2013 Research Annual Report

Section of Neonatology, Perinatal and Pulmonary Biology

Division Details

Division Data Summary

Research and Training Details

Number of Faculty54
Number of Joint Appointment Faculty1
Number of Research Fellows6
Number of Research Students12
Direct Annual Grant Support$8,157,006
Direct Annual Industry Support$285,409
Peer Reviewed Publications126

Clinical Activities and Training

Number of Clinical Staff25
Number of Clinical Fellows12
Number of Other Students2

Division Photo

Section of Neonatology Perinatal and Pulmonary Biology

Row 1: S Bhattacharyya, L Muglia, J Greenberg, S Wert, A Perl, A Nathan K Wedig

Row 2: H Kaplan, B Kamath-Rayne, T Le Cras, S Glasser, M Pavlicev, S Kallapur, T Kalin, J Whitsett, K Wikenheiser-Brokamp, K Melton

Row 3: L Nommsen-Rivers, T Weaver, E Hall, T Korfhagen, T Suzuki, Y Maeda, J Shannon, W Rice, D Sinner, A Jobe, A Morrow, V Kalinichenko, J Bridges

Row 4: L Ward, B Trapnell



Significant Accomplishments

Significant Accomplishments

March of Dimes Prematurity Research Center Ohio Collaboration

The March of Dimes Prematurity Research Center Ohio Collaborative comprises a new transdisciplinary group of investigators aimed at discovering the fundamental causes of preterm birth. It brings together investigators from 20 different disciplines to work together for healthier newborns. We believe this collaborative will become a world leader in research to discover the unknown causes of preterm birth and develop precise ways to prevent it. The March of Dimes has pledged $10 million over five years to fund this initiative. The project brings together Ohio’s leading health research institutions – Cincinnati Children’s Hospital Medical Center (the coordinating site; Dr. Louis Muglia, MD, PhD; Drs. James Greenberg, Jeffrey Whitsett, and SK Dey, Co-Directors) and the University of Cincinnati; the Ohio State University and Nationwide Children’s Hospital; and Case Western Reserve University and University Hospitals / MetroHealth.

National Institutes of Health

New awards were obtained from the NHLBI, including the T32 training grant entitled “Pulmonary and Cardiac Development and Disease” Drs. Jeffrey Whitsett, Bruce Trapnell and Frank McCormack (Co-PIs), a new K12 “Omics of Lung Diseases” Dr. Jeffrey Whitsett (PI), a collaborative project with the Divisions of Biomedical Informatics and the College of Engineering at the University of Cincinnati College of Medicine; and the NHLBI R01 “Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelia” Dr. Jeffrey Whitsett (PI).

Collaborative for Infant Mortality Reduction

The Perinatal Institute facilitated the creation of a regional public/private/governmental collaborative to reduce the infant mortality rate. The collaborative brings together leaders from Hamilton County, the City of Cincinnati, the University of Cincinnati Colleges of Medicine and Nursing, Cincinnati Children’s, all regional hospital maternity providers, and local nonprofit agencies as a collective impact collaborative. The collaborative has a five year, $1.25 million funding commitment based upon an agreement between the Board of Hamilton County Commissioners, UC Health and Drake Center, LLC. Collaborative operations are based at CCHMC. Drs. James M. Greenberg and Elizabeth Kelly provide operational leadership of the Collaborative, along with a newly appointed Director, Mr. Ryan Adcock. County Commissioner Todd Portune and City of Cincinnati Councilmember Wendell Young Co-Chair the Advisory Board created through a memorandum of understanding signed by all parties on June 13, 2013.


Research Highlights

Suhas Kallapur and Alan Jobe

Suhas Kallapur and Alan Jobe in the Perinatal Institute, together with Claire Chougnet in the Division of Cellular and Molecular Immunology, have developed a novel non-human primate model for investigating the effects of intra-uterine inflammation on the developing fetus. Administration of the cytokine interleukin-1 beta to pregnant rhesus macaques resulted in chorioamnionitis and induction of robust lung inflammation in the fetus and preterm newborn. Their findings suggest that boosting regulatory T cells and/or controlling IL-17 may provide a means to prevent or limit the complications for preterm infants exposed to infection or inflammation prior to birth.

Louis Muglia

Louis Muglia and colleagues have identified genes in families with recurrent preterm birth as contributors to the risk of preterm birth in the general population. Whole-exome sequencing was performed on two mother-daughter pairs, and genes harboring rare variants were tested for association with preterm birth in the general population. The complement and coagulation cascade was one of the most enriched pathways in our two mother-daughter pairs, and was confirmed by analysis in six other mothers’ exomes and association analysis in over 500 nuclear families. These results demonstrated the importance of the complement and coagulation cascades in the pathophysiology of preterm birth, and suggest potential screening and intervention approaches to prevent prematurity that target this pathway.

Scott Wexelblatt, Laura Ward, Eric Hall, and James Greenberg

Scott Wexelblatt, Laura Ward, Eric Hall and James Greenberg in the Perinatal Institute, evaluated the value of a universal testing strategy in a community hospital setting to improve diagnostic accuracy and treatment for neonatal abstinence syndrome. They found that universal testing is feasible, cost effective, and does not generate an excessive burden upon social service providers or local government agencies. This strategy identifies newborns, exposed to in-utero narcotics, not identified through standard risk-based screening approaches, who would otherwise be at high risk to develop untreated neonatal abstinence syndrome.


Significant Publications

Balli, D., Ustiyan, V., Zhang, Y., Wang, I.-C., Masino, A.J., Ren, X., Whitsett, J.A., Kalinichenko, V.V., Kalin, T.V.Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchynmal transition. EMBO 2013. J 32, 231-244.
This work was part of Dr. Balli’s Ph.D. graduate thesis in the Molecular and Developmental Biology program. The work demonstrates a critical role of the Foxm1 transcription factor in the pathogenesis of pulmonary fibrosis. Epithelial-to-mesenchymal transition (EMT) was demonstrated during radiation-induced pulmonary fibrosis and the molecular targets of Foxm1 were identified. Inhibition of this pathway provides a novel, potential, therapeutic target for pulmonary fibrosis, a enigmatic disease that remains without effective therapy.
Kamath-Rayne, B.D., DeFranco, E.A., Chung, E., Chen, A., Subtypes of preterm birth and the risk of postneonatal death. J Pediatr 2013. 162, 28-34.
This work demonstrates increased morbidity and mortality in preterm birth, showing risks even at older gestational ages when many clinicians consider that the infants are mature enough to adapt normally after birth. The work emphasizes the risk of “late preterm” birth, and the need to minimize the “iatrogenic” prematurity. This paper examined the differences in post-neonatal death risk among the three most common clinical subtypes of preterm birth: preterm premature rupture of membranes (PROM), indicated preterm birth, and spontaneous preterm labor. The authors found that preterm PROM was associated with significantly higher risk of post-neonatal death compared with spontaneous preterm labor in infants born at 27 weeks gestation or later. Similarly, indicated preterm birth was associated with a significantly higher risk of post-neonatal death than spontaneous preterm labor in infants born at 25 weeks gestation or later. Thus, different etiologies for preterm birth carry different risks of post-neonatal mortality and suggest preventative measures may be different amongst these groups.
Kenny, A.P., A., R.S., Allbee, A.W., Prewitt, A.R., Zhang, Z., Tabangin, M.E., Shifley, E.T., Louza, M.P., Zorn, A.M., Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. Dev Cell 2012. 23, 292-304.
This work utilizes Xenopus (the frog) to identify the genes and processes involved in the induction of foregut from which critical organs, including thyroid, liver, lung, stomach, and pancreas are formed. The work identifies a new role for Sizzled and Tolloid in the formation of foregut organs relevant to common birth defects affecting newborn infants.
Korfhagen, T.R., Kitzmiller, J., Chen, G., Sridharan, A., Haitchi, H.M., Hegde, R.S., Divanovic, S., Karp, C.L., Whitsett, J.A., SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia. Proc Natl Acad Sci. 2012 109, 16630-16635.
This work identifies a critical role of the transcription factor SPDEF in mucous metaplasia and host defense in the airway. SPDEF is induced in asthma, cystic fibrosis, and chronic obstructive lung diseases where it is required for mucus hyperproduction. SPDEF was shown to inhibit cellular responses to infection, providing a molecular mechanism by which patients with these disorders are susceptible to viral and bacterial infections. The work provides a potential therapeutic target for treatment of these diseases.
Ren, X., Shah, T.A., Ustiyan, V., Zhang, Y., Shinn, J., Chen, G., Whitsett, J.A., Kalin, T.V., Kalinichenko, V.V.FOXM1 Promotes Allergen-Induced Goblet Cell Metaplasia and Pulmonary Inflammation. Mol Cell Biol 2013 33, 371-386.
This work demonstrates a novel role for Foxm1 in the pathogenesis of inflammation and mucus hyperproduction related to asthma. Foxm1 was shown to be induced during allergy and to enhance goblet cell differentiation by regulating a number of genes controlling mucus production. Inhibition of the Foxm1 pathway provides a potential therapeutic strategy for asthma and other common lung diseases complicated by mucus hyperproduction and infection.

