2013 Research Annual Report

Pulmonary Medicine

Division Details

Division Data Summary

Research and Training Details

Number of Faculty22
Number of Joint Appointment Faculty3
Number of Research Fellows5
Number of Research Students11
Number of Support Personnel22
Direct Annual Grant Support$2,656,761
Direct Annual Industry Support$322,333
Peer Reviewed Publications52

Clinical Activities and Training

Number of Clinical Staff75
Number of Clinical Fellows9
Inpatient Encounters692
Outpatient Encounters9093

Division Photo

Pulmonary Medicine

Row 1: N Simakajornboon, R Wood, R Amin, C Kercsmar, L Burns, N Zhang

Row 2: M Schecter, J Crisalli, J Woods, R Szczesniak, K McDowell, A Shamsuzzaman

Row 3: S Madala, W Hardie, R Bokulic, D Grossoehme, G McPhail, A Naren



Significant Accomplishments

Significant Accomplishments

Lung Transplant Program to Begin in Spring 2014

In collaboration with the Heart Institute, we are developing Cincinnati’s first Lung Transplant Program. We anticipate beginning lung transplants and lung-heart transplants by spring 2014.

Upper-Airway Center Established

Our newly established Upper-Airway Center is a multidisciplinary program that includes expertise from Pulmonology, Human Genetics, Plastic Surgery, Radiology , the ENT Outpatient Treatment Center and the Jane and Richard Thomas Center for Down Syndrome. The Center provides additional assessment and innovative care for patients with persistent upper-airway obstruction after receiving standard therapy.

No. 2 in the Nation

We were ranked No. 2 in the nation for Pulmonology by US News & World Report for the second year in a row, with an overall score of 96.8 out of 100. We received “superior” rankings in more than half of the categories judged, including asthma-management success, commitment to best practices and quality improvement, and efforts to involve families.

New faculty bring research, clinical strength

Jason Woods, PhD, has been appointed Director of the Center for Pulmonary Imaging Research, a multidisciplinary research and training program between Pulmonary Medicine and Radiology. Woods is one of the world’s leading experts on using  hyperpolarized-gas MRI to measure regional lung function, microstructure, and physiology.  Woods is the academic principal investigator for an NIH-funded study entitled, “Single-session bronchial thermoplasty for severe asthmatics guided by HXe MRI.” This project will quantify regional ventilation abnormalities in patients with severe asthma and evaluate the outcomes of using image guidance to reduce risk to patients receiving bronchial thermoplasty.

Anjaparavanda Naren, PhD, has joined our faculty to continue his research of the structural and functional aspects of cystic fibrosis transmembrane conductance regulator (CFTR) ion-channel biology. His work includes developing and exploring the therapeutic potential of reagents used to augment the current activity of CFTR mutants, understanding the physical and functional coupling of the channel (CFTR) to the receptor (beta 2AR and LPA2) and its relevance to CFTR-dysfunction diseases, and defining a role for CFTR and t-SNARE (syntaxin 1A and SNAP23) interaction in vesicular translocation.

Satish Madala, PhD, was promoted to Assistant Professor. He also  was awarded a Parker B. Francis Fellowship to initiate his independent research program entitled, “Molecular Mechanisms of TGFα-driven Pulmonary Fibrosis.” His other research interests include using transgenic and non-transgenic mouse models to identify cellular and molecular mechanisms of fibrotic diseases including idiopathic pulmonary fibrosis, cystic fibrosis and scleroderma.


Research Highlights

CHAT Study

The Childhood Adenotonsillectomy Trial (CHAT funded by the National Institutes of Health) was a multi-institutional, collaborative clinical research study designed to determine the effect of adenotonsillectomy surgery on obstructive sleep apnea syndrome (OSAS) in children. OSAS can cause health problems including poor growth, high blood pressure, diabetes, and behavioral and learning difficulties. Although adenotonsillectomy is the usual treatment for children with OSAS, it was not previously known with any certainty whether OSAS symptoms significantly improve after surgery or if earlier surgery would be more beneficial than watchful waiting with supportive care prior to surgery.

Raouf S. Amin, MD is one of the principal investigators for the CHAT study. Over 450 children with OSAS, five through nine years of age were randomly assigned to early adenotonsillectomy or watchful waiting and assessed for polysomnographic, cognitive, behavioral, and health outcomes. The findings of the study recently were reported in the New England Journal of Medicine paper, “A randomized trial of adenotonsillectomy for childhood sleep apnea”. It was determined that adenotonsillectomy reduces symptoms and improves secondary outcomes of behavior, quality of life, and polysomnographic measures, thus providing evidence of the beneficial effects of early surgical intervention for children with OSAS.

Drug Discovery in CF

Cystic fibrosis (CF) is a disorder affecting over 30,000 patients in the US and &gt 70,000 worldwide. Mutations in the CF gene lead to defects in the CFTR protein, which works as a regulator of salt and water movement throughout the body. CF patients develop problems with mucus in the lungs and abnormal food absorption that lead to lung infections, poor growth, and death in early adulthood. Although improvements have been made in CF patient care for several decades, all previous therapies have targeted downstream symptoms of CF rather than early steps in the disease cascade.

