Neurology

Division Details

Division Data Summary

Research and Training Details

Number of Faculty30
Number of Joint Appointment Faculty2
Number of Research Fellows1
Number of Research Students1
Number of Support Personnel40
Direct Annual Grant Support$6,802,888
Direct Annual Industry Support$1,202,848
Peer Reviewed Publications83

Clinical Activities and Training

Number of Clinical Staff89
Number of Clinical Fellows3
Number of Clinical Students0
Number of Other Students23
Inpatient Encounters5270
Outpatient Encounters21.123

Division Photo

Neurology

Row 1: B Wong, J Xiang, P Horn, J Taylor

Row 2: J Vannest, T Arthur, R Arya, A Hershey

Row 3: J Wilson, T Glauser, D Gilbert, M Schapiro

Significant Accomplishments

Significant Accomplishments

Comprehensive Neuromuscular program

Our Comprehensive Neuromuscular Care Center continues to be a center of excellence for the coordinated care of patients with pediatric neuromuscular disorders, especially Duchenne muscular dystrophy (DMD). More than 80 percent of our DMD patients travel here from other states and nations, including some from as far as Russia and Ireland.  We also have become world-class experts in caring for patients with dystrophinopathy. Meanwhile, our new “one stop” interdisciplinary neuromuscular clinic brings specialists from as many as nine different fields to one location to serve our patients with multi-system needs.

Our Research in Neuromuscular Disease

We participate in ongoing industry-sponsored clinical trials as well as in a transcriptomics and proteomics study in DMD. This has been attained through training of residents and fellows and collaboration with multiple divisions, including endocrinology, cardiology and radiology.

Breakthrough Headache Research

Our Headache Center, formed 16 years ago, continues to grow in the management, treatment and understanding of headaches in children, adolescents and young adults. Our multidisciplinary outpatient clinic, acute treatment center, young adult headache program and a focused inpatient service provide the basis for the research and educational activities, including an UCNS-certified Headache Medicine fellowship. Our research highlights from the past year include an NIH-sponsored study that demonstrated significant effectiveness of cognitive behavioral therapy in a multidisciplinary care model of the treatment of chronic migraine that is comparable to pharmaceutical treatment in adults. We also are comparing the effectiveness of amitriptyline and topiramate in the prevention of pediatric and adolescent migraine (CHAMP) study with significant collaborative effort from Behavioral Medicine and Clinical Psychology, the Center for Clinical and Translation Research and the Department of Biostatistics and Clinical Trials Statistical and Data Management Center at the University of Iowa.

Tuberous Sclerosis Program is the World’s Largest

Our Tuberous Sclerosis Program, now designated a Center of Excellence, is the largest in the world and the only one that manages every aspect of the disorder in both adults and children. We receive increasing numbers of national and international referrals because our program conducts leading-edge research while offering unique social and emotional support to patients and families, such as our TSC summer camp, the first and only one of its kind. Research conducted or led by our physicians has resulted in 15 peer-reviewed publications over the past year.  We also have launched an NIH-sponsored, multisite, national study to continue to improve care for children with TSC.

Research Highlights

Mark Schapiro, MD

We previously showed differences in neural activation during language processing in adolescents and young adults with Down syndrome in comparison with typically developing individuals matched for chronological age. We now show that activation in the adolescents and young adults with Down syndrome differs significantly in magnitude and spatial extent when compared with both chronological and mental age-matched typically developing control groups during a story listening task. These results provide additional support for an atypical pattern of functional organization for language processing in this population.

Reference: Jacola LM, Byars AW, Hickey F, Vannest J, Holland SK, Schapiro MB. Functional magnetic resonance imaging of story listening in adolescents and young adults with Down syndrome: evidence for atypical neurodevelopment. Journal of Intellectual Disability Research, in press.

Movement disorder (Donald Gilbert, MD and Steve Wu, MD)

ADHD/ Tourette Syndrome: We have two ongoing NIH-funded studies of motor cortex physiology as a biomarker of behavioral control impairments and of pharmacological treatment responses in ADHD.

Neuroplasticity: Long Term Potentiation/Depression: Dr. Steve Wu has led a series of exciting studies piloting new methods of using Transcranial Magnetic Stimulation to study long term potentiation and long term depression in motor cortex.

Tourette Syndrome Genetics: We are a site in a new, international, NIMH funded collaborative study of genetics of Tourette Syndrome.

Clinical Trials in Tourette Syndrome: We just completed a phase 2a study of a new pharmacological treatment for Tourette Syndrome, and we are participating in an ongoing study.

Tuberous Sclerosis (Darcy Krueger, MD, PhD and David Franz, MD)

The TSC Center, led by Drs. Franz and Dr. Krueger, has seen considerable expansion in both clinical care and research projects in 2013, building on similar successes of 2012. In 2013 alone, two major NIH-funded research studies and one major multicenter phase III clinical trial were officially launched. Major publications by the group included manuscripts in high-impact journals such as Lancet, Annals of Neurology, PlosOne, and Chest.

