Otolaryngology

Division Details

Division Data Summary

Research and Training Details

Number of Faculty13
Number of Joint Appointment Faculty4
Number of Research Fellows3
Number of Research Students1
Number of Support Personnel51
Direct Annual Grant Support$587,920
Peer Reviewed Publications15

Clinical Activities and Training

Number of Clinical Staff1
Number of Clinical Fellows6
Number of Other Students3
Inpatient Encounters852
Outpatient Encounters49,225

Division Photo

Otolaryngology

Row 1: S Riazuddin, C Myer III, D Choo, R Cotton, C Hart, S Shott

Row 2: R Elluru, M Rutter, A deAlarcon, D Deliyski, J Willging, E Arjmand, K Johnson, J Greinwald Jr

Significant Accomplishments

Significant Accomplishments

Choo Becomes Division Director

After more than 37 years in the role, Robin Cotton, MD, stepped down as Division Director in 2012. Cotton built the Division into the world's premier center for diagnosing and treating  airway abnormalities. The Division has grown into one of the nation’s busiest otolaryngology practices, with more than 33,000 outpatient visits and more than 11,000 procedures performed a year. After an exhaustive national search, Daniel Choo, MD, was named Cotton’s successor in October 2012.

Cotton Receives William Cooper Procter Medallion

In February 2013, Robin Cotton, MD, became only the ninth scientist since 1960 to be awarded the William Cooper Procter Medallion, the highest award bestowed by the Cincinnati Children’s Board of Trustees. Tom Cody, chairman of the board, called Cotton “a remarkable innovator, surgeon, educator and leader...”

Breakthrough Study in Usher Syndrome

Saima Riazuddin, PhD, and colleagues published a study entitled "Alterations of the CIB2 calcium- and integrin-binding protein, cause Usher syndrome type 1J and nonsyndromic deafness DFNB48” in Nature Genetics. This breakthrough work also was featured in the Editor’s Choice of Science Journal.

Significant Publications

Riazuddin S, Belyantseva I, Giese A, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZM. Alterations of the CIB2 calcium- and integrin-binding protein, cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Nature Genetics. 2012. 44:1265-71.

Several genes associated with different types of Usher syndrome have been identified. Most of these genes encode common structural and motor proteins that build sensory cells in the eye and inner ear. However, the gene reported in our paper, CIB2, which encodes a calcium and integrin binding protein, is believed to play a functional role in mechanoelectrical transduction, the process of converting sound energy into an electrical signal that the brain recognized as sound.

Our studies suggest that CIB2 might be important in maintaining calcium level in the sensory cells. Given that there are many cardiac ischemia and hypertension drugs that work by affecting calcium handling in the muscle cells, it is possible that one day a similar drug may be used to target a type of Usher syndrome that we described in our study

Division Publications

Otolaryngology Publications

  1. Averin K, Uzark K, Beekman RH, 3rd, Willging JP, Pratt J, Manning PB. Postoperative assessment of laryngopharyngeal dysfunction in neonates after Norwood operation. Ann Thorac Surg. 2012; 94:1257-61.
  2. de Alarcon A, Rutter MJ. Cervical slide tracheoplasty. Arch Otolaryngol Head Neck Surg. 2012; 138:812-6.
  3. Elluru RG. Cutaneous vascular lesions. Facial Plast Surg Clin North Am. 2013; 21:111-26.
  4. Fleck RJ, Mahmoud M, McConnell K, Shott SR, Gutmark E, Amin RS. An adverse effect of positive airway pressure on the upper airway documented with magnetic resonance imaging. JAMA Otolaryngol Head Neck Surg. 2013; 139:636-8.
  5. Greinwald J, DeAlarcon A, Cohen A, Uwiera T, Zhang K, Benton C, Halstead M, Meinzen-Derr J. Significance of unilateral enlarged vestibular aqueduct. Laryngoscope. 2013; 123:1537-46.
  6. Hart CK, Choo DI. What is the optimal workup for a child with bilateral sensorineural hearing loss?. Laryngoscope. 2013; 123:809-10.
  7. Hart CK, Wiley S, Choo DI, Eby C, Tucker L, Schapiro M, Meinzen-Derr J. Developmental disabilities and intracranial abnormalities in children with symptomatic cytomegalovirus and cochlear implants. ISRN Otolaryngol. 2012; 2012:502746.
  8. Johnson K, Geis G, Oehler J, Meinzen-Derr J, Bauer J, Myer C, Kerrey B. Simulation to implement a novel system of care for pediatric critical airway obstruction. Arch Otolaryngol Head Neck Surg. 2012; 138:907-11.
  9. Migally K, Hart C, Klein M. A neonate with neck swelling and fever. Clin Pediatr (Phila). 2013; 52:275-8.
  10. Prager JD, Neidich MJ, Perkins JN, Meinzen-Derr J, Greinwald JH, Jr.. Minimal access and standard cochlear implantation: a comparative study. Int J Pediatr Otorhinolaryngol. 2012; 76:1102-6.
  11. Sadhasivam S, Myer CM, 3rd. Preventing opioid-related deaths in children undergoing surgery. Pain Med. 2012; 13:982-3; author reply 984.
  12. Shankar RK, Rutter MJ, Chernausek SD, Samuels PJ, Mo JQ, Rutter MM. Medullary thyroid cancer in a 9-week-old infant with familial MEN 2B: Implications for timing of prophylactic thyroidectomy. Int J Pediatr Endocrinol. 2012; 2012:25.
  13. Sivakumaran TA, Husami A, Kissell D, Zhang W, Keddache M, Black AP, Tinkle BT, Greinwald JH, Jr., Zhang K. Performance evaluation of the next-generation sequencing approach for molecular diagnosis of hereditary hearing loss. Otolaryngol Head Neck Surg. 2013; 148:1007-16.
  14. Son HJ, Choo D. Optimal management of single-sided deafness. Laryngoscope. 2013; 123:304-5.
  15. Subramanyam R, Varughese A, Willging JP, Sadhasivam S. Future of pediatric tonsillectomy and perioperative outcomes. Int J Pediatr Otorhinolaryngol. 2013; 77:194-9.