John P. Clancy, MD, is the director of the Cincinnati Children’s Cystic Fibrosis Center. Over the past 18 months, dramatic changes have occurred in CF care, starting with the FDA approval of kalydeco for the treatment of CF caused by the G551D CFTR mutation (found in about 5% of CF patients). Kalydeco is a 'CFTR modulator', which is a class of drugs that targets the root cause of CF on a mutation by mutation basis. Currently, Phase II and Phase III studies are underway testing kalydeco in combination with other drugs ('correctors' of the F508del CFTR mutation) that target the most-common CF-causing mutation. Also, studies are underway examining kalydeco as a monotherapy in new CF populations beyond those with the G551D CFTR mutation. It is hoped that within a few years, essentially all CF patients will be treated with medications that target the root cause of CF and restore activity to disease-causing CFTR mutations. Cincinnati Children’s is playing a critical role in these studies, and enthusiasm for these breakthrough therapies is at an all-time high in the global CF care and research communities.

Summer Research Fellowship Training Program

Our division was one of only two pediatric pulmonary centers in the United States to receive the National Institutes of Health Ruth L. Kirschstein National Research Service Award (NRSA) in 2012 for a Short-Term Institutional Training Grant program for Clinician Scientists in Pediatric Respiratory Medicine. The program provides funding for research training opportunities in basic or clinical research areas in pediatric pulmonary and sleep medicine for medical students in the summer between the first and second years of medical school.

William D. Hardie, MD is the director of this training program. Recruitment efforts for the second year resulted in an increase in applicants from 18 in 2012 from six institutions to 36 in 2013 from 17 institutions, including three from countries outside of the United States. The eight applicants accepted into the 2013 program were matched with mentors for research projects in a variety of pediatric respiratory research areas, including asthma, cystic fibrosis, lung cancer, and sleep apnea. The strengths of our research programs, combined with an enthusiastic faculty and a well-organized summer program, continue to provide an excellent opportunity to attract physician trainees at a critical stage in their careers and increase the likelihood they will want to further pursue research as physician-scientists.


Significant Publications

Marcus CL, Moore RH, Rosen CL, Giordani B, Garetz SL, Taylor HG, Mitchell RB, Amin R, Katz ES, Arens R, Paruthi S, Muzumdar H, Gozal D, Thomas NH, Ware J, Beebe D, Snyder K, Elden L, Sprecher RC, Willging P, Jones D, Bent JP, Hoban T, Chervin RD, Ellenberg SS, Redline S; Childhood Adenotonsillectomy Trial (CHAT). A randomized trial of adenotonsillectomy for childhood sleep apnea. New England Journal of Medicine. 2013 Jun 20;368(25):2366-76. doi: 10.1056/NEJMoa1215881. Epub 2013 May 21. 
Although adenotonsillectomy is commonly performed in children with obstructive sleep apnea (OSA), its usefulness in reducing symptoms and improving cognition, behavior, quality of life, and polysomnographic findings has not been rigorously evaluated. As compared with a strategy of watchful waiting with supportive care, adenotonsillectomy was determined to reduce symptoms and improve secondary outcomes of behavior, quality of life, and polysomnographic findings, thus providing evidence of the beneficial effects of early surgical intervention for children with OSA.
Vandyke RD, McPhail GL, Huang B, Fenchel MC, Amin RS, Carle AC, Chini BA, Seid M. Inhaled tobramycin effectively reduces FEV1 decline in cystic fibrosis. An instrumental variables analysisAnnals of the American Thoracic Society. 2013 Jun;10(3):205-12. doi: 10.1513/AnnalsATS.201209-082OC.
Little is known about the clinical effectiveness of tobramycin on lung function (FEV1) decline in cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa infections outside of randomized and controlled trial settings; conventional analysis of existing registry data has heretofore been confounded by treatment-selection bias. To determine the effectiveness of inhaled tobramycin on FEV1 decline, observational data from the Cystic Fibrosis Foundation Patient Registry were used. Center-specific prescription rates were chosen as an instrument to reduce treatment-by-condition bias. The instrumental variables analysis showed less FEV1 decline for patients who received tobramycin when first eligible compared with those who did not receive tobramycin. This approach can correct for treatment-by-condition bias arising from observational studies.
Fleck R, McPhail G,Szczesniak R, Knowlton J, Radhakrishnan R, Clancy J, Amin R.Aortopulmonary collateral flow in cystic fibrosis assessed with phase-contrast MRI.Pediatric Radiology. 2013 May 16. [Epub ahead of print].
Chronic pulmonary disease with progressive destruction of the pulmonary parenchyma is a major morbidity of cystic fibrosis (CF), but the relationship between clinical severity of CF and aortopulmonary collateral blood flow has not been assessed.  Changes in aortopulmonary collateral blood flow were measured by phase-contrast magnetic resonance imaging (MRI) in children with CF across the spectrum of disease severity.  The findings suggest that phase-contrast MRI can be performed reliably with consistent results and without interobserver variability and support that aortopulmonary collateral blood flow may serve as a novel and sensitive biomarker of early pulmonary disease in children with CF.
Grossoehme DH, Szczesniak R, McPhail GL, Seid M.Is adolescents' religious coping with cystic fibrosis associated with the rate of decline in pulmonary function?-A preliminary study. Journal of Health Care Chaplaincy. 2013 Apr;19(1):33-42. doi: 10.1080/08854726.2013.767083. 
Religious coping has been associated with health outcomes in adolescents with chronic disease.  The purpose of this study was to determine if associations exist between rate of change in pulmonary function and subsequent religious coping by adolescents with cystic fibrosis.  More-severe lung function decline was associated with use of pleading or negative religious coping.  Establishing an association between health outcomes and religious coping is a first step to understanding how to intervene, and suggests opportunities for chaplains to explore alternative religious coping options or to cognitively reframe negative religious coping. 
Margolis PA, Peterson LE, Seid M. Collaborative Chronic Care Networks (C3Ns) to transform chronic illness care. Pediatrics. 2013 Jun;131 Suppl 4:S219-23. doi: 10.1542/peds.2012-3786J. 
A Collaborative Chronic Care Network (C3N) is a network-based production system that harnesses the collective intelligence of patients, clinicians, and researchers and distributes the production of knowledge, information, and know-how over large groups of people, dramatically accelerating the discovery process.  A C3N is a platform of "operating systems" on which interconnected processes and interventions are designed, tested, and implemented.  A fully realized C3N represents a discontinuous leap to a self-developing learning health system capable of producing a qualitatively different approach to improving health.

