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Research Cores

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Summary of Cores Available at Cincinnati Children's Research Foundation

Cincinnati Children's Research Foundation has put in place core support capabilities for both basic and clinical research. These core resources enhance access to cutting-edge technology and data analysis for a wide variety of projects. Researchers in the Research Foundation can access these shared resources by using the contact information below.

Animal Behavioral Core

  1. Purpose The Animal Behavioral Collaborative Core facility, located in the Division of Neurology, is available to PIs at CCRF, UC and outside Principle Investigators. The core offers a variety of behavioral assays to enable the characterization of CNS dysfunction in mice or rats.
  2. Location Location R 5007
  3. Web Site http://www.cincinnatichildrens.org/research/cores/abc/
  4. Director Charles Vorhees, charles.vorhees@cchmc.org, 513-636-8622
  5. Fee Structure Please contact Charles Vorhees, charles.vorhees@cchmc.org, 513-636-8620
  6. Open to All CCRF and UC research personnel; other researchers as allowed by core staff. Animal Behavorial Core

Biomedical Informatics

  1. Purpose Provides computational resources, services and support to investigators at Cincinnati Children's Research Foundation and the University of Cincinnati College of Medicine; serves as the initial point of contact for all inquiries about hardware, software and other information technology related to research.
  2. Location Location S 10.200
  3. Web Site http://bmi.cchmc.org
  4. Director John Hutton, MD, john.hutton@cchmc.org, 513-636-2051
  5. Fee Structure Please contact Eszter Belcher, eszter.belcher@cchmc.org, 513-636-0148
  6. Open to All CCRF and UC research personnel; other researchers as allowed by core staff.

Biostatistics Core, Center for Epidemiology and Biostatistics

  1. Purpose Provides consultation and/or ongoing support to research at CCRF such as: development of clinical research plans; guidance and assistance in the development of grant proposals; data entry and management services using Teleform; and data analysis.
  2. Location Location S, 10th floor
  3. Web Site http://www.cincinnatichildrens.org/research/div/ceb/
  4. Director Ardythe Morrow, PhD, ardythe.morrow@cchmc.org, 513-636-7584
  5. Director of Biostatistics Judy Bean, judy.bean@cchmc.org, 513-636-3430
  6. Fee Structure Please contact Ron DeMarco, ronald.demarco@cchmc.org, 513-636-7859
  7. Open to All CCRF research personnel; other researchers as allowed by core staff.

Cell Manipulations Laboratory

  1. Purpose Provides controlled access clean room facility that was designed and built for the purpose of performing ex-vivo cell manipulations, including gene therapy protocols, for Phase I & II clinical trials. The facility is dedicated to the selection, expansion transduction, and/or other culture aspects of producing extensively manipulated cell products for clinical trial applications.
  2. Location Location S11.401
  3. Web Site http://www.cincinnatichildrens.org/research/div/exp-hematology/translational/cml/  
  4. Director Punam Malik, punam.malik@cchmc.org, 513-636-8588
  5. Fee structure Please contact the Core Director.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Child Policy Research Center

  1. Purpose Develops, translates and communicates evidence to measurably improve child health and well-being and the quality of health care for children. Our partners include community, local, state and national policy makers, program managers and advocates. The Center addresses the most urgent challenges facing children and families.
  2. Location Location S
  3. Web Site http://www.cincinnatichildrens.org/research/cores/cprc/ 
  4. Director Lisa Simpson, MB, BCh, MPH, FAAP, lisa.simpson@cchmc.org, 513-636-2781
  5. Fee structure Please contact the Core Director.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Cincinnati Center for Clinical Research

  1. Purpose Supports both pediatric (Phase I-IV) and adult (Phase I-III) clinical research studies. Provides sponsors and researchers with scientific tools, facilities, and services to conduct effective clinical research studies.
  2. Location Oak Campus
  3. Web Site http://www.cincinnatichildrens.org/research/cores/cccr/
  4. Director Michael Spigarelli, MD, PhD, michael.spigarellli@cchmc.org, 513-636-8597
  5. Primary Contact Melinda Muenich, melinda.muenich@cchmc.org, 513-636-7130
  6. Fee Structure Please contact the Core Director.
  7. Open to All CCRF research personnel; other researchers as allowed by core staff.

