

On March 31, 2013, Christopher Wylie, PhD, retired as Director of our Division. His role in expanding the Division from 11 faculty members in 2000, when he first joined Cincinnati Children’s, to 22 primary faculty and 22 secondary appointments is an outstanding accomplishment. Combined, this is now one of the largest groupings of developmental biologists in the world. Wylie understood the value of establishing a major center for model organism developmental biology at world-class children’s hospital, staffed with clinicians diagnosing and treating childhood diseases. Indeed, our Division has established close ties with as a many as 17 clinical divisions at the hospital. These interactions will provide better diagnoses, treatments and ultimately cures for childhood disorders. Thus in his 13 years here, Wylie has built a remarkable developmental biology research enterprise and positioned it well to play a major role in changing the outcome for children locally, nationally and internationally.

Kopan Named New Division Director

Following Dr. Wylie’s retirement, we were able to recruit a world-renowned developmental biologist, Raphael Kopan, PhD, to take over division leadership starting in August 2013. Kopan had been the Wolff Distinguished Professor of Developmental Biology at the Washington University School of Medicine in St. Louis. His research focuses on the role of Notch signaling in development and disease. His strong international reputation in developmental biology will help to maintain the visibility of our division both on a national and international level, which is essential for continued growth and success of the division. Moreover, Kopan’s collaborative instincts will dovetail nicely with the traditions at Cincinnati Children’s as he plans to move the division forward. By all the early accounts, the transition in leadership will be smooth and effective.

Developmental Biology Retreat Hosts 175 Participants

Our two-day retreat, held in Spring 2013, was the largest and most diverse to date. We had 175 participants, including clinicians, basic scientists and students, with 62 posters from 16 different divisions at Cincinnati Children’s. This is roughly on par with regional meetings of the Society of Developmental Biology and reflects the impressive size and depth of the developmental biology community here.

Significant Publications

Kenny AP, Rankin SA, Allbee AW, Prewitt AR, Zhang Z, Tabangin ME, Shifley ET, Louza MP, Zorn AM. Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. Developmental Cell. 2012. 23: 292-304.
This paper describes a new mechanism by which the matrix of extracellular proteins, laying between tissues in the embryo, regulate the growth factor signals required for the development of early liver and lung cells.  This work has implications for the directed differentiation of stem cells and informs our understanding of how growth factors are involved in many developmental and disease contexts.
Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R. Roles of Bmp4 during tooth morphogenesis and sequential tooth formationDevelopment. 2013. 140: 423-432.
This paper demonstrates that the Bmp4 signaling molecule and the Msx1 transcription factor function in a positive feedback loop to propagate tooth inductive signals across the developing jaw mesenchyme while the Osr2 transcription factor and Wnt signaling antagonists act to block the propagation of the Msx1-Bmp4 pathway to restrict the field of tooth induction. As Bmp and Wnt signaling pathways are repeatedly deployed in embryonic development and organogenesis, this paper provides new insights into the cross-regulation of these pathways in organogenesis and developmental disorders.
Lopez-Juárez A., Howard J., Ullom, K., Howard L., Grande A., Pardo A., Waclaw R.R., Sun Y-Y., Yang D., Kuan C-Y., Campbell KNakafuku M. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone. Genes and Development. 2013. 27: 1272-1287.
This paper describes new control mechanisms of stem cells in the adult brain. In particular, it demonstrates that the transcription factor Gsx2 controls the first and crucial step of the recruitment of a specific subset of stem cells toward the production of new neurons in the adult brain, and moreover, plays an important role in neuronal replacement after brain damage.
Kohli V, Schumacher JA, Desai SP, Rehn K, Sumanas S. Arterial and venous progenitors of the major axial vessels originate at distinct locations. Developmental Cell. 2013. 25: 196-206.
Arterial and venous differentiation is critical for functionality of blood vessels, however, it has not been well understood how vascular endothelial progenitors choose between arterial and venous fates. Using the zebrafish embryonic model, this paper demonstrates that arterial and venous progenitors originate at distinct time points and spatial locations. As a result, arterial progenitors are exposed to higher concentrations of Hedgehog and VEGF factors, which promote arterial differentiation. Our results explain how progenitors of the major axial vessels choose between arterial and venous fates and will be important in understanding the ontogeny of the related human disorders such as arterial-venous malformations.
Zou Y, Chiu H, Zinovyeva A, Ambros V, Chuang CF, Chang C. Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science. 2013. 340: 372-376.
Neurons lose regeneration ability as they age, but it is not known why. This paper has important implications for the treatment of brain and spinal cord injury or neurodegenerative diseases as it suggests that it may be possible to turn back the clock on regeneration in old neurons through therapeutic inhibition of the let-7 microRNA, and thereby restoring regenerative capacity. 