Division Publications

Pulmonary Medicine Publications

  1. Beebe DW, Rausch J, Byars KC, Lanphear B, Yolton K. Persistent snoring in preschool children: predictors and behavioral and developmental correlates. Pediatrics. 2012; 130:382-9.
  2. Burt RS, Meltzer DO, Seid M, Borgert A, Chung JW, Colletti RB, Dellal G, Kahn SA, Kaplan HC, Peterson LE, Margolis P. What's in a name generator? Choosing the right name generators for social network surveys in healthcare quality and safety research. BMJ Qual Saf. 2012; 21:992-1000.
  3. Castro M, Woods J. Insights into pediatric asthma with hyperpolarized magnetic resonance imaging of the lung. J Allergy Clin Immunol. 2013; 131:377-8.
  4. Chaudhry H, Brockbank J, Vandyke R, Fenchel M, Dixon M, Amin R, Simakajornboon N. Night to Night Variability of Polysomnographic Parameters in Obese Children and Adolescents with Obstructive Sleep Apnea (Osa). Sleep. 2012; 35:A352-A352.
  5. Clancy JP, Donaldson S, Gabriel S, Hornick D, Starner TD, Rowe S, VanDyke R, Fenchel M, Sun H. Centralized Intestinal Current Measurements (Icm): Cftr Activity in Fresh and Cold-Stored Rectal Biopsies, and Comparison of Forceps Vs Suction Biopsy. Pediatric Pulmonology. 2012; 47:296-296.
  6. Clancy JP, Jain M. Personalized Medicine in Cystic Fibrosis Dawning of a New Era. American Journal of Respiratory and Critical Care Medicine. 2012; 186:593-597.
  7. Crisalli JA, McConnell K, Vandyke RD, Fenchel MC, Somers VK, Shamszumann A, Chini B, Daniels SR, Amin RS. Baroreflex sensitivity after adenotonsillectomy in children with obstructive sleep apnea during wakefulness and sleep. Sleep. 2012; 35:1335-43.
  8. Field MJ, Ellinger LK, Boat TF. IOM Review of FDA--approved biologics labeled or studied for pediatric use. Pediatrics. 2013; 131:328-35.
  9. Fleck RJ, Mahmoud M, McConnell K, Shott SR, Gutmark E, Amin RS. An adverse effect of positive airway pressure on the upper airway documented with magnetic resonance imaging. JAMA Otolaryngol Head Neck Surg. 2013; 139:636-8.
  10. Foster K, Chini BA, Tan C, Crisalli J. Exercise: Perceptions of Patients with Cystic Fibrosis. Pediatric Pulmonology. 2012; 47:369-369.
  11. Gergen PJ, Teach SJ, Mitchell HE, Freishtat RF, Calatroni A, Matsui E, Kattan M, Bloomberg GR, Liu AH, Kercsmar C, O'Connor G, Pongracic J, Rivera-Sanchez Y, Morgan WJ, Sorkness CA, Binkley N, Busse W. Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents. Am J Clin Nutr. 2013; 97:1228-34.
  12. Gottschlich MM, Mayes T, Khoury J, Simakajornboon N, Kagan RJ. Comparison of sleep parameters obtained from actigraphy and polysomnography during the rehabilitative phase after burn. J Burn Care Res. 2013; 34:183-90.
  13. Grossoehme DH, Cotton S, McPhail G. Use and sanctification of complementary and alternative medicine by parents of children with cystic fibrosis. J Health Care Chaplain. 2013; 19:22-32.
  14. Grossoehme DH, Cotton S, Ragsdale J, Quittner AL, McPhail G, Seid M. "I honestly believe god keeps me healthy so i can take care of my child": parental use of faith related to treatment adherence. J Health Care Chaplain. 2013; 19:66-78.
  15. Grossoehme DH, Ragsdale JR, Cotton S, Meyers MA, Clancy JP, Seid M, Joseph PM. Using spirituality after an adult CF diagnosis: cognitive reframing and adherence motivation. J Health Care Chaplain. 2012; 18:110-20.
  16. Grossoehme DH, Ragsdale JR, Snow A, Seid M. We were chosen as a family: parents' evolving use of religion when their child has cystic fibrosis. J Relig Health. 2012; 51:1347-58.
  17. Grossoehme DH, Szczesniak R, McPhail GL, Seid M. Is adolescents' religious coping with cystic fibrosis associated with the rate of decline in pulmonary function?-A preliminary study. J Health Care Chaplain. 2013; 19:33-42.
  18. Grossoehme DH, VanDyke R, Dimitriou S, Britton LJ, McPhail GL, Seid M. Airway Clearance Adherence: Influence of Parental Spirituality and Depression. Pediatric Pulmonology. 2012; 47:435-435.
  19. Gupta S, Cepeda-Valery B, Romero-Corral A, Shamsuzzaman A, Somers VK, Pressman GS. Association between QRS duration and obstructive sleep apnea. J Clin Sleep Med. 2012; 8:649-54.
  20. Harris WT, Boyd JT, VanDyke R, Fenchel M, Brody A, McPhail GL, Clancy JP. Cf-Related Constrictive Bronchiolitis in Adolescents with Refractory Pulmonary Decline. Pediatric Pulmonology. 2012; 47:357-357.
  21. Jaacks LM, Oza-Frank R, D'Agostino R, Jr., Dolan LM, Dabelea D, Lawrence JM, Pihoker C, O'Connor MR, Linder B, Imperatore G, Seid M, Narayan KM, Mayer-Davis EJ. Migration status in relation to clinical characteristics and barriers to care among youth with diabetes in the US. J Immigr Minor Health. 2012; 14:949-58.
  22. Jacobson CJ, Farrell JE, Kashikar-Zuck S, Seid M, Verkamp E, Dewitt EM. Disclosure and self-report of emotional, social, and physical health in children and adolescents with chronic pain--a qualitative study of PROMIS pediatric measures. J Pediatr Psychol. 2013; 38:82-93.
  23. Jain SV, Horn PS, Simakajornboon N, Glauser TA. Obstructive sleep apnea and primary snoring in children with epilepsy. J Child Neurol. 2013; 28:77-82.
  24. Jain SV, Simakajornboon N, Glauser TA. Provider practices impact adequate diagnosis of sleep disorders in children with epilepsy. J Child Neurol. 2013; 28:589-95.
  25. Khan MS, Fraser CD, Morales DLS, McKenzie ED, Adachi I, Schecter MG, Mallory GB, Heinle JS. Pediatric Thoracic Multiorgan Transplantation in the United States. Journal of Heart and Lung Transplantation. 2013; 32:S151-S151.
