Laboratory of Applied Pharmacokinetics and Therapeutic Drug Management (LAP-TDM)
Most drug development programs require pharmacology expertise. The Laboratory of Applied Pharmacokinetics and Therapeutic Drug Management is a center of excellence for population PK/PD Modeling and Monte Carlo simulation through Pharsight's Academic Licensing program and serves as a Pharmacometrics Core for the NIH Pediatric Pharmacology Research Network (PPRU). It provides expertise in drug bioavailability, metabolism, pharmacokinetic and pharmacodynamic (PK/PD) studies as well as clinical trials methodology. It explores new pediatric therapeutic modalities, including:
- Molecular approaches to the treatment of diseases
- Application of new technology to pharmacodynamic studies and novel drug delivery systems
- Pediatric formulations and validation of biomarkers and surrogate endpoints
Other research interests include the developmental characteristics and genetic polymorphisms of drug metabolizing enzymes and receptors, as well as population pharmacokinetic pharmacodynamic (PK-PD) modeling and trial simulation technology.
Experienced staff support PK-PD analysis of study data:
- Develops assays for drugs and metabolites using HPLC Fluorescence and diode array detection
- Performs LC Tandem Mass Spectrometry analyses
- Serves as centralized resource for multi-center pharmacokinetic studies and concentration-controlled trials
- Provides population pharmacokinetic analysis and pharmacokinetic/pharmacodynamic modeling and simulation
- GLP compliant
Credentials and Certifications
CAP and CLIA accredited
Faculty and Staff
Alexander Vinks, PharmD, PhD, director
Contact Us
For more information about the Laboratory of Applied Pharmacokinetics and Therapeutic Drug Management (LAP-TDM) contact 513-636-3232 or sander.vinks@cchmc.org