Division Publications

Section of Neonatology, Perinatal and Pulmonary Biology Publications

  1. Albert RK, Jobe A. Gas exchange in the respiratory distress syndromes. Compr Physiol. 2012; 2:1585-617.
  2. Althabe F, Belizán JM, Mazzoni A, Berrueta M, Hemingway-Foday J, Koso-Thomas M, McClure E, Chomba E, Garces A, Goudar S, Kodkany B, Saleem S, Pasha O, Patel A, Esamai F, Carlo WA, Krebs NF, Derman RJ, Goldenberg RL, Hibberd P, Liechty EA, Wright LL, Bergel EF, Jobe AH, Buekens P. Antenatal corticosteroids trial in preterm births to increase neonatal survival in developing countries: study protocol. Reprod Health. 2012; 9:22.
  3. Ambalavanan N, Carlo WA, McDonald SA, Das A, Schendel DE, Thorsen P, Hougaard DM, Skogstrand K, Higgins RD, Cytokine, Generic Database Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health Human Development Neonatal Research N. Cytokines and posthemorrhagic ventricular dilation in premature infants. Am J Perinatol. 2012; 29:731-40.
  4. Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am. 2013; 60:49-74.
  5. Balli D, Ren X, Chou FS, Cross E, Zhang Y, Kalinichenko VV, Kalin TV. Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation. Oncogene. 2012; 31:3875-88.
  6. Balli D, Ustiyan V, Zhang Y, Wang IC, Masino AJ, Ren X, Whitsett JA, Kalinichenko VV, Kalin TV. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J. 2013; 32:231-44.
  7. Bancalari EH, Jobe AH. Reply to Been et al. J Pediatr. 2013; 162:657-8.
  8. Bancalari EH, Jobe AH. Reply to Hjalmarson and Sandberg. J Pediatr. 2013; 162:656-7.
  9. Bancalari EH, Jobe AH. The respiratory course of extremely preterm infants: a dilemma for diagnosis and terminology. J Pediatr. 2012; 161:585-8.
  10. Batton B, Li L, Newman NS, Das A, Watterberg KL, Yoder BA, Faix RG, Laughon MM, Stoll BJ, Van Meurs KP, Carlo WA, Poindexter BB, Bell EF, Sánchez PJ, Ehrenkranz RA, Goldberg RN, Laptook AR, Kennedy KA, Frantz ID 3rd, Shankaran S, Schibler K, Higgins RD, Walsh MC, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Use of antihypotensive therapies in extremely preterm infants. Pediatrics. 2013; 131:e1865-73.
  11. Belizán JM, McClure EM, Goudar SS, Pasha O, Esamai F, Patel A, Chomba E, Garces A, Wright LL, Koso-Thomas M, Moore J, Althabe F, Kodkany BS, Sami N, Manasyan A, Derman RJ, Liechty EA, Hibberd P, Carlo WA, Hambidge KM, Buekens P, Jobe AH, Goldenberg RL. Neonatal death in low- to middle-income countries: a global network study. Am J Perinatol. 2012; 29:649-56.
  12. Bell SM, Zhang L, Xu Y, Besnard V, Wert SE, Shroyer N, Whitsett JA. Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013; 375:128-39.
  13. Bhattacharya S, Go D, Krenitsky DL, Huyck HL, Solleti SK, Lunger VA, Metlay L, Srisuma S, Wert SE, Mariani TJ, Pryhuber GS. Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2012; 186:349-58.
  14. Bliss JM, Wong AY, Bhak G, Laforce-Nesbitt SS, Taylor S, Tan S, Stoll BJ, Higgins RD, Shankaran S, Benjamin DK Jr, Candida Subcommittee of the Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Candida virulence properties and adverse clinical outcomes in neonatal candidiasis. J Pediatr. 2012; 161:441-447 e2.
  15. Boghossian NS, Page GP, Bell EF, Stoll BJ, Murray JC, Cotten CM, Shankaran S, Walsh MC, Laptook AR, Newman NS, Hale EC, McDonald SA, Das A, Higgins RD, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Late-onset sepsis in very low birth weight infants from singleton and multiple-gestation births. J Pediatr. 2013; 162:1120-4, 1124 e1.
  16. Bolte C, Zhang Y, York A, Kalin TV, Schultz Jel J, Molkentin JD, Kalinichenko VV. Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling. PLoS One. 2012; 7:e48713.
  17. Bream EN, Leppellere CR, Cooper ME, Dagle JM, Merrill DC, Christensen K, Simhan HN, Fong CT, Hallman M, Muglia LJ, Marazita ML, Murray JC. Candidate gene linkage approach to identify DNA variants that predispose to preterm birth. Pediatr Res. 2013; 73:135-41.
  18. Burt RS, Meltzer DO, Seid M, Borgert A, Chung JW, Colletti RB, Dellal G, Kahn SA, Kaplan HC, Peterson LE, Margolis P. What's in a name generator? Choosing the right name generators for social network surveys in healthcare quality and safety research. BMJ Qual Saf. 2012; 21:992-1000.
  19. Campo I, Mariani F, Rodi G, Paracchini E, Tsana E, Piloni D, Nobili I, Kadija Z, Corsico A, Cerveri I, Chalk C, Trapnell BC, Braschi A, Tinelli C, Luisetti M. Assessment and management of pulmonary alveolar proteinosis in a reference center. Orphanet J Rare Dis. 2013; 8:40.
  20. Chen L, Acciani T, Le Cras T, Lutzko C, Perl AK. Dynamic regulation of platelet-derived growth factor receptor alpha expression in alveolar fibroblasts during realveolarization. Am J Respir Cell Mol Biol. 2012; 47:517-27.
  21. Chinta R, Rao MB, Narendran V, Malla G, Joshi H. Economic recession and headache-related hospital admissions. Hosp Top. 2013; 91:37-42.
  22. Collins JJ, Kallapur SG, Knox CL, Kemp MW, Kuypers E, Zimmermann LJ, Newnham JP, Jobe AH, Kramer BW. Repeated Intrauterine Exposures to Inflammatory Stimuli Attenuated Transforming Growth Factor-β Signaling in the Ovine Fetal Lung. Neonatology. 2013; 104:49-55.
  23. Collins JJ, Kunzmann S, Kuypers E, Kemp MW, Speer CP, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Antenatal glucocorticoids counteract LPS changes in TGF-β pathway and caveolin-1 in ovine fetal lung. Am J Physiol Lung Cell Mol Physiol. 2013; 304:L438-44.
  24. Collins JJ, Kuypers E, Nitsos I, Jane Pillow J, Polglase GR, Kemp MW, Newnham JP, Cleutjens JP, Frints SG, Kallapur SG, Jobe AH, Kramer BW. LPS-induced chorioamnionitis and antenatal corticosteroids modulate Shh signaling in the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol. 2012; 303:L778-87.
  25. Cordero L, Valentine CJ, Samuels P, Giannone PJ, Nankervis CA. Breastfeeding in women with severe preeclampsia. Breastfeed Med. 2012; 7:457-63.
  26. De Jesus LC, Pappas A, Shankaran S, Kendrick D, Das A, Higgins RD, Bell EF, Stoll BJ, Laptook AR, Walsh MC, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants. J Pediatr. 2012; 161:70-4 e1-2.
  27. de Onis M, Onyango A, Borghi E, Siyam A, Blössner M, Lutter C, Group WHOMGRS. Worldwide implementation of the WHO Child Growth Standards. Public Health Nutr. 2012; 15:1603-10.
  28. Defranco EA, Valent AM, Newman T, Regan J, Smith J, Muglia LJ. Adjunctive therapies to cerclage for the prevention of preterm birth: a systematic review. Obstet Gynecol Int. 2013; 2013:528158.