Division Publications

Developmental Biology Publications

  1. Brunskill EW, Potter AS, Potter SS. Defining Genetic Blueprints – Kidney and Craniofacial Development. In: JJ Hutton, ed. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research. Dordrecht ; New York: Springer; 2012:335-358.
  2. Brunskill EW, Potter SS. RNA-Seq defines novel genes, RNA processing patterns and enhancer maps for the early stages of nephrogenesis: Hox supergenes. Dev Biol. 2012; 368:4-17.
  3. Brunskill EW, Potter SS. Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy. BMC Nephrol. 2012; 13:70.
  4. Butler DL, Dyment NA, Shearn JT, Kinneberg KR, Breidenbach AP, Lalley AL, Gilday SD, Gooch C, Rao MB, Liu CF, Wylie C. Evolving strategies in mechanobiology to more effectively treat damaged musculoskeletal tissues. J Biomech Eng. 2013; 135:020301.
  5. Cha SW, McAdams M, Kormish J, Wylie C, Kofron M. Foxi2 is an animally localized maternal mRNA in Xenopus, and an activator of the zygotic ectoderm activator Foxi1e. PLoS One. 2012; 7:e41782.
  6. Chapman H, Waclaw RR, Pei Z, Nakafuku M, Campbell K. The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors. Development. 2013; 140:2289-98.
  7. Deck M, Lokmane L, Chauvet S, Mailhes C, Keita M, Niquille M, Yoshida M, Yoshida Y, Lebrand C, Mann F, Grove EA, Garel S. Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron. 2013; 77:472-84.
  8. Dyment NA, Liu CF, Kazemi N, Aschbacher-Smith LE, Kenter K, Breidenbach AP, Shearn JT, Wylie C, Rowe DW, Butler DL. The paratenon contributes to scleraxis-expressing cells during patellar tendon healing. PLoS One. 2013; 8:e59944.
  9. Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H. Sema3A regulates bone-mass accrual through sensory innervations. Nature. 2013; 497:490-3.
  10. Glenn NO, McKane M, Kohli V, Wen KK, Rubenstein PA, Bartman T, Sumanas S. The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish. Mol Cell Biol. 2012; 32:3527-40.
  11. Godin JD, Thomas N, Laguesse S, Malinouskaya L, Close P, Malaise O, Purnelle A, Raineteau O, Campbell K, Fero M, Moonen G, Malgrange B, Chariot A, Metin C, Besson A, Nguyen L. p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration. Dev Cell. 2012; 23:729-44.
  12. Haas M, Qu Z, Kim TH, Vargas E, Campbell K, Petrou S, Tan SS, Reid CA, Heng J. Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice. Eur J Neurosci. 2013; 37:1584-93.
  13. Hsieh YW, Chang C, Chuang CF. The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans. PLoS Genet. 2012; 8:e1002864.
  14. Hufnagel RB, Riesenberg AN, Quinn M, Brzezinski JA 4th, Glaser T, Brown NL. Heterochronic misexpression of Ascl1 in the Atoh7 retinal cell lineage blocks cell cycle exit. Mol Cell Neurosci. 2013; 54:108-20.
  15. James-Zorn C, Ponferrada VG, Jarabek CJ, Burns KA, Segerdell EJ, Lee J, Snyder K, Bhattacharyya B, Karpinka JB, Fortriede J, Bowes JB, Zorn AM, Vize PD. Xenbase: expansion and updates of the Xenopus model organism database. Nucleic Acids Res. 2013; 41:D865-70.
  16. Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development. 2013; 140:423-32.
  17. Katayama K, Leslie JR, Lang RA, Zheng Y, Yoshida Y. Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord. J Neurosci. 2012; 32:10396-407.
  18. Kattamuri C, Luedeke DM, Nolan K, Rankin SA, Greis KD, Zorn AM, Thompson TB. Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. J Mol Biol. 2012; 424:313-27.
  19. Kenny AP, Rankin SA, Allbee AW, Prewitt AR, Zhang Z, Tabangin ME, Shifley ET, Louza MP, Zorn AM. Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. Dev Cell. 2012; 23:292-304.
  20. Kim TH, Bae CH, Lee JC, Ko SO, Yang X, Jiang R, Cho ES. beta-catenin is required in odontoblasts for tooth root formation. J Dent Res. 2013; 92:215-21.
  21. Kohli V, Schumacher JA, Desai SP, Rehn K, Sumanas S. Arterial and venous progenitors of the major axial vessels originate at distinct locations. Dev Cell. 2013; 25:196-206.
  22. Korfhagen TR, Kitzmiller J, Chen G, Sridharan A, Haitchi HM, Hegde RS, Divanovic S, Karp CL, Whitsett JA. SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia. Proc Natl Acad Sci U S A. 2012; 109:16630-5.
  23. Lee N, Batt MK, Cronier BA, Jackson MC, Bruno Garza JL, Trinh DS, Mason CO, Spearry RP, Bhattacharya S, Robitz R, Nakafuku M, MacLennan AJ. Ciliary neurotrophic factor receptor regulation of adult forebrain neurogenesis. J Neurosci. 2013; 33:1241-58.
  24. Liu CF, Breidenbach A, Aschbacher-Smith L, Butler D, Wylie C. A role for hedgehog signaling in the differentiation of the insertion site of the patellar tendon in the mouse. PLoS One. 2013; 8:e65411.
  25. Lopez-Juarez A, Howard J, Ullom K, Howard L, Grande A, Pardo A, Waclaw R, Sun YY, Yang D, Kuan CY, Campbell K, Nakafuku M. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone. Genes Dev. 2013; 27:1272-87.
  26. Martin-Ibanez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martinez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM. Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons. Stem Cells Dev. 2012; 21:2239-51.
  27. Matsuoka RL, Sun LO, Katayama K, Yoshida Y, Kolodkin AL. Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development. PLoS One. 2013; 8:e63207.
  28. McCracken KW, Wells JM. Molecular pathways controlling pancreas induction. Semin Cell Dev Biol. 2012; 23:656-62.
  29. McNairn AJ, Doucet Y, Demaude J, Brusadelli M, Gordon CB, Uribe-Rivera A, Lambert PF, Bouez C, Breton L, Guasch G. TGFbeta signaling regulates lipogenesis in human sebaceous glands cells. BMC Dermatol. 2013; 13:2.
  30. Rankin SA, Gallas AL, Neto A, Gómez-Skarmeta JL, Zorn AM. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/beta-catenin-mediated lung specification in Xenopus. Development. 2012; 139:3010-20.
  31. Rao S, Chun C, Fan J, Kofron JM, Yang MB, Hegde RS, Ferrara N, Copenhagen DR, Lang RA. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013; 494:243-6.
  32. Riazuddin S, Belyantseva IA, Giese AP, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZM. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet. 2012; 44:1265-71.
  33. Schumacher JA, Hsieh YW, Chen S, Pirri JK, Alkema MJ, Li WH, Chang C, Chuang CF. Intercellular calcium signaling in a gap junction-coupled cell network establishes asymmetric neuronal fates in C. elegans. Development. 2012; 139:4191-201.
  34. Suetsugu-Maki R, Maki N, Nakamura K, Sumanas S, Zhu J, Del Rio-Tsonis K, Tsonis PA. Lens regeneration in axolotl: new evidence of developmental plasticity. BMC Biol. 2012; 10:103.
  35. Tadjuidje E, Hegde RS. The Eyes Absent proteins in development and disease. Cell Mol Life Sci. 2013; 70:1897-913.
  36. Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL. Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013; 521:1561-84.
  37. Wang D, El-Amouri SS, Dai M, Kuan CY, Hui DY, Brady RO, Pan D. Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier. Proc Natl Acad Sci U S A. 2013; 110:2999-3004.
  38. Yang D, Sun YY, Nemkul N, Baumann JM, Shereen A, Dunn RS, Wills-Karp M, Lawrence DA, Lindquist DM, Kuan CY. Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia. Cereb Cortex. 2013; 23:1218-29.
  39. Zhang Z, Rankin SA, Zorn AM. Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells. Dev Biol. 2013; 378:1-12.
  40. Zhu S, Chen K, Lan Y, Zhang N, Jiang R, Hu J. Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats. Bone. 2013; 53:340-9.
  41. Zou Y, Chiu H, Zinovyeva A, Ambros V, Chuang CF, Chang C. Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science. 2013; 340:372-6.