Cincinnati Center for Nutritional Research Analysis

  1. Purpose Was established in 1991 to collect and analyze nutrition data from research studies. To date it has handled over 30,000 diet records and recalls from numerous studies using the Nutrient Data System from the University of Minnesota. 
  2. Location Winslow, Floor 4, Suite 4222
  3. Web Site http://www.cincinnatichildrens.org/research/cores/ccnra
  4. Director Marcia Schmidt MS, RD, LD, marcia.schmidt@cchmc.org, 513-636-4142
  5. Primary Contact Marcia Schmidt MS, RD, LD, marcia.schmidt@cchmc.org, 513-636-4142
  6. Fee Structure Please contact the Core Director.
  7. Open to All CCRF research personnel; other researchers as allowed by core staff. 

Comprehensive Mouse and Cancer Core

  1. Purpose Provides animals from specific inbred mouse strains primarily used in cancer and hematopoietic research (like nude, NOD/SCID and C57BL/6CD45.1); offers animal and cell irradation services; cell transplant and hematopoietic cell harvest services and handling of animal cancer model systems involving xenotransplant procedures.
  2. Location Location S 7.205
  3. Web Site http://www.cincinnatichildrens.org/research/div/exp-hematology/eh-cores/CMCC.htm
  4. Director Hartmut Geiger, 513-636-1338
  5. Contacts Please contact Jeff Bailey or Victoria Summey at 513-636-5879 or via email Jeff.Bailey@cchmc.org or Victoria.Summey@cchmc.org.
  6. Fee Structure Please contact the Core Director.
  7. Open to All CCRF research personnel; other researchers as allowed by core staff.

Echocardiography

  1. Purpose Provides non-invasive cardiac ultrasound imaging in support of animal and human research studies The Laboratory personnel can image a variety of animals including mice, rabbits, dogs, sheep, and pigs. In addition, fetal lamb and embryonic mice imaging can be performed. In support of human research, echocardiography can be performed on human fetuses, neonates, infants, children and adults. In all cases, complete cardiac anatomic detail is provided. In addition, quantitative assessment of cardiac geometry, systolic function, diastolic function and vascular function is made.
  2. Location Veterinary Services Suite and Echocardiography Laboratory in Division of Cardiology
  3. Director Tom Kimball, MD, thomas.kimball@cchmc.org, 513-636-3577
  4. Primary Contact Vicky Moore, vicky.moore@cchmc.org, 513-636-7489
  5. Fee Structure Please contact the Core Director.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Flow Cytometry and Cell Sorting Services

Research flow (analysis and sorting) will be consolidated into a single facility in January '09 under the leadership of Sherry Thornton, PhD. 

  1. Purpose Offers cell sorting and analysis capability and expertise to the entire clinical and research community.
  2. Location Location R 1315
  3. Web Site http://www.cincinnatichildrens.org/research/cores/flow-cyto/
  4. Director Alexandra Filipovich, MD, alexandra.filopovich@cchmc.org
  5. Manager Dan Marmer, MS, MT(ASCP) Daniel.Marmer@cchmc.org, 513-636-8614
  6. Fee Structure
    Sorting (FACSVantage SE) CCRF Users: Sterile-$68 set-up charge; $68/hour run time; Other Users: Contact laboratory for pricing.
    Acquisition (FACSCalibur) CCRF Users: $33/hour; Other Users: Contact laboratory.
  7. Open to All CCRF clinical and research personnel and other community hospital research investigators.

Flow Cytometry

  1. Purpose Provides analytical flow cytometry of cells in suspension. No sorting capability is available.
  2. Location Location R, Room 7576
  3. Director Jose Cancelas, 513-558-1324
  4. Fee structure $33/hour CCHMC; $50/hour non-CCHMC
  5. Open to All CCRF research personnel; other researchers as allowed by core staff.

General Clinical Research Center (GCRC)

  1. Purpose Provides facilities and resources for inpatient and outpatient research, including program administration, clinical services, nutrition research services, behavioral core services, biostatistical and informatics services, and laboratory services.
  2. Location Location A 3.300
  3. Web Site http://www.cincinnatichildrens.org/research/cores/gcrc/
  4. Director Jim Heubi, MD, james.heubi@cchmc.org, 513-636-8046
  5. Primary Contact Andrea Smith, Andrea.Smith@cchmc.org, 513-636-4273
  6. Fee Structure Please contact the Core Director.
  7. Open to All CCRF research personnel; other researchers as allowed by core staff.

