2013 Research Annual Report

Pathology and Laboratory Medicine

Division Details

Division Data Summary

Research and Training Details

Number of Faculty23
Direct Annual Grant Support$1,410,756
Direct Annual Industry Support$144,205
Peer Reviewed Publications59

Clinical Activities and Training

Inpatient Encounters811418
Outpatient Encounters1071753

Division Photo

Pathology and Laboratory Medicine

Row 1: J Mo, P Tang

Row 2: K Shanmukhappa, L Miles, P Steele, M Warren, J Stanek, R Sheridan, A Gupta

Row 3: J Mortensen, A Sheil, D Witte, K Wikenheiser-Brokamp, K Bove

Row 4: M Collins, K Setchell



Significant Accomplishments

Significant Accomplishments

Progress Against Pediatric Lung Disease

Kathryn Wikenheiser-Brokamp, MD, PhD, studies the genetic and developmental basis of lung disease, with specific interest in the pediatric lung tumor pleuropulmonary blastoma (PPB), chronic obstructive pulmonary disease and lung cancer. Wikenheiser-Brokamp has identified critical biologic functions for the Rb/p16 and p53 pathways in pulmonary epithelial progenitor/stem cell growth in the context of lung development, repair after injury and carcinogenesis.

Wikenheiser-Brokamp also studies how DICER1 and the microRNAs it generates control organogenesis and protect against PPB. She leads the basic science research for a multi-institutional team of researchers that recently discovered the first human syndrome associated with DICER1 mutations. She also serves as principal investigator on a consortium grant to explore the key regulatory pathways underlying DICER1 related lung phenotypes.

Wikenheiser-Brokamp has developed mouse models based upon genetic alterations in human disease along with complementary cell culture systems to identify key regulatory networks controlling lung development and disease pathogenesis. Her research is supported by the NIH, American Cancer Society, and the St. Baldrick’s Foundation. This year, Wikenheiser-Brokamp also was appointed Associate Director of the Medical Scientist (MD/PhD) Training Program.

Breakthrough Findings in Pediatric Liver Disease

Since joining the Department of Pediatrics in 1984, Kenneth Setchell, PhD, has focused his work in bile acid metabolism. He has identified and described six genetic defects in the pathway for bile acid synthesis, which are manifested as progressive neonatal liver disease. His research group now serves as an international center for the diagnosis and treatment of liver disease caused by genetic defects in cholesterol and bile acid syntheses.

In a recent study published in Gastroenterology, Setchell and colleagues characterized the clinical, biochemical, molecular and morphologic features of a genetic defect in bile acid conjugation in 10 pediatric patients with fat soluble vitamin deficiency, and some patients with growth failure or transient neonatal cholestatic liver disease. Their findings reveal the importance of bile acid conjugation in lipid absorption and indicate that patients with idiopathic neonatal cholestasis or later onset of unexplained fat soluble vitamin deficiency should be screened for defects in bile acid conjugation.

This study has been recognized in multiple published commentaries due to the significance of these observations, which may represent only the tip of an iceberg of patients with hereditary defects in bile acid conjugation.

Mass Spectrometry Expands

We have invested heavily in expanding our mass spectroscopy capabilities,  including increased technical support and state-of-the-art equipment. We now operate 10 mass spectrometers ranging from simple quadrupole mass specs to highly accurate triple quadrupole time-of-flight equipment that will be the cornerstone of our developing metabolomics program.

Currently, our mass spectrometry labs perform more than 17,000 clinical assays a year. We also are working to develop and implement a personalized therapy drug management program in collaboration with colleagues in Clinical Pharmacology and Pathology and Laboratory Medicine.

Neuropathology Program Grows

Brain tumors are the leading cause of childhood cancer deaths. Pediatric brain tumors are recognized as being biologically different from adult tumors and require a different treatment approach. Cincinnati Children’s has become a nationally recognized center for treating childhood brain tumors, evaluating approximately 100 new brain tumor cases a year.

Lili Miles, MD, who joined our Division in 2003, brings special expertise in pediatric neuropathology and muscle disorders to the battle against pediatric brain tumors. She has worked closely with a clinical team including members of Neuro-Oncology, Neurology, Neurosurgery, and Radiology to develop the brain tumor program at Cincinnati Children’s. Miles also provides pathology review expertise for the Diffuse Intrinsic Pontine Glioma International Repository, which is based at Cincinnati Children’s and supported by funds from The Cure Starts Now Foundation. Miles recently presented a review of the tumor repository and ongoing studies at a Foundation-sponsored symposium in Cincinnati.