Faculty, Staff, and Trainees

Faculty Members

Christopher C. Wylie, PhD (Retired 3/31/13), Professor Emeritus
Leadership Director; Associate Chair for Basic Science
Research Interests Early Vertebrate Development, Xenopus, Mammal
Nadean Brown, PhD, Adjunct
Research Interests Eye Development, Mouse and Drosophila
Kenneth Campbell, PhD, Professor
Leadership Associate/Interim Director; Director, Transgenic Core Facility; Director, Basic Science Research in Surgical Services
Research Interests CNS Patterning, Mammal
Sang-Wook Cha, PhD, Assistant Professor
Research Interests Early Vertebrate Development
Chieh Chang, PhD, Assistant Professor
Research Interests Nervous System, C. Elegans
Chiou-Fen Chuang, PhD, Assistant Professor
Research Interests Nervous System, C. Elegans, Laterality
Vaughn Cleghon, PhD, Associate Professor
Research Interests Kinase Function In Development, Signaling
Brian Gebelein, PhD, Assistant Professor
Research Interests Transcriptional Regulation, Drosophila, Body Patterning, Nervous System
Geraldine Guasch, PhD, Assistant Professor
Research Interests Stem Cells in Epithelial Tissues and Their Role in Tumorigenesis, Transitional Epithelium and Anorectal Malformations
Rashmi S. Hegde, PhD, Professor
Leadership Director, Molecular and Developmental Biology Graduate Program
Research Interests Protein Structure/Function
Rulang Jiang, PhD, Professor
Research Interests Genetic Basis and Developmental Mechanisms of Structural Birth Defects; Mammalian Organogenesis
J. Matthew Kofron, PhD, Assistant Professor
Leadership Imaging Core Director
Research Interests Ectodermal Organ Development In Vertebrates, Xenopus
Chia-Yi Kuan, MD, PhD (End 9/9/12), Associate Professor
Research Interests Nervous System Patterning, Stroke, Cell Death, Mammal
James L. Lessard, PhD (Retired 6/29/12), Professor Emeritus
Research Interests Muscle Development, Mammal
Hung-Chi Liang, PhD, Instructor
Research Interests Affymetrix Core Manager
Xinhua Lin, PhD, Professor
Research Interests Cell Signaling, Drosophila
Christopher Mayhew, PhD, Assistant Professor
Leadership Co-Director, Stem Cell Core
Research Interests Human ES Biology and Differentiation
Masato Nakafuku, MD, PhD, Professor
Research Interests Nervous System Patterning And Stem Cells, Mammal
S. Steven Potter, PhD, Professor
Leadership Director, Affymetrix Core
Research Interests Transcription Regulation And Kidney Development, Mammal
Saulius Sumanas, PhD, Assistant Professor
Research Interests Vascular Development, Zebrafish
James M. Wells, PhD, Associate Professor
Leadership Co-Director, Stem Cell Core
Research Interests Vertebrate Gut Development, Stem Cells, Mammal
Dan A. Wiginton, PhD, Associate Professor
Research Interests Gut Differentiation, Mammal
Yutaka Yoshida, PhD, Assistant Professor
Research Interests Nervous System, Cell Migration, Mammal, Chicken
Aaron Zorn, PhD, Associate Professor
Research Interests Vertebrate Gut Development, Xenopus, Mammal

Joint Appointment Faculty Members

Bruce Aronow, PhD, Professor (Pediatric Bioinformatics)
Research Interests Bioinformatics
Samantha Brugmann, PhD, Assistant Professor (Plastic Surgery)
Research Interests Molecular Basis for Craniofacial Development and Disease
Tiffany Cook, PhD, Assistant Professor (Pediatric Ophthalmology)
Research Interests Eye Development, Drosophila
Steven Crone, PhD, Assistant Professor (Neurosurgery)
Research Interests Spinal Circuit Development and Repair
Tony DeFalco, PhD, Assistant Professor (Reproductive sciences)
Research Interests Gonad Development, Mammal
Sudhansu Dey, PhD, Professor (Director, Reproductive Sciences)
Research Interests Reproductive Biology
Prasad Devarajan, MD, Professor (Director, Nephrology and Hypertension)
Research Interests Urinary Tract Differentiation, Mammal
Stacey Huppert, PhD, Associate Professor (Gastroenterology, Hepatology, and Nutrition)
Research Interests Hepatic Development and Regeneration
Vladimir Kalinichenko, MD PhD, Associate Professor (Pulmonary Biology and Neonatology)
Research Interests Transcriptional Regulation of Lung Embryonic Development
Yu Lan, PhD, Associate Professor (Plastic Surgery)
Research Interests Genetic Control of Craniofacial Development, Mutant Mouse Models
Richard A. Lang, PhD, Professor (Pediatric Opthalmology)
Research Interests Visual System Development, Mammal
Jun Ma, PhD, Professor (Pediatric Bioinformatics)
Research Interests Transcriptional Regulation, Drosophila
Takahisa Nakamura, PhD, Assistant Professor (Endocrinology)
Research Interests Obesity-induced Metabolic Diseases
Satoshi Namekawa, PhD, Assistant Professor (Reproductive Sciences)
Research Interests Germ Cells, Epigenetics, Reproduction, Mouse
Yuya Ogawa, PhD, Assistant Professor (Reproductive Sciences)
Research Interests Long Noncoding RNA-mediated Transcriptional Regulation in Mammals
Joo-Seop Park, PhD, Assistant Professor (Urology)
Research Interests Molecular Biology, Genetics
Noah F. Shroyer, PhD, Associate Professor (Gastroenterology, Hepatology, and Nutrition)
Research Interests Vertebrate Gut Development, Mammal
Rolf Stottmann, PhD, Assistant Professor
Research Interests Genetic Approaches to Understanding Human Congenital Defects Affecting the Face and Forebrain.
Ronald Waclaw, PhD, Assistant Professor (Experimental Hematology)
Research Interests Forebrain Progenitor Cell Differentiation
Joshua Waxman, PhD, Assistant Professor (Molecular Cardiovascular Biology)
Research Interests Molecular Genetics of Cardiovascular Development
Jeffrey A. Whitsett, MD, Professor (Chief, Section of Neonatology, Perinatal, and Pulmonary Biology)
Research Interests Respiratory System, Mammal
Chunyue Yin, PhD, Assistant Professor (Gastroenterology, Hepatology, and Nutrition)
Research Interests Liver Development and Diseases