Epilepsy (Tracy Glauser, MD; Todd Arthur, MD; Hans Greiner, MD; Barb Hallinan, MD; Katherine Holland, MD; Sejal Jain, MD; Diego Morita, MD; Douglas Rose, MD; Shannon Standridge, MD; Jeff Tenney, MD; Cameron Thomas, MD)

The Comprehensive Epilepsy Center discoveries ranged the entire spectrum from clinical trials results through epilepsy surgical evaluation techniques to animal models of epileptogenesis. In the ongoing NIH funded Childhood Absence epilepsy study, 12-month outcome data from the double blind portion of the study confirmed that ethosuximide is the optimal initial empirical monotherapy for CAE and established this study as the first randomized controlled trial meeting International League Against Epilepsy criteria for class I evidence for any type of generalized seizure in adults or children. In addition, this study reported the EEG characteristics of untreated Childhood Absence Epilepsy along with the associations between specific EEG findings and baseline measure of attention and short term outcome. The surgical epilepsy team identified that ictal high-frequency oscillations are commonly seen with intracranial EEG and have localizing value. Complete resection of the high-frequency oscillations region was a favorable prognostic indicator for surgical outcome. Lastly, using a transgenic mouse model, the epilepsy basic scientists discovered that deletion of PTEN from postnatally generated dentate granule cells led to hyperactivation of the mTOR pathway and subsequent spontaneous seizures, confirming that these abnormal dentate granule cells can cause epilepsy.

