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How Our Cores Can Enhance Your Research
Cincinnati Children’s Research Foundation is dedicated to advancing basic, translational, clinical and outcomes-based research. Why choose our cores for your research? We can provide you with cutting-edge, cost-effective technology and data analysis that would be unattainable on an individual research basis. Our fee-for-service program also offers unique studies that you can’t find anywhere else.
Our faculty also has access to the research cores hosted at the University of Cincinnati College of Medicine.
Our behavioral and nonbehavioral assays will help you characterize the nervous system function in mice and rats. There is no fee for our services. Our mission is to form collaborative partnerships with researchers that will benefit science. Our measurement protocols include video tracking and photocell technology. Directors: Charles V. Vorhees, PhD and Michael T. Williams, PhDPhone: 513-636-8622
Read more about the Animal Behavioral Core.
We allow you access to state-of-the-art imaging technology and measurement tools for cardiovascular research. We also offer consulting, databases and education and training opportunities. Our equipment will enhance the quality of your research and save you time.Director: Thomas Kimball, MDPhone: Vicky Moore, 513-636-7489
Read more about the Cardiovascular Imaging Core.
We offer a controlled-access clean room facility that was designed and built to perform ex vivo cell manipulations, including gene therapy protocols, for Phase 1 and 2 clinical trials.
Co-Directors: Diana Nordling, Carolyn Lutzko, PhDPhone: Diana Nordling, 513-803-1063
For General Inquiries please email the CML Coordinator
Read more about the Cell Manipulations Laboratory.
We supply mononuclear cells, stem cells or other enriched cell populations from peripheral blood, bone marrow and cord blood.Co-Directors: Diana Nordling, Carolyn Lutzko, PhDPhone: Lab Coordinator: Kevin Link, 513.803.1062
For General Inquiries please email the CPC Lab
Read more about the Cell Processing Core.
We provide researchers with access to standardized and centralized acquisition, processing, storage and distribution of high-quality biospecimens. We will help you plan and execute sample collection protocols. Director: Michael Barnes, PhDPhone: 513-636-1319
Read more about the Cincinnati Biobank.
We are one of the leading nutrition research centers in the world, featuring first-rate quality control, turnaround time and personalized attention. Services include coding and data analysis for food records, dietary recall, menus, recipes and supplements. Phone: Marcia Gavin, 513-636-7644, or Brad Gruber, 513-803-1374
Read more about the Cincinnati Center for Nutritional Research and Analysis.
We can help you study cancer systems with animal models. We will provide you with specific mice strains as well as perform cell transplants, harvest and irradiation services and xenotransplant procedures. Director: Hartmut Geiger, PhDPhone: Jeff Bailey or Victoria Summey, 513-636-5879
Read more about the Comprehensive Mouse and Cancer Core.
We will train you to use state-of-the-art confocal microscopes for your research. We provide access to confocal microscopes, deconvolution microscopes and computer analysis workstations. Once you’ve been trained by our staff, you may access our facilities 24 hours a day.
Director: Matthew Kofron, PhDPhone: 513.803.9055
Read more about the Confocal Imaging Core.
If your research involves the study of developmental and disease processes, we can help you perform expression level analysis of thousands of genes in parallel. We use commercial microarrays available from Affymetrix and Illumina. We offer data analysis and guidance on preparing RNA for labeling. Director: S. Steven Potter, PhDPhone: Hung-Chi Liang, or Shawn Smith 513-636-0290
Read more about the Gene Expression Microarray Core.
We specialize in sequencing with template preparation from bacterial cultures, sequencing without template preparation and electrophoresis. Director: Greg Grabowski, MDPhone: 513-636-7290Lab phone: 513-636-2801Email: firstname.lastname@example.org
Read more about Genetic Variation and Gene Discovery.
We offer a unique combination of animal services and mouse strains to assist in the generation of humanized mouse models to fit various needs.Director: Jim Mulloy, PhDPhone: 513-636-1844Read more about the Humanized Mouse Resource.
We make modern imaging technology available to researchers. Services include a whole-body scanner with EEG monitoring, clinical MRI scanners, CT, PET-CT and gamma camera and scanners, fluoroscopy systems and longitudinal imaging for animals. Director: Charles Dumoulin, PhDPhone: Deborah Ohl, 513-636-7230
Read more about the Imaging Research Center.
Our technology directly extracts single cells from any tissue section, giving you a pure cell population for analysis. We will train you to operate the microdissection equipment and give general advice on preparing samples. Director: Xiaonan Han, PhDPhone: 513-636-7592
Read more about the Laser Capture Microdissection Microscopy.