Cincinnati Children’s also is the primary site for the national Pediatric Brain Tumor Consortium under the direction of Maryam Fouladi, MD. In the Consortium’s medulloblastoma protocol study, Miles will be providing state-of-the-art pathology support to characterize potential biological markers that could enhance the classification of these tumors and potentially serve as targets for improved therapy.


Division Publications

Pathology and Laboratory Medicine Publications

  1. Aceves S, Hirano I, Furuta GT, Collins MH. Eosinophilic gastrointestinal diseases--clinically diverse and histopathologically confounding. Semin Immunopathol. 2012; 34:715-31.
  2. Anderson NW, Buchan BW, Mayne D, Mortensen JE, Mackey TL, Ledeboer NA. Multicenter clinical evaluation of the illumigene group A Streptococcus DNA amplification assay for detection of group A Streptococcus from pharyngeal swabs. J Clin Microbiol. 2013; 51:1474-7.
  3. Azam M. An in vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents. Methods Mol Biol. 2012; 928:175-84.
  4. Brunner HI, Bennett MR, Mina R, Suzuki M, Petri M, Kiani AN, Pendl J, Witte D, Ying J, Rovin BH, Devarajan P. Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Arthritis Rheum. 2012; 64:2687-97.
  5. Burrow T, Witte D, Bailey L, Prada C, Sun Y, Cohen M, Wu S, Grabowski G. Abnormal pathology findings in a patient with Gaucher disease type 3 treated with enzyme replacement therapy. Molecular Genetics and Metabolism. 2013; 108:S27-S27.
  6. Chen W, Adams D, Patel M, Gupta A, Dasgupta R. Generalized lymphatic malformation with chylothorax: long-term management of a highly morbid condition in a pediatric patient. J Pediatr Surg. 2013; 48:e9-12.
  7. Currier MA, Eshun FK, Sholl A, Chernoguz A, Crawford K, Divanovic S, Boon L, Goins WF, Frischer JS, Collins MH, Leddon JL, Baird WH, Haseley A, Streby KA, Wang PY, Hendrickson BW, Brekken RA, Kaur B, Hildeman D, Cripe TP. VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells. Mol Ther. 2013; 21:1014-23.
  8. Divanovic A, Witte D, Michelfelder E. A fetus with hypoplastic left heart syndrome and tricuspid stenosis with evolving hydrops fetalis. Pediatr Cardiol. 2012; 33:1210-2.
  9. Gupta N, Aragaki A, Wikenheiser-Brokamp KA, Benzaquen S, Panos RJ. Occam's razor or Hickam's dictum?. J Bronchology Interv Pulmonol. 2012; 19:216-9.
  10. Harmon N, Mortensen JE. Case Twenty-Four: Bacteremia Caused by an Uncommon Gram-Negative Organism. Journal of Continuing Education Topics and Issues. 2012; 14.
  11. Hirai H, Kamio N, Huang G, Matsusue A, Ogino S, Kimura N, Satake S, Ashihara E, Imanishi J, Tenen DG, Maekawa T. Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein β. PLoS One. 2013; 8:e54862.
  12. Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI. The fanconi anemia pathway limits human papillomavirus replication. J Virol. 2012; 86:8131-8.
  13. Hummel TR, Miles L, Mangano FT, Jones BV, Geller JI. Clinical heterogeneity of desmoplastic infantile ganglioglioma: a case series and literature review. J Pediatr Hematol Oncol. 2012; 34:e232-6.
  14. Jodele S, Hirsch R, Laskin B, Davies S, Witte D, Chima R. Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2013; 19:202-7.
  15. Jurickova I, Collins MH, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer JS, Falcone RA, Trapnell BC, Denson LA. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. Clin Exp Immunol. 2013; 172:455-65.
  16. Kamthan A, Kamthan M, Azam M, Chakraborty N, Chakraborty S, Datta A. Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality. Sci Rep. 2012; 2:951.
  17. Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer Res. 2012; 72:3405-13.
  18. Keng VW, Watson AL, Rahrmann EP, Li H, Tschida BR, Moriarity BS, Choi K, Rizvi TA, Collins MH, Wallace MR, Ratner N, Largaespada DA. Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. Sarcoma. 2012; 2012:620834.
  19. Kohli R, Bradley D, Setchell KD, Eagon JC, Abumrad N, Klein S. Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids. J Clin Endocrinol Metab. 2013; 98:E708-12.
  20. Littleton RM, Haworth KJ, Tang H, Setchell KD, Nelson S, Hove JR. Automated in vivo platform for the discovery of functional food treatments of hypercholesterolemia. PLoS One. 2013; 8:e52409.