  26. Kong M, Peng N, Jackson P, Clancy JP, Blalock E, Gaggar A. Dysregulated Matrix Metalloproteinase-9 Activity and Elevated Proline-Glycine-Proline (Pgp) Levels Are Observed in Pediatric Rsv-Induced Lung Injury. Critical Care Medicine. 2012; 40:U54-U55.
  27. Kotha K, Sun H, Ostmann A, Clancy JP. Nitric Oxide Donors Downregulate Corrected F508del Cftr and Cl- Transport in Human Airway Monolayers. Pediatric Pulmonology. 2012; 47:234-234.
  28. Lawrence JM, Yi-Frazier JP, Black MH, Anderson A, Hood K, Imperatore G, Klingensmith GJ, Naughton M, Mayer-Davis EJ, Seid M, Group SfDiYS. Demographic and clinical correlates of diabetes-related quality of life among youth with type 1 diabetes. J Pediatr. 2012; 161:201-7 e2.
  29. Lemons J, Ragsdale J, Vaughn L, Grossoehme D. "I Didn't Know It Existed Before You Called": Protestant Clergy Experience, Education and Perceptions Regarding Genetics. Journal of Genetic Counseling. 2013; 22:226-237.
  30. Lotstein DS, Seid M, Klingensmith G, Case D, Lawrence JM, Pihoker C, Dabelea D, Mayer-Davis EJ, Gilliam LK, Corathers S, Imperatore G, Dolan L, Anderson A, Bell RA, Waitzfelder B, Group SfDiYS. Transition from pediatric to adult care for youth diagnosed with type 1 diabetes in adolescence. Pediatrics. 2013; 131:e1062-70.
  31. Madala SK, Edukulla R, Davis KR, Schmidt S, Davidson C, Kitzmiller JA, Hardie WD, Korfhagen TR. Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis. Respir Res. 2012; 13:51.
  32. Marcus CL, Moore RH, Rosen CL, Giordani B, Garetz SL, Taylor HG, Mitchell RB, Amin R, Katz ES, Arens R, Paruthi S, Muzumdar H, Gozal D, Thomas NH, Ware J, Beebe D, Snyder K, Elden L, Sprecher RC, Willging P, Jones D, Bent JP, Hoban T, Chervin RD, Ellenberg SS, Redline S, Childhood Adenotonsillectomy T. A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med. 2013; 368:2366-76.
  33. Margolis PA, Peterson LE, Seid M. Collaborative Chronic Care Networks (C3Ns) to Transform Chronic Illness Care. Pediatrics. 2013; 131 Suppl 4:S219-23.
  34. Mayes T, Gottschlich MM, Khoury J, McCall J, Simakajornboon N, Kagan RJ. A pilot review of the long-term impact of burn injury on sleep architecture in children. J Burn Care Res. 2013; 34:e15-21.
  35. McPhail G, Clancy JP. LUMACAFTOR Corrector of CFTR Folding Treatment of Cystic Fibrosis. Drugs of the Future. 2012; 37:717-723.
  36. McPhail GL, Boesch RP, Chini BA, Fenchel M, VanDyke R, Clancy JP. Vitamin D Status Is Associated with Pulmonary Exacerbations in Children with Cystic Fibrosis. Pediatric Pulmonology. 2012; 47:364-364.
  37. McPhail GL, Boesch RP, Chini BA, Weiland J, Hoberman-Martinez A, Fenchel M, VanDyke R, Clancy JP. Improving Rapid Fev1 Decline through Quality Improvement. Pediatric Pulmonology. 2012; 47:389-389.
  38. McPhail GL, Clancy JP. Ivacaftor: the first therapy acting on the primary cause of cystic fibrosis. Drugs Today (Barc). 2013; 49:253-60.
  39. Natarajan N, Jain SV, Chaudhry H, Hallinan BE, Simakajornboon N. Narcolepsy-cataplexy: is streptococcal infection a trigger?. J Clin Sleep Med. 2013; 9:269-70.
  40. Raju SV, Jackson PL, McNicholas CM, Sloane PA, Sabbatini GM, Tang L, Mazur M, Liu B, Clancy JP, Bowen L, Accurso F, Blalock J, Dransfield M, Rowe SM. Deficits in Cftr Activity Can Be Acquired and Transmitted by a Systemic Pathway. Pediatric Pulmonology. 2012; 47:250-250.
  41. Rama JA, Fan LL, Faro A, Elidemir O, Morales DL, Heinle JS, Smith EO, Hazen ML, Moonnumakal SP, Mallory GB, Schecter MG. Lung transplantation for childhood diffuse lung disease. Pediatr Pulmonol. 2013; 48:490-6.
  42. Ratjen F, Durham T, Navratil T, Schaberg A, Accurso FJ, Wainwright C, Barnes M, Moss RB, Group T-SI. Long term effects of denufosol tetrasodium in patients with cystic fibrosis. J Cyst Fibros. 2012; 11:539-49.
  43. Rowe SM, Borowitz DS, Burns JL, Clancy JP, Donaldson SH, Retsch-Bogart G, Sagel SD, Ramsey BW. Progress in cystic fibrosis and the CF Therapeutics Development Network. Thorax. 2012; 67:882-90.
  44. Rutter MM, Collins J, Rose SR, Woo JG, Sucharew H, Sawnani H, Hor KN, Cripe LH, Wong BL. Growth hormone treatment in boys with Duchenne muscular dystrophy and glucocorticoid-induced growth failure. Neuromuscul Disord. 2012; 22:1046-56.
  45. Saqr A, Sun H, Ostmann A, Vandyke R, Fenchel M, Clancy J. Cftr Biomarkers in Human and Murine Colonic Tissue: Similarities and Differences in Ion Transport and Protein Detection. Pediatric Pulmonology. 2012; 47:284-284.
  46. Sun H, Kotha K, Ostmann A, Clancy J. Acquired Cftr and Tmem16a Dysfunction in Vivo Associated with Tgf-Beta Activation. Pediatric Pulmonology. 2012; 47:284-284.
  47. Trapnell BC. Induced sputum biomarkers for monitoring cystic fibrosis lung disease. Am J Respir Crit Care Med. 2012; 186:812-4.
  48. VanDyke R, Clancy JP. Self-Modeling Structure of Intestinal Current Measurements in Patients with Cystic Fibrosis. Pediatric Pulmonology. 2012; 47:314-314.
  49. VanDyke R, McPhail GL, Fenchel M, Clancy JP, Amin R, Seid M. Feasible Statistical Monitoring to Identify Onset of Rapid Fev1 Decline and Facilitate Cystic Fibrosis Care Delivery. Pediatric Pulmonology. 2012; 47:387-387.
  50. Vandyke RD, McPhail GL, Huang B, Fenchel MC, Amin RS, Carle AC, Chini BA, Seid M. Inhaled tobramycin effectively reduces FEV1 decline in cystic fibrosis. An instrumental variables analysis. Ann Am Thorac Soc. 2013; 10:205-12.
  51. Woods JC. Mine the moon for 3He MRI? Not yet. J Appl Physiol. 2013; 114:705-6.
  52. Yuan Y, Yeh LK, Liu H, Yamanaka O, Hardie WD, Kao WW, Liu CY. Targeted overexpression of TGF-α in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling. Invest Ophthalmol Vis Sci. 2013; 54:1829-37.

