Division Data Summary
Research and Training Details
|Number of Faculty||13|
|Number of Joint Appointment Faculty||4|
|Number of Research Fellows||3|
|Number of Research Students||1|
|Number of Support Personnel||51|
|Direct Annual Grant Support||$587,920|
|Peer Reviewed Publications||15|
Clinical Activities and Training
|Number of Clinical Staff||1|
|Number of Clinical Fellows||6|
|Number of Other Students||3|
Row 1: S Riazuddin, C Myer III, D Choo, R Cotton, C Hart, S Shott
Row 2: R Elluru, M Rutter, A deAlarcon, D Deliyski, J Willging, E Arjmand, K Johnson, J Greinwald Jr
Choo Becomes Division Director
After more than 37 years in the role, Robin Cotton, MD, stepped down as Division Director in 2012. Cotton built the Division into the world's premier center for diagnosing and treating airway abnormalities. The Division has grown into one of the nation’s busiest otolaryngology practices, with more than 33,000 outpatient visits and more than 11,000 procedures performed a year. After an exhaustive national search, Daniel Choo, MD, was named Cotton’s successor in October 2012.
Cotton Receives William Cooper Procter Medallion
In February 2013, Robin Cotton, MD, became only the ninth scientist since 1960 to be awarded the William Cooper Procter Medallion, the highest award bestowed by the Cincinnati Children’s Board of Trustees. Tom Cody, chairman of the board, called Cotton “a remarkable innovator, surgeon, educator and leader...”
Breakthrough Study in Usher Syndrome
Saima Riazuddin, PhD, and colleagues published a study entitled "Alterations of the CIB2 calcium- and integrin-binding protein, cause Usher syndrome type 1J and nonsyndromic deafness DFNB48” in Nature Genetics. This breakthrough work also was featured in the Editor’s Choice of Science Journal.
- Riazuddin S, Belyantseva I, Giese A, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZM. Alterations of the CIB2 calcium- and integrin-binding protein, cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nature Genetics. 2012. 44:1265-71.
Several genes associated with different types of Usher syndrome have been identified. Most of these genes encode common structural and motor proteins that build sensory cells in the eye and inner ear. However, the gene reported in our paper, CIB2, which encodes a calcium and integrin binding protein, is believed to play a functional role in mechanoelectrical transduction, the process of converting sound energy into an electrical signal that the brain recognized as sound.
Our studies suggest that CIB2 might be important in maintaining calcium level in the sensory cells. Given that there are many cardiac ischemia and hypertension drugs that work by affecting calcium handling in the muscle cells, it is possible that one day a similar drug may be used to target a type of Usher syndrome that we described in our study
- Postoperative assessment of laryngopharyngeal dysfunction in neonates after Norwood operation. Ann Thorac Surg. 2012; 94:1257-61., , , , , .
- Cervical slide tracheoplasty. Arch Otolaryngol Head Neck Surg. 2012; 138:812-6., .
- Cutaneous vascular lesions. Facial Plast Surg Clin North Am. 2013; 21:111-26..
- An adverse effect of positive airway pressure on the upper airway documented with magnetic resonance imaging. JAMA Otolaryngol Head Neck Surg. 2013; 139:636-8., , , , , .
- Significance of unilateral enlarged vestibular aqueduct. Laryngoscope. 2013; 123:1537-46., , , , , , , .
- What is the optimal workup for a child with bilateral sensorineural hearing loss?. Laryngoscope. 2013; 123:809-10., .
- Developmental disabilities and intracranial abnormalities in children with symptomatic cytomegalovirus and cochlear implants. ISRN Otolaryngol. 2012; 2012:502746., , , , , , .
- Simulation to implement a novel system of care for pediatric critical airway obstruction. Arch Otolaryngol Head Neck Surg. 2012; 138:907-11., , , , , , .
- A neonate with neck swelling and fever. Clin Pediatr (Phila). 2013; 52:275-8., , .
- Minimal access and standard cochlear implantation: a comparative study. Int J Pediatr Otorhinolaryngol. 2012; 76:1102-6., , , , .
- Preventing opioid-related deaths in children undergoing surgery. Pain Med. 2012; 13:982-3; author reply 984., .
- Medullary thyroid cancer in a 9-week-old infant with familial MEN 2B: Implications for timing of prophylactic thyroidectomy. Int J Pediatr Endocrinol. 2012; 2012:25., , , , , .
- Performance evaluation of the next-generation sequencing approach for molecular diagnosis of hereditary hearing loss. Otolaryngol Head Neck Surg. 2013; 148:1007-16., , , , , , , , .
- Optimal management of single-sided deafness. Laryngoscope. 2013; 123:304-5., .
- Future of pediatric tonsillectomy and perioperative outcomes. Int J Pediatr Otorhinolaryngol. 2013; 77:194-9., , , .