Trainees

  • Chitra Dahia*, PhD, Facult, Indian Institute of Science (end 4/19/13)
  • Kei-Ichi Katayama, PhD, DVM, Vis Re, University of Tokyo (end 2/8/13)
  • Eui Kyun Park, PhD, Vis Re, Kyungpook National University (end 12/21/12)
  • Masaki Ueno, PhD, Vis Ob, Osaka University
  • Baoyan Bai, PhD, Res. A, Johns Hopkins University
  • Tatyana Belenkaya, PhD, Res. A, Russian Academy of Science
  • Eric Brunskill, PhD, Res. A, University of Maryland
  • Kevin Burns, PhD, Res. A, University of Cincinnati
  • Bharesh Chauhan*, PhD, Res. A, Oxford University, United Kingdom
  • Eunah Chung*, PhD, Res. A, Cornell University
  • Lisa Ehrman*, PhD, Res. A, University of Cincinnati
  • Christina James-Zorn, PhD, Res. A, University of Queenland, Australia
  • Matthew Hass, PhD, Res. A, Harvard University Medical School
  • Yasuko Kato*, PhD, Res. A, Kyoto Institute of Technology, Japan
  • Junbo Lui*, PhD, Res. A, Fudan University, China
  • Athanasia Nikolaou*, PhD, Res. A, University of Melbourne, Australia
  • Taeko Noah*, PhD, Res. A, University of Nevada
  • Timothy Plageman*, PhD, Res. A, University of Cincinnati
  • Virgilio Ponferrada, PhD, Res. A, Wright State University
  • Sujata Rao*, PhD, Res. A, Cornell University
  • Jennifer Schumacher, PhD, Res. A, University of Pennsylvania
  • Ho-Su Sin*, PhD, Res. A, Kanazawa University, Japan
  • Emmanuel Tadjuidje, PhD, Res. A, University of Göttingen, Germany
  • Huirong Xie*, PhD, Res. A, Vanderbilt University
  • Dianer Yang, PhD, Res. A, Chinese Academy of Sciences (end 9/9/12)
  • Sivan Bezalel*, PhD, Res. F, University Medical School, Isreal
  • Sarah Beckman*, PhD, Res. F, University of Pittsburgh
  • Ching-Fang Chang, PhD, Res. F, University of Alabama
  • Enrico D'Aniello*, PhD, Res. F, Stazione Zoologica Anton Dohrn, Italy
  • Ashley Driver*, PhD, Res. F, University of Wisconsin-Madison
  • Tarsis Ferreira, PhD, Res. F, Universidade Federal de Sao Paulo, Brazil
  • Amy Gresser, PhD, Res. F, Harvard University
  • Yi-Wen Hsieh, PhD, Res. F, University of California, Los Angeles
  • Fumiyasu Imai, PhD, Res. F, Yokohama City University of Medicine, Japan
  • Shihai Jia, PhD, Res. F, Shanghai Institute for Biological Sciences, China
  • Maximiliano Jimenez-Dalmaroni, PhD, Res. F, University of Oxford, UK (end 4/13/13)
  • Donatien Kamdem Toukam, PhD, Res. F, Ruhr University Bochum, Germany
  • Avedis Kazanjian*, PhD, Res. F, University of Louisville
  • Vikram Kohli*, PhD, Res. F, University of Alberta, Canada
  • Hyuk-Jae Kwon, PhD, Res. F, Yonsei University, Korea
  • Cheng-Hao Li, PhD, Res. F, Sichuan University, China (end 3/29/13)
  • Chia-Feng Liu, PhD, Res. F, University of Chicago at Urbana (end 3/29/13)
  • Han Liu, PhD, Res. F, University of Rochester
  • Alejandro Lopez Juarez, PhD, Res. F, University of Mexico
  • Mayur Madhavan, PhD, Res. F, Miami University
  • Paloma Merchan Sala, PhD, Res. F, University of Murcia, Spain
  • Jorge Munera, PhD, Res. F, University of California, San Diego
  • Craig Park*, PhD, Res. F, McGill University, Canada
  • Anna Raines, PhD, Res. F, University of Wisconsin
  • Latasha Redmond, PhD, Res. F, Virginia Commonwealth University (end 8/10/12)
  • Kaushik Roychoudhury, PhD, Res. F, Jadavpur University, India
  • Jacqueline Schiesser, PhD, Res. F, Monash University, Australia
  • Emily Shifley, PhD, Res. F, Ohio State University
  • Xiaofei Sun*, PhD, Res. F, Vanderbilt University
  • Yu-Yo Sun, PhD, Res. F, Taipei Medial University, Taiwan (end 9/9/12)
  • Xiaofang Tang, PhD, Res. F, Univeristy of Cincinnati
  • Jumpei Terakawa*, PhD, Res. F, Yamaguchi University, Japan
  • Marcin Wlizla, PhD, Res. F, University of Chicago
  • Baotang Xie*, PhD, Res. F, Chinese Academy of Sciences
  • Jingyue Xu, PhD, Res. F, Nanjing University, China
  • Norishige Yamada*, PhD, Res. F, Kagoshima University, Japan
  • Eun-Jin Yeo*, PhD, Res. F, Seoul National University, South Korea
  • Celvie Yuan, PhD, Res. F, Case Western Reserve University
  • Jing Zhou, PhD, Res. F, Shanghai Institute for Biological Sciences, China
  • Yan Zou, PhD, Res. F, Chinese Academy of Sciences
  • Jonathan Howell, MD PhD, Clin., Indiana University
  • Alan Kenny, MD PhD, Clin., University of Rochester, School of Medicine and Dentistry
  • Andrea Pardo, MD, Clin., Johns Hopkins University (end 8/31/12)
  • Douglas Brown*, , Grad., University of Cincinnati - College of Medicine
  • Marion Brusadelli, , Grad. , Luminy University, France
  • Michael Craig, , Grad. , University of Cincinnati
  • Pauline Fritsch, , Grad., Luminy University, France (end 8/17/12)
  • Christine Marques, , Grad., ESIL, France (end 8/24/12)
  • Milesa Simic, , Grad. , Luminy University, France
  • Jurate Skerniskyte, , Grad., Vilnius Univ, Lithuania
  • Mustafa Turkoz, , Grad., Washington University
  • Mathieu Viereria, , Grad., University of Paris
  • Hanane Yahia, , Grad., University of Paris Diderot, France (end 8/31/12)
  • Brittany Bayne, , Underg, University of Cincinnati
  • Emily Blatz, , Underg, University of Cincinnati
  • Claudia Carrelli, , Underg, University of Cincinnati
  • Matthew Carter, , Underg, Miami University, Oxford, OH
  • Emily Cata, , Underg, Xavier University
  • Calyn Crawford, , Underg, Xavier University
  • Mahima Devarajan, , Underg, Case Western Reserve
  • Andrew DiStasio, , Underg, University of Cincinnati
  • Allison Estep, , Underg, University of Cincinnati
  • Abigail Evans, , Underg, Ohio State University
  • Arif Ghasletwala, , Underg, University of Cincinnati
  • Matthew Grazyk, , Underg, Xavier University (end 5/10/13)
  • Tiffany Hoang, , Underg, California State University - Fullerton (PSTP Summer Student)
  • Sarah Kastner, , Underg, Cincinnati State
  • Osama Kasem, , Underg, University of Cincinnnati
  • Mishi Liang, , Underg, University of Cincinnati
  • Kelsey Lin, , Underg, Ohio State University
  • Madhulika Mamidi, , Underg, University of Cincinnati
  • Mhadhumithan Naresh, , Underg, University of Cincinnati
  • Jesse Niehaus, , Underg, University of Cincinnati
  • Mosep Okonny, , Underg, University of Cincinnati (end 8/3/12)
  • Thanh Phan, , Underg, University of Cincinnati
  • Alyna Williams, , Underg, University of Cincinnati (end 8/24/12)
  • Blair Wissel, , Underg, Xavier University (end 3/5/13)