Division Publications

Neurology Publications

  1. Amann JP, Glauser T, Chiron C. Developing antiepileptic drugs in children: balancing protection and access. Handb Clin Neurol. 2013; 111:741-6.
  2. Amos-Kroohs RM, Williams MT, Braun AA, Graham DL, Webb CL, Birtles TS, Greene RM, Vorhees CV, Pisano MM. Neurobehavioral phenotype of C57BL/6J mice prenatally and neonatally exposed to cigarette smoke. Neurotoxicol Teratol. 2013; 35:34-45.
  3. Arya R, Glauser TA. Pharmacotherapy of focal epilepsy in children: a systematic review of approved agents. CNS Drugs. 2013; 27:273-86.
  4. Arya R, Greiner HM, Lewis A, Mangano FT, Gonsalves C, Holland KD, Glauser TA. Vagus nerve stimulation for medically refractory absence epilepsy. Seizure. 2013; 22:267-70.
  5. Arya R, Mangano FT, Horn PS, Holland KD, Rose DF, Glauser TA. Adverse events related to extraoperative invasive EEG monitoring with subdural grid electrodes: a systematic review and meta-analysis. Epilepsia. 2013; 54:828-39.
  6. Arya R, Shinnar S, Glauser TA. Corticosteroids for the treatment of infantile spasms: a systematic review. J Child Neurol. 2012; 27:1284-8.
  7. Bigras C, Shear PK, Vannest J, Allendorfer JB, Szaflarski JP. The effects of temporal lobe epilepsy on scene encoding. Epilepsy Behav. 2013; 26:11-21.
  8. Buelow JM, Perkins SM, Johnson CS, Byars AW, Fastenau PS, Dunn DW, Austin JK. Adaptive functioning in children with epilepsy and learning problems. J Child Neurol. 2012; 27:1241-9.
  9. Castro OW, Santos VR, Pun RY, McKlveen JM, Batie M, Holland KD, Gardner M, Garcia-Cairasco N, Herman JP, Danzer SC. Impact of corticosterone treatment on spontaneous seizure frequency and epileptiform activity in mice with chronic epilepsy. PLoS One. 2012; 7:e46044.
  10. Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. Neurotoxicol Teratol. 2012; 34:450-7.
  11. Dodge HS, Ekhator NN, Jefferson-Wilson L, Fischer M, Jansen I, Horn PS, Hurford WE, Geracioti TD. Cigarette smokers have reduced risk for post-dural puncture headache. Pain Physician. 2013; 16:E25-30.
  12. Edden RA, Crocetti D, Zhu H, Gilbert DL, Mostofsky SH. Reduced GABA concentration in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2012; 69:750-3.
  13. Elliott I, Kadis DS, Lach L, Olds J, McCleary L, Whiting S, Snyder T, Smith ML. Quality of life in young adults who underwent resective surgery for epilepsy in childhood. Epilepsia. 2012; 53:1577-86.
  14. Epstein LG, Shinnar S, Hesdorffer DC, Nordli DR, Hamidullah A, Benn EK, Pellock JM, Frank LM, Lewis DV, Moshe SL, Shinnar RC, Sun S, team Fs. Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study. Epilepsia. 2012; 53:1481-8.
  15. Fisher RS, Blum DE, DiVentura B, Vannest J, Hixson JD, Moss R, Herman ST, Fureman BE, French JA. Seizure diaries for clinical research and practice: limitations and future prospects. Epilepsy Behav. 2012; 24:304-10.
  16. Fletcher S, Adkin CF, Meloni P, Wong B, Muntoni F, Kole R, Fragall C, Greer K, Johnsen R, Wilton SD. Targeted exon skipping to address "leaky" mutations in the dystrophin gene. Mol Ther Nucleic Acids. 2012; 1:e48.
  17. Frank LM, Shinnar S, Hesdorffer DC, Shinnar RC, Pellock JM, Gallentine W, Nordli DR, Jr., Epstein LG, Moshe SL, Lewis DV, Sun S, Team FS. Cerebrospinal fluid findings in children with fever-associated status epilepticus: results of the consequences of prolonged febrile seizures (FEBSTAT) study. J Pediatr. 2012; 161:1169-71.
  18. Franz DN. Everolimus for astrocytomas in tuberous sclerosis - author's reply. Lancet. 2013; 381:1275.
  19. Franz DN, Agricola KD, Tudor CA, Krueger DA. Everolimus for tumor recurrence after surgical resection for subependymal giant cell astrocytoma associated with tuberous sclerosis complex. J Child Neurol. 2013; 28:602-7.
  20. Franz DN, Belousova E, Sparagana S, Bebin EM, Frost M, Kuperman R, Witt O, Kohrman MH, Flamini JR, Wu JY, Curatolo P, de Vries PJ, Whittemore VH, Thiele EA, Ford JP, Shah G, Cauwel H, Lebwohl D, Sahmoud T, Jozwiak S. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet. 2013; 381:125-32.
  21. Fujiwara H, Greiner HM, Lee KH, Holland-Bouley KD, Seo JH, Arthur T, Mangano FT, Leach JL, Rose DF. Resection of ictal high-frequency oscillations leads to favorable surgical outcome in pediatric epilepsy. Epilepsia. 2012; 53:1607-17.
  22. Gilbert DL. Drug Treatments for Tourette Syndrome and Co-Morbid Disorders. In: JT Walkup, JW Mink, KS McNaught, eds. A Family's Guide to Tourette Syndrome. Bloomington, IN: iUniverse Press; 2012:110-124.
  23. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kälviäinen R, Mattson R, French JA, Perucca E, Tomson T, Guidelines ISoA. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2013; 54:551-63.
  24. Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Adamson PC, Childhood Absence Epilepsy Study T. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months. Epilepsia. 2013; 54:141-55.
  25. Glauser TA, Loddenkemper T. Management of childhood epilepsy. Continuum (Minneap Minn). 2013; 19:656-81.
  26. Golekoh MC, Hu S, Norman AM, Horn PS, Brady RC, Wong BL. Comparison of the immunogenicity of intramuscular versus subcutaneous administration of trivalent inactivated influenza vaccine in individuals with neuromuscular diseases. J Child Neurol. 2013; 28:596-601.
  27. Graham DL, Amos-Kroohs RM, Braun AA, Grace CE, Schaefer TL, Skelton MR, Williams MT, Vorhees CV. Neonatal +-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists. Int J Neuropsychopharmacol. 2013; 16:377-91.
  28. Graham DL, Schaefer TL, Vorhees CV. Neurobehavioral Testing for Developmental Toxicity. In: RD Hood, ed. Developmental and Reproductive Toxicology, A Practical Approach. London: Informa Healthcare; 2012:346-387.
