2013 Research Annual Report

Neurosurgery

Division Details

Division Data Summary

Research and Training Details

Number of Faculty4
Number of Joint Appointment Faculty4
Number of Research Fellows1
Direct Annual Grant Support$459,376
Peer Reviewed Publications16

Clinical Activities and Training

Number of Clinical Fellows1

Division Photo

Neurosurgery

Row 1: J Goto, E Air, K Bierbrauer, S Vadivelu

Row 2: K Campbell, T Vogel, S Crone, F Mangano, C Stevenson



Significant Accomplishments

Significant Accomplishments

Diverse, Collaborative Clinical and Research Activities

Pediatric Neurosurgery at Cincinnati Children’s is headed by Division Chief  Francesco Mangano,  DO.  He focuses on the surgical treatment of intractable epilepsy in children. In collaboration with the Comprehensive Epilepsy Program, we are very active in the evaluation and treatment of afflicted patients. Our ongoing research focuses on finding new techniques to continue to improve outcomes while minimizing morbidity.

Ellen Air, MD, leads the surgical arm of our Dystonia and Surgical Movement Disorders Clinic, a unique program in collaboration with Neurology that focuses on the evaluation and advanced medical and surgical treatment of pediatric movement disorders. Air’s work also focuses on  real-time, intra-operative imaging techniques to maximize surgical treatment while minimizing patient discomfort. Her research focuses on the detailed understanding of electrical brain activity and she is the principal investigator of a study that evaluates low frequency electrical activity in response to traumatic brain injury in adults and children.

Karin Bierbrauer, MD, collaborates with other institutions to further our understanding of complex injuries and diseases that affect children in unique ways. She serves as site principal investigator for a national registry of children with Chiari I malformations and syringomyelia. An active member of the Fetal Care Program, she also conducts clinical research in spina bifida and other neurologic conditions detected in utero.  Bierbrauer recently presented research on the timing of the development of syringomyelia cavities in fetuses with spina bifida.

Focus on Hydrocephalus

Mangano and Weihong Yuan, PhD, Department of Radiology, are co-principal investigators on an NIH-funded study of advanced MR imaging techniques in hydrocephalus. Work from this multi-institutional study has been presented and published regionally, nationally and internationally.

Sudhakar Vadivelu, DO, and Timothy Vogel, MD, recently joined the division. Vadivelu’s research is in cerebrovascular neurosurgery and the effect of medications on the blood brain barrier. Vogel’s research focuses on targeting neural progenitor cells in treating congenital hydrocephalus.

Kenneth Campbell, PhD, is the Robert and Sarah McLaurin Chair of Pediatric Neurosurgery Research.  His work is focuses on the molecular genetic mechanisms that control normal brain development. He and Mangano are collaborating to establish a hydrocephalus research program that spans from the lab bench to the clinic. So far, their work includes recruiting two new  researchers: June Goto, PhD, and Tim Vogel, MD.

Goto studies the molecular and cellular basis of obstructive and communicating hydrocephalus using both genetic and acquired animal models. In the past year, she has generated several new genetic models of neurological disorders such as tuberous sclerosis complex and hydrocephalus and performed pre-clinical trials targeting epilepsy, developmental delay, and brain malformations in the animal models.

Battling Brain Tumors, Studying Neural Circuits

Collaborating with physicians in Neuro-Oncology and Radiation Oncology, Dr. Charles Stevenson, MD, leads our Division’s brain tumor program, which provides state-of-the-art surgical and medical treatment for children from around the world. The program continues to participate in new clinical trials as a member of the Pediatric Brain Tumor Consortium. Stevenson and colleagues in the Fetal Care Program also perform in utero repair of myelomeningocele defects, with good success rates. Cincinnati Children’s is one of the few pediatric centers in the US that performs fetal myelomeningocele repairs.

Steven Crone, PhD, joined the division as an Assistant Professor in 2012. Dr. Crone’s laboratory performs basic research studying the development and function of neural circuits that control motor behavior and how they are altered by disease or injury. Crone has received an Emerging Investigator Award from the FightSMA! and Gwendolyn Strong Foundations and a Starter Grant from the Amyotrophic Lateral Sclerosis Association. He presented his work as an invited speaker at the FightSMA! National Meeting in Washington, D.C.