  21. Marsh RA, Allen CE, McClain KL, Weinstein JL, Kanter J, Skiles J, Lee ND, Khan SP, Lawrence J, Mo JQ, Bleesing JJ, Filipovich AH, Jordan MB. Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab. Pediatr Blood Cancer. 2013; 60:101-9.
  22. Melvin AJ, Litsky AS, Mayerson JL, Stringer K, Juncosa-Melvin N. Extended healing validation of an artificial tendon to connect the quadriceps muscle to the Tibia: 180-day study. J Orthop Res. 2012; 30:1112-7.
  23. Meraj R, Wikenheiser-Brokamp KA, Young LR, Byrnes S, McCormack FX. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Front Med. 2012; 6:395-405.
  24. Meraj R, Wikenheiser-Brokamp KA, Young LR, McCormack FX. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Semin Respir Crit Care Med. 2012; 33:486-97.
  25. Miles L, Miles MV, Horn PS, Degrauw TJ, Wong BL, Bove KE. Importance of muscle light microscopic mitochondrial subsarcolemmal aggregates in the diagnosis of respiratory chain deficiency. Hum Pathol. 2012; 43:1249-57.
  26. Morgan NV, Hartley JL, Setchell KD, Simpson MA, Brown R, Tee L, Kirkham S, Pasha S, Trembath RC, Maher ER, Gissen P, Kelly DA. A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease. Orphanet J Rare Dis. 2013; 8:74.
  27. Mortensen JE, Mayne D. Isothermal Amplification and Detection of Group A Streptococci from Throat Swabs Using illumigene Group A Strep. Journal of Molecular Diagnostics. 2012; 14:694-694.
  28. Pandey MK, Rani R, Zhang W, Setchell K, Grabowski GA. Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease. Mol Genet Metab. 2012; 106:310-22.
  29. Patmore DM, Welch S, Fulkerson PC, Wu J, Choi K, Eaves D, Kordich JJ, Collins MH, Cripe TP, Ratner N. In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1. Cancer Res. 2012; 72:5317-27.
  30. Perumbeti A, O'Leary MF, Carey PM, Scientific Publications Committee of America’s Blood Centers. (2012) Alloimmunization of RhD Following Platelet Transfusion. Blood Bulletin. Americas Blood Centers. .
  31. Phillips CL, Davies SM, McMasters R, Absalon M, O'Brien M, Mo J, Broun R, Moscow JA, Smolarek T, Garzon R, Blum W, Schwind S, Marcucci G, Perentesis JP. Low dose decitabine in very high risk relapsed or refractory acute myeloid leukaemia in children and young adults. Br J Haematol. 2013; 161:406-10.
  32. Powell E, Mortensen JE. Update on Kingella Kingae: Pathogenesis, Identification, and Treatment. Journal of Continuing Education Topics and Issues. 2013; 15:18-25, 56-59.
  33. Privette Vinnedge LM, Ho SM, Wikenheiser-Brokamp KA, Wells SI. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS One. 2012; 7:e46985.
  34. Qiu Q, Li R, Jiang P, Xue L, Lu Y, Song Y, Han J, Lu Z, Zhi S, Mo JQ, Guan MX. Mitochondrial tRNA mutations are associated with maternally inherited hypertension in two Han Chinese pedigrees. Hum Mutat. 2012; 33:1285-93.
  35. Quarmyne MO, Gupta A, Adams DM. Lymphangiosarcoma of the thorax and thoracic vertebrae in a 16-year-old girl. J Clin Oncol. 2012; 30:e294-8.
  36. Schönheit J, Kuhl C, Gebhardt ML, Klett FF, Riemke P, Scheller M, Huang G, Naumann R, Leutz A, Stocking C, Priller J, Andrade-Navarro MA, Rosenbauer F. PU.1 Level-Directed Chromatin Structure Remodeling at the Irf8 Gene Drives Dendritic Cell Commitment. Cell Rep. 2013; 3:1617-28.
  37. Setchell KD, Heubi JE, Shah S, Lavine JE, Suskind D, Al-Edreesi M, Potter C, Russell DW, O'Connell NC, Wolfe B, Jha P, Zhang W, Bove KE, Knisely AS, Hofmann AF, Rosenthal P, Bull LN. Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. Gastroenterology. 2013; 144:945-955 e6; quiz e14-5.
  38. Sheridan R, Heubi JE, Bove KE. Hepatic Lymph Node Histology at Time of Kasai Procedure for Biliary Atresia. Hepatology. 2012; 56:735a-735a.
  39. Sheridan RM, Stanek J, Khoury J, Handwerger S. Abnormal expression of transcription factor activator protein-2alpha in pathologic placentas. Hum Pathol. 2012; 43:1866-74.
  40. Siddiqui I, Teran C, Ruger K, Mortensen JE. Case Twenty Five: A Disseminated Fungal Infection. Journal of Continuing Education Topics and Issues. 2013; 15:36-37, 44, 48.