  29. Delfosse NM, Ward L, Lagomarcino AJ, Auer C, Smith C, Meinzen-Derr J, Valentine C, Schibler KR, Morrow AL. Donor human milk largely replaces formula-feeding of preterm infants in two urban hospitals. J Perinatol. 2013; 33:446-51.
  30. Derbise A, Pierre F, Merchez M, Pradel E, Laouami S, Ricard I, Sirard JC, Fritz J, Lemaître N, Akinbi H, Boneca IG, Sebbane F. Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response. J Infect Dis. 2013; 207:1535-43.
  31. Donovan EF, Sparling K, Lake MR, Narendran V, Schibler K, Haberman B, Rose B, Meinzen-Derr J, Ohio Perinatal Quality C. The investment case for preventing NICU-associated infections. Am J Perinatol. 2013; 30:179-84.
  32. Downes KJ, Narendran V, Meinzen-Derr J, McClanahan S, Akinbi HT. The lost art of intubation: assessing opportunities for residents to perform neonatal intubation. J Perinatol. 2012; 32:927-32.
  33. Fairbrother G, Donauer S, Staat MA, Broder K, Salisbury S, Morrow AL, Tabangin ME, Altaye M, Holloway M, Schwartz B. Cincinnati pediatricians' measured and reported immunizing behavior for children during the national shortages of pneumococcal conjugate vaccine. Vaccine. 2013; 31:2177-83.
  34. Falah N, McElroy J, Snegovskikh V, Lockwood CJ, Norwitz E, Murray JC, Kuczynski E, Menon R, Teramo K, Muglia LJ, Morgan T. Investigation of genetic risk factors for chronic adult diseases for association with preterm birth. Hum Genet. 2013; 132:57-67.
  35. Gao X, McMahon RJ, Woo JG, Davidson BS, Morrow AL, Zhang Q. Temporal changes in milk proteomes reveal developing milk functions. J Proteome Res. 2012; 11:3897-907.
  36. Glasser SW, Senft AP, Maxfield MD, Ruetschilling TL, Baatz JE, Page K, Korfhagen TR. Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury. Respir Res. 2013; 14:19.
  37. Goudar SS, Carlo WA, McClure EM, Pasha O, Patel A, Esamai F, Chomba E, Garces A, Althabe F, Kodkany B, Sami N, Derman RJ, Hibberd PL, Liechty EA, Krebs NF, Hambidge KM, Buekens P, Moore J, Wallace D, Jobe AH, Koso-Thomas M, Wright LL, Goldenberg RL. The Maternal and Newborn Health Registry Study of the Global Network for Women's and Children's Health Research. Int J Gynaecol Obstet. 2012; 118:190-3.
  38. Goyal NK, Zubizarreta JR, Small DS, Lorch SA. Length of stay and readmission among late preterm infants: an instrumental variable approach. Hospital Pediatrics. 2013; 3:7-15.
  39. Greenberg RG, Benjamin DK Jr, Gantz MG, Cotten CM, Stoll BJ, Walsh MC, Sánchez PJ, Shankaran S, Das A, Higgins RD, Miller NA, Auten KJ, Walsh TJ, Laptook AR, Carlo WA, Kennedy KA, Finer NN, Duara S, Schibler K, Ehrenkranz RA, Van Meurs KP, Frantz ID 3rd, Phelps DL, Poindexter BB, Bell EF, O'Shea TM, Watterberg KL, Goldberg RN, Smith PB, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Empiric antifungal therapy and outcomes in extremely low birth weight infants with invasive candidiasis. J Pediatr. 2012; 161:264-9 e2.
  40. Grzenda A, Shannon J, Fisher J, Arkovitz MS. Timing and expression of the angiopoietin-1-Tie-2 pathway in murine lung development and congenital diaphragmatic hernia. Dis Model Mech. 2013; 6:106-14.
  41. Gupta N, Aragaki A, Wikenheiser-Brokamp KA, Benzaquen S, Panos RJ. Occam's razor or Hickam's dictum?. J Bronchology Interv Pulmonol. 2012; 19:216-9.
  42. Hall ES. Support of Perinatal and Neonatal Research. In: JJ Hutton, ed. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research.. New York: Springer; 2012:211-229.
  43. Hall ES, South AP, Jones DE, Meinzen-Derr J, Huo S, Liu L, Greenberg JM. Spatial analysis in support of community health intervention strategies. AMIA Annu Symp Proc. 2012; 2012:311-20.
  44. Hill CD, Jadcherla SR. Esophageal mechanosensitive mechanisms are impaired in neonates with hypoxic-ischemic encephalopathy. J Pediatr. 2013; 162:976-82.
  45. Hillman NH, Kallapur SG, Jobe AH. Physiology of transition from intrauterine to extrauterine life. Clin Perinatol. 2012; 39:769-83.
  46. Hillman NH, Moss TJ, Nitsos I, Jobe AH. Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep. Pediatr Res. 2012; 72:593-9.
  47. Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI. The fanconi anemia pathway limits human papillomavirus replication. J Virol. 2012; 86:8131-8.
  48. Im SK, Jeong H, Jeong HW, Kim KT, Hwang D, Ikegami M, Kong YY. Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. PLoS One. 2013; 8:e58511.
  49. Isemann B, Sorrels R, Akinbi H. Effect of heparin and other factors associated with complications of peripherally inserted central venous catheters in neonates. J Perinatol. 2012; 32:856-60.
  50. Jadcherla SR, Chan CY, Moore R, Malkar M, Timan CJ, Valentine CJ. Impact of feeding strategies on the frequency and clearance of acid and nonacid gastroesophageal reflux events in dysphagic neonates. JPEN J Parenter Enteral Nutr. 2012; 36:449-55.
  51. Jobe AH. 50 Years ago in The Journal of Pediatrics: Respiratory distress syndrome of newborn infants: I. Diagnosis and incidence Miller H. J Pediatr 1962;61:2-8. Respiratory Distress Syndrome of Newborn Infants: II. Clinical Study of Pathogenesis Miller H. J Pediatr 1962;61:9-16. J Pediatr. 2012; 161:93.
  52. Jobe AH. Effects of chorioamnionitis on the fetal lung. Clin Perinatol. 2012; 39:441-57.
  53. Jurickova I, Collins MH, Chalk C, Seese A, Bezold R, Lake K, von Allmen D, Frischer JS, Falcone RA, Trapnell BC, Denson LA. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. Clin Exp Immunol. 2013; 172:455-65.
  54. Kallapur SG, Kramer BW, Jobe AH. Ureaplasma and BPD. Semin Perinatol. 2013; 37:94-101.
  55. Kamath-Rayne BD, DeFranco EA, Chung E, Chen A. Subtypes of preterm birth and the risk of postneonatal death. J Pediatr. 2013; 162:28-34 e2.
  56. Kamath-Rayne BD, Saal H, Lang S, Habli M. Recurrent severe oligohydramnios and fetal pulmonary hypoplasia associated with ErbB4 mutation. Obstet Gynecol. 2013; 121:499-501.
  57. Karjalainen MK, Huusko JM, Ulvila J, Sotkasiira J, Luukkonen A, Teramo K, Plunkett J, Anttila V, Palotie A, Haataja R, Muglia LJ, Hallman M. A potential novel spontaneous preterm birth gene, AR, identified by linkage and association analysis of X chromosomal markers. PLoS One. 2012; 7:e51378.
  58. Kavaliers M, Clipperton-Allen A, Cragg CL, Gustafsson JA, Korach KS, Muglia L, Choleris E. Male risk taking, female odors, and the role of estrogen receptors. Physiol Behav. 2012; 107:751-61.
  59. Kemp MW, Kannan PS, Saito M, Newnham JP, Cox T, Jobe AH, Kramer BW, Kallapur SG. Selective Exposure of the Fetal Lung and Skin/Amnion (but Not Gastro-Intestinal Tract) to LPS Elicits Acute Systemic Inflammation in Fetal Sheep. PLoS One. 2013; 8:e63355.
