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Charles Dumoulin, PhD Scientific Director, Imaging Research Center
is interested in the physics and engineering of magnetic resonance, MRI of neonates, and interventional MRI. His interests in interventional MR include: MR-guided Focused Ultrasound ablation for non-invasive "surgery" and MR-guided vascular interventions in which an MR scanner is used to guide catheters for procedures such as cardiac electrophysiology.
Scientific Director, Imaging Research Center
Professor, UC Department of Pediatrics
UC Department of Radiology
Medical imaging as it applies to radiology; cardiology; neonatology; neurology and pulmonary medicine
Alan S. Brody, MD Radiologist, Department of Radiology and Medical Imaging
Radiologist, Department of Radiology and Medical Imaging
Chief, Thoracic Imaging
Assistant Director of Clinical Research
Professor, UC Department of Radiology
Dr. Brody completed his fellowship in pediatric radiology in 1987 and then returned to the Department of Radiology and Medical Imaging at Cincinnati Children’s Hospital Medical Center in 1995. Dr. Brody is active in the Department of Radiology of University of Cincinnati as well as Cincinnati Children’s Hospital Medical Center in clinical care, research, teaching and administration. The primary focus of his clinical duties is pediatric thoracic imaging.
Dr. Brody’s research efforts are focused on the use of CT scanning in the evaluation of cystic fibrosis and diffuse lung disease in children. He began and continues to direct the National Resource Center for Imaging of the Cystic Fibrosis Foundation Therapeutic Development Network. This center is currently funded by the Cystic Fibrosis Foundation and by industry sponsors to provide expertise in the use of imaging endpoints for clinical trials. Dr. Brody is a founding member and chair of the imaging committee of the childhood Interstitial Disease Consortium.
Dr. Brody is a fellow of the American Academy of Pediatrics and is board certified in pediatrics and radiology. He holds a certificate of special qualification in pediatric radiology from the American Board of Radiology. Dr. Brody is a member of multiple national and international medical societies including senior membership in the Society for Thoracic Radiology, and membership in the Fleischner Society. Dr. Brody has been recognized as one of America’s top physicians since 2008.
AB: Biology, Kenyon College, Gambier, OH, 1975.
MD: Albert Einstein College of Medicine, Bronx, NY, 1980.
Residency: Pediatrics, University of California San Francisco, San Francisco, CA, 1980-1983; Radiology, University of California San Francisco, San Francisco, CA, 1983-1986.
Fellowship: Pediatric Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986-1987.
Certification: Pediatrics, 1986; Radiology, 1986; Certificate of Additional Qualification in Pediatric Radiology, 1995.
Kim M. Cecil, PhD Spectroscopist, Imaging Research Center
focuses on the application of MR spectroscopy and imaging in several populations by characterizing the features of inborn errors in metabolism and evaluating the effects of environmental neurotoxicants and radiation, respectively, on brain anatomy and function.
Spectroscopist, Imaging Research Center
MR spectroscopy and imaging; evaluating the effects of environmental neurotoxicants and radiation
Kim M. Cecil, PhD, received her undergraduate and postgraduate training in chemistry. After a post-doctoral fellowship in magnetic resonance spectroscopy and imaging at the Hospital of the University of Pennsylvania, Dr. Cecil joined the Department of Radiology and the Imaging Research Center at Cincinnati Children’s Hospital Medical Center in 1998. She serves as an imaging research scientist and clinical MR spectroscopist.
In 2000, Kim M. Cecil, PhD, Antonius deGrauw, MD, PhD and Gajja Salomons, PhD, discovered creatine transporter deficiency syndrome, a genetic disorder caused by mutations in the creatine transporter gene (SLC6A8). Male patients demonstrate a significant reduction or absence of creatine in the brain, as indicated by MR spectroscopy. This is an X-linked mental retardation disorder thought to be second only to fragile X in prevalence.
Mark DiFrancesco, PhD Assistant Director, Pediatric Neuroimaging Research Consortium
is interested in the use of concurrent EEG and fMRI to detect functional correlates of spontaneous brain activity, the study of the neurocognitive effects of Lupus using fMRI, applying functional imaging to investigate attentional deficits arising from sleep restriction in adolescents and assessing the impact of field strength on the quality of small animal brain imaging.
Assistant Director, Pediatric Neuroimaging Research Consortium
Assistant Professor, UC Department of Radiology
PhD: Physics, University of Pittsburgh, Pittsburgh, PA, 1989.
MS: Physics, University of Pittsburgh, Pittsburgh, PA, 1985.
BS: Physics, Carnegie-Mellon University, Pittsburgh, PA, 1981.