  41. Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jorda M, Lee S, Yang H, Ng F, Zhang J, Leddin M, Silberstein LE, Hoefler G, Orkin SH, Göttgens B, Rosenbauer F, Huang G, Tenen DG. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell. 2013; 49:934-46.
  42. Stacpoole PW, deGrauw TJ, Feigenbaum AS, Hoppel C, Kerr DS, McCandless SE, Miles MV, Robinson BH, Tang PH. Design and implementation of the first randomized controlled trial of coenzyme CoQ₁₀ in children with primary mitochondrial diseases. Mitochondrion. 2012; 12:623-9.
  43. Stanek J. Hypoxic patterns of placental injury: a review. Arch Pathol Lab Med. 2013; 137:706-20.
  44. Stanek J. Placental membrane laminar necrosis and chorionic microcysts. Pediatr Dev Pathol. 2012; 15:514-6.
  45. Sun Y, Zamzow M, Ran HM, Zhang WJ, Quinn B, Barnes S, Witte DP, Setchell KDR, Williams MT, Vorhees CV, Grabowski GA. Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Human Molecular Genetics. 2013; 22:2435-2450.
  46. Sun Y, Zhang W, Xu YH, Quinn B, Dasgupta N, Liou B, Setchell KD, Grabowski GA. Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease. PLoS One. 2013; 8:e57560.
  47. Szafranski P, Dharmadhikari AV, Brosens E, Gurha P, Kolodziejska KE, Zhishuo O, Dittwald P, Majewski T, Mohan KN, Chen B, Person RE, Tibboel D, de Klein A, Pinner J, Chopra M, Malcolm G, Peters G, Arbuckle S, Guiang SF, 3rd, Hustead VA, Jessurun J, Hirsch R, Witte DP, Maystadt I, Sebire N, Fisher R, Langston C, Sen P, Stankiewicz P. Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder. Genome Res. 2013; 23:23-33.
  48. Tang PH. Quantification of Antifungal Drug Voriconazole in Serum and Plasma by HPLC-UV. J Drug Metab Toxicol. 2013; 4:144.
  49. Thigpen JE, Setchell KD, Kissling GE, Locklear J, Caviness GF, Whiteside T, Belcher SM, Brown NM, Collins BJ, Lih FB, Tomer KB, Padilla-Banks E, Camacho L, Adsit FG, Grant M. The estrogenic content of rodent diets, bedding, cages, and water bottles and its effect on bisphenol a studies. J Am Assoc Lab Anim Sci. 2013; 52:130-41.
  50. Torres J, Bao X, Iuga AC, Chen A, Harpaz N, Ullman T, Cohen BL, Pineton de Chambrun G, Asciutti S, Odin JA, Sachar DB, Gaskins HR, Setchell K, Colombel JF, Itzkowitz SH. Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia. Inflamm Bowel Dis. 2013; 19:275-82.
  51. Willson TA, Kuhn BR, Jurickova I, Gerad S, Moon D, Bonkowski E, Carey R, Collins MH, Xu H, Jegga AG, Guthery SL, Denson LA. STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2012; 55:32-43.
  52. Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res. 2012; 160:167-77.
  53. Wolfe K, Lewis D, Witte D, Kline-Fath B, Lim FY, Jaekle R, Habli M, Hostiuck J, Baregamian N, Keswani S, Crombleholme T. Fetal cervical teratoma: what is the role of fetal MRI in predicting pulmonary hypoplasia?. Fetal Diagn Ther. 2013; 33:252-6.
  54. Zhang Y, Chen A, Yan XM, Huang G. Disordered epigenetic regulation in MLL-related leukemia. Int J Hematol. 2012; 96:428-37.
  55. Zhang Y, Yan X, Sashida G, Zhao X, Rao Y, Goyama S, Whitman SP, Zorko N, Bernot K, Conway RM, Witte D, Wang QF, Tenen DG, Xiao Z, Marcucci G, Mulloy JC, Grimes HL, Caligiuri MA, Huang G. Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells. Blood. 2012; 120:1118-29.
  56. Zhao J, Fang LJ, Setchell KD, Chen R, Li LT, Wang JS. Primary 4-3-oxosteroid 5beta-reductase deficiency: two cases in China. World J Gastroenterol. 2012; 18:7113-7.
  57. Zhao X, Zhao Z, Guo J, Huang P, Zhu X, Zhou X, Yang Z, Zhao L, Xu L, Xu J, Fu L, Zhang J, Zhang X, Dong Y, Huang G, Wang Q, Li B, Song X, Yang X, Liu S, Yi S, Yu T, Yu C, Hou L, Li J, Chen W. Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line. J Biomol Screen. 2013; 18:378-87.
  58. Zhou X, Qian Y, Zhang J, Tong Y, Jiang P, Liang M, Dai X, Zhou H, Zhao F, Ji Y, Mo JQ, Qu J, Guan MX. Leber's hereditary optic neuropathy is associated with the T3866C mutation in mitochondrial ND1 gene in three Han Chinese Families. Invest Ophthalmol Vis Sci. 2012; 53:4586-94.
  59. Zorko NA, Bernot KM, Whitman SP, Siebenaler RF, Ahmed EH, Marcucci GG, Yanes DA, McConnell KK, Mao C, Kalu C, Zhang X, Jarjoura D, Dorrance AM, Heerema NA, Lee BH, Huang G, Marcucci G, Caligiuri MA. Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias. Blood. 2012; 120:1130-6.