  60. Kenny AP, Rankin SA, Allbee AW, Prewitt AR, Zhang Z, Tabangin ME, Shifley ET, Louza MP, Zorn AM. Sizzled-tolloid interactions maintain foregut progenitors by regulating fibronectin-dependent BMP signaling. Dev Cell. 2012; 23:292-304.
  61. Kocalis HE, Turney MK, Printz RL, Laryea GN, Muglia LJ, Davies SS, Stanwood GD, McGuinness OP, Niswender KD. Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity. PLoS One. 2012; 7:e42981.
  62. Korfhagen TR, Kitzmiller J, Chen G, Sridharan A, Haitchi HM, Hegde RS, Divanovic S, Karp CL, Whitsett JA. SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia. Proc Natl Acad Sci U S A. 2012; 109:16630-5.
  63. Lambermont VA, Been JV, Kunzmann S, Vanterpool SF, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Sex differences in lung gas volumes after lipopolysaccharide-induced chorioamnionitis in fetal sheep. Gend Med. 2012; 9:278-86.
  64. Laryea G, Arnett MG, Muglia LJ. Behavioral Studies and Genetic Alterations in Corticotropin-Releasing Hormone (CRH) Neurocircuitry: Insights into Human Psychiatric Disorders. Behav Sci (Basel). 2012; 2:135-171.
  65. Laryea G, Arnett MG, Wieczorek L, Muglia LJ. Site-specific modulation of brain glucocorticoid receptor and corticotropin-releasing hormone expression using lentiviral vectors. Mol Cell Endocrinol. 2013; 371:160-5.
  66. Lee GB, Brandt EB, Xiao C, Gibson AM, Le Cras TD, Brown LA, Fitzpatrick AM, Khurana Hershey GK. Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma. PLoS One. 2013; 8:e60632.
  67. Lutter CK, Morrow AL. Protection, promotion, and support and global trends in breastfeeding. Adv Nutr. 2013; 4:213-9.
  68. Maeda Y, Tsuchiya T, Hao H, Tompkins DH, Xu Y, Mucenski ML, Du L, Keiser AR, Fukazawa T, Naomoto Y, Nagayasu T, Whitsett JA. Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung. J Clin Invest. 2012; 122:4388-400.
  69. Martin MA, Lassek WD, Gaulin SJ, Evans RW, Woo JG, Geraghty SR, Davidson BS, Morrow AL, Kaplan HS, Gurven MD. Fatty acid composition in the mature milk of Bolivian forager-horticulturalists: controlled comparisons with a US sample. Matern Child Nutr. 2012; 8:404-18.
  70. McClure EM, Rouse DJ, Macguire ER, Jones B, Griffin JB, Jobe AH, Kamath-Rayne BD, Shaffer C, Goldenberg RL. The MANDATE model for evaluating interventions to reduce postpartum hemorrhage. Int J Gynaecol Obstet. 2013; 121:5-9.
  71. McGregor TL, Van Driest SL, Brothers KB, Bowton EA, Muglia LJ, Roden DM. Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: pediatric BioVU. Clin Pharmacol Ther. 2013; 93:204-11.
  72. Meraj R, Wikenheiser-Brokamp KA, Young LR, Byrnes S, McCormack FX. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Front Med. 2012; 6:395-405.
  73. Meraj R, Wikenheiser-Brokamp KA, Young LR, McCormack FX. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Semin Respir Crit Care Med. 2012; 33:486-97.
  74. Merhar SL, Kline-Fath BM, Meinzen-Derr J, Schibler KR, Leach JL. Fetal and postnatal brain MRI in premature infants with twin-twin transfusion syndrome. J Perinatol. 2013; 33:112-8.
  75. Metzakopian E, Lin W, Salmon-Divon M, Dvinge H, Andersson E, Ericson J, Perlmann T, Whitsett JA, Bertone P, Ang SL. Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012; 139:2625-34.
  76. Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013; 10:S12-6.
  77. Morrow AL, Chantry CJ. Pediatric Clinics of North America. Breastfeeding updates for the pediatrician. Preface. Pediatr Clin North Am. 2013; 60:xv-xvii.
  78. Morrow AL, Lutter CK. Strategic global approaches to improve breastfeeding rates. Adv Nutr. 2012; 3:829-30.
  79. Mushaben EM, Brandt EB, Hershey GK, Le Cras TD. Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma. PLoS One. 2013; 8:e54426.
  80. Natarajan G, Pappas A, Shankaran S, Laptook AR, Walsh M, McDonald SA, Ehrenkranz RA, Tyson JE, Goldberg RN, Bara R, Higgins RD, Das A, Munoz B. Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial. Pediatr Res. 2012; 72:414-9.
  81. Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012; 17:167-88.
  82. Newman JE, Bann CM, Vohr BR, Dusick AM, Higgins RD, Follow-Up Study Group of Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Improving the Neonatal Research Network annual certification for neurologic examination of the 18-22 month child. J Pediatr. 2012; 161:1041-6.
  83. Nommsen-Rivers LA. 50 years ago in the Journal of Pediatrics: breast-feeding, weaning, and acculturation. J Pediatr. 2013; 162:807.
  84. Payne AH, Hintz SR, Hibbs AM, Walsh MC, Vohr BR, Bann CM, Wilson-Costello DE, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. JAMA Pediatr. 2013; 167:451-9.
  85. Privette Vinnedge LM, Ho SM, Wikenheiser-Brokamp KA, Wells SI. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS One. 2012; 7:e46985.
  86. Ren X, Shah TA, Ustiyan V, Zhang Y, Shinn J, Chen G, Whitsett JA, Kalin TV, Kalinichenko VV. FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Mol Cell Biol. 2013; 33:371-86.
  87. Robinson JW, Dando SJ, Nitsos I, Newnham J, Polglase GR, Kallapur SG, Pillow JJ, Kramer BW, Jobe AH, Payton D, Knox CL. Ureaplasma parvum serovar 3 multiple banded antigen size variation after chronic intra-amniotic infection/colonization. PLoS One. 2013; 8:e62746.
  88. Rogers LK, Valentine CJ, Keim SA. DHA supplementation: current implications in pregnancy and childhood. Pharmacol Res. 2013; 70:13-9.
  89. Sato A, Ikegami M. SP-B and SP-C containing new synthetic surfactant for treatment of extremely immature lamb lung. PLoS One. 2012; 7:e39392.
  90. Sato A, Xu Y, Whitsett JA, Ikegami M. CCAAT/enhancer binding protein-alpha regulates the protease/antiprotease balance required for bronchiolar epithelium regeneration. Am J Respir Cell Mol Biol. 2012; 47:454-63.
  91. Sato A, Yamada N, Ogawa Y, Ikegami M. CCAAT/enhancer-binding protein-alpha suppresses lung tumor development in mice through the p38alpha MAP kinase pathway. PLoS One. 2013; 8:e57013.
  92. Schug TT, Erlebacher A, Leibowitz S, Ma L, Muglia LJ, Rando OJ, Rogers JM, Romero R, vom Saal FS, Wise DL. Fetal programming and environmental exposures: implications for prenatal care and preterm birth. Ann N Y Acad Sci. 2012; 1276:37-46.
  93. Sengupta A, Kalinichenko VV, Yutzey KE. FoxO1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell-cycle withdrawal and IGF1 gene regulation. Circ Res. 2013; 112:267-77.
  94. Shah TA, Meinzen-Derr J, Gratton T, Steichen J, Donovan EF, Yolton K, Alexander B, Narendran V, Schibler KR. Hospital and neurodevelopmental outcomes of extremely low-birth-weight infants with necrotizing enterocolitis and spontaneous intestinal perforation. J Perinatol. 2012; 32:552-8.