  29. Greiner HM, Horn PS, Holland K, Collins J, Hershey AD, Glauser TA. mRNA blood expression patterns in new-onset idiopathic pediatric epilepsy. Epilepsia. 2013; 54:272-9.
  30. Gummadavelli A, Wang Y, Guo X, Pardos M, Chu H, Liu Y, Horn P, Zhang F, Xiang J. Spatiotemporal and frequency signatures of word recognition in the developing brain: A magnetoencephalographic study. Brain Res. 2013; 1498:20-32.
  31. Guo X, Xiang J, Wang Y, O'Brien H, Kabbouche M, Horn P, Powers SW, Hershey AD. Aberrant neuromagnetic activation in the motor cortex in children with acute migraine: a magnetoencephalography study. PLoS One. 2012; 7:e50095.
  32. Hart CK, Wiley S, Choo DI, Eby C, Tucker L, Schapiro M, Meinzen-Derr J. Developmental disabilities and intracranial abnormalities in children with symptomatic cytomegalovirus and cochlear implants. ISRN Otolaryngol. 2012; 2012:502746.
  33. Hedera P, Xiao J, Puschmann A, Momčilović D, Wu SW, LeDoux MS. Novel PRRT2 mutation in an African-American family with paroxysmal kinesigenic dyskinesia. BMC Neurol. 2012; 12:93.
  34. Hemmerle AM, Dickerson JW, Herring NR, Schaefer TL, Vorhees CV, Williams MT, Seroogy KB. (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain. J Comp Neurol. 2012; 520:2459-74.
  35. Hershey AD. Perimenstrual headache in adolescence. Curr Pain Headache Rep. 2012; 16:474-6.
  36. Hershey AD, Powers SW, Coffey CS, Eklund DD, Chamberlin LA, Korbee LL, Group CS. Childhood and Adolescent Migraine Prevention (CHAMP) study: a double-blinded, placebo-controlled, comparative effectiveness study of amitriptyline, topiramate, and placebo in the prevention of childhood and adolescent migraine. Headache. 2013; 53:799-816.
  37. Hesdorffer DC, Shinnar S, Lewis DV, Moshe SL, Nordli DR, Jr., Pellock JM, MacFall J, Shinnar RC, Masur D, Frank LM, Epstein LG, Litherland C, Seinfeld S, Bello JA, Chan S, Bagiella E, Sun S, team Fs. Design and phenomenology of the FEBSTAT study. Epilepsia. 2012; 53:1471-80.
  38. Holland K, Shinnar S. Status epilepticus in children. Handb Clin Neurol. 2012; 108:795-812.
  39. Jain SV, Horn PS, Simakajornboon N, Glauser TA. Obstructive sleep apnea and primary snoring in children with epilepsy. J Child Neurol. 2013; 28:77-82.
  40. Jain SV, Simakajornboon N, Glauser TA. Provider practices impact adequate diagnosis of sleep disorders in children with epilepsy. J Child Neurol. 2013; 28:589-95.
  41. Korostenskaja M, Harris E, Giovanetti C, Horn P, Wang Y, Rose D, Fujiwara H, Xiang J. Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder. Psychiatry Res. 2013; 212:132-40.
  42. Krueger DA, Care MM, Agricola K, Tudor C, Mays M, Franz DN. Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma. Neurology. 2013; 80:574-80.
  43. Lebowitz ER, Motlagh MG, Katsovich L, King RA, Lombroso PJ, Grantz H, Lin H, Bentley MJ, Gilbert DL, Singer HS, Coffey BJ, Tourette Syndrome Study G, Kurlan RM, Leckman JF. Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder. Eur Child Adolesc Psychiatry. 2012; 21:451-7.
  44. Malinowska IA, Lee N, Kumar V, Thiele EA, Franz DN, Ashwal S, Sagalowsky A, Dimario FJ, Jr., Cutler D, Krueger D, Camposano S, Paolini J, Dabora SL. Similar trends in serum VEGF-D levels and kidney angiomyolipoma responses with longer duration sirolimus treatment in adults with tuberous sclerosis. PLoS One. 2013; 8:e56199.
  45. Miles L, Miles MV, Horn PS, Degrauw TJ, Wong BL, Bove KE. Importance of muscle light microscopic mitochondrial subsarcolemmal aggregates in the diagnosis of respiratory chain deficiency. Hum Pathol. 2012; 43:1249-57.
  46. Modi AC, Ingerski LM, Rausch JR, Glauser TA, Drotar D. White coat adherence over the first year of therapy in pediatric epilepsy. J Pediatr. 2012; 161:695-9 e1.
  47. Modi AC, Wu YP, Guilfoyle SM, Glauser TA. Uninformed clinical decisions resulting from lack of adherence assessment in children with new-onset epilepsy. Epilepsy Behav. 2012; 25:481-4.
  48. Morita DA, Glauser TA, Modi AC. Development and validation of the Pediatric Epilepsy Side Effects Questionnaire. Neurology. 2012; 79:1252-8.
  49. Morrison JA, Glueck CJ, Daniels SR, Horn PS, Wang P. Determinants of ApoB, ApoA1, and the ApoB/ApoA1 ratio in healthy schoolgirls, prospectively studied from mean ages 10 to 19 years: the Cincinnati National Growth and Health Study. Metabolism. 2012; 61:1377-87.
  50. Namasivayam AK, Pukonen M, Goshulak D, Yu VY, Kadis DS, Kroll R, Pang EW, De Nil LF. Relationship between speech motor control and speech intelligibility in children with speech sound disorders. J Commun Disord. 2013; 46:264-80.
  51. Natarajan N, Jain SV, Chaudhry H, Hallinan BE, Simakajornboon N. Narcolepsy-cataplexy: is streptococcal infection a trigger?. J Clin Sleep Med. 2013; 9:269-70.
  52. Ngamprasertwong P, Michelfelder EC, Arbabi S, Choi YS, Statile C, Ding L, Boat A, Eghtesady P, Holland K, Sadhasivam S. Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model. Anesthesiology. 2013; 118:796-808.
  53. Okun MS, Foote KD, Wu SS, Ward HE, Bowers D, Rodriguez RL, Malaty IA, Goodman WK, Gilbert DM, Walker HC, Mink JW, Merritt S, Morishita T, Sanchez JC. A trial of scheduled deep brain stimulation for Tourette syndrome: moving away from continuous deep brain stimulation paradigms. JAMA Neurol. 2013; 70:85-94.
  54. Pestian J, Matykiewicz P, Holland-Bouley K, Standridge S, Spencer M, Glauser T. Selecting anti-epileptic drugs: a pediatric epileptologist's view, a computer's view. Acta Neurol Scand. 2013; 127:208-15.
  55. Pun RY, Rolle IJ, Lasarge CL, Hosford BE, Rosen JM, Uhl JD, Schmeltzer SN, Faulkner C, Bronson SL, Murphy BL, Richards DA, Holland KD, Danzer SC. Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy. Neuron. 2012; 75:1022-34.