Faculty, Staff, and Trainees

Faculty Members

David Witte, MD, Professor
Leadership Division Director
Research Interests Renal pathology, molecular pathology
Mohammad Azam, PhD, Assistant Professor
Research Interests Cancer Biology and Neural Tumors Program
Kevin E Bove, MD, Professor
Research Interests Pediatric liver disease, biliary atresia
J. Todd Boyd, DO, Assistant Professor
Research Interests Pulmonary pathology, graduate medical education
Margaret H Collins, MD, Professor
Research Interests Pediatric gastrointestinal pathology, especially pediatric eosinophilic gastrointestinal disorders, pediatric inflammatory bowel disease, pediatric bowel motility disorders
Anita Gupta, MD, Assistant Professor
Research Interests Liver tumor pathology, vascular anomalies
Gang Huang, PhD, Assistant Professor
Research Interests Cancer pathology
Richard L McMasters, MD, Assistant Professor
Research Interests Hematopathology
Lili Miles, MD, Associate Professor
Leadership Director, Training Program
Research Interests Brain tumor, epilepsy research, neuromuscular diseases and NASH liver
Michael Miles, PharmD, Professor
Research Interests Neuropathology of mitochondrial disease
Jun Q Mo, MD, Associate Professor
Research Interests Hematopathology
Joel E Mortensen, PhD, Associate Professor
Leadership Director, Diagnostic Infectious Disease Lab
Research Interests Microbiology
Mandy F O'Leary, MD, Assistant Professor
Research Interests Transfusion medicine
Kenneth D Setchell, PhD, Professor
Leadership Director, Mass Spec Lab
Research Interests Biochemistry,Bile acids,Sterol and cholesterol metabolism,Steroids, Liver disease, Liver transplantation, Gastroenterology, Nutrition/Diet, Phytochemicals, Isoflavones/Lignans, Breast cancer, Colon cancer, Mass spectrometry – biomedical mass spectrometry, Chromatography, Analytical Biochemistry, Assay development, Therapeutic drug monitoring, Pharmacokinetics and metabolism, Genetics
S. Kumar Shanmukhappa, PhD, Assistant Professor
Research Interests Experimental animal models
Amy Sheil, MD, Assistant Professor
Rachel Sheridan, MD, Assistant Professor
Research Interests Liver pathology, biliary atresia
Jerzy W Stanek, MD, PhD, Professor
Research Interests Pathology and pathomechanisms of in-utero hypoxia, particularly in the placenta; Pathology of perinatal mortality and morbidity
Paul E Steele, MD, Associate Professor
Leadership Medical Director, Clinical Lab
Research Interests Clinical lab medicine
Keith F Stringer, MD, Assistant Professor
Research Interests Microscopic techniques for assessing mRNA expression, protein production and cellular identity in eukaryotic tissues
Peter Tang, PhD, Assistant Professor
Research Interests Special chemistry
Mikako Warren, MD, Assistant Professor
Research Interests Renal pathology
Kathryn Wikenheiser-Brokamp, MD, PhD, Associate Professor
Research Interests Genetic and developmental basis of lung disease, lung cancer and pediatric cystic lung disease