Affymetrix GENECHIP" Microarray Core

  1. Purpose Performs simultaneous analysis of expression levels of tens of thousands of genes using high density oligonucleotide microarrays, with over one million hybridization features per gene chip. Uses commercial Affymetrix microarrays that are highly redundant, with 22 separate hybridization squares per gene. Available for mapping of single nucleotide polymorphisms for use in the mapping of disease loci and for performing re-sequencing.
  2. Location Location R 3403
  3. Web Site http://www.cincinnatichildrens.org/research/cores/affymetrix/
  4. Director S. Steven Potter, PhD, steve.potter@cchmc.org, 513-636-4850
  5. Primary Contact Shawn Smith, affymetrix_core@cchmc.org, 513-636-0290
  6. Fee Structure http://www.cincinnatichildrens.org/research/cores/affymetrix/gene-fees.htm
  7. Open to All CCRF research personnel; other researchers as allowed by core staff.

Health Policy and Clinical Effectiveness

  1. Purpose Provides resources for data management and data analysis, process implementation, data analysis and outcomes research, and additional resources and expertise from health services research investigators in other divisions of the Research Foundation and the University of Cincinnati for research pertaining to improving the health and quality of life of children and their families.
  2. Location Ste. 5100, Winslow Office Building, Oak Campus
  3. Web Site http://www.cincinnatichildrens.org/research/cores/health-policy/
  4. Director Uma Kotagal, MBBS, MSc, uma.kotagal@cchmc.org, 513-636-0178
  5. Fee Structure Please contact the Core Director. 
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Imaging Research Center

  1. Purpose Provides access to state of the art MRI Research Instrumentation and diagnostic imaging technologies related to the diagnosis and treatment of diseases in children and young adults. An in-vivo microimaging laboratory is being established and will available for use in April, 2004 to develop micro and molecular imaging techniques in models of pediatric disease.
  2. Location Location R, R055 
  3. Web Site http://www.cincinnatichildrens.org/research/cores/irc/
  4. Director Alan Brody, MD, alan.brody@cchmc.org, 513-636-8508
  5. Fee Structure Please contact Donna Lyons, donna.lyons@cchmc.org, 513-636-2863
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Laser Capture Microdissection

  1. Purpose Offers the ability to directly extract single cells from any tissue section, providing a pure cell population for subsequent quantitative analysis.
  2. Location Location R 5409
  3. Web Site http://www.cincinnatichildrens.org/research/cores/laser-capture/
  4. Director Xiaonan Han, PhD,  513-636-7592
  5. Fee Structure The only direct cost associated with the operation of the LCM is tube caps containing the transfer film. Each researcher using the LCM will be required to purchase their caps.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff. Time on the LCM will be reserved for investigators on a first-come first-serve basis

Mass Spectrometry

  1. Purpose Provides an analytical resource that focuses on the application of mass spectrometry and allied chromatographic approaches to the analysis of complex biological samples.
  2. Location Location R, R028-030
  3. Web Site http://www.cincinnatichildrens.org/research/cores/mass-spec/default.htm
  4. Director Ken Setchell, PhD, kenneth.setchell@cchmc.org, 513-636-4548
  5. Fee Structure Please contact the Core Director.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Pediatric Pharmacology Research Unit

  1. Purpose  Provides support for both pediatric (Phase I-IV) and adult (Phase I-III) clinical research studies. Provides sponsors and researchers with scientific tools, facilities, and services to conduct effective clinical research studies. 
  2. Location Location S 9.400
  3. Web Site http://www.cincinnatichildrens.org/research/cores/ppru/default.htm
  4. Director Alexander Vinks, PhD, sander.vinks@cchmc.org, 513-636-0159
  5. Fee Structure Please contact Mindy Muenich, melinda.meunich@cchmc.org, 513-636-7130
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Proteomics Laboratory at the Genome Research Institute

  1. Purpose Provides assistance to investigators in the analysis and identification of purified proteins as well as complex protein mixtures. In addition, the laboratory provides expertise in the planning and design of proteomics experiments. The laboratory is equipped with instrumentation to address the two major areas of proteomics research: protein separation and protein identification.
  2. Location Genome Research Institute, 2180 E. Galbraith Rd, Cincinnati, OH 45237
  3. Web Site http://gri.uc.edu/
  4. Director Ken Greis, PhD, ken.greis@uc.edu,  513-558-7102
  5. Fee Structure Please contact the Core Director.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Office of Research Compliance and Regulatory Affairs

  1. Purpose Assures research compliance of Cincinnati Children's Hospital Medical Center and Research Foundation in following all local, state, and federal regulations governing the use of all biological materials and human subjects.
  2. Location Location R 3325
  3. Director Jeremy Corsmo, MPH, CIP, jeremy.Corsmo@cchmc.org, 513-636-5449
  4. Fee Structure Please contact the Core Director.
  5. Open to All CCRF research personnel; other researchers as allowed by core staff.

