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How Can Our Shared Facilities Enhance Your Research
Cincinnati Children’s Research Foundation is dedicated to advancing basic, translational, clinical and outcomes-based research. Why choose our facilities for your research? We can provide you with cutting-edge, cost-effective technology and data analysis that would be unattainable on an individual research basis. Our fee-for-service program also offers unique studies that you can’t find anywhere else.
Our faculty also has access to the research cores hosted at the University of Cincinnati College of Medicine.
Our behavioral and nonbehavioral assays will help you characterize the nervous system function in mice and rats. There is no fee for our services. Our mission is to form collaborative partnerships with researchers that will benefit science. Our measurement protocols include video tracking and photocell technology. Directors: Charles V. Vorhees, PhD and Michael T. Williams, PhDPhone: 513-636-8622
Visit the Animal Behavioral Core website.
The Animal Behavioral Core is now using the CORES Billing system. For questions, please contact firstname.lastname@example.org.
We allow you access to state-of-the-art imaging technology and measurement tools for cardiovascular research. We also offer consulting, databases and education and training opportunities. Our equipment will enhance the quality of your research and save you time.Director: Thomas Kimball, MDPhone: Vicky Moore, 513-636-7489
Visit the Cardiovascular Imaging Core website..
We offer a controlled-access clean room facility that was designed and built to perform ex vivo cell manipulations, including gene therapy protocols and pluripotent stem cell protocols, for Phase 1 and 2 clinical trials.
Co-Directors: Diana Nordling, Carolyn Lutzko, PhDLab Manager: Ami Terwilliger, 513-803-1069Phone: Diana Nordling, 513-803-1063
For General Inquiries please email the CML Coordinator
Visit the Cell Manipulations Laboratory website..
We provide researchers with access to standardized and centralized acquisition, processing, storage and distribution of high-quality biospecimens. We will help you plan and execute sample collection protocols. Contact: Justin HoganPhone: 513-803-5166
Visit the Cincinnati Biobank website..
We are one of the leading nutrition research centers in the world, featuring first-rate quality control, turnaround time and personalized attention. Services include coding and data analysis for food records, dietary recall, menus, recipes and supplements. Phone: Marcia Gavin, 513-636-7644, or Brad Gruber, 513-803-1374
Visit the Cincinnati Center for Nutritional Research and Analysis website..
We can help you study cancer systems with animal models. We will provide you with specific mice strains as well as perform cell transplants, harvest and irradiation services and xenotransplant procedures. Director: Hartmut Geiger, PhDPhone: Jeff Bailey or Victoria Summey, 513-636-5879
Visit the Comprehensive Mouse and Cancer Core website.
We will train you to use state-of-the-art confocal microscopes for your research. We provide access to confocal microscopes, deconvolution microscopes and computer analysis workstations. Once you’ve been trained by our staff, you may access our facilities 24 hours a day.
Director: Matthew Kofron, PhDPhone: 513.803.9055
Visit the Confocal Imaging Core website.
The Confocal Imaging Core is now using the CORES Billing system. For questions, please contact email@example.com.
We specialize in sequencing with template preparation from bacterial cultures, sequencing without template preparation and electrophoresis. Phone: 513-636-2801Email: firstname.lastname@example.org
Visit the DNA Sequencing and Genotyping Facility website.
If your research involves the study of developmental and disease processes, we can help you perform expression level analysis of thousands of genes in parallel. We use commercial microarrays available from Affymetrix and Illumina. We offer data analysis and guidance on preparing RNA for labeling. Director: S. Steven Potter, PhDPhone: Hung-Chi Liang, or Shawn Smith 513-636-0290
Visit the Gene Expression Microarray Core website.
We offer a unique combination of animal services and mouse strains to assist in the generation of humanized mouse models to fit various needs.Director: Jim Mulloy, PhDPhone: 513-636-1844
Visit the Humanized Mouse Resource website.
