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The Animal Behavioral Core at Cincinnati Children’s collaborated with researchers on projects that led to these recent publications. For more information on collaborating with the Animal Behavioral Core, call us at 513-636-8622.
Sun, Y., Zamzow, M., Ran, H., Zhang, W., Quinn, B., Barnes, S., Witte, D.P., Setchell, K.D.R., Williams, M.T., Vorhees, C.V., and Grabowski, G.A. Tissue-specific effects of saposin A and saposin B on glycosphingolipid degradation in mutant mice. Hum. Mol. Genet., 22, 2435-2450. 2013.
Mayes, D.A., Rizvi, T.A., Titus-Mitchell, H., Oberst, R., Ciraolo, G.M., Vorhees, C.V., Robinson, A.P., Miller, S.D., Cancelas, J.A., Stemmer-Rachamimov, A.O., and Ratner, N. Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature. Cell Reports, 4, 1197-1212. 2013.
Ehrman, L.A., Mu, X., Waclaw, R.R., Yoshida, Y., Vorhees, C.V., Klein, W.H., and Campbell, K. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proceedings of the National Academy of Sciences, 110, E4026-4035. 2013.
Chen, Y, Curran, C.P., Nebert, D.W., Patel, K.V., Williams, M.T., and Vorhees, C.V. Effects of vitamin C deficiency during postnatal development on adult behavior: functional behavioral phenotype of Gulo(-/-) mice. Genes Brain Behav., 11, 269-277. 2012.
Chen, Y., Curran, C.P., Nebert, D.W., Patel, K.V., Williams, M.T., and Vorhees, C.V. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm(-/-) knockout mice. Neurotoxicol. Teratol., 34, 450-457. 2012.
Schaefer TL, Lingrel JB, Moseley AE, Vorhees CV, Williams MT. Targeted mutations in the Na,K-ATPase alpha 2 isoform confer ouabain resistance and result in abnormal behavior in mice. Synapse. 2011.
Skelton MR, Schaefer TL, Graham DL, deGrauw TJ, Clark JF, Williams MT, Vorhees CV. Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. PLoS One. 2011.
Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannum YA, Grabowski GA. Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Human Mol. Genet. 19, 634-647. 2010.
Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu Y-H, Grabowski GA. Neuronopathic Gaucher disease in the mouse: Viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Human Mol. Genet. 19, 1088-1097. 2010.
Grace CE, Schaefer TL, Herring NR, Graham DL, Skelton MR, Gudelsky GA, Williams MT, Vorhees CV. Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice. Neurotoxicol. Teratol. 32, 346-355. 2010.
Zhu H, Mingler MK, McBride ML, Murphy AJ, Valenzuela DM, Yancopoulos GD, Williams MT, Vorhees* CV, Rothenberg* ME. Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1. Psychoneuroendocrinology. 35, 1119-1132. *coequal senior authors. 2010.
Loepke AW, Istaphanous GK, Miles L, Hughes EH, McCann JC, Kurth CD, Williams MT, Vorhees CV, Danzer SC. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth. Analges. 108, 90-104. 2009.
McAuliffe JJ, Loepke AW, Miles L, Joseph B, Hughes E, Vorhees CV. Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm. Anesthesiology. 111, 533-546. 2009.
Schaefer TL, Vorhees CV, Williams MT. Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness. Neuroscience. 164, 1431-1443. 2009.
Pan D, Sciascia A 2nd, Vorhees CV, Williams MT. Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome. Brain Res. 1188, 241-253. 2008.
McAuliffe JJ, Joseph B, Hughes E, Miles L, Vorhees CV. Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT I,II deficient mice have inherent behavioral impairments. Brain Res. 1190, 175-185. 2008.
Sun Y, Witte DP, Ran H, Zamzow M, Barnes S, Cheng H, Han X, Williams MT, Skelton MR, Vorhees CV, Grabowski GA. Neurological deficits and glycosphingolipid accumulation in Saposin B deficient mice. Human Mol. Genet. 17, 2345-2356. 2008.
Sun Y, Jia L, Williams MT, Zamzow M, Ran H, Quinn B, Aronow BJ, Vorhees CV, Witte DP, Grabowski GA. Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice. BMC Neurosci. 9, 76. 2008.
Vorhees CV, He E, Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Amos-Kroohs R, Williams MT. Comparison of (+)-methamphetamine, (±)-methylenedioxymethamphetamine (MDMA), (+)-amphetamine and (±)-fenfluramine in rats on egocentric learning in the Cincinnati water maze. Synapse. 2011.
Braun AA, Skelton MR, Vorhees CV, Williams MT. Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents. Pharmacol. Biochem. Behav. 2011.
Graham DL, Herring NR, Schaefer TL, Vorhees CV, Williams MT. Glucose and corticosterone changes in developing and adult rats following exposure to (±)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine. Neurotoxicol. Teratol. 32, 152-157. 2010.
Grace CE, Schaefer TL, Graham DL, Skelton MR, Williams MT, Vorhees CV. Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels. Int. J. Dev. Neurosci. 28, 331-342. 2010.
Herring NR, Gudelsky GA, Vorhees CV, Williams MT. (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia. Synapse. 64, 773-85. 2010.
Vorhees CV, Skelton MR, Grace CR, Schaefer TL, Graham DL, Braun AA, Williams MT. Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats. Int. J. Dev. Neurosci. 27, 289-298. 2009.
Vorhees CV, Schaefer TL, Skelton MR, Grace CE, Herring NR, Williams MT. ±3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the Morris water maze after exposure of rats to different five-day intervals from birth to postnatal day 20. Dev. Neurosci. 31, 107-120. 2009.
Skelton MR, Schaefer TL, Herring NR, Grace CE, Vorhees CV, Williams MT. Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (±)-3,4-methylenedioxymethamphetamine (ecstasy) in rats. Psychopharmacology. 204, 287-297. 2009.
Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC Neurosci. 9, 49. 2008.
Vorhees CV, Herring NR, Schaefer TL, Grace CE, Skelton MR, Johnson HL, Williams MT. Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: Effects of dose and rearing conditions. Int. J. Dev. Neurosci. 26, 599-610. 2008.
Herring NR, Schaefer TL, Gudelsky GA, Vorhees CV, Williams MT. Effect of (+)-Methamphetamine on path integration, novel object recognition, and neurotoxicity in rats. Psychopharmacology. 199, 637-650. 2008.
Skelton MR, Able JA, Grace CE, Herring NR, Schaefer TL, Gudelsky GA, Vorhees CV, Williams MT. (±)-3,4-methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single versus once per week treatment for five weeks. Neuropharmacology. 55, 1121-1130. 2008.
For more information on collaborating with the Animal Behavioral Core, call 513-636-8622.
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