Division Collaboration

Human Genetics » Rolf Stottmann
A translational approach towards the identification of causative genetic elements for ciliopathies with Samantha Brugmann
Neurosurgery » Francesco Mangano
Animals models of hydrocephalus with Kenny Campbell
Ophthalmology » Zubair Ahmed
Conservation of photoreceptor development - from flies to humans with Tiffany Cook
Biomedical Informatics » Anil Jegga
Development with Respect to Endocannabinoid Signaling with SK Dey
Endocrinology » Stuart Handwerger
Role of Endocannabinoid in Uterine Decidualization with SK Dey
Molecular Immunology » Senad Divanovic
Role of Endocannabinoid in Preterm Birth with SK Dey
Pulmonary Biology » Jeff Whitsett
Role of KLF5 in Uterine Biology and Implantation with SK Dey
Ophthalmology » Tiffany Cook
Determining the molecular interactions underlying cell-specific gene expression in the peripheral nervous system with Brian Gebelein
Immunobiology » H. Leighton Grimes
Assessing the role of Hox and Gfi-1 antagonism in regulating microRNA expression and blood cell proliferation during hematopoiesis and leukemia progression with Brian Gebelein
Ophthalmology » Tiffany Cook
Transcriptional control of cell type specification during Drosophila neurogenesis with Brian Gebelein
Colorectal Center; Urology » Marc Levitt, Alberto Pena, and Shumyle Alam
Using the Shh knock out mouse model to investigate the mechanism of persistent cloaca in human with Geraldine Guasch
Ophthalmology » Richard Lang
Molecular mechanisms in retinal angiogenesis with Rashmi Hegde
Molecular Immunology » Christopher Karp
SAM Pointed Domain Ets Factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia with Rashmi Hegde
Ophthalmology; Otolaryngology » Zubair Ahmed and Saima Riazuddin
Mutations of CIB2, a calcium and integrin binding protein, cause Usher syndrome type 1J and nonsyndromic deafness DFNB48 with Rashmi Hegde
Pulmonary Biology » Jeff Whitsett
SAM Pointed Domain Ets Factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia; FOXA3 Regulates Goblet Cell Metaplasia and Innate Immunity in the Airway with Rashmi Hegde.
Molecular Immunology » Senad Divanovic
Studies on the role of adult neurogenesis in obesity with Masato Nakafuku
Human Genetics » Rolf Stottmann
Molecular basis of congenital brain anomaly with Masato Nakafuku
Experimental Hematology » Ronald Waclaw
Development of oligodendrocytes and astrocytes in early postnatal brains with Masato Nakafuku
Experimental Hematology and Cancer Biology » Paul Andreassen
DNA damage response pathways in epigenetic programming with Satoshi Namekawa
Allergy and Immunology » Artem Barski
Epigenomic landscape of the sex chromosomes in germ cells with Satoshi Namekawa
Reproductive Sciences » SK Dey
To characterize reproductive defects in Hox mutant mice with Steve Potter
Pediatric General and Thoracic Surgery; Hemangioma and Vascular Malformation Center » Belinda Dickie and Peter Dickie
Identifying genetic causes of vascular and lymphatic malformations with Saulius Sumanas
Plastic Surgery; Biomedical Informatics » Christopher Gordon and Bruce Aronow
Functional role of miRNAs in craniofacial development with Saulius Sumanas
Critical Care Medicine » Brian Varisco
Role of elastase like proteins in vertebrates with Saulius Sumanas
Plastic Surgery » Samantha Brugmann
Generating Human Intestinal Organoids with an ENS with Jim Wells
Ophthalmology; Experimental Hematology » Richard Lang and Yi Zheng
Role of Rho GTPases molecules in mammalian nervous system with Yutaka Yoshida
Urology » Joo-Seop Park
Transcriptome analysis of wnt signaling in liver development with Aaron Zorn

Grants, Contracts, and Industry Agreements

Developmental Biology Grants

Grant and Contract AwardsAnnual Direct

Campbell, K

Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
R01 MH 09074004/01/10-01/31/15$237,600
Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
R01 NS 04408007/01/08-06/30/13$428,750

Chang, C

Understanding MicroRNA Mechanisms for Developmental Decline in Axon Growth Activity
06/01/10-05/31/13$58,993

Chuang, C

Specification of Stochastic Left-Right Asymmetric Neuronal Fates in C. Elegans
R01 GM 098026-0108/31/12-07/31/17$190,000

Cleghon, V

Fundamental Mechanisms of Protein Kinase Activation Loop Autophosphorylation
R01 GM 08737404/15/10-02/28/14$186,293

Guasch, G

Defining the Transcriptional and Signaling Networks Involved in Epithelial Cancers of Transitional Epithelia
SKF-11-03607/01/11-06/30/13$86,957
Using a Novel Mouse Model of Transitional Epithelial Tumor to Investigate Cancer Initiation and Progression
11/01/11-10/31/13$100,000

Jiang, R

Molecular Genetic Analysis of Craniofacial Development
R01 DE 1368107/01/11-06/30/15$439,824

Kofron, M.

Ectoderm Formation in the Early Xenopus Embryo
R01 HD 04573704/01/10-03/31/15$189,041

Kohli, V

Lineage Tracing of Endothelial Progenitor Cells: Patterning the Vascular Cord
12POST1204012307/01/12-10/31/12$15,232

Lin, X

Regulation of Wingless (Wg) Signaling and Morphogen Gradient Formation
R01 GM 06389104/01/12-03/31/16$193,000
Roles of Retromer Complex in Development
R01 GM 08751703/01/10-02/28/14$181,517

MAYHEW, C

Digestive Health Center: Stem Cell Core
U01 DK 06249709/10/09-05/31/14$28,261

Nakafuku, M

Endogenous CNTF Receptors and Adult, In Vivo Neurogenesis
R01 NS 06605107/01/09-06/30/14$10,392

NAKAFUKU, M / CAMPBELL, K (MPI)

Molecular Control of Neurogenesis in the Adult Subventricular Zone
R01 NS 06989304/01/10-03/31/15$291,422

Potter, S

Generating Molecular Markers that Selectively Label Urothelial Sub-Populations
U01 DK 09453009/30/11-08/31/16$31,311
Global Gene Expression Atlas of Craniofacial Development
U01 DE 02004909/21/09-04/30/14$175,411
Digestive Health Center - Gene Expression Core
U01 DK 06249709/10/09-05/31/14$40,695

Schumacher, J

Training in Cardiovascular Biology
T32 HL 00738201/01/13-08/31/13$33,256

Shroyer, N

bHLH factor Regulation of Mammalian Retinal Neuron Development
01/01/12-12/31/14$57,000

Sumanas, S

Molecular Mechanisms of Arterial-Venous Differentiation in Zebrafish
R01 HL 10736904/01/11-03/31/16$238,000

Wells, J

Directing Differentiation of Human Pluripotent Stem Cells to Generate 3-Dimensional Lung Tissue In Vitro
R21 HL 11532208/10/12-06/30/14$41,250
Generating Human Intestinal Organoids with an ENS
U18 TR 00054607/24/12-06/30/14$225,000

WELLS, J / SHROYER N

Human Endocrine Cell Development
04/07/12-02/28/17$287,003

Wylie , C

A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
R01 AR 05694307/10/09-06/30/14$178,001

Yoshida, Y

Properties of Interneurons Before and After SCI
01/01/13-06/30/13$15,000
Regulation of Sensory-Motor Connectivity by Semaphorin-Plexin Signaling
R01 NS 06504804/01/09-03/31/14$206,872

Zorn, A

Cadherin-based Actin Assembly in the Xenopus Embryo
R01 HD 04476403/12/09-01/31/14$187,150
Cell Cycle Proteomics in Xenopus
R01 GM 10378509/01/12-06/30/14$10,873
Collaborative Research: Ontology-Enabled Reasoning across Phenotypers from Evolution and Model Organisms
DBI-106254207/01/11-06/30/15$16,021
Osr Transcription Factors Regulate Embryonic Lung Development
R01 HL 114898-0108/10/12-06/30/17$250,000
Production, Validation and Distribution of the Xenopus ORFeome
R01 HD 06935208/01/11-05/31/16$108,702
Xenbase: a Xenopus Model Organism Database
P41 HD 06455606/01/10-05/31/15$671,039
Current Year Direct$5,409,866
Industry Contracts

Wells

$115,500
Current Year Direct Receipts$115,500
Total$5,525,366

Additional Information

Molecular and Developmental Biology Graduate Program

The Graduate Program in Molecular and Developmental Biology is an interdepartmental program within the University of Cincinnati that offers the PhD degree. It has been based in the Department of Pediatrics for over 35 years. Drs. Timothy Weaver and Rashmi Hegde served as Directors of the Program with Associate Directors Drs. Jeffrey Whitsett - finance, Aaron Zorn - curriculum, Tim Le Cras - admissions, Edith Markoff – recruitment, Yi Zheng – faculty membership, and John Shannon– graduate studies.