  56. Richtand NM, Ahlbrand R, Horn PS, Chambers B, Davis J, Benoit S. Effects of prenatal immune activation and peri-adolescent stress on amphetamine-induced conditioned place preference in the rat. Psychopharmacology (Berl). 2012; 222:313-24.
  57. Riviello JJ, Jr., Claassen J, LaRoche SM, Sperling MR, Alldredge B, Bleck TP, Glauser T, Shutter L, Treiman DM, Vespa PM, Bell R, Brophy GM, Neurocritical Care Society Status Epilepticus Guideline Writing C. Treatment of status epilepticus: an international survey of experts. Neurocrit Care. 2013; 18:193-200.
  58. Roenker NL, Gudelsky GA, Ahlbrand R, Horn PS, Richtand NM. Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex. Neuropharmacology. 2012; 63:575-81.
  59. Rose DF, Fujiwara H, Holland-Bouley K, Greiner HM, Arthur T, Mangano FT. Focal Peak Activities in Spread of Interictal-Ictal Discharges in Epilepsy with Beamformer MEG: Evidence for an Epileptic Network?. Front Neurol. 2013; 4:56.
  60. Rutter MM, Collins J, Rose SR, Woo JG, Sucharew H, Sawnani H, Hor KN, Cripe LH, Wong BL. Growth hormone treatment in boys with Duchenne muscular dystrophy and glucocorticoid-induced growth failure. Neuromuscul Disord. 2012; 22:1046-56.
  61. Schaefer TL, Braun AA, Amos-Kroohs RM, Williams MT, Ostertag E, Vorhees CV. A new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects. Genes Brain Behav. 2012; 11:614-22.
  62. Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrio GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, North American Brain Expression C, Hardy J, Database UKHBE, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti DV, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, Pauls DL. Genome-wide association study of Tourette's syndrome. Mol Psychiatry. 2013; 18:721-8.
  63. Sethi NK, Tenney JR. Child Neurology: Hemiconvulsion-hemiplegia-epilepsy syndrome. Neurology. 2012; 79:2367; author reply 2367-8.
  64. Shinnar S, Glauser T. Commentary on Anticonvulsant Screening Program update: children are not little adults. Epilepsia. 2012; 53:1843-4.
  65. Siegel M, Allendorfer JB, Lindsell CJ, Vannest J, Szaflarski JP. The effects of linguistic relationships among paired associates on verbal self-generation and recognition memory. Brain Behav. 2012; 2:789-95.
  66. Slater SK, Kashikar-Zuck SM, Allen JR, LeCates SL, Kabbouche MA, O'Brien HL, Hershey AD, Powers SW. Psychiatric comorbidity in pediatric chronic daily headache. Cephalalgia. 2012; 32:1116-22.
  67. Stacpoole PW, deGrauw TJ, Feigenbaum AS, Hoppel C, Kerr DS, McCandless SE, Miles MV, Robinson BH, Tang PH. Design and implementation of the first randomized controlled trial of coenzyme CoQ₁₀ in children with primary mitochondrial diseases. Mitochondrion. 2012; 12:623-9.
  68. Standridge SM, Horn PS. Variations in hospitalization outcomes in children admitted with seizures between 2003 and 2006. J Child Neurol. 2012; 27:898-906.
  69. Sun Y, Zamzow M, Ran H, Zhang W, Quinn B, Barnes S, Witte DP, Setchell KD, Williams MT, Vorhees CV, Grabowski GA. Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum Mol Genet. 2013; 22:2435-50.
  70. Szaflarski JP, Allendorfer JB, Banks C, Vannest J, Holland SK. Recovered vs. not-recovered from post-stroke aphasia: The contributions from the dominant and non-dominant hemispheres. Restor Neurol Neurosci. 2013; 31:347-60.
  71. Tate ED, Pranzatelli MR, Verhulst SJ, Markwell SJ, Franz DN, Graf WD, Joseph SA, Khakoo YN, Lo WD, Mitchell WG, Sivaswamy L. Active comparator-controlled, rater-blinded study of corticotropin-based immunotherapies for opsoclonus-myoclonus syndrome. J Child Neurol. 2012; 27:875-84.
  72. Tenney JR, Glauser TA. The current state of absence epilepsy: can we have your attention?. Epilepsy Curr. 2013; 13:135-40.
  73. Tenney JR, Schapiro MB. Child neurology: hemiconvulsion-hemiplegia-epilepsy syndrome. Neurology. 2012; 79:e1-4.
  74. Uzark K, King E, Cripe L, Spicer R, Sage J, Kinnett K, Wong B, Pratt J, Varni JW. Health-related quality of life in children and adolescents with Duchenne muscular dystrophy. Pediatrics. 2012; 130:e1559-66.
  75. Vannest J, Szaflarski JP, Eaton KP, Henkel DM, Morita D, Glauser TA, Byars AW, Patel K, Holland SK. Functional magnetic resonance imaging reveals changes in language localization in children with benign childhood epilepsy with centrotemporal spikes. J Child Neurol. 2013; 28:435-45.
  76. Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand NM, Williams MT. Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC. Synapse. 2012; 66:725-37.
  77. Wang Y, Adamson C, Yuan W, Altaye M, Rajagopal A, Byars AW, Holland SK. Sex differences in white matter development during adolescence: a DTI study. Brain Res. 2012; 1478:1-15.
  78. Winawer MR, Connors R, Investigators E. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia. 2013; 54:288-95.
  79. Wu SW, Gilbert DL. Gilles de la Tourette Syndrome. In: ET Bope, R Kellerman, eds. Conn's Current Therapy. Philadelphia, PA: Oxford/Saunders; 2013:605-607.
  80. Wu SW, Gilbert DL. Altered neurophysiologic response to intermittent theta burst stimulation in Tourette syndrome. Brain Stimul. 2012; 5:315-9.
  81. Wu SW, Gilbert DL, Shahana N, Huddleston DA, Mostofsky SH. Transcranial magnetic stimulation measures in attention-deficit/hyperactivity disorder. Pediatr Neurol. 2012; 47:177-85.
  82. Wu SW, Shahana N, Huddleston DA, Gilbert DL. Effects of 30Hz theta burst transcranial magnetic stimulation on the primary motor cortex. J Neurosci Methods. 2012; 208:161-4.
  83. Wu SW, Shahana N, Huddleston DA, Lewis AN, Gilbert DL. Safety and tolerability of theta-burst transcranial magnetic stimulation in children. Dev Med Child Neurol. 2012; 54:636-9.