Faculty, Staff, and Trainees
- Daniel I. Choo, MD, Associate Professor
- Leadership Director, Department of Pediatric Otolaryngology
- Robin T. Cotton, MD, Professor
- Leadership Director, Aerodigestive and Sleep Center
- Ellis M. Arjmand, MD, PhD, Associate Professor
- Leadership Director, Ear and Hearing Center
- Alessandro deAlarcon, MD, Associate Professor
- Leadership Director, Voice Clinic
- Ravindhra G. Elluru, MD, PhD, Associate Professor
- John. H. Greinwald Jr., MD, Associate Professor
- Catherine Hart, MD, Assistant Professor
- Kaalan Johnson, MD, Assistant Professor
- Leadership Director, Otolaryngology Simulation Program
- Charles M. Myer III, MD, Professor
- Leadership Director, Pediatric Otolaryngology Residency Program
- Saima Riazuddin, PhD, Assistant Professor
- Leadership Director, Laboratory of Molecular Genetics
- Michael J. Rutter, MD, Associate Professor
- Sally R. Shott, MD, Professor
- J. Paul Willging, MD, Professor
- Leadership Director, Pediatric Otolaryngology Fellowship Program
Joint Appointment Faculty Members
- Zubair Ahmed, PhD, Assistant Professor (Opthalmology)
- Research Interests Genetics
- Dimitar Deliyski, PhD, Associate Professor (Communication Science Research Center)
- Research Interests Communication Disorders
- Scott Holland, PhD, Professor (Neuroimaging Research Consortium)
- Research Interests Neuroimaging
- Jareen Meinzen-Derr, MPH, PhD, Assistant Professor (Biostatistics & Epidemiology)
- Research Interests Epidemiology
Clinical Staff Members
- Michael Bowen, PA-C, RN, MA, Adult Airway
- Angela Black, MD, PGYVII, University of Minnesota
- Charles Myer, IV, MD, PGYVII, University of Cincinnati College of Medicine
- Michel Nassar, MD, PGYII, Hôtel-Dieu de France
- Matthew Provenzano, MD, PGYVII, University of Iowa
- Karthik Balakrishnan, MD, MPH, PGYVI, University of Washington at Seattle
- Douglas Sidell, MD, PGYVI, UCLA
- Genetics; Speech Pathology » Ann Kummer
- VPI (Velopharyngeal Insufficiency) Clinic-Monitoring associated diagnoses and treatment outcomes.
- Speech Pathology »
- FEES (Flexible Endoscopic Evaluation of Swallowing) Clinic-Evaluating swallowing disorders, etiology, treatment strategies and outcomes.
- Speech Pathology; Occupational Therapy; Dieticians; Genetics; Gastroenterology; Social Work; Nursing »
- Interdisciplinary Feeding Team – Evaluating safety of swallowing and treatment strategies for children with complex dysphagia problems.
- Speech Pathology »
- Pediatric Voice Clinic – Evaluation of quality of life factors associated with voice disorders, determining etiology and treatment strategies for children with voice problems.
- Pediatric Surgery; Dermatology; Plastic Surgery; Oncology » Denise Adams and Richard Azizkhan
- Vascular Malformation clinic –Determining treatment outcomes for complex vascular malformations.
- Audiology; Speech Pathology; Developmental Pediatrics »
- Cochlear Implant Team – Determine candidacy of patients for implantation, following outcomes of speech and language and hearing abilities.
- Gastroenterology; Pulmonary; Occupational Therapy; Feeding Team; Speech Pathology; Voice Team; Pediatric Surgery »
- ADSC-Coordinated care of patients with complex conditions requiring multiple service involvement.
- Anesthesia; Emergency Department »
- Surgical Simulation-Providing training and simulation/situational awareness using state of the art simulation models.
- Neonatology » Jim Greenberg and Laurel Bookman
- Collaborative quality improvement project to standardize the diagnosis and treatment of neonates with tongue-based airway obstruction.
- Pulmonary; Developmental Pediatrics; Genetics; Plastics » Raouf Amin
- Upper Airway Center-Provides care coordination for patients suffering from upper airway abnormalities requiring intervention from multiple services.
Grants, Contracts, and Industry Agreements
|Grant and Contract Awards||Annual Direct|
|Functional Analyses of Tricellular Tight Junctions in Hearing and Deafness|
|R01 DC 011748||07/01/11-06/30/16||$250,000|
|Identifying Genes for Non-Syndromic Recessive Deafness - A Collaborative Study|
|R01 DC 011803||04/15/12-03/31/17||$201,875|
|The Regulation and Cellular Activities of the Arl2 GTPase|
|R01 GM 090158||08/01/12-07/31/14||$56,250|
|Understanding Suppression of Deafness Due to a Dominant Modifier Gene|
|Current Year Direct||$587,920|