There are 87 faculty members in the program. During the past year, there were 70 pre-doctoral students in the program, 8 of whom are pursuing MD/PhD degrees. Students and faculty continue to be productive as measured by their numbers of publications, presentations at meetings, honors and awards received. Grant support to faculty remains high.

During the past year, the University of Cincinnati continued to support the program by providing University Graduate Assistantships and funds appropriated from the Dean's office to support 6 first year students. The remaining students are supported through a variety of sources including Ryan Fellowships (2), NIH training grants (5), external grants to their advisors (50), CHRF Special Purpose Funds to their advisors (5) and funds from the Children's Hospital Research Foundation to the Graduate Program (5).

The MDB Program provides an excellent research educational experience for students and has an excellent record in the placement of its graduates in scientific careers.

Molecular and Developmental Biology Graduate Program Students, 2012-2013

Student

Faculty Mentor

Admission

Thomas Acciani Timothy Le Cras 2009
Amel Alqadah Chiou-Fen Chuang 2010
Robyn Amos-Kroohs Michael Williams 2009
Aria Attia Jeffrey Whitsett 2010
David Balli Tanya Kalin 2008
Kristin Bell Noah Shroyer 2010
Katie Bezold Louis Muglia 2011
Gregory Bick Paul Andreassen 2010
Markaisa Black Rotating 2012
Caitlin (Maynard) Braitsch Katherine Yutzey 2006
Adam Burr** Jeffery Molkentin 2009
Jeeyeon Cha** Sudhansu K. Dey 2009
Heather Chapman Kenneth Campbell 2007
Mark Charlton-Perkins Tiffany Cook 2010
Jason Cowan Stephanie Ware 2009
Angela (Matthews) Damen Katherine Yutzey 2011
Sharina Desai Saulius Sumanas 2008
Tracy Dohn Joshua Waxman 2009
Jieqing Fan Richard Lang 2007
Ming Fang Katherine Yutzey 2010
Alyssa Gallas Geraldine Guasch 2011
Chen Gao Tanya Kalin 2011
Margaret Gardner Kathryn Wikenheiser-Brokamp 2010
Nicole Glenn Saulius Sumanas 2006
Vicky Gomez Katherine Yutzey 2011
Zirong Gu Yutaka Yoshida 2008
David Hahn Timothy Weaver 2006
Lu Han Aaron Zorn 2011
Jamie Havrilak John Shannon 2008
Michael Hester Steve Danzer 2009
Benjamin Hogan Rotating 2012
Jillian Hufgard Rotating 2012
Diva Jonatan James Wells 2006
Abigail (Bower) Kasberg Steve Potter 2008
Jed Kendall** Nancy Ratner 2011
Andrew Koenig Rotating 2012
Jeff Kuerbitz** Kenneth Campbell 2012
Julie Lander** Stephanie Ware 2011
Mary (Horn) Lee Katherine Yutzey 2007
Shan Lin James Mulloy 2009
Mariana Louza Aaron Zorn 2010
Bliss Magella Steve Potter 2011
Amrita Mandal Joshua Waxman 2011
Kate Maurer Nadean Brown 2009
Heather McCauley Geraldine Guasch 2009
Kyle McCracken** James Wells 2010
Patrick “Sean” McGrath James Wells 2012
Anna (Hake) Method James Wells 2007
Edward “David” Muench Rotating 2012
Elizabeth Mushaben Timothy Le Cras 2007
Shenyue Qin Kenneth Campbell 2011
Megan Rost Saulius Sumanas 2008
Ariel Rydeen Joshua Waxman 2011
Betsy Schock Rotating 2012
Moen Sen Kathryn Wikenheiser-Brokamp 2011
Katie Sinagoga Rotating 2012
Shatrunjai Singh Steve Danzer 2010
Mardi Sutherland Stephanie Ware 2008
Xiaofang Tang Xinhua Lin 2006
David Terrell** Tiffany Cook 2008
Chelsea Tolentino Timothy Le Cras 2010
Juli Uhl Brian Gebelein 2008
Sha Wang Christopher Wylie/Aaron Zorn 2009
Michael Workman Rotating 2012
Jiadi Xu John Harley 2010
Jia You Xinhua Lin 2007
Inuk Zandvakili** Yi Zheng 2009
Xuzhe Zhang Rotating 2012
Zheng Zhang Aaron Zorn 2008
Xuan Zhou Yi Zheng 2007

Students completing their PhD work

  • David Terrell – “A Comparative Analysis of Otd/OTX Factor Function in the Drosophila eye: Examining Mechanisms of Evolutionarily Conserved Function,” August 9, 2012.
  • Elizabeth Mushaben – “MTOR and BMPR2 Signaling Pathways in Inflammatory Lung Disease,” August 20, 2012.
  • Diva Jonatan – “The Role of Sox17 in Normal and Pathological Beta Cells,” August 30, 2012.
  • Xiaofang Tang – “Regulation of Wingless (Wg) secretion distribution and signaling,” October 30, 2012.
  • Nikki Glenn – “Roles of alpha-cardiac actin during zebrafish heart development and the role of etsrp/etv2 during zebrafish primitive neutropoiesis,” December 7, 2012.
  • Caitlin Braitsch – “The role of Pod1/Tcf21 in epicardium-derived cells in cardiac development and disease,” March 1, 2013.
  • Xuan Zhou – “RhoA GTPase Controls Cytokinesis and Programmed Necrosis of Hematopoietic Progenitors,” May 20, 2013.
  • Sharina Palencia Desai – “Transcriptional Regulation of Early Endocardial Development,” June 6, 2013.
  • David Balli – “Foxm1 is a novel regulator of EMT in fibrosis and cancer,” June 17, 2013.
  • Jeeyeon Cha – “The role of muscle segment homeobox genes in early pregnancy events,” June 20, 2013.

Students completing their MS work

  • Chen Gao – “Role of SPDEF in prostate cancer,” June 21, 2012.
  • Jiadi Xu – “DNA repair defects as a mechanism contributing to the development of lupus,” March 7, 2013.
  • Chelsea Tolentino – “Identifying Genetic Modifiers Contributing to Pulmonary Arterial Hypertension,” June 4, 2013.

Student Publications

During the past year, students from the Program authored or co-authored 33 articles.

Amos-Kroohs RM, Williams MT, Braun AA, Graham DL, Webb CL, Birtles TS, Greene RM, Vorhees CV, Pisano MM. Neurobehavioral phenotype of C57BL/6J mice prenatally and neonatally exposed to cigarette smoke. Neurotoxicol Teratol. 2013 Jan-Feb;35:34-45. doi: 10.1016/j.ntt.2013.01.001. Epub 2013 Jan 11.PubMed [citation] PMID: 23314114, PMCID: PMC3593942

Balli D, Ren X, Chou FS, Cross E, Zhang Y, Kalinichenko VV, Kalin TV. Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formationOncogene. 2012 Aug 23;31(34):3875-88. doi: 10.1038/onc.2011.549. Epub 2011 Dec 5.PubMed [citation] PMID: 22139074, PMCID: PMC3297705

Balli D, Ustiyan V, Zhang Y, Wang IC, Masino AJ, Ren X, Whitsett JA, Kalinichenko VV, Kalin TV. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J. 2013 Jan 23;32(2):231-44. doi: 10.1038/emboj.2012.336. Epub 2013 Jan 4.PubMed [citation] PMID: 23288041, PMCID: PMC3553386

Bezold KY, Karjalainen MK, Hallman M, Teramo K, Muglia LJ. The genomics of preterm birth: from animal models to human studies. Genome Med. 2013 Apr 29;5(4):34. [Epub ahead of print] PubMed PMID: 23673148; PubMed Central PMCID: PMC3707062.