Faculty, Staff, and Trainees

Faculty Members

Raouf Amin, MD, Professor
Leadership Director, Division of Pulmonary Medicine;; Endowed Chair, Hubert and Dorothy Campbell Professorship in Pediatric Pulmonology
Research Interests Cardiovascular morbidity of sleep apnea in children
Thomas Boat, MD, Professor
Leadership Executive Associate Dean, University of Cincinnati College of Medicine
Ronald Bokulic, DO, Associate Professor
Lisa Burns, MD, Assistant Professor
Research Interests CF Transition of Care;Pulmonary Vascular Disease
Barbara Chini, MD, D-ABSM, FAAP, Associate Professor
Leadership Director, Pulmonary Fellowship Program; Associate Director, Cystic Fibrosis Center; Medical Director, A7C1
Research Interests Sleep Disordered Breathing, Outcomes Research, Self-Management of Chronic diseases
John P. Clancy, MD, Professor
Leadership Thomas Boat Endowed Chair; Director, Clinical and Translational Research
Research Interests Airway and epithelial biology, examining novel targets to treat cystic fibrosis;
Joseph Crisalli, MD, Assistant Professor
Research Interests Pediatric Sleep, Exercise Physiology
Daniel Grossoehme, DMin, BCC, Assistant Professor
Research Interests Religion/ spirituality, adherence, coping, cystic fibrosis
William Hardie, MD, Professor
Leadership Director, Pulmonary Function Laboratory
Research Interests Molecular mechanism of pulmonary fibrosis, pediatric pulmonary function tests, pediatric pneumonia complications
Patricia Joseph, MD, Associate Professor
Research Interests Cystic fibrosis infections and quality improvement
Carolyn Kercsmar, MD, Professor
Leadership Co-Director, Division of Pulmonary Medicine; Director, Asthma Center
Research Interests Asthma, inner city asthma, clinical outcomes and clinical trials, airway inflammation
Satish Madala, PhD, Instructor
Research Interests Immunoregulatory Mechanisms in pulmonary inflammation and fibrosis; Stromal cell contribution in pulmonary fibrosis
Karen McDowell, MD, Associate Professor
Leadership Director, Infant Pulmonary Function Laboratory
Research Interests Asthma self management, utilization of technology for chronic disease management, bronchoscopy and wheezing/asthma, health care effectiveness, outcomes.
Gary McPhail, MD, Assistant Professor
Leadership Director, Cystic Fibrosis Center; Associate Director, Fellowship Training Program
Research Interests Cystic fibrosis, quality improvement, clinical outcomes, pulmonary vascular disease
Hemant Sawnani, MD, Assistant Professor
Research Interests Pulmonary Management of children with Neuromuscular diseases; sleep disordered breathing in Duchenne Muscular Dystrophy; Infant Apnea; Obstructive Sleep Apnea; Outcomes in Sleep Medicine
Marc Schecter, MD, Associate Professor
Leadership Medical Director, Pediatric Lung Transplant Program
Michael Seid, PhD, Professor
Leadership Director, Health Outcomes and Quality of Care Research
Research Interests Health outcomes for children with chronic health conditions, interventions to overcome barriers to care and adherence, clinical behavior and effects on self-management, quality improvement research
Abu Shamsuzzaman, MD, Assistant Professor
Research Interests Sleep and Cardiovascular Diseases
Narong Simakajornboon, MD, Professor
Leadership Director, Sleep Disorders Center; Director, Sleep Medicine Fellowship Program
Research Interests Sleep-disordered breathing in children, sleep apnea, restless legs syndrome, periodic limb movement disorders
Cherie Torres-Silva, MD, Assistant Professor
Research Interests Biomarkers in bronchoalveolar lavage and Pulmonary Outcomes in childhood cancer survivors
Robert Wood, PhD, MD, Professor
Leadership Director, Pulmonary Bronchology Program
Research Interests Airway abnormalities; pulmonary alveolar proteinosis
Jason Woods, Ph.D., Professor
Leadership Director, Pulmonary Imaging Research Center