We make modern imaging technology available to researchers. Services include a whole-body scanner with EEG monitoring, clinical MRI scanners, CT, PET-CT and gamma camera and scanners, fluoroscopy systems and longitudinal imaging for animals. Director: Charles Dumoulin, PhDPhone: Deborah Ohl, 513-636-7230
Visit the Imaging Research Center website..
Our technology directly extracts single cells from any tissue section, giving you a pure cell population for analysis. We will train you to operate the microdissection equipment and give general advice on preparing samples. Director: Xiaonan Han, PhDPhone: 513-636-7592
Visit the Laser Capture Microdissection Microscopy website..
Our high-throughput screening allows discovery of novel genes that affect biologic pathways of interest. Our mouse and human libraries encode 160,000 shRNA clones against 32,000 genes and have been designed for automated handling and production of lentivirus. You may choose either single-gene selection or whole-library screening for your research. Director: Jeff Molkentin, PhDConsultant: John Elrod, PhDCore Manager: Greg DavisCore Technician: Tim DwyerEmail: email@example.com
Visit the Lenti-shRNA Library Core website.
We provide researchers with access to state of the art 275-channel whole head human magnetometry with data acquisition rates up to 12 kHz per channel. The system can also do simultaneous EEG recordings. We provide orientation to data collection with the magnetometer including a stimulus presentation computer for auditory, visual, somatosensory stimuli, and bimanual 5 finger response pads for task-based studies.
Director: Douglas Rose, MDEmail: firstname.lastname@example.orgPhone: 513-636-0322
Visit the MEG Core website.
The MEG Core is now using the CORES Billing system. For questions, please contact email@example.com.
The NMR-based Metabolomics Core will provide technology that will help clinical and basic scientists develop rapid detection methods, as well as elucidate the complex metabolic pathways involved in a number of diseases and infections. A more comprehensive understanding of metabolism can lead to such advances as a more personalized approach to drug therapies. We provide all NMR –related metabolomics services on human and animal cells, biopsies and biological fluids. We strive to foster collaborative efforts that will advance translational research using metabolomics approaches.
Director: Lindsey Romick-RosendaleEmail: Metabolomics@cchmc.orgPhone: 513-803-2765
Visit the NMR-based Metabolomics Core website.
The Mouse Cytogenetics Core is part of the Cytogenetics Laboratory in the Division of Human Genetics. We provide research investigators support for mouse classic karyotyping and molecular cytogenetic studies.
Director: Teresa Smolarek, PhDPhone: 513-636-7221
Visit the Mouse Cytogenetics Core website.
Our services include tissue trimming, processing and embedding, slide sectioning, H&E staining, special staining, immunohistochemistry, in situ hybridization, antibody or probe workup and electron microscopy. We will help you interpret results and, if desired, will collaborate on publications. Phone: 513-636-8159 or 513-803-0741
Visit the Pathology Research Core website.
We are dedicated to providing high-quality, well-characterized and reliably archived human embryonic stem cells for distribution to researchers. Additionally, the facility will provide investigators with reagents and expertise for the generation of induced pluripotent stem cells (iPSCs) as well as expert training in the protocols and techniques for proper handling and manipulation of human pluripotent stem cells. Our mission is to facilitate all aspects of pluripotent stem cell experimentation to contribute to advancing stem cell therapies for human disease. Director: James Wells, PhDEmail: PSCF@cchmc.orgPhone: 513-636-3744
Visit the Pluripotent Stem Cell Facility website.
The Pluripotent Stem Cell Facility is now using the CORES Billing system. For questions, please contact firstname.lastname@example.org.
Our core specializes in measuring locus-specific DNA methylation, genetic variations and mutations in a high throughput fashion.
Director: Hong JI, PhDPhone: 513-803-5055Lab Phone: Ashley Ulm, 513-803-0562Email: Hong.Ji@cchmc.org
Visit the Pyrosequencing Lab for Genomic and Epigenomic Research website.