  95. Shankaran S, Barnes PD, Hintz SR, Laptook AR, Zaterka-Baxter KM, McDonald SA, Ehrenkranz RA, Walsh MC, Tyson JE, Donovan EF, Goldberg RN, Bara R, Das A, Finer NN, Sánchez PJ, Poindexter BB, Van Meurs KP, Carlo WA, Stoll BJ, Duara S, Guillet R, Higgins RD, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2012; 97:F398-404.
  96. Shifley ET, Kenny AP, Rankin SA, Zorn AM. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Dev Biol. 2012; 12:27.
  97. Snyder CC, Wolfe KB, Gisslen T, Knox CL, Kemp MW, Kramer BW, Newnham JP, Jobe AH, Kallapur SG. Modulation of lipopolysaccharide-induced chorioamnionitis by Ureaplasma parvum in sheep. Am J Obstet Gynecol. 2013; 208:399 e1-8.
  98. Squires RH, Duggan C, Teitelbaum DH, Wales PW, Balint J, Venick R, Rhee S, Sudan D, Mercer D, Martinez JA, Carter BA, Soden J, Horslen S, Rudolph JA, Kocoshis S, Superina R, Lawlor S, Haller T, Kurs-Lasky M, Belle SH, Pediatric Intestinal Failure C. Natural history of pediatric intestinal failure: initial report from the Pediatric Intestinal Failure Consortium. J Pediatr. 2012; 161:723-8 e2.
  99. Stewart GA, Ridsdale R, Martin EP, Na CL, Xu Y, Mandapaka K, Weaver TE. 4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-C. Am J Respir Cell Mol Biol. 2012; 47:324-31.
  100. Sun Y, Wilkinson BJ, Standiford TJ, Akinbi HT, O'Riordan MX. Fatty acids regulate stress resistance and virulence factor production for Listeria monocytogenes. J Bacteriol. 2012; 194:5274-84.
  101. Taniguchi Ishikawa E, Chang KH, Nayak R, Olsson HA, Ficker AM, Dunn SK, Madhu MN, Sengupta A, Whitsett JA, Grimes HL, Cancelas JA. Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking. Nat Commun. 2013; 4:1660.
  102. Tkach JA, Hillman NH, Jobe AH, Loew W, Pratt RG, Daniels BR, Kallapur SG, Kline-Fath BM, Merhar SL, Giaquinto RO, Winter PM, Li Y, Ikegami M, Whitsett JA, Dumoulin CL. An MRI system for imaging neonates in the NICU: initial feasibility study. Pediatr Radiol. 2012; 42:1347-56.
  103. Trapnell BC. Induced sputum biomarkers for monitoring cystic fibrosis lung disease. Am J Respir Crit Care Med. 2012; 186:812-4.
  104. Tyson JE, Pedroza C, Langer J, Green C, Morris B, Stevenson D, Van Meurs KP, Oh W, Phelps D, O'Shea M, McDavid GE, Grisby C, Higgins R, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Does aggressive phototherapy increase mortality while decreasing profound impairment among the smallest and sickest newborns?. J Perinatol. 2012; 32:677-84.
  105. Ustiyan V, Wert SE, Ikegami M, Wang IC, Kalin TV, Whitsett JA, Kalinichenko VV. Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways. Dev Biol. 2012; 370:198-212.
  106. Valentine CJ, Morrow G, Pennell M, Morrow AL, Hodge A, Haban-Bartz A, Collins K, Rogers LK. Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. Human milk donors. Breastfeed Med. 2013; 8:86-91.
  107. Valentine CJ, Wagner CL. Nutritional management of the breastfeeding dyad. Pediatr Clin North Am. 2013; 60:261-74.
  108. Vanek VW, Borum P, Buchman A, Fessler TA, Howard L, Jeejeebhoy K, Kochevar M, Shenkin A, Valentine CJ, Novel Nutrient Task Force PM-V, Multi-Trace Element Working G, American Society for P, Enteral Nutrition Board of D. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012; 27:440-91.
  109. Vaucher YE, Peralta-Carcelen M, Finer NN, Carlo WA, Gantz MG, Walsh MC, Laptook AR, Yoder BA, Faix RG, Das A, Schibler K, Rich W, Newman NS, Vohr BR, Yolton K, Heyne RJ, Wilson-Costello DE, Evans PW, Goldstein RF, Acarregui MJ, Adams-Chapman I, Pappas A, Hintz SR, Poindexter B, Dusick AM, McGowan EC, Ehrenkranz RA, Bodnar A, Bauer CR, Fuller J, O'Shea TM, Myers GJ, Higgins RD, Network SSGotEKSNNR. Neurodevelopmental outcomes in the early CPAP and pulse oximetry trial. N Engl J Med. 2012; 367:2495-504.
  110. Visscher MO, Taylor T, Narendran V. Neonatal intensive care practices and the influence on skin condition. J Eur Acad Dermatol Venereol. 2013; 27:486-93.
  111. Vohr BR, Stephens BE, Higgins RD, Bann CM, Hintz SR, Das A, Newman JE, Peralta-Carcelen M, Yolton K, Dusick AM, Evans PW, Goldstein RF, Ehrenkranz RA, Pappas A, Adams-Chapman I, Wilson-Costello DE, Bauer CR, Bodnar A, Heyne RJ, Vaucher YE, Dillard RG, Acarregui MJ, McGowan EC, Myers GJ, Fuller J, Eunice Kennedy Shriver National Institute of Child H, Human Development Neonatal Research N. Are outcomes of extremely preterm infants improving? Impact of Bayley assessment on outcomes. J Pediatr. 2012; 161:222-8 e3.
  112. Wan H, Liu C, Wert SE, Xu W, Liao Y, Zheng Y, Whitsett JA. CDC42 is required for structural patterning of the lung during development. Dev Biol. 2013; 374:46-57.
  113. Wang IC, Snyder J, Zhang Y, Lander J, Nakafuku Y, Lin J, Chen G, Kalin TV, Whitsett JA, Kalinichenko VV. Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Mol Cell Biol. 2012; 32:3838-50.
  114. Ward L, Auer C, Smith C, Schoettker PJ, Pruett R, Shah NY, Kotagal UR. The human milk project: a quality improvement initiative to increase human milk consumption in very low birth weight infants. Breastfeed Med. 2012; 7:234-40.
  115. Ward LP, Tisdale EA, Brady RC. Challenges in caring for the neonate who acquires methicillin-resistant Staphylococcus aureus via vertical transmission. Clin Pediatr (Phila). 2013; 52:468-70.
  116. Whitsett JA. The molecular basis of pulmonary surfactant - lessons from newborn infants. Hamdan Medical Journal. 2012; 5:263-271.
  117. Wiles JR, Vinks AA, Akinbi H. Federal legislation and the advancement of neonatal drug studies. J Pediatr. 2013; 162:12-5.
  118. Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res. 2012; 160:167-77.
  119. Wolfs TG, Kallapur SG, Knox CL, Thuijls G, Nitsos I, Polglase GR, Collins JJ, Kroon E, Spierings J, Shroyer NF, Newnham JP, Jobe AH, Kramer BW. Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner. Mucosal Immunol. 2013; 6:547-56.
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  121. Wu TW, Tabangin M, Kusano R, Ma Y, Ridsdale R, Akinbi H. The utility of serum hepcidin as a biomarker for late-onset neonatal sepsis. J Pediatr. 2013; 162:67-71.
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  125. Zhang L, Saito M, Jobe A, Kallapur SG, Newnham JP, Cox T, Kramer B, Yang H, Kemp MW. Intra-amniotic administration of E coli lipopolysaccharides causes sustained inflammation of the fetal skin in sheep. Reprod Sci. 2012; 19:1181-9.
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Faculty, Staff, and Trainees