Randy O. Giaquinto Senior Imaging Research Engineer, Imaging Research Center
is interested in RF coil design, CAD and fabrication. Mr. Giaquinto has designed RF coils and system hardware for over 30 years, and is an expert on the design and clinical application of multi-channel array RF coils for MRI of the torso, heart, head, prostate and breast.
Senior Imaging Research Engineer, Imaging Research Center
Instructor, UC Department of Radiology
UC Department of Pediatrics
High channel MRI imaging
Randy Giaquinto currently holds 16 patents, and over 60 publications related to MRI Imaging. Prior to coming to Cincinnati Children's, he was a principle RF coil designer for GE Global Research Center for 30 years. Randy Giaquinto recently accepted a senior RF imaging engineering position at Cincinnati Children's Hospital Medical Center in July 2010.
Arunachalam A, Whitt D, Fish K, Giaquinto R, Piel J, Watkins R, Hancu I. Accelerated spectroscopic imaging of hyperpolarized C-13 pyruvate using SENSE parallel imaging. NMR Biomed. 2009 Oct;22(8):867-73.
Hardy CJ, Giaquinto RO, Piel JE, Rohling KW, Marinelli L, Blezek DJ, Fiveland EW, Darrow RD, Foo TK. 128-channel body MRI with a flexible high-density receiver-coil array. J Magn Reson Imaging. 2008 Nov;28(5):1219-25.
Niendorf T, Hardy CJ, Giaquinto RO, Gross P, Cline HE, Zhu Y, Kenwood G, Cohen S, Grant AK, Joshi S, Rofsky NM, Sodickson DK. Toward single breath-hold whole-heart coverage coronary MRA using highly accelerated parallel imaging with a 32-channel MR system. Magn Reson Med. 2006 Jul;56(1):167-76.
Hardy CJ, Cline HE, Giaquinto RO, Niendorf T, Grant AK, Sodickson DK. 32-element receiver-coil array for cardiac imaging. Magn Reson Med. 2006 May;55(5):1142-9.
Ohliger MA, Greenman RL, Giaquinto R, McKenzie CA, Wiggins G, Sodickson DK. Concentric coil arrays for parallel MRI. Magn Reson Med. 2005 Nov;54(5):1248-60.
Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications. Acad Radiol. 2005 May;12(5):626-35.
Lian J, Xing L, Hunjan S, Dumoulin C, Levin J, Lo A, Watkins R, Rohling K, Giaquinto R, Kim D, Spielman D, Daniel B. Mapping of the prostate in endorectal coil-based MRI/MRSI and CT: a deformable registration and validation study. Med Phys. 2004 Nov;31(11):3087-94.
Zhu Y, Hardy CJ, Sodickson DK, Giaquinto RO, Dumoulin CL, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Rofsky NM. Highly parallel volumetric imaging with a 32-element RF coil array. Magn Reson Med. 2004 Oct;52(4):869-77.
Hardy CJ, Darrow RD, Saranathan M, Giaquinto RO, Zhu Y, Dumoulin CL, Bottomley PA. Large field-of-view real-time MRI with a 32-channel system. Magn Reson Med. 2004 Oct;52(4):878-84.
Lee RF, Giaquinto RO, Hardy CJ. Coupling and decoupling theory and its application to the MRI phased array. Magn Reson Med. 2002 Jul;48(1):203-13.
Scott K. Holland, PhD Director, Pediatric Neuroimaging Research Consortium
focuses on pediatric neuroimaging applications of MRI at high field, which includes perfusion MRI, functional MRI, micro-imaging of transgenic mice, and image processing methods.
Director, Pediatric Neuroimaging Research Consortium
Director, Research in Patient Services
Director, Reading and Literacy Discovery Center
Advanced neuroimaging applications of MRI in pediatrics; functional MRI of language, hearing and neuroplasticity following brain injury; brain development.
Scott Holland is a physicist by training with a BS (1980) in Physics from Muhlenberg College, Allentown, PA. and an MS (1982) and PhD (1985) in Engineering and Applied Science from Yale University.
After a year (1985-86) as a Research Engineer with the Electromagnetic Sciences Laboratory at Stanford Research Institute (SRI International), Menlo Park, CA, Scott returned to the Yale School of Medicine as a post-doctoral fellow (1986-88) and later as an assistant professor (1988-94) of Diagnostic Radiology.
He joined the faculty of the University of Cincinnati College of Medicine in 1994 as associate professor of Radiology and Pediatrics and served as scientific director of the Imaging Research Center at Children's Hospital Medical Center until 2003.