Research Interests Pulmonary MRI, translational imaging, and image-guided pulmonary interventions

Joint Appointment Faculty Members

Kelly Byars, PsyD, Associate Professor (Psychology)
Research Interests Current research focuses on improving the assessment and treatment of pediatric insomnia and pediatric obstructive sleep apnea
Rhonda Szczesniak, PhD, Assistant Professor (Biostatistics & Epidemiology)
Research Interests Current areas of interest are Mixture Models and Functional Data Analysis with focus on Bayesian statistics, primarily using Markov Chain Monte Carlo. Content-specific areas include integration of fMRI and MEG modalities; developing statistical models to assess impact of OSA; CF outcomes research
Bruce Trapnell, MD, Professor (Neonatology and Pulmonary Biology)

Clinical Staff Members

  • Moutazz Abdulhadi, RPSGT, PSG Tech/RRT III
  • Nick Allen, RN, Nurse Coordinator
  • Rosalynn Allie, RRT, RT I
  • Denetra Bamonte, RRT, RPSGT, PSG Tech III
  • Sallie Bauer, RRT, RPSGT, PSG Tech III
  • Emily Beech, RD, RD
  • Marsha Blount, CNP, Certified Nurse Practitioner
  • Walter Blower, RRT, Resp Therapist III
  • Ginger Browning, RRT, BS, Airway Clearance Specialist
  • Johnny Bryant, RRT, RPSGT, PSG Tech
  • Carolyn Burrows, CNP, Certified Nurse Practitioner
  • Monica Chapman, RN, Care Manager
  • Jessica Co, CNP, Certified Nurse Practitioner
  • Amy Cole, RRT, RPSGT, Clinical Manager
  • Adrienne Conrad, RRT, PSG Tech/RRT
  • Shannon Deidesheimer, RN, Nurse Coordinator
  • Geri Dinkins, RN, Care Manager
  • Melodie Dixon, RRT, RPSGT, PSG Tech III
  • Amanda Dressman, CNP, Certified Nurse Practitioner
  • Lori Duan, RN, Clinical Manager
  • Rebekah Dunning, RRT, RT II
  • Julie Feldstein, RRT, CPFT, RTIII
  • Karla Foster, MS, Exercise Physiologist
  • Janice Gramke, RN, Nurse Coordinator
  • Chuck Grone, RT, RT
  • Neepa Gurbani, DO, Staff Physician
  • Robin Hamilton, RN, Clinical Director
  • Joann Harmeyer, RRT, RPSGT, PSG Tech III
  • Amanda Hatfield, RRT, PSG Tech III
  • Jami Johnson, CNP, Certified Nurse Practitioner
  • Marion Johnson, RRT, PSG Tech II
  • Robin Johnson, RRT, PSG Tech I
  • Shannon Johnson, RN, Clinical Manager
  • Sharon Kadon, RN, Nurse Coordinator
  • Laura Kalb, RN, Nurse Coordinator
  • Michelle Kaiser, RRT, RRT III
  • Amanda Kelly, RRT, PSG Tech
  • Michelle Kleinhenz, RRT, PSG Tech II
  • Beth Koch, RRT, RPFT, Clinical Manager
  • Margaret Landers, RRT, RPSGT, PSG Tech III
  • Denise Leonard, RN, Care Manager
  • Jean Luchini, RN, Nurse Coordinator
  • Julie Malkin, CNP, Nurse Practitioner
  • Janice MacBrair, CNP, Certified Nurse Practitioner
  • Susan McCarthy, RRT, RPSGT, PSG Tech III
  • Connie Meeks, RN, Care Manager
  • Steven Moore, RN, Clinical Coordinator
  • Mohr Alyssa, RN, Nurse Coordinator
  • Karen Murphy, MSW, LISW-S, Social Worker
  • Patricia Norton, RN, Clinical Program Manager
  • Laura Ogilby, RRT, RT II
  • Teresa O'Hara, RN, Care Manager
  • John Pack, RRT, RT III (Bronch)
  • Rebecca Quarles, RN, Care Manager
  • Melissa Rice, CNP, Certified Nurse Practitioner
  • Rachel Sackenheim, MSW, LSW, Social Worker
  • Valerie Sackenheim, RN, Nurse Coordinator
  • Kathy Santoro, RD, LD, RD III
  • Joshua Shannon, RT, RT II
  • Erika Skovmand, RT, PSG Tech II
  • Dianne Stratton, RRT, RT II
  • Jackie Taylor, RD, LD, RD III
  • Jenetta Thomas, RN, Nurse Coordinator
  • Sarah Thomas, CNP, Certified Nurse Practitioner
  • Karin Tiemeyer, RN, Care Manager
  • Aarthi Vemana, M.D., Staff Physician
  • Mark Washam, CNP, Certified Nurse Practitioner
  • Debbie Webster, BA, RRT, RPSGT, RRT II
  • Tonya Weddle, RRT, PSG Tech II
  • Jeanne Weiland, CNP, Certified Nurse Practitioner
  • Erin Wells, RN, Transplant Care Manager
  • Patricia White, , Health Unit Coordinator
  • Kathy Witschger, RRT, RT II
  • Lilianna Wooten, CNP, Certified Nurse Practitioner
  • Brenda Young, RRT, PSG Tech