Faculty, Staff, and Trainees

Faculty Members

Andrew Hershey, MD, PhD, Professor
Leadership Division Director; Director Headache Center
Research Interests Migraine, blood genomics
Todd Arthur, MD, Assistant Professor
Research Interests Brain concussion
Anna W Byars, PhD, Associate Professor
Research Interests Cognitive effects of epilepsy
James Collins, MD, PhD, Assistant Professor
Research Interests Congenital Muscular Dystrophy; Neuromuscular Disease
David Franz, MD, Professor
Leadership Director Tuberous Sclerosis program
Research Interests Tuberous sclerosis
Donald Gilbert, MD, Professor
Leadership Director Movement Disorders program; Director Neurology Residency Program
Research Interests Tourette syndrome, Transcranial Magnetic Stimulation (TMS)
Tracy A Glauser, MD, Professor
Leadership Director Comprehensive Epilepsy program
Research Interests Epilepsy, pharmacology
Hansel Greiner, MD, Assistant Professor
Research Interests Epilepsy
Barbara Hallinan, MD, PhD, Assistant Professor
Research Interests CSF steroid profiles
Katherine Holland-Bouley, MD, PhD, Associate Professor
Research Interests Ion channels and epilepsy
Sejal Jain, MD, Assistant Professor
Research Interests Epilepsy, sleep
Marielle A Kabbouche, MD, Associate Professor
Research Interests Migraine
Darren Kadis, PhD, Assistant Professor
Research Interests Neuroimaging and MEG of language
Darcy Krueger, MD, PhD, Associate Professor
Research Interests Tuberous Sclerosis
Diego Morita, MD, Assistant Professor
Research Interests Epilepsy, pharmacology
Hope O'Brien, MD, Assistant Professor
Research Interests Headaches
Douglas Rose, MD, Professor
Leadership Director, MEG lab
Research Interests Magneto-Encephalography (MEG)
Mark Schapiro, MD, Professor
Research Interests Neurodevelopmental disorders
Matthew Skelton, PhD, Assistant Professor
Research Interests Neurobehavioral and neurometabolic
Shannon Standridge, DO, Assistant Professor
Research Interests Outcomes study, epilepsy
Mary Sutton, MD, Associate Professor
Research Interests Neuro-oncology
Jeffrey Tenney, MD, PhD, Assistant Professor
Research Interests Neurophysiology and genesis of absence epilepsy
Cameron Thomas, MD, Assistant Professor
Research Interests Neonatal neurology
Jennifer Vannest, PhD, Associate Professor
Research Interests Speech and language development
Charles Vorhees, PhD, Professor
Leadership Director Animal Neurobehavior Core
Research Interests Drugs/toxicants and brain development
Kristen Wesselkamper, MD, Assistant Professor
Research Interests Improvement science
Michael Williams, PhD, Associate Professor
Research Interests Drugs/toxicants and brain development
Brenda Wong, MD, Professor
Leadership Director Neuromuscular program
Research Interests Duchenne's Muscular Dystrophy, Spinal Muscular Atrophy
Steve Wu, MD, Assistant Professor
Research Interests Movement Disorder; Transcranial Magnetic Stimulation (TMS)
Jing Xiang, MD, PhD, Associate Professor
Leadership Director MEG Research program
Research Interests MEG