The Pyrosequencing Lab for Genomic and Epigenomic Research is now using the CORES Billing system. For questions, please contact email@example.com.
We will train you to use cytometers for your research. We provide cell sorting, data analysis and even computer workstations. Once you’ve been trained by our staff, you may access our facilities 24 hours a day. Director: Sherry Thornton, PhDPhone: Cell sorting appointments, 513-636-2770; analyzer training, 513-636-3575
Visit the Research Flow Cytometry Core website..
The Research Flow Cytometry Core is now using the CORES Billing system. For questions, please contact firstname.lastname@example.org.
We supply mononuclear cells, stem cells or other enriched cell populations from peripheral blood, bone marrow and cord blood.Co-Directors: Diana Nordling, Carolyn Lutzko, PhDPhone: Lab Coordinator: Kevin Link, 513-803-1062; Stacy Bush, 513-636-0596
For General Inquiries please email the CPC Lab
Visit the Stem Cell Processing Core website.
We provide streamlined service from DNA to founder animals. We use the latest genome-editing technologies, such as CRISPR-Cas9 and TALEN, to generate animals carrying multiple knockout or knock-in alleles in a highly efficient and time-saving fashion. We also provide conventional approaches to generate transgenic mice by pronuclear microinjection and chimeric mice using embryonic stem cells. The facility has also undertaken several new initiatives including implementation of a fast CRISPR-Cas9 genetic screen system and generation of genetically modified rats. Other services available in the facility include cell targeting, targeting vector construction, sperm and embryo cryopreservation, BAC transgenics, ICSI, mouse recovery from cryopreserved sperm, and embryo transfer (re-derivation).
Director: Yueh-Chiang Hu, PhDPhone: 513-803-4962
Visit the Transgenic Animal and Genome Editing Core Facility website.
The Translational Core Labs include The Viral Vector Core, The Vector Production Facility, The Stem Cell Processing Lab, The Cell Manipulations Lab and the Translational Trial Development and Support Lab (TTDSL). We specialize in the translation and scale up of gene therapy and cell therapy including iPSC and HEK in addition to the patient testing associated with these trials.
Lab Directors: Punam Malik, MD, Diana NordlingPhone: Diana Nordling, 513-803-1063
Visit the Translational Core Labs website.
We coordinate and perform cellular and molecular testing required to document purity, function, clonal composition and overall safety of research preparations and preclinical and clinical samples. This is a CAP / CLIA-certified laboratory.
Director: Elke Grassman, PhDLab Manager: Kim MurphyPhone: 513-636-5998
For General Inquiries please contact the TTDSL Lab
Visit the Translational Trials Developmental and Support Laboratory(TTDSL) website.
We provide GMP-grade viral vectors, master cell banks and master viral banks in support of gene therapy trials. Director: Han van der Loo, PhDPhone: 513-803-1066Email: email@example.com
Visit the Vector Production Facility website.
The Vector Production Facility is now using the CORES Billing system. For questions, please contact firstname.lastname@example.org.
We offer routine and specialized husbandry, surgical support and expert consultation on regulatory issues (IACUC submissions) and animal transfers.Director: Gary Keller, DVMPhone: 513-636-4441
We provide research-grade retroviral lentiviral and adeno-associated virus vectors. Director: Han van der Loo, PhDLab Coordinator: Thouwa Samake, 513-803-1064
Visit the Viral Vector Core website.
The Viral Vector Core is now using the CORES Billing system. For questions, please contact email@example.com.
Cincinnati Children’s Research Foundation is working to incorporate all of our Shared Facilities into the CORES Billing system, a web-based interface for centralized ordering, billing and reporting.
Expand the accordion to the left to see if a Shared Facility is currently active in CORES Billing.
If you are a new user, please contact firstname.lastname@example.org to request an account.
Login to CORES Billing.
Our scientists and physicians work collaboratively to conduct innovative laboratory and clinical research to improve care for children, to investigate the outcomes of treatments, to study health care systems and to train the next generation of investigators.
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