Trainees

  • Dan Benscoter, DO, PL-7, Geisinger Medial Center
  • Justin Brockbank, MD, PL-5, Virginia Comm. Univ. Medical Center
  • Zarmina Ehsan, MBBS, PL-4, Indiana University
  • Kavitha Kotha, MD, PL-7, Children's Hospital Medical Center Akron
  • Averity Setty, MD, PL-4, Hurley Medical Center
  • Christopher Siracusa, MD, PL-4, Akron Children's Hospital
  • Chee Tan, MD, PL-7, Winthrop University Hospital
  • Colby Wyatt, MD, PhD, PL-5, Cincinnati Children's Hospital Medical Center
  • Daniela Zgherea, MD, PL-6, Maimonides Infants and Children's Hospital

Division Collaboration

Pediatric Surgery; Pediatric Otolaryngology/Head and Neck Surgery; Gastroenterology, Hepatology and Nutrition; Interdisciplinary Feeding Clinic » Richard Azizkhan, MD, Robin Cotton, MD, Alessandro de Alarcon, MD, Thomas Inge, MD, Ajay Kaul, MD, Charles Myer, MD, Philip Putnam, MD, Michael Rutter, MD, Sally Shott, MD, and Paul Willging, MD
Aerodigestive and Sleep Center-Treatment of chronically ill children with complex airway, pulmonary, upper digestive tract, sleep and feeding disorders.
Anesthesia; Cardiology; Endocrinology; Developmental and Behavioral Pediatrics; Gastroenterology, Hepatology and Nutrition; Genetic Counseling; International Health; Neurology; Nutrition Therapy; Orthopaedics; Palliative Care; Pediatric Surgery; Physical Therapy; Rehabilitative Medicine; Social Work » Rebecca Brown, MD, Jim Collins, MD, Linda Cripe, MD, Thomas Inge, MD, Viral Jain, MD, Ajay Kaul, MD, Mary McMahon, MD, Mark Meyer, MD, Susan Rose, MD, Meilan Rutter, MD, Irena Rybalsky, MD, David Schonfield, MD, Robert Spicer, MD, Jeffrey Towbin, MD, Martha Walker, MD, Norbert Weidner, MD, and Brenda Wong, MD
Comprehensive Neuromuscular Center-Treatment of children with neuromuscular disorders.
Allergy and Immunology; General Pediatrics » Amal Assa'ad, MD, Gurjit Hershey, MD, Maria Britto, MD, Thomas DeWitt, MD, Keith Mandel, MD, Mona Mansour, MD, Marc Rothernberg, MD, and Jeffrey Simmons, MD
Asthma Center - Treatment of children and adolescents with asthma; development of an asthma repository.
Molecular Immunology; Pulmonary Biology » John P Clancy, MD, Jeff Whitsett, MD, and Bruce Trapnell, MD
Cystic Fibrosis Research - The Cystic Fibrosis Research Program examines the underlying causes of CF and novel treatment strategies.
Pulmonary Biology » Thomas Korfhagen, MD and Jeffrey Whitsett, MD
Pulmonary Fibrosis Research
Radiology; Pulmonary Biology; ; ; » Alan Brody, MD and Bruce Trapnell, MD
Rare Lung Disease Center - Diagnosis and management of children with rare lung diseases, including interstitial lung disease, surfactant mutations, lung development disorders, lymphatic disorders and chronic lung diseases associated with immunodeficiency/immune dysfunction, rheumatologic disorders and other systemic disorders.
Audiology; Human Genetics; Neurosurgery; Otolaryngology; Pediatric Dentistry; Orthodontics; Plastic Surgery; Behavioral Medicine and Clinical Psychology; Speech Pathology » David Billmire, MD, Richard Campbell, MD, Kerry Crone, MD, Christopher Gordan, MD, William Greenhill, DMD, Ann Kummer, PhD, Francesco Mangano, DO, Jane Middendorf, MA, Cynthia Prows, MSN, Gayle Riemer, MD, Howard Saal, MD, Iris Sageser, RDH, and J Paul Willging, MD
Craniofacial Team
Orthopaedics » Peter Sturm, MD, Viral Jain, MD, and Eric Wall, MD
Spine Center
Neurology; Imaging Research; Behavioral Medicine and Clinical Psychology; Pediatric Otolaryngology/Head and Neck Surgery » Sejal Jain, MD, Kelly Byars, PsyD, DiFrancesco, Mark PhD, Dean Beebe, PhD, Shott, Sally MD, and Ishman, Stacey MD
Sleep Center
The Heart Institute » David Morales, MD
Lung Transplant
Pediatric Otolaryngology/Head and Neck Surgery; Plastic Surgery; Genetics; Developmental and Behavioral Pediatrics; Radiology » Sally Shott, MD, Stacey Ishman, MD, David Billmire, MD, Christopher Gordon, MD, Howard Saal, MD, Sonya Oppenheimer, MD, and Robert Fleck, MD
Upper Airway Center-A multidisciplinary approach to treat children with complex upper airway disorders resulting in sleep apnea.
Endocrinology; Behavioral Medicine and Clinical Psychology; Behavioral Medicine and Clinical Psychology » Deborah Elder, MD, Stepanie Filigno, PhD, and Lori Stark, PhD
Cystic Fibrosis Center
Cardiology » John Jeffries, MD
Cardiomyopathy Clinic
Cardiology » Russell Hirsch, MD
Pulmonary Hypertension Clinic