Sequencing

  1. Purpose Serves as a technical and expertise resource for the genomic research community at Children's Hospital and the University of Cincinnati. Offers a wide variety of services for DNA Sequencing and Genotyping.
  2. Location Location R 1038
  3. Web Site http://dna.cchmc.org/
  4. Director Greg Grabowski, greg.grabowski@cchmc.org, 513-636-7290
  5. Primary Contact Mehdi Keddache, mehdi.keddache@cchmc.org, 513-636-0122
  6. Fee Structure http://dna.cchmc.org/dnaseq/html/pricing.html
  7. Open to All CCRF research personnel; other researchers as allowed by core staff.

Tissue Culture Laboratory

  1. Purpose Provides clinical and research service; establishes cell lines, immortalizes lymphoid lines, and provides storage facility.
  2. Location Location R 1012A
  3. Director Dr. Howard Saal, howard.saal@cchmc.org, 513-636-4474
  4. Fee structure - Please contact the Core Director.
  5. Open to All CCRF research personnel; other researchers as allowed by core staff.

Transgenic and Gene Targeting Core

  1. Purpose Generates genetically altered mice and rabbits; provides embryo cryopreservation
  2. Location Location R 2047
  3. Web Site http://www.cincinnatichildrens.org/research/cores/transgenic-mice/
  4. Director Richard Lang, PhD, Richard.Lang@cchmc.org, 513-636-2700
  5. Primary Contact Sandy Falcone, sandy.falcone@cchmc.org, 513-636-7098
  6. Fee Structure Please contact the Core Director.
  7. Open to All CCRF research personnel; other researchers as allowed by core staff.

Translational Research

  1. Purpose Stimulates the development of pre-clinical and human translational trials that will improve the care of children with severe diseases. Provides adequate infrastructure that has been developed to insure support for pre-clinical and clinical translational research projects.
  2. Location Location C 4320 
  3. Web Site http://www.cincinnatichildrens.org/research/administration/translational/
  4. Director Tim Cripe, MD, PhD, timothy.cripe@cchmc.org, 513-636-4553
  5. Fee Structure Services from the Translational Research Trials Office are available to all divisions and departments within the institution.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Translational Research Development and Support Laboratory

  1. Purpose Coordinates and/or performs cellular and molecular testing required to document purity, function, clonal composition, and overall safety of human ex vivo manipulated cell preparations, vector preparations, gene modified cell preparations, and patient molecular and safety monitoring samples, making compiled data accessible to investigators within and outside of Cincinnati Children's Hospital Medical Center.
  2. Location Location S, 11.401
  3. Web Site http://www.cincinnatichildrens.org/research/div/exp-hematology/translational/ttdsl.htm  
  4. Director Punam Malik, punam.malik@cchmc.org  513-636-8588
  5. Fee structure Please contact the Core Director.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Viral Vector Core

  1. Purpose To provide the investigators with research-grade viral vectors including Gamma-Retroviral vectors, Lentiviral vectors and Adeno-Associated Virus (AAV) vectors based on a fee-for-service model. Services include titration, concentration, and safety testing as listed in detail on the Web site. For master cell banks, scale-up production and GMP-grade vectors for clinical use contact the Core Director.
  2. Location Location S, S11.601, Translational Core Laboratory, Viral Vector Core,
  3. Web Site http://www.cincinnatichildrens.org/research/cores/vvc/default.htm
  4. Director Han van der Loo, han.vanderloo@cchmc.org, 513-803-1066
  5. Fee Structure The costs for services are charged to the account listed by the investigator. Fees are subsidized for investigators at Cincinnati Children's Hospital Medical Center and the Cincinnati Children's Hospital Research Foundation, University of Cincinnati, Genome Research Institute, and Ohio State University. Contact the Core Director for details.
  6. Open to All CCRF research personnel; other researchers as allowed by core staff.

Veterinary Services

  1. Purpose Provides veterinary support and consultation to the researchers involved in animal research. Ensures the vivarium is in compliance with all Federal, State and Local Regulations and all animals are provided appropriate veterinary care and husbandry, meeting or exceeding the "Guide for the Care and Use of Laboratory Animals."
  2. Location Location R, 6th floor
  3. Director Gary Keller, DVM, gary.keller@cchmc.org , 513-636-4441
  4. Fee Structure Please contact the Core Director.
  5. Open to All CCRF research personnel; other researchers as allowed by core staff.