Biology of Vascular Disease – Peter Dickie, PhD
Dr. Dickies’ research laboratory was established to explore the underlying cellular defects associated with the development of lymphatic malformations in humans. Several unique lymphatic endothelial cell lines have been established from patient lesions. Indicative of disease-causing potential, these have displayed aberrant behavior in in vitro functional assays and continue to be studied.
Trauma – Richard Falcone, MD
Dr. Falcone received funding from the Ohio Department of Public Safety for his work in trauma epidemiology, education and prevention. Dr. Falcone is the Director of the Trauma and Injury Prevention Program.
Solid Organ Cancers – Jason Frischer, MD
Dr. Frischer is continuing his basic science research to study solid organ cancers by identifying, and then overcoming, the mechanisms by which they become resistant to current therapies. He intends on applying to the National Institute of Health for a K08 in the fall of 2012. Dr. Frischer is the Extracorporeal Membrane Oxygenation Program Director.
Intestinal Rehabilitation – Michael Helmrath, MD
Dr. Helmrath is the Director of Surgical Research. He has expertise in gastrointestinal diseases resulting in intestinal failure. His basic science research is focused on the adaptive response of stem cells following surgical loss of the bowel. Multiple projects in the laboratory are focusing on the expansion of intestinal stem cells and the ability to culture and expand both murine and human intestinal epithelium. These projects are support by the National Institutes of Health. Clinically, he is the surgical director of the intestinal rehabilitation center and is actively involved in establishment of the intestinal failure registry and outcome trials in this patient population.
Bariatric Surgery – Thomas Inge, MD, PhD
Dr. Inge and Dr. Jenkins together direct the Center for Bariatric Research and Innovation. In addition to participation in a long and growing list of collaborative studies, this Center partners with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to lead the national effort to prospectively gather data and publish evidence-based recommendations for use of weight loss surgery in adolescents. The Teen LABS study continues to be funded by the NIDDK, the largest multicenter study to document outcomes of adolescents undergoing weight loss surgery. The Teen-LABS Competitive Renewal Grant was awarded another five years of funding in September 2011 to continue this important research. Dr. Inge is the Surgical Director of the Surgical Weight Loss Program for Teens.
Teen-LABS Data Coordinator Center (DCC) – Todd Jenkins, PhD
Dr. Jenkins and Dr. Buncher together direct the Teen-LABS Data Coordinator Center (DCC) that was awarded 5-year renewal funds in September 2011. The DCC provides data management and statistical expertise, as well as administrative support to the Teen-LABS consortium and ancillary investigations. Dr. Jenkins co-directs the Center for Bariatric Research and Innovation.
Molecular Fetal Therapy – Helen Jones, PhD
Dr. Jones’ research investigates placental function in cases of placental insufficiency with a focus on developing a nanoparticle delivery method for placental treatment. Furthermore, novel observations of placental micropathologies in tissue from HLHS cases has led to further research into the placentas from Hypoplastic Left Heart Syndrome. Her research is funded by a K99/R00 Pathway to Independence Award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
Wound Care Services – Sundeep Keswani, MD
Dr. Keswani is focusing on the molecular mechanisms underlying the fetal regenerative wound healing phenotype. If the goals of the project are realized, his work may yield a wide range of therapeutics for diseases characterized by excessive fibroplasia. His basic science interests in fetal wound healing are closely paired with his clinical practice in fetal surgery, and he is the Surgical Director for the Pediatric Advanced Wound Care Service which opened in January, 2012. His research is funded by a K08 award from the National Institute of Health, and he intends on applying for a R01 in the fall of 2013.
Colorectal Center – Marc Levitt, MD
Dr. Levitt is actively engaged in a quality of life research project, (the FISH study) to assess how patients are doing following their participation in the Bowel Management Program to treat fecal incontinence. Dr. Levitt traveled to Africa to train pediatric surgeons in colorectal techniques. Dr. Levitt is the Director of the Colorectal Center.
Fetal Care Center – Foong-Yen Lim, MD
Dr. Lim has expertise in wound healing and fetal cellular and molecular therapeutics research. He is the Surgical Director of the Fetal Care Center.
Chronic Liver Disease – Jaimie Nathan, MD
Dr. Nathan continues to focus on elucidating the role of gut microbiota in the modulation of liver injury and cholangiopathies. His studies involve a novel mouse model of small bowel bacterial overgrowth, in which a small bowel self-filling blind loop is surgically created. With this model, he is studying the gut-liver axis as it relates to the pathogenesis of a number of cholangiopathies which can progress to end-stage liver disease. Dr. Nathan is Surgical Director of the Intestinal Transplant Program.
Biliary Atresia – Gregory Tiao, MD
Dr. Tiao continues to develop his research in Biliary Atresia through an ongoing R01 project funded by the National Institutes of Health. Dr. Tiao is the Surgical Director of Liver Transplantation and the Director of the Small Bowel Program.
Fetal Care Center – Aimen Shaaban, MD
Dr. Shaaban joined the Division of General Surgery and the Fetal Care Center in September 2012 from the University of Iowa Carver College of Medicine where he served as an associate professor of surgery with tenure and as director of the Laboratory for Fetal Cellular Therapy. He will continue his research interests in the mechanisms of immunologic tolerance to prenatally transplanted stem cells with the long term goal of treating congenital diseases such as immunodeficiency, sickle cell disease, thalassemia and metabolic disorders long before birth. His research is funded by an R01 award from the National Institute of Health which he transferred from the University of Iowa. He is the Director of the Center for Fetal Cellular and Molecular Therapy.