Trainees

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Division Collaboration

Human Genetics » Gregory Grabowski MD
Providing technical and professional support for NIH study to characterize a metabolic disease animal model.
Gastroenterology, Hepatology and Nutrition » Mitch Cohen MD, Jorge Bezerra MD, Xiaonan Han PhD, and Noah Shroyer PhD
Digestive Health Center: Integrated morphology core lab, provides technical and professional support to members of the DHC involved in basic and translational research in gastrointestinal tract.
Gastroenterology, Hepatology and Nutrition » James Heubi MD, John Bucuvalas MD, Jorge Bezerra MD, and Kathleen Campbell MD
Director of Pathology Core for multicenter BARC and CLIC studies on biliary atresia and other chronic liver disorders in children.
Endocrinology » Stuart Handwerger MD
Providing technical and professional support for NIH placental studies.
Rheumatology » John Harley MD, Sue Thompson PhD, and Hermine Brunner MD
Providing pathology professional and technical support for establishment of Biorepository service and support for Rheumatology core lab for Cincinnati Rheumatic Diseases Center and multicenter study for lupus nephritis.
Allergy and Immunology » Marc Rothenberg MD and Pablo Abonia MD
Providing professional support for the Cincinnati Center for Esoinophilic Disorders program and related research.
Hematology/Oncology » Maryam Fouladi MD and Richard Dressi PhD
Providing pathology professional and technical support for multicenter referral service for the High Grade Glioma program and basic research program.
Hematology/Oncology Research » Yi Zheng PhD, James Mulloy PhD, and Jose Cancelas MD, PhD
Joint development of Leukemia Biology program at Cincinnati Children’s.
Division of Hematology/Oncology; Department of Pediatric Surgery » Denise Adams MD, Richard Azizkhan MD, and Anusa Dasgupta MD
Hemangioma/vascular malformation clinical program. Providing professional diagnostic and technical pathology support for multidisciplinary patient care program.
Division of Clinical Pharmacology » Sander Vinks, PharmD, PhD
Development of a centralized therapeutic drug monitoring program for personalized medical care.
»

Grants, Contracts, and Industry Agreements

Pathology and Laboratory Medicine Grants

Grant and Contract AwardsAnnual Direct

Azam, M

Mechanisms of Drug Resistance in Myeloproliferative Neoplasms Treated With JAK2 Inhibitor
R21 HL 11407406/01/13-03/31/15$119,000
Improved Therapeutic Approaches for Hematological Disorder Treated with Tyrosine
R01 CA 15509105/01/12-03/31/17$195,050

Bove, K

Clinical Center for Cholestatic Liver Disease in Children - Histopathy Core
U01 DK 06249709/10/09-05/31/14$33,176

Chen, A

Identification and Targeting Mutations of a Novel Tumor Suppressor SETD2 in Pediatric Cancer
06/01/13-05/31/14$40,000

Huang, G

Molecular Mechanisms of Leukemogenesis Mediated by MLL-Partial Tandem Duplication
07/01/11-06/30/13$27,273
Molecular Mechanisms of MLL-PTD Oncoprotein Transformation
07/01/12-06/30/13$100,000

Wikenheiser-Brokamp, K

Mechanisms Underlying DICER1 Suppression of Pleuropulmonary Blastoma
07/01/11-06/30/16$186,222
Rb-p16 Regulatory Pathway in Lung Carcinogenesis
07/01/10-06/30/14$150,000
Role of Rb Family in Lung Epithelial Response to Injury
R01 HL 07919304/01/10-03/31/14$235,620
Mechanisms of DICER1 Function in Lung Organogenesis and Cystic Lung Disease
R01 HL 1092656/15/2011-05/31/2015$246,281

Witte, D

Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Disease - Integrative Morphology Core
P30 DK 07839206/01/12-05/31/17$78,134
Current Year Direct$1,410,756
Industry Contracts

Mortensen, J

$41,083

Setchell, K

$39,785
$63,337
Current Year Direct Receipts$144,205
Total$1,554,961