Braitsch CM, Combs MD, Quaggin SE, Yutzey KE. Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev Biol. 2012 Aug 15;368(2):345-57. doi: 10.1016/j.ydbio.2012.06.002. Epub 2012 Jun 9. PubMed [citation] PMID: 22687751, PMCID: PMC3414197

Bryantsev AL, Duong S, Brunetti TM, Chechenova MB, Lovato TL, Nelson C, Shaw E, Uhl JD, Gebelein B, Cripps RM. Extradenticle and homothorax control adult muscle fiber identity in Drosophila. Dev Cell. 2012 Sep 11;23(3):664-73. doi: 10.1016/j.devcel.2012.08.004. PubMed [citation] PMID: 22975331, PMCID: PMC3575643

Cai Y, Balli D, Ustiyan V, Fulford LA, Hiller A, Misetic V, Zhang Y, Paluch AM, Waltz SE, Kasper S, Kalin TV. Foxm1 Expression in Prostate Epithelial Cells is Essential for Prostate Carcinogenesis. J Biol Chem. 2013 Jun 17. [Epub ahead of print] PubMed PMID: 23775078.

Cha J, Sun X, Bartos A, Fenelon J, Lefèvre P, Daikoku T, Shaw G, Maxson R, Murphy BD, Renfree MB, Dey SK. A new role for muscle segment homeobox genes in mammalian embryonic diapause. Open Biol. 2013 Apr 24;3(4):130035. doi: 10.1098/rsob.130035. PubMed PMID: 23615030.

Cha J, Sun X, Dey SK. Mechanisms of implantation: strategies for successful pregnancy. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PubMed [citation] PMID: 23223073

Chapman H, Waclaw RR, Pei Z, Nakafuku M, Campbell K. The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors. Development. 2013 Jun;140(11):2289-98. doi: 10.1242/dev.091090. Epub 2013 May 1. PubMed PMID: 23637331; PubMed Central PMCID: PMC3653554.

Chen L, Acciani T, Le Cras T, Lutzko C, Perl AK.Dynamic regulation of platelet-derived growth factor receptor α expression in alveolar fibroblasts during realveolarization. Am J Respir Cell Mol Biol. 2012 Oct;47(4):517-27. doi: 10.1165/rcmb.2012-0030OC. Epub 2012 May 31. PubMed [citation] PMID: 22652199, PMCID: PMC3488620

Daikoku T, Yoshie M, Xie H, Sun X, Cha J, Ellenson LH, Dey SK. Conditional deletion of Tsc1 impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice. Mol Hum Reprod. 2013 Mar 7. [Epub ahead of print] PubMed [citation] PMID: 23475984

Davis J, Burr AR, Davis GF, Birnbaumer L, Molkentin JD. A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Dev Cell. 2012 Oct 16;23(4):705-15. doi: 10.1016/j.devcel.2012.08.017. Epub 2012 Sep 27. PubMed [citation] PMID: 23022034, PMCID: PMC3505601

Glenn NO, McKane M, Kohli V, Wen KK, Rubenstein PA, Bartman T, Sumanas S. The W-loop of alpha-cardiac actin is critical for heart function and endocardial cushion morphogenesis in zebrafish. Mol Cell Biol. 2012 Sep;32(17):3527-40. doi: 10.1128/MCB.00486-12. Epub 2012 Jul 2. PubMed [citation] PMID: 22751927, PMCID: PMC3422001

Graham DL, Amos-Kroohs RM, Braun AA, Grace CE, Schaefer TL, Skelton MR, Williams MT, Vorhees CV. Neonatal +-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists. Int J Neuropsychopharmacol. 2013 Mar;16(2):377-91. doi: 10.1017/S1461145712000144. Epub 2012 Mar 6. PubMed [citation] PMID: 22391043

Hester MS, Danzer SC. Accumulation of abnormal adult-generated hippocampal granule cells predicts seizure frequency and severity. J Neurosci. 2013 May 22;33(21):8926-36. doi: 10.1523/JNEUROSCI.5161-12.2013. PubMed PMID: 23699504.

Kenny AP, Rankin SA, Allbee AW, Prewitt AR, Zhang Z, Tabangin ME, Shifley ET, Louza MP, Zorn AM. Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. Dev Cell. 2012 Aug 14;23(2):292-304. doi: 10.1016/j.devcel.2012.07.002. Epub 2012 Aug 2. PubMed [citation] PMID: 22863744

Krishnan K, Feng X, Powers-Fletcher MV, Bick G, Richie DL, Woollett LA, Askew DS. Effects of a defective endoplasmic reticulum-associated degradation (ERAD) pathway on the stress response, virulence and antifungal drug susceptibility of the mold pathogen Aspergillus fumigatus. Eukaryot Cell. 2013 Jan 25. [Epub ahead of print] PubMed [citation] PMID: 23355008

Liu M, Bi F, Zhou X, Zheng Y. Rho GTPase regulation by miRNAs and covalent modifications. Trends Cell Biol. 2012 Jul;22(7):365-73. doi: 10.1016/j.tcb.2012.04.004. Epub 2012 May 7. Review. PubMed [citation] PMID: 22572609, PMCID: PMC3383930

McCracken KW, Wells JM. Molecular pathways controlling pancreas induction. Semin Cell Dev Biol. 2012 Aug;23(6):656-62. doi: 10.1016/j.semcdb.2012.06.009. Epub 2012 Jun 26. Review. PubMed [citation] PMID: 22743233, PMCID: PMC3423525

Mushaben EM, Brandt EB, Hershey GK, Le Cras TD. Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma. PLoS One. 2013;8(1):e54426. doi: 10.1371/journal.pone.0054426. Epub 2013 Jan 17. PubMed [citation] PMID: 23349887, PMCID: PMC3547928

Pun RY, Rolle IJ, Lasarge CL, Hosford BE, Rosen JM, Uhl JD, Schmeltzer SN, Faulkner C, Bronson SL, Murphy BL, Richards DA, Holland KD, Danzer SC. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron. 2012 Sep 20;75(6):1022-34. doi: 10.1016/j.neuron.2012.08.002. PubMed [citation] PMID: 22998871, PMCID: PMC3474536

Rankin SA, Gallas AL, Neto A, Gomez-Skarmeta JL, Zorn AM. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Development. 2012 Aug;139(16):3010-20. doi: 10.1242/dev.078220. Epub 2012 Jul 12.PubMed [citation] PMID: 22791896, PMCID: PMC3403107

Rao S, Chun C, Fan J, Kofron JM, Yang MB, Hegde RS, Ferrara N, Copenhagen DR, Lang RA. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013 Feb 14;494(7436):243-6. doi: 10.1038/nature11823. Epub 2013 Jan 16. PubMed [citation] PMID: 23334418

Riazuddin S, Belyantseva IA, Giese AP, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, et al. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nat Genet. 2012 Nov;44(11):1265-71. doi: 10.1038/ng.2426. Epub 2012 Sep 30. PubMed [citation] PMID: 23023331, PMCID: PMC3501259