Our high-throughput screening allows discovery of novel genes that affect biologic pathways of interest. Our mouse and human libraries encode 160,000 shRNA clones against 32,000 genes and have been designed for automated handling and production of lentivirus. You may choose either single-gene selection or whole-library screening for your research. Director: Jeff Molkentin, PhDConsultant: John Elrod, PhDCore Manager: Greg DavisCore Technician: Tim DwyerEmail: email@example.com
Learn more about the Lenti-shRNA Library Core.
The Mouse Cytogenetics Core is part of the Cytogenetics Laboratory in the Division of Human Genetics. We provide research investigators support for mouse classic karyotyping and molecular cytogenetic studies.
Director: Liming Bao, MD, PhDPhone: 513-636-4474
Read more about the Mouse Cytogenetics Core
Our services include tissue trimming, processing and embedding, slide sectioning, H&E staining, special staining, immunohistochemistry, in situ hybridization, antibody or probe workup and electron microscopy. We will help you interpret results and, if desired, will collaborate on publications. Phone: 513-636-8159 or 513-803-0741
Read more about the Pathology Research Core.
We are dedicated to providing high-quality, well-characterized and reliably archived human embryonic stem cells for distribution to researchers. Additionally, the facility will provide investigators with reagents and expertise for the generation of induced pluripotent stem cells (iPSCs) as well as expert training in the protocols and techniques for proper handling and manipulation of human pluripotent stem cells. Our mission is to facilitate all aspects of pluripotent stem cell experimentation to contribute to advancing stem cell therapies for human disease. Director: James Wells, PhDEmail: PSCF@cchmc.orgPhone: 513-636-3744
Read more about the Pluripotent Stem Cell Facility.
Our core specializes in measuring locus-specific DNA methylation, genetic variations and mutations in a high throughput fashion.
Director: Hong JI, PhDPhone: 513-803-5055Lab Phone: Ashley Ulm, 513-803-0562Email: Hong.Ji@cchmc.org
Read more about the Pyrosequencing Lab for Genomic and Epigenomic Research.
We will train you to use cytometers for your research. We provide cell sorting, data analysis and even computer workstations. Once you’ve been trained by our staff, you may access our facilities 24 hours a day. Director: Sherry Thornton, PhDPhone: Cell sorting appointments, 513-636-2770; analyzer training, 513-636-3575
Read more about the Research Flow Cytometry Core.
We supply mononuclear cells, stem cells or other enriched cell populations from peripheral blood, bone marrow and cord blood.
Co-Directors: Diana Nordling, Carolyn Lutzko, PhDPhone: Lab Coordinator: Kevin Link, 513.803.1062
Read more about the Stem Cell Processing Core.
We specialize in embryo cryopreservation and the generation of genetically altered mice and rabbits. The laboratory is accessible to non-Research Foundation faculty. Services are provided with a user charge.
Director: Kenneth Cambell, PhDPhone: 513-636-0246
The Translational Core Labs include The Viral Vector Core, The Vector Production Facility, The Stem Cell Processing Lab, The Cell Manipulations Lab and the Translational Trial Development and Support Lab (TTDSL). We specialize in the translation and scale up of gene therapy and cell therapy including iPSC and HEK in addition to the patient testing associated with these trials.
Lab Directors: Punam Malik, MD, Diana NordlingPhone: Diana Nordling, 513-803-1063
Read more about the Translational Core Labs.
We coordinate and perform cellular and molecular testing required to document purity, function, clonal composition and overall safety of research preparations and preclinical and clinical samples. This is a CAP / CLIA-certified laboratory.
Director: Elke Grassman, PhDLab Manager: Kim MurphyPhone: 513-636-5998
For General Inquiries please contact the TTDSL Lab
Read more about the Translational Trials Developmental and Support Laboratory(TTDSL).
We provide GMP-grade viral vectors, master cell banks and master viral banks in support of gene therapy trials. Director: Han van der Loo, PhDPhone: 513-803-1066Email: firstname.lastname@example.org
Read more about the Vector Production Facility.
We offer routine and specialized husbandry, surgical support and expert consultation on regulatory issues (IACUC submissions) and animal transfers.Director: Gary Keller, DVMPhone: 513-636-4441
We provide research-grade retroviral lentiviral and adeno-associated virus vectors. Director: Han van der Loo, PhDLab Manager: Scott Cross, 513-803-1067
Read more about the Viral Vector Core.
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