Faculty Members

Jeffrey A. Whitsett, MD, Professor
Leadership Co-Director, Perinatal Institute; Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Research Interests Lung Development; Surfactant
Henry T. Akinbi, MD, Associate Professor
Research Interests Neonatal Infections and Blood Transfusions
Sandip Bhattacharyya, MSc, PhD, Assistant Professor
Research Interests Inflammation Immunology, Signal Transduction
Laurel B. Bookman, MD, Assistant Professor
Research Interests Implementation Science, International Health
James P. Bridges, PhD, Instructor
Research Interests Hypoxia Inducible Factors and Downstream Target Genes in Chronic Lung Disease
Tanya E. Cahill, MD, Assistant Professor
Leadership Director, High Risk Infant Follow-Up Program
Research Interests Neonatal Abstinence Syndrome and High Risk Infant Follow-Up
Michael W. Crossman, MD, PhD, Assistant Professor
Research Interests Bioethics
Jay H. Dritz, MD, Assistant Professor
Research Interests Neonatal resuscitation, quality improvement
Stephan W. Glasser, PhD, Associate Professor
Research Interests Gene Regulation in the Lung
Neera K. Goyal, MD, MSHP, Assistant Professor
James M. Greenberg, MD, Professor
Leadership Co-Director, Perinatal Institute; Director, Division of Neonatology
Research Interests Preterm Birth, Community Health, Pulmonary Vascular Development
Beth E. Haberman, MD, Associate Professor
Leadership Medical Director, Cincinnati Children's NICU & Co-Medical Director, Mercy Anderson Hospital Nurseries
Research Interests Infant Follow-up
Eric S. Hall, PhD, Assistant Professor
Research Interests Biomedical Informatics
Crystal D. Hill, MD, Assistant Professor
Research Interests Simulation and motility
Steven B. Hoath, MD, Professor Emeritus
Research Interests Skin Development & Environmental Interactions
Alan H. Jobe, MD, PhD, Professor
Leadership Director, Division of Perinatal Biology
Research Interests Injury and Repair of the Preterm Lung
Beth Ann Johnson, MD, Assistant Professor
Tanya V. Kalin, MD, PhD, Assistant Professor
Research Interests Transcriptional Regulation of Carcinogenesis and Radiation-Induced Lung Fibrosis
Vladimir V. Kalinichenko, MD, PhD, Associate Professor
Research Interests Fox Proteins in Lung Development
Suhas G. Kallapur, MD, Professor
Leadership Director, Neonatology CME
Research Interests Fetal Inflammation/Physiology, Lung Development/Inflammation, BPD, Developmental Immunology
Beena D. Kamath-Rayne, MD, MPH, Assistant Professor
Research Interests Neonatal Outcomes and Public Health; Fetal Lung Maturity; Global Health
Heather C. Kaplan, MD, MSCE, Assistant Professor
Research Interests Health Services Research; Improvement Science
Alan P. Kenny, MD, PhD, Instructor
Research Interests Molecular Development of the Foregut Organs
Paul S. Kingma, MD, PhD, Associate Professor
Research Interests Innate Immune Systems; Cystic Fibrosis; Neonatal Infection
Thomas R. Korfhagen, MD, PhD, Professor
Research Interests Lung Defense
Timothy D. Le Cras, PhD, Associate Professor
Leadership Director of Admissions, Molecular & Developmental Biology Graduate Program
Research Interests Chronic Lung Diseases; Lung Development, Pulmonary Hypertension
Yutaka Maeda, DVM, PhD, Assistant Professor
Research Interests Lung cancer, Asthma
Kristin R. Melton, MD, Associate Professor
Leadership Associate Director, Neonatal-Perinatal Medicine Fellowship Training Program
Research Interests Developmental Biology, Neural Crest Biology
Stephanie L. Merhar, MD, MS, Assistant Professor
Research Interests Neonatal neuroimaging, infant follow up
Nagendra K. Monangi, MD, Assistant Professor
Research Interests Maternal/Infant nutrition and vitamin D in preterm infants
Ardythe L. Morrow, PhD, Professor
Leadership Director, Center for Interdisciplinary Research in Human Milk and Lactation
Research Interests Molecular Epidemiology of Human Milk, Epidemiologic Methods, Prevention of Infectious Disease, Predictive Biomarkers of Neonatal Outcomes
Louis J. Muglia, MD, PhD, Professor
Leadership Co-Director, Perinatal Institute; Division of Neonatology; Director, Center for Prevention of Preterm Birth
Research Interests Genetics of Birth Timing; Neurobiology of the Stress Response
Vivek Narendran, MD, MBA, Professor
Leadership Medical Director, Univ. Hosp. NICU & Newborn Nursery; Medical Director, The Christ Hospital Nursery; Chair, Department of Pediatrics, the University Hospital
Research Interests C-PAP; Business Case for Quality Improvements; Preterm Infant Skin
Amy T. Nathan, MD, Assistant Professor
Leadership Medical Director, TriHealth Nurseries
Research Interests Immunobiology
Laurie A. Nommsen-Rivers, PhD, RD, IBCLC, Assistant Professor
Leadership Co-Chair, Seminar Series in Human Milk and Lactation
Research Interests Human Lactation and Breastfeeding
Anne-Karina T. Perl, PhD, Assistant Professor
Research Interests Alveolar Regeneration and Bronchiolar Injury/Repair
John H. Reuter, MD, PhD, Associate Professor
Leadership Chair, Department of Pediatrics at Bethesda North Hospital Nurseries
Ward R. Rice, MD, PhD, Professor
Leadership Director, Neonatal Fellowship Training Program; Director, Newborn Services, St. Elizabeth Medical Center
Research Interests Lung Development, Surfactant Biology
Jerod M. Rone, MD, Associate Professor
Leadership Medical Director, Kettering Medical Center NICU
Kurt R. Schibler, MD, Associate Professor
Leadership Director, Neonatology Clinical Research Program
Research Interests Neonatal Immunology, Necrotizing Enterocolitis
John M. Shannon, PhD, Professor
Leadership Director of Graduate Studies, Program in Molecular and Developmental Biology
Research Interests Lung Development, Foregut Embryology
Debora I. Sinner, PhD, Instructor
Research Interests Wnt Signaling and Sox Transcription Factors in Lung Development and Disease
Andrew P. South, MD, MPH, Assistant Professor
Research Interests Outcomes and Etiology of Gastroschisis, Epidemiology of Late-Preterm Birth
Jean J. Steichen, MD, Professor Emeritus
Research Interests Infant Follow-up
Takuji Suzuki, MD, PhD., Instructor
Research Interests Lung Immunology
Bruce C. Trapnell, MD, MS, Professor
Leadership Director, Rare Lung Diseases Network; Scientific Director, PAP Foundation; Co-Director, Cystic Fibrosis TDN Center
Research Interests Rare Lung Diseases; GM-CSF, Gene Therapy
Christina J. Valentine, MD, Assistant Professor
Research Interests Maternal and Infant Nutrition to improve perinatal health
Laura Ward, MD, Assistant Professor
Leadership Co-Medical Director, Mercy Anderson Hospital Nurseries
Research Interests Use of Human Milk in the NICU
Timothy E. Weaver, MS, PhD, Professor
Leadership Associate Director, Division of Pulmonary Biology; Co-Director, Molecular and Developmental Biology Program
Research Interests Pathogenesis of Interstitial Lung Diseases
Kathryn E. Wedig, MD, Associate Professor
Leadership Director, High Risk Clinic @ GSH; Medical Director, Mercy Hospital Fairfield
Research Interests Infant Follow-up, Neonatal Abstinence Syndrome
Susan E. Wert, PhD, Associate Professor
Leadership Director, Molecular Morphology Core, Division of Pulmonary Biology
Research Interests Lung Development, Molecular Morphology of the Lung, Ultrastructural Analysis of the Lung, Genetic Surfactant Disorders
Scott L. Wexelblatt, MD, Assistant Professor
Leadership Medical Director, Regional Newborn Services; Co-Medical Director Bethesda North Hospital Nurseries
Research Interests Late Preterm Infant, Quality Improvement
Jonathan R. Wispé, MD, Professor
Research Interests Perinatal Ethics, Theological Studies
Yan Xu, PhD, Associate Professor
Leadership Director, Bioinformatics Microarray Core, Division of Pulmonary Biology
Research Interests Bioinformatics, Systems Biology, Transcriptional Network