Joint Appointment Faculty Members

Michael Miles, PhD, Professor (Pathology)

Clinical Staff Members

  • Jamie Capal, MD, Neurodevelopment and neurobehavior
  • Irina Rybalsky, MD, Duchenne's Muscular Dystrophy

Trainees

  • Ravindra Arya, MD, DM, PGYX, All India Institute of Medical Sciences
  • Haneul Lee, MD, PGYV, Yonsei University
  • Nina Natarajan, MD, PGYV, University of Cincinnati
  • Sarah Weatherspoon, MD, PGYV, University of Texas Southwestern
  • Katrina Peariso, MD, PGYV, University of New Mexico
  • Thomas Dye, MD, PGYV, St. Louis University
  • Tanishia Williams, MD, PGYV, University of Medicine & Dentistry of New Jersey
  • Gewalin Aungaroon, MD, PGYIV, Faculty of Medicine Ramathibodi
  • Dror Kraus, MD, PGYIV, Hebrew University
  • Michael Oldham, MD, PGYIV, George Washington University
  • Cuixia Tian, MD, PGYIV, Medical Center of Fudan University
  • Vinita Knight, MD, PGYIII, Eastern Virginia Medical School
  • Kelly Kremer, MD, PGYIII, University of Cincinnati
  • Michael Sweeney, MD, PGYIII, Medical College of Wisconsin
  • Marissa Vawter, MD, PGYIII, Indiana University

Division Collaboration

Human Genetics; Neurosurgery; Neuroradiology; Psychology/Neuropsychology; Developmental Pediatrics; Psychiatry » Drs. T.A. Burrow, Derek Neilson, Taoshang Huang , Dr. E. Air, Dr. K. Cecil, Dr. B. Lejeune, Dr. C. Erickson, and Dr. E. Harris
Movement Disorders Clinic/Tourette's Disorder Clinic
Neurosurgery; Anesthesia; Bioinformatics; Radiology » Dr. F. Mangano, Dr. S. Danzer, Dr. J. Pestian, and Drs. J. Leach, M. Gelfand
Comprehensive Epilepsy Program
Pulmonary Medicine; Nephrology; Plastic Surgery; Radiology; Neurosurgery; Cardiology; Human Genetics; Psychiatry; Genetics; DDBP » Drs. L. Young, F. McCormack, Dr. C. Gordon, Drs. M. Care, J. Leach, Drs. K. Crone, M. Care, S. Serai, W. Yuan, Dr. T. Knilans, Dr. B. Schorry, Dr. D. Nelson, Dr. E. Schorry, and Drs. D. Murray, N. Bing; B. Kent
Tuberous Sclerosis Program
Behavioral Medicine and Clinical Psychology; Hematology » Drs. S. Powers, A Lynch-Jordan, L. Crosby, S. Slater and Drs. Karen Kalinyak, Charles Quinn
Headache Center
Cardiology; Developmental and Behavioral Pediatrics; Nutrition; Human Genetics; Gastroenterology; Endocrinology; Orthopedics; Speech Therapy; Rehabilitative Medicine; Pulmonary; Physical Therapy; Pathology; Pediatric Surgery; Anesthesia & Palliative Care; Pain Services; Social Services; Translational Research; Nephrology » Drs. J. Towbin, JL Jefferies, R. Spicer, L. Cripe, Dr. D. Schonfeld, B. Godshall, D. Boutwell, M. Walker genetic counselor, Drs. A Kaul, N. Yazigi, A. Miethke, Drs. M. Rutter, S. Rose, Drs. J. McCarthy, V. Jain, P. Sturm, J. Linck, Dr. M. McMahon, Drs. R. Amin, H. Sawnani, J. Crisalli, A. McCormick, M. McGuire, Drs. L. Miles, K. Bove, Drs. R. Brown, T. Inge, Dr. N. Weidner, M. Meyer, Dr. K. Goldschneider, L. Demosthenes, Dr. J. Molkentin, and Dr. E. Jackson
Comprehensive Neuromuscular Center
Sport Medicine; Physical Medicine & Rehabilitation » Drs. J. Divine, N. Edwards, M. Shaffer and B. Kurowski
Concussion Clinic
Neonatology & Pulmonary Biology; Cardiology; Hematology » Drs. B. Haberman, T. Cahill, S. Merhar, N. Monangi, Drs. B. Marino, J. Anderson, and Dr. D. Adams, A. Hammill
Neonatal Follow-up Clinic
Pulmonary » Drs. N. Simakajornboon, M. Ednick, J. Crisalli, H. Sawnani, G. McPhail
Sleep Clinic
Human Genetics; Allergy & Immunology; Anesthesiology; Developmental Biology; Experimental Hematology ; Psychiatry; General & Thoracic Surgery; Endocrinology; Neurosurgery; Neuroimaging Research Consortium; Pulmonary Biology » Drs. G. Grabowski, Y. Sun, T. Huang, R. Stottmann, Drs. M. Rothenberg, H. Zhu, Dr. S. Danzer, A. Lepke, Drs. K. Campbell, M. Nafafuku, Drs. R. Waclaw, L. Ehrman, D. Pan, N. Ratner, Dr. C. Erickson; T. Schaefer, Dr. M. Helmrath, Dr. T. Nakamura, Dr. F. Mangano, Dr. W. Yuan, and Dr. J. Bridges
Neurobehavioral Animal Core (Vorhees and Williams lab)
Rehabilitative Medicine » Drs. D. Pruitt, L. Michaud
Pediatric Demyelinating Disease Clinic
Speech Pathology; Pediatric Neuroimaging Research Consortium; Biomedical Informatics; Radiology; Biostatistics & Epidemiology; Heart Institute Research/Heart Institute Neurodevelopmental Clinic; Pulmonary; Autism Speaks; Human Genetics » Dr. E. Redle, Drs. S. Holland, V. Schmithorst, Dr. M. Wagner, Dr. J. Tkach, S. Holland, G. Lee, Dr. M Altaye, Dr. B. Marino, Dr. R. Amin; Keith McConnell - Sr. Biomedical Engineer, Dr. D. Murray, and Dr. E. Schorry