Faculty, Staff, and Trainees

Faculty Members

Daniel I. Choo, MD, Associate Professor
Leadership Director, Department of Pediatric Otolaryngology
Robin T. Cotton, MD, Professor
Leadership Director, Aerodigestive and Sleep Center
Ellis M. Arjmand, MD, PhD, Associate Professor
Leadership Director, Ear and Hearing Center
Alessandro deAlarcon, MD, Associate Professor
Leadership Director, Voice Clinic
Ravindhra G. Elluru, MD, PhD, Associate Professor
John. H. Greinwald Jr., MD, Associate Professor
Catherine Hart, MD, Assistant Professor
Kaalan Johnson, MD, Assistant Professor
Leadership Director, Otolaryngology Simulation Program
Charles M. Myer III, MD, Professor
Leadership Director, Pediatric Otolaryngology Residency Program
Saima Riazuddin, PhD, Assistant Professor
Leadership Director, Laboratory of Molecular Genetics
Michael J. Rutter, MD, Associate Professor
Sally R. Shott, MD, Professor
J. Paul Willging, MD, Professor
Leadership Director, Pediatric Otolaryngology Fellowship Program

Joint Appointment Faculty Members

Zubair Ahmed, PhD, Assistant Professor (Opthalmology)
Research Interests Genetics
Dimitar Deliyski, PhD, Associate Professor (Communication Science Research Center)
Research Interests Communication Disorders
Scott Holland, PhD, Professor (Neuroimaging Research Consortium)
Research Interests Neuroimaging
Jareen Meinzen-Derr, MPH, PhD, Assistant Professor (Biostatistics & Epidemiology)
Research Interests Epidemiology

Clinical Staff Members

  • Michael Bowen, PA-C, RN, MA, Adult Airway

Trainees

  • Angela Black, MD, PGYVII, University of Minnesota
  • Charles Myer, IV, MD, PGYVII, University of Cincinnati College of Medicine
  • Michel Nassar, MD, PGYII, Hôtel-Dieu de France
  • Matthew Provenzano, MD, PGYVII, University of Iowa
  • Karthik Balakrishnan, MD, MPH, PGYVI, University of Washington at Seattle
  • Douglas Sidell, MD, PGYVI, UCLA

Division Collaboration

Genetics; Speech Pathology » Ann Kummer
VPI (Velopharyngeal Insufficiency) Clinic-Monitoring associated diagnoses and treatment outcomes.
Speech Pathology »
FEES (Flexible Endoscopic Evaluation of Swallowing) Clinic-Evaluating swallowing disorders, etiology, treatment strategies and outcomes.
Speech Pathology; Occupational Therapy; Dieticians; Genetics; Gastroenterology; Social Work; Nursing »
Interdisciplinary Feeding Team – Evaluating safety of swallowing and treatment strategies for children with complex dysphagia problems.
Speech Pathology »
Pediatric Voice Clinic – Evaluation of quality of life factors associated with voice disorders, determining etiology and treatment strategies for children with voice problems.
Pediatric Surgery; Dermatology; Plastic Surgery; Oncology » Denise Adams and Richard Azizkhan
Vascular Malformation clinic –Determining treatment outcomes for complex vascular malformations.
Audiology; Speech Pathology; Developmental Pediatrics »
Cochlear Implant Team – Determine candidacy of patients for implantation, following outcomes of speech and language and hearing abilities.
Gastroenterology; Pulmonary; Occupational Therapy; Feeding Team; Speech Pathology; Voice Team; Pediatric Surgery »
ADSC-Coordinated care of patients with complex conditions requiring multiple service involvement.
Anesthesia; Emergency Department »
Surgical Simulation-Providing training and simulation/situational awareness using state of the art simulation models.
Neonatology » Jim Greenberg and Laurel Bookman
Collaborative quality improvement project to standardize the diagnosis and treatment of neonates with tongue-based airway obstruction.
Pulmonary; Developmental Pediatrics; Genetics; Plastics » Raouf Amin
Upper Airway Center-Provides care coordination for patients suffering from upper airway abnormalities requiring intervention from multiple services.

Grants, Contracts, and Industry Agreements

Otolaryngology Grants

Grant and Contract AwardsAnnual Direct

Riazuddin, S

Functional Analyses of Tricellular Tight Junctions in Hearing and Deafness
R01 DC 01174807/01/11-06/30/16$250,000
Identifying Genes for Non-Syndromic Recessive Deafness - A Collaborative Study
R01 DC 01180304/15/12-03/31/17$201,875
The Regulation and Cellular Activities of the Arl2 GTPase
R01 GM 09015808/01/12-07/31/14$56,250
Understanding Suppression of Deafness Due to a Dominant Modifier Gene
12/01/11-11/30/14$79,795
Current Year Direct$587,920
Total$587,920