Joint Appointment Faculty Members

Kathryn A. Wikenheiser-Brokamp, MD, PhD, Associate Professor (Pathology)
Research Interests Pulmonary Pathology, Pediatric and Adult Lung Diseases

Clinical Staff Members

  • Beth A. Baisden, MD
  • Stephen Bird, MD
  • Mary Burwinkel, MD
  • Thomas Catalanotto, MD
  • Diane Donley, MD
  • Dena Elkeeb, MD
  • Horacio Falciglia, MD
  • Michelle French, MD
  • Angelique Gloster, MD
  • Girish Gowda, MD
  • Pamela Holmes, MD
  • Jill Klein, MD
  • Katie Loudermilk, MD
  • Alisa McGill, MD
  • John Morrison, MD
  • Miriam Peri, MD
  • Ajay Ponkshe, MD
  • Danna Premer, MD
  • John Robinson, MD
  • Deborah Rufner, MD
  • Kelley Shultz, MD
  • Jean Steichen, MD
  • Nicole Tocco, MD
  • Wambui Waruingi, MD
  • Kira Zimmerly, MD

Trainees

  • Thomas Acciani, BS, University of Illinois, Urbana, IL
  • Melinda Arnett, PhD, University of Kansas Medical Center, Kansas City, KS
  • Aria Attia, MS, Georgetown University, Washington, DC
  • Olivia Ballard, BA, Miami University, Oxford, OH
  • David Balli, BA, DePauw University, Greencastle, IN
  • Katie Bezold, BS, Xavier University, Cincinnati, OH
  • Craig Bolte, PhD, University of Cincinnati, Cincinnati, OH
  • Yuqi Cai, PhD, Zhejiang University School of Medicine, Hangzhou, China
  • Gang Chen, MS , PhD, Yangzhou University, Jiangsu, China
  • Xin-Hua Cheng, PhD, Miami University, Oxford, OH
  • Rebecca Currier, BS, Louisiana Tech University, Ruston, LA
  • David Dewar, MD, PL6, Michigan State University, East Lansing, MI
  • Jill Fritz, BS, Miami University, Oxford, OH
  • Logan Fulford, BS, Indiana State University, Terre Haute, IN
  • Chen Gao, BS, Beijing Normal University, Beijing, China
  • Tate Gisslen, MD, PL6, University of Minnesota Medical School, Minneapolis, MN
  • Jennifer Goetz, MD, PL6, University of Louisville School of Medicine, Louisville, KY
  • David Hahn, BS, Northern Kentucky University, Highland Heights, KY
  • Jamie Havrilak, BS, Susquehanna University, Selinsgrove, PA
  • Melissa Landis, MD, PL5, Columbia University School of Medicine, New York, NY
  • Gloria Laryea, BS, University of Maryland, Eastern Shore, Princess Anne, MD
  • Candice Lengyel, MD, PL4, University of Michigan, Ann Arbor, MI
  • Masahiko Murase, MD, PhD, IBCLC, Showa University, Tokyo, Japan
  • Chan-Wook Park, MD, PhD, Seoul National University College of Medicine, Seoul, Korea
  • Priya Rajavelu, PhD, University of Madras, Chennai, Tamil Nadu, India
  • Malia Ray, MD, University of Louisville, Louisville, KY
  • Melissa Rice, MD, PL5, Indiana University School of Medicine, Indianapolis, IN
  • Tony Sallese, BS, University of St. Francis, Joliet, IL
  • Atsuyasu Sato, MD, PhD, Kyoto University, Kyoto, Japan
  • Teresa Seto, MD, PL4, Nationwide Children's Hospital, Columbus, OH
  • Heather Smith, MD, PL5, Miller School of Medicine, Miami, FL
  • Kevin Stutey, MD, PL6, Eastern Virginia Medical School, Norfolk, VA
  • Tayaramma Thatava, PhD, University of Braunschweig - Institute of Technology, Germany
  • Emily Wayman, BS, University of Alabama, Tuscaloosa, AL
  • Emily Wiland, MD, PL4, Rainbow Babies & Children's Hospital, Cleveland, OH
  • Jason Wiles, MD, PL5, University of Louisville School of Medicine, Louisville, KY
  • Tim Wolfs, PhD, Royal Netherlands Academy of Arts and Sciences, The Netherlands
  • Koryse Woodrooffe, MD, PL4, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
  • Giridhar Vummidi Giridhar, PhD, University of Madras, Tamil Nadu, India
  • Hongping Xia, MS, PhD, Fudan University, Shanghai, China