Neuroimaging of Childhood Apraxia of Speech,

Cincinnati MR Imaging of Neural Development-(C-MIND study)

Gastroenterology and Nutrition; Pathology; Neurosurgery » Drs. R. Kohli, S. Xanthakos, Dr. L. Miles, and Dr. F. Mangano
Mitochondrial & Pathological Studies in Epilepsy Surgery/Evaluation of Coenzyme Q10 as a biomarker in liver disease
Child & Adolescent Psychiatry; Physical Medicine & Rehabilitation » Dr. E. Harris and Dr. J. Vargus-Adams
MEG Research

Grants, Contracts, and Industry Agreements

Neurology Grants

Grant and Contract AwardsAnnual Direct

Gilbert, D

2/2-Anomalous Motor Physiology in ADHD
R01 MH 09501405/01/12-04/30/17$168,003
4/8-Collaborative Genomic Studies of Tourette Disorder
R01 MH 09252009/15/11-06/30/14$50,000

Glauser, T

Cincinnati Neuroscience Clinical Trials Research Center
U10 NS 07731109/30/11-08/31/18$100,000
Impact of Initial Therapy and Response on Long Term Outcome in Children with CAE
U01 NS 04591109/01/10-08/31/14$2,539,145
Midazolam for the Pediatric Trials Network
HHSN275201000003108/01/12-09/30/13$12,838

Hershey, A / Powers, S

Amitriptyline and Topiramate in the Prevention of Childhood Migraine
U01 NS 0767889/30/11-8/31/16$2,414,730

Holland-Bouley, K

Sodium Channel Gene Variation in the Treatment of Epilepsy
R01 NS 06275604/01/09-03/31/14$192,938

Krueger, D

Early Biomarkers of Autism Spectrum Disorders in Infants with Tuberous Sclerosis
U01 NS 08232009/01/12-08/31/17$519,972
Potential EEG Biomarkers and Antiepileptogenic Strategies for Epilepsy in TSC
P20 NS 08019909/01/12-08/31/15$29,568
Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex
W81WH-11-1-024008/31/12-08/31/13$3,240
TSC Autism Center of Excellence Research Network (TACERN) Research
2012-CRN-0110/01/12-12/31/13$41,118
TSC Neurocognitive Clinical Trial
01-11B07/01/12-11/30/13$54,491

Moran, M

Genetic Susceptibility to PCB-Induced Motor Dysfunction
R15 ES 02005302/18/13-06/30/13$5,229

Vannest, J

Imaging the Effect of Centrotemporal Spikes and Seizures on Language in Children
R01 NS 06584009/15/11-06/30/16$382,402

Vorhees, C

Training Grant in Teratology
T32 ES 0705107/01/12-06/30/17$289,214
Current Year Direct$6,802,888
Industry Contracts

Franz, D

$453,043
$9,047

$51,292
$40,771

Hershey, A

$7,700

Holland-Bouley, K

$3,536

Kabbouche, M

$6,930

Krueger, D

$11,496
$101,411
$152,759

Morita, D

$15,775

Vorhees, C

$69,829

Wong, B

$47,004
$213,621
$11,088
$7,546
Current Year Direct Receipts$1,202,848
Total$8,005,736