In 2005 he founded the Pediatric Neuroimaging Research Consortium with the Department of Pediatric Radiology and the Divisions of Neurosurgery, Neurology, Psychiatry and Biostatistics at Cincinnati Children's. The PNRC continues to grow and currently consists of 8 full-time faculty members engaged in research using a broad range of neuroimaging techniques to study the developing brain under the influence of diseases of childhood. From 2009 to 2013, Scott led the Communication Sciences Research Center as its founding director. Currently he is serving as director of the new Division of Research in Patient Services.
His research currently focuses on pediatric neuroimaging applications of MRI, MEG and EEG methods; including perfusion MRI, functional MRI, and image processing methods, to study development of the neural circuitry of hearing, language, speech and reading capabilities through childhood. His discoveries regarding changes in brain activity and connectivity during typical childhood development and under the influence of neurological disorders have been influential in our understanding of neuroplasticity and reorganization of the developing brain in response to injury.
Res Hafeman DM, Bebko G, Bertocci MA, Fournier JC, Bonar L, Holland SK, Phillips ML. Abnormal Deactivation of the Inferior Frontal Gyrus During Implicit Emotion Processing in Youth with Bipolar Disorder: Attenuated by Medication. J Psychiatr Res. 2014;58:129-136.
Horowitz-Kraus T, Cicchino N, Amiel M, Holland SK, Breznitz Z. Reading Improvement in English- and Hebrew-Speaking Children with Reading Difficulties after Reading Acceleration Training. Ann Dyslexia. 2014;64(3):183-201.
Jacola LM, Byars AW, Hickey F, Vannest J, Holland SK, Schapiro MB. Functional Magnetic Resonance Imaging of Story Listening in Adolescents and Young Adults with Down Syndrome: Evidence for Atypical Neurodevelopment. J Intellect Disabil. 2014;58(10):892-902.
Bertocci MA, Bebko G, Olino T, Fournier J, Hinze AK, Bonar L, Phillips ML. Behavioral and Emotional Dysregulation Trajectories Marked by Prefrontal-Amygdala Function in Symptomatic Youth. Psychol Med. 2014;44(12),:2603-2615.
Horowitz-Kraus T, Wang Y, Plante E, Holland SK. Involvement of the Right Hemisphere in Reading Comprehension: A Dti Study. Brain Res. 2014;1582:34-44.
Schmithorst VJ, Vannest J, Lee G, Hernandez-Garcia L, Plante E, Rajagopal A, The CMIND Authorship Consortium. Evidence That Neurovascular Coupling Underlying the Bold Effect Increases with Age During Childhood. Hum Brain Mapp. 2014.
Vannest J, Rajagopal A, Cicchino ND, Franks-Henry J, Simpson SM, Lee G, The CMIND Authorship Consortium. Factors Determining Success of Awake and Asleep Magnetic Resonance Imaging Scans in Nonsedated Children. Neuropediatrics. 2014.
*Farah R, Schmithorst VJ, Keith RW, Holland SK. Altered White Matter Microstructure Underlies Listening Difficulties in Children Suspected of Auditory Processing Disorders: A Dti Study. Brain and Behavior. 2014;4(4):531-543.
Rajagopal A, Byars A, Schapiro M, Lee GR, Holland SK. Success Rates for Functional MR Imaging in Children. AJNR Am J Neuroradiol. 2014.
Wilke M, Rose DF, Holland SK, Leach JL. Multidimensional Morphometric 3d MRI Analyses for Detecting Brain Abnormalities in Children: Impact of Control Population. Hum Brain Mapp. 2014;35(7):3199-3215.
Reading & Literacy Discovery Center Tier 3. Principal Investigator. Schroth Charitable Trust. Jan 14 - Dec 16.
Developing a Reading and Literacy Discovery Center. Principal Investigator. Farmer Family Foundation. Nov 13 - Jun 15.
Developing a Reading and Literacy Discovery Center. Principal Investigator. Fischer Family Foundation. Jan 13 - Dec 15.
Structural and Network-Function Correlates of Fragmented Early Life Across Species. Consultant. National Institutes of Health. Jun 13 - Apr 18. 1P50MH096889-01.
Longitudinal Assessment of Manic Symptoms 2 (LAMS2). Collaborator. National Institutes of Health. Oct 10 - Sept 15. R01- MH073816.
Imaging the Effect of Centrotemporal Spikes and Seizures on Language in Children. Collaborator. National Institutes of Health. Jul 11 - Jun 16. R01 NS065840-01A1.
Yu Li, PhD
focuses on the technological development and clinical applications of high speed MR imaging and spectroscopy. Specifically, Dr. Li is interested in RF coil array for clinical MRI, parallel imaging, image reconstruction, microcoil array for NMR spectroscopy and clinical applications of parallel imaging.
Clinical applications of magnetic resonance imaging
Diana