Schaefer TL, Braun AA, Amos-Kroohs RM, Williams MT, Ostertag E, Vorhees CV. A new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects. Genes Brain Behav. 2012 Jul;11(5):614-22. doi: 10.1111/j.1601-183X.2012.00796.x. Epub 2012 May 8. PubMed [citation] PMID: 22487514

Schaefer TL, Grace CE, Braun AA, Amos-Kroohs RM, Graham DL, Skelton MR, Williams MT, Vorhees CV. Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA. Int J Neuropsychopharmacol. 2013 Jan 11:1-12. [Epub ahead of print] PubMed [citation] PMID: 23308402

Shang X, Marchioni F, Evelyn CR, Sipes N, Zhou X, Seibel W, Wortman M, Zheng Y. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60. doi: 10.1073/pnas.1212324110. Epub 2013 Feb 4.PubMed [citation] PMID: 23382194, PMCID: PMC3581902

Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Burns LN, Amos-Kroohs RM, Williams MT, Vorhees CV. Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats. Int J Neuropsychopharmacol. 2012 Jul;15(6):811-24. doi: 10.1017/S1461145711000952. Epub 2011 Jun 28. PubMed [citation] PMID: 21733225

Stefater JA 3rd, Rao S, Bezold K, Aplin AC, Nicosia RF, Pollard J, Ferrara N, Lang RA. Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood. 2013 Jan 9. [Epub ahead of print] PubMed [citation] PMID: 23303818

Sutherland MJ, Wang S, Quinn ME, Haaning A, Ware SM. Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning. Hum Mol Genet. 2013 Feb 28. [Epub ahead of print] PubMed [citation] PMID: 23303524

Zhang F, Bick G, Park JY, Andreassen PR. MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination. J Cell Sci. 2012 Dec 15;125(Pt 24):6049-57. doi: 10.1242/jcs.111872. Epub 2012 Oct 4. PubMed [citation] PMID: 23038782

Zhang Y, You J, Ren W, Lin X. Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development. Dev Biol. 2013 Mar 1;375(1):23-32. doi: 10.1016/j.ydbio.2012.12.019. Epub 2013 Jan 8. PubMed [citation] PMID: 23313126

Student Honors

  • Amos-Kroohs, R. – Supported by NIH Training Grant (Teratology)
  • Balli, D. – Supported by the Dissertation Completion Fellowship, University of Cincinnati
  • Cha, J. – Supported by NHLBI Ruth L. Kirchenstein National Research Service Award for Individual Pre-doctoral MD/PhD Fellows
  • Chapman, H. – Supported by NIH Training Grant (Teratology)
  • Charlton-Perkins, M. – Supported by an Albert J. Ryan Foundation Fellowship
  • Gardner, M. – Supported by NIH Training Grant (Pulmonary & Cardiovascular Biology)
  • Kasberg, A. – Supported by NIH Training Grant (Teratology)
  • McCracken, K. – Supported by an Albert J. Ryan Foundation Fellowship
  • Rost, M. – Outstanding Poster by a Graduate Student, North American Vascular Biology Organization Workshop
  • Singh, S. – 3rd Prize, Graduate Student Poster Forum, University of Cincinnati; Supported by a University Research Council Summer Fellowship, University of Cincinnati
  • Uhl, J. – Supported by a University Research Council Summer Fellowship, University of Cincinnati

Richard A. Akeson Fellowship Fund

The Richard A. Akeson Fellowship and Memorial Lectureship Fund continues to support the Annual Richard Akeson Memorial Lectureship and travel by students in our graduate program to relevant courses and meetings in which they are presenting results of their research. Dr. David M. Ornitz presented the Seventeenth Annual Richard Akeson Memorial Lectureship in conjunction with the annual Molecular and Developmental Biology Graduate Student Symposium in 2012.

In addition to the travel stipends, the program also instituted two new student achievement awards in 2011. The Akeson Award for Outstanding Contributions to the Graduate Program is awarded to a first or second year student with outstanding participation in student recruitment, hosting visiting seminar speakers, volunteering for University of Cincinnati events and other contributions. The Akeson Award for Academic Excellence is awarded to a student in the third year or beyond with a strong publication record, pre-doctoral fellowships, grants (both submitted and awarded) and presentations at national and international meetings. Nominations are accepted for both awards from MDB program faculty and students and awards are made in the spring. For 2013, the Akeson Award for Outstanding Contributions was awarded to Moen Sen and the Akeson Award for Academic Excellence was awarded to Juli Uhl.

The following students received funding from the Richard A. Akeson Fellowship and Memorial Fund for travel in 2012 - 2013:

Student

Meeting

Location

Presentation

Date

Heather Chapman8thFederation of European Neurosciences Forum of NeuroscienceBarcelona, SpainPosterJuly 2012
Abigail KasbergSociety for Developmental Biology 71st Annual MeetingMontreal, CanadaPosterJuly 2012
Jamie HavrilakFederation of American Societies for Experimental Biology Science Research ConferenceSaxtons River, VermontPosterJuly 2012
Mark Charlton-PerkinsGordon Research Conference Visual System Development Meeting New London, New Hampshire Poster August 2012
Thomas Acciani European Respiratory Society Annual Congress Vienna, Austria Poster September 2012
Zirong Gu Axon Guidance, Synapse Formation and Regeneration Meeting Cold Spring Harbor, New York Poster September 2012
Mariana Louza 14th International Xenopus Conference Giens Peninsula, France Poster September 2012
Robyn Amos-Kroohs Society for Neuroscience Annual Meeting New Orleans, Louisiana Poster October 2012
Megan Rost North American Vascular Biology Organization Workshops in Vascular Biology Asilomar, California Poster October 2012
Shatrunjai Singh 66th American Epilepsy Society Annual Meeting San Diego, California Poster December 2012
Sha Wang The American Society for Cell Biology Annual Meeting San Francisco, California Poster December 2012
Kyle McCracken American Physician Scientists Association 9th Annual Meeting Chicago, Illinois Poster April 2013
Jia You Genetics Society of American 54th Annual Drosophila Research Conference Washington, DC Poster April 2013
Juli Uhl Genetics Society of American 54th Annual Drosophila Research Conference Washington, DC Oral Presentation April 2013
Ariel Rydeen Weinstein Cardiovascular Conference Tucson, Arizona Moderated Poster May 2013
Tracy Dohn Weinstein Cardiovascular Conference Tucson, Arizona Poster May 2013
Julie Lander Weinstein Cardiovascular Conference Tucson, Arizona Poster May 2013
Mardi Sutherland Weinstein Cardiovascular Conference Tucson, Arizona Poster May 2013
Jason Cowan Weinstein Cardiovascular Conference Tucson, Arizona Poster May 2013
Sharina Desai Weinstein Cardiovascular Conference Tucson, Arizona Poster May 2013
Betsy Schock Marine Biological Laboratory Embryology Course Woods Hole, Massachusetts Poster June 2013
Grethel Millington 19th International C. elegans Meeting Los Angeles, California Poster June 2013
Amel Alqadah 19th International C. elegans Meeting Los Angeles, California Poster June 2013
Lu Han Cold Spring Harbor Laboratory Mouse Development, Stem Cells and Cancer Course Cold Spring Harbor, New York Poster June 2013