Division Collaboration

Reproductive Sciences; Developmental Biology; Pulmonary Medicine; Biomedical Informatics; Safety - The James A. Anderson Center; Infectious Disease; Human Genetics; Biostatistics and Epidemiology; Cellular and Molecular Immunology; General Pediatrics; Gastroenterology; Radiology; Fetal Care Center; Rheumatology/CAGE; Cancer and Blood Disease Institute » SK Dey, Takiko Daikoku, Christopher Wylie, James Wells, Noah Schroyer, Aaron Zorn, Richard Lang, William Hardie, Imre Solti, Steven Muething, Margaret Hostetter, Ge Zhang, and Maurizio Macaluso
The causes of preterm birth, complications of prematurity and birth defects span the spectrum of divisional interests and approaches at Cincinnati Children’s. To make substantial progress in reducing infant mortality from these causes requires collaborative efforts across many programs. The Perinatal Institute at Cincinnati Children’s provides an organizing center, and driver, for efforts to improve outcomes for infants born prematurely, prevent prematurity, and reduce the incidence of birth defects to synergistically reduce infant mortality in our region. As such, our Institute’s faculty have close collaborations with investigators in multiple divisions within Cincinnati Children’s, the University of Cincinnati, the other leading research institutions in Ohio, and globally in Japan, Germany, Mexico, Argentina, Finland, China, and Australia. For the past three years, the Division has offered a day-long educational seminar series addressing new approaches to patient care and clinical research for visiting faculty neonatologists from China Taiwan, and Southeast Asia.

Grants, Contracts, and Industry Agreements

Section of Neonatology, Perinatal and Pulmonary Biology Grants

Grant and Contract AwardsAnnual Direct

Bridges, J

The Role of HIF2a in Airway Smooth Muscle Remodeling
07/01/11-06/30/13$40,000

Chen, G

The Role of Foxa3 in the Regulation of Mucus Metaplasia and Innate Immunity in the Lung
07/01/12-02/28/13$21,323

Glasser, S

Role of Surfactant Protein-C and Innate Lung Defense
R01 HL 05004608/01/09-07/31/13$247,500

Hillman, N

Lung Injury with Resuscitation in the Preterm
K08 HL 09708508/01/09-02/28/13$63,589

Jobe, A / Chougnet, C (MPI)

Biomarkers of Immunologic Function and Preterm Respiratory Outcomes
U01 HL 10180005/01/10-04/30/14$364,354
Jobe, ACore$171,178
Chougnet, CProject$80,237
Chougnet, CProject$31,216
Kingma, PProject$20,228
Hardie, WProject$55,739
Morrow, AProject$14,011
Data Coordinating Center for the Prematurity and Respiratory Outcomes Program
U01 HL 10179409/20/10-04/30/15$28,079
Jobe, ACapitation$80,542
Initiation and Progression of Preterm Lung Injury with Ventilation
R01 DH 07284208/01/12-05/31/17$202,274

Jobe, A / Kallapur, S

Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease
R01 HL 09706409/24/09-07/31/13$347,743

Kalin, T

Role of Foxm1 in Lung Cancer Microenvironment
R01 CA 14272407/01/10-06/30/15$201,275

Kalinichenko, V

Foxf1 Transcription Factor in Development of Pulmonary Capillaries
R01 HL 08415105/01/11-04/30/15$238,000

Kallapur, S

Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis
R01 HD 05786902/03/09-01/31/14$237,900

Kamath, B

Novel Amniotic Fluid Biomarkers to Predict Fetal Lung Maturity
K12 HD 05195307/01/11-06/30/13$100,000

Kenny, A

Secreted BMP Antagonists in Foregut Organ Development
K08 HL 10566112/08/10-11/30/15$121,300

Kingma, P

Surfactant Protein D in Pulmonary and Systemic Host Defense
K08 HL 08950507/01/08-06/30/13$121,600

LeCras, T / Hershey, G

Impact of Early Life Diesel Exposure on Immune Patterning and Lung Structure/Function
R01 HL 09713509/01/09-07/31/14$332,402
LeCras$131,186
Hershey$201,548

Merhar, S

Functional MRI to Predict Visual, Auditory, and Motor Outcomes in Infants with Brain Injury
08/01/12-07/31/14$9,450
Protein Supplementation in Infants with Brain Injury
06/01/12-05/31/15$6,664

Morrow, A

Novel Genetic and Salivary Glycan Biomarkers for Risk of NEC in ELBW Infants
R01 HD 05914001/15/09-12/31/13$537,158
The Role of Human Milk in Infant Nutrition and Health
P01 HD 01302108/01/09-07/31/14$957,390
MorrowCore A, C & Project 1, 3$504,629
MorrowCore B$177,233
JiangProject 2$115,600
JiangCore D$85,577

Muglia, L

Genetic Analysis of Human Preterm Birth
21-FY11-58301/01/12-02/28/14$177,044
Amygdala Glucocorticoid Receptor Function in Stress
R01 MH 07901001/01/12-12/31/13$236,027

Perl, A

FGF and PDGF Regulate Myofibroblast Differentiation in Alveolar Regeneration
R01 HL 10400307/01/10-06/30/14$247,500

Schibler,K

NICHD Cooperative Multicenter Neonatal Research Network
U10 HD 02785304/01/11-03/31/16$186,953
Schibler, KCapitation$84,882

Shannon, J

LPCAT1 is Essential for Perinatal Lung Function and Survival
R01 HL 09831907/01/10-06/30/14$313,566

Sinner, D

Molecular Mechanisms Underlying Lung Growth and Hypoplasia: Role of Wntless
02/01/12-01/31/14$68,182
Molecular Mechanisms Underlying Upper Airway Patterning and Tracheomalacia
K01 HL 11544708/01/12-07/31/17$104,071

Trapnell, B

Role of GM-CSF in Myeloid Cell Function and Innate Immunity
R01 HL 08545304/01/11-03/31/16$238,000
Cincinnati Center for Clinical and Translational Sciences and Training (Pilot/Collaborative Studies)
UL1 TR 00007704/03/09-03/31/14$23,181

Valentine, C

DHA Attenuates Inflammatory Responses through Altering Rage Signaling
R01 AT 00688009/30/11-06/30/15$17,787

Weaver, T

Role of SFTPC in Pathogenesis of Interstitial Lung Disease
R01 HL 08649212/01/08-11/30/13$292,260
The Role of Autophagy in the Pathogenesis of interstitial Lung Disease
R01 HL 10392308/01/11-06/30/15$333,612

Wexelblatt, S

Neonatal Abstinence Syndrome (NAS) Project
G121307056107/01/12-06/30/13$35,970
Wexelblatt, SCapitation$1,402

Whitsett, J

Airway Progenitor Cell Proliferation and Differentiation During Lung Repair
U01 HL 11096401/01/12-12/31/16$520,096
Pulmonary and Cardiovascular Development Training Grant
T32 HL 00775207/01/09-06/30/14$258,283
Transcriptional Control of Submucosal Gland Formation and Function
R01 HL 10890707/01/11-04/30/15$246,546
Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelia
R01 HL 0955804/15/13-03/31/18$328,882
Cystic Fibrosis Foundation Research Development Program (Core 1)
03/01/12-06/30/15$50,000

Xu, Y

Role of SREBP Network in Surfactant Lipid Homeostasis and Lung Maturation
R01 HL 10543307/01/11-06/30/15$301,045
Current Year Direct$8,157,006
Industry Contracts

Kallapur, S

$19,250

Kingma, P

$13,000

Morrow, A

$8,983
$116,502

Valentine, C

$81,045
$46,629
Current Year Direct Receipts$285,409
Total$8,442,415