Division Publications

Neurosurgery Publications

  1. Arya R, Greiner HM, Lewis A, Mangano FT, Gonsalves C, Holland KD, Glauser TA. Vagus nerve stimulation for medically refractory absence epilepsy. Seizure. 2013; 22:267-70.
  2. Arya R, Mangano FT, Horn PS, Holland KD, Rose DF, Glauser TA. Adverse events related to extraoperative invasive EEG monitoring with subdural grid electrodes: a systematic review and meta-analysis. Epilepsia. 2013; 54:828-39.
  3. Chapman H, Waclaw RR, Pei Z, Nakafuku M, Campbell K. The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors. Development. 2013; 140:2289-98.
  4. de Hemptinne C, Ryapolova-Webb ES, Air EL, Garcia PA, Miller KJ, Ojemann JG, Ostrem JL, Galifianakis NB, Starr PA. Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease. Proc Natl Acad Sci U S A. 2013; 110:4780-5.
  5. Fujiwara H, Greiner HM, Lee KH, Holland-Bouley KD, Seo JH, Arthur T, Mangano FT, Leach JL, Rose DF. Resection of ictal high-frequency oscillations leads to favorable surgical outcome in pediatric epilepsy. Epilepsia. 2012; 53:1607-17.
  6. Godin JD, Thomas N, Laguesse S, Malinouskaya L, Close P, Malaise O, Purnelle A, Raineteau O, Campbell K, Fero M, Moonen G, Malgrange B, Chariot A, Metin C, Besson A, Nguyen L. p27(Kip1) is a microtubule-associated protein that promotes microtubule polymerization during neuron migration. Dev Cell. 2012; 23:729-44.
  7. Haas M, Qu Z, Kim TH, Vargas E, Campbell K, Petrou S, Tan SS, Reid CA, Heng J. Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice. Eur J Neurosci. 2013; 37:1584-93.
  8. Hummel TR, Miles L, Mangano FT, Jones BV, Geller JI. Clinical heterogeneity of desmoplastic infantile ganglioglioma: a case series and literature review. J Pediatr Hematol Oncol. 2012; 34:e232-6.
  9. López-Juárez A, Howard J, Ullom K, Howard L, Grande A, Pardo A, Waclaw R, Sun YY, Yang D, Kuan CY, Campbell K, Nakafuku M. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone. Genes Dev. 2013; 27:1272-87.
  10. Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martinez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM. Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons. Stem Cells Dev. 2012; 21:2239-51.
  11. Miles L, Miles M, Greiner H, Mangano F, Horn P, Leach J, Lee K, DeGrauw T. Akt-Positive Neurons and Age are Associated with Surgical Outcome in Children with Epilepsy and Focal Cortical Dysplasia. Journal of Neuropathology & Experimental Neurology. 2013; 72:571.
  12. Prabhakar S, Goto J, Zuang X, Sena-Esteves M, Bronson R, Brockmann J, Gianni D, Wojtkiewicz GR, Chen JW, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO. Stochastic model of Tsc1 lesions in mouse brain. PLoS One. 2013; 8:e64224.
  13. Rose DF, Fujiwara H, Holland-Bouley K, Greiner HM, Arthur T, Mangano FT. Focal Peak Activities in Spread of Interictal-Ictal Discharges in Epilepsy with Beamformer MEG: Evidence for an Epileptic Network?. Front Neurol. 2013; 4:56.
  14. Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behav Genet. 2013; 43:51-9.
  15. Wang B, Long JE, Flandin P, Pla R, Waclaw RR, Campbell K, Rubenstein JL. Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants. J Comp Neurol. 2013; 521:1561-84.
  16. Yuan W, McKinstry RC, Shimony JS, Altaye M, Powell SK, Phillips JM, Limbrick DD, Jr., Holland SK, Jones BV, Rajagopal A, Simpson S, Mercer D, Mangano FT. Diffusion tensor imaging properties and neurobehavioral outcomes in children with hydrocephalus. AJNR Am J Neuroradiol. 2013; 34:439-45.

Faculty, Staff, and Trainees

Faculty Members

Francesco T. Mangano, DO, Associate Professor
Leadership Director Pediatric Neurosurgery
Karin S. Bierbrauer, MD, Associate Professor
Kerry Crone, MD, Professor
Charles Stevenson, MD, Assistant Professor

Joint Appointment Faculty Members

Ellen Air, MD,PhD, Assistant Professor (Neurosurgery )
Kennth Campbell, PhD, Professor (Developmental Biology and Neurosurgery )
Steven Crone, PhD, Assistant Professor (Neurosurgery)
June Goto, PhD, Instructor (Neurosurgery)

Clinical Staff Members

  • Brian Crowley, MSN, RN, CFNP
  • Cristina Carone, PA-C, MSPA
  • Kelly Clapp, MSN, RN, CPNP
  • Michelle Haimowitz, MSN, RN, CPNP
  • Candace Sturm, MSN, RN, CPNP
  • Mary Miller, MSN, RN, CPN
  • Rodolfo Canos, MSN, RN, CPN
  • Rachel Griffiths, MSN, RN, CPN

Trainees

  • Kaveh Asadi-Moghaddam, MD, Fellow, 2012, Ohio State University PGY6
  • Mohan S., MD, Resident, 2012, Henry Ford Hospital PGY5
  • Paul Mazaris, MD, Resident, 2012, Henry Ford Hospital PGY5
  • Michael Sawvel, DO Resident, 2013, West Virgina University PGY4
  • Daniel Harwell, MD, Resident, 2012, University of Cincinnati PGY3
  • Ryan Tackla, MD, Resident, 2012, University of Cincinnati PGY3
  • Jennifer Kosty, MD, Resident, 2013, University of Cincinnati, PGY1
  • Mohammed Alsaidi, MD, Resident, 2013, Henry Ford Hospital PGY5
  • Jonathan York, MD Resident, 2013, University Of Cincinnati PGY3
  • Christopher Carroll, MD Resident, 2013, University of Cincinnati PGY1
  • Shawn Vuong, MD Resident, 2013, University of Cincinnati PGY1
  • Lauren Ostling, MD Resident, 2012, University of Cincinnati PGY4

Grants, Contracts, and Industry Agreements

Neurosurgery Grants

Neurosurgery

Grant and Contract AwardsAnnual Direct

Bierbrauer, K

Park-Reeves Syringomyelia Research Consortium
03/22/12-03/21/16$27,027

Crone,S

Degeneration of Spinal Circuitry in Mouse Models of ALS
08/01/2012-06/31/2014$40,000
A Circuit Mechanism of Degeneration in Mouse Models of SMA
06/01/2013-11/30/2013$22,500

Mangano, F / Yuan, W (MPI)

Longitudinal DTI Study in Children Treated for Congenital Hydrocephalus
R01 NS 06693209/30/09-06/30/14$369,849
Current Year Direct$459,376
Total$459,376