Grants, Contracts, and Industry Agreements

Pulmonary Medicine Grants

Grant and Contract AwardsAnnual Direct

Amin, R

Passive Stretch of the Chest Wall in Patients with Congenital Muscular Dystrophy
05/03/13-05/02/15$40,000
Pediatric Sleep Research Program
K24 HL 07898903/01/11-02/29/16$139,466

AMIN, R / FLECK, R / GUTMARK, E / SHOTT, S

Dynamic Computational Modeling of Obstructive Sleep Apnea in Down Syndrome
R01 HL10520609/17/10-08/31/14$750,679

Clancy, J

CFF Research Development Program
R457-CR1103/01/12-06/30/15$377,328
Hoebe, KPilot & Feasibility Study$65,000
Szczesniak, RPilot & Feasibility Study$65,000
Hogan, SPilot & Feasibility Study$65,000
Whitsett, JPilot & Feasibility Study$50,000
MR Predictors of Infection, Inflammation, and Structural Lung Damage in CF
R01 HL 11622609/26/12-06/30/16$402,128
Translational Therapeutics Development Center
01/01/09-12/31/13$113,665
CFFT Biomarker Consortium
01/01/11-12/31/2013$23,136

Grossoehme, D

Adherence and Psychosocial Factors Related to Spirituality: Examining Causality to Inform an Intervention
12/01/12-11/30/13$37,940
Parental Adherence to CF Homecare: Research Chaplaincy Career Commitment
K23 HD 06264208/13/10-05/31/15$109,527

Hardie, W

Ruth L. Kirschstein National Research Service Award Short-Term Institutional Research Program
T35 HL 11322905/01/12-04/30/16$50,255
Biomarkers of Immunologic Function and Preterm Respiratory Outcomes
U01 HL 10180005/01/10-04/30/14$55,739

Heubi, J

Baby Observational and Nutritional Supplement (BONUS) Study
12/01/10-04/30/15$35,804

Kotha, K

CFRT Regulation Biomarkers Based on Nitric Oxide
07/01/12-06/30/13$68,250

Madala, S

Role of TGFa-induced Fibrocytes in Pulmonary Fibrosis and Pulmonary Hypertension
12SDG913004001/01/12-12/31/15$70,000

McPhail, G

Cystic Fibrosis Center Program Accreditation And Funding
C090-1207/01/94-06/30/13$113,020

Seid, M

FL3X: An Adaptive Intervention to Improve Outcomes for Youth with Type 1 Diabetes
R34 DK 09778509/17/12-08/31/13$27,071
Multidisciplinary Clinical Research Center
P60 AR 04778408/18/08-07/31/13$139,417

Siracusa, C

First/Second Year Clinical Fellowship Training Grant
07/01/12-06/30/13$48,000

Woods, J

Severe Asthma Research Program
U10 HL 10925702/01/13-05/31/17$5,586

Wyatt, C

First/Second Year Clinical Fellowship Training Grant
07/01/11-06/30/13$49,750
Current Year Direct$2,656,761
Industry Contracts

Amin, R

$44,942

Clancy, J

$12,138
$14,165
$49,545
$21,271
$14,856
$82,555

Simakajornboon, N

$9,000

Trapnell, B

$14,391
$59,470
Current Year Direct Receipts$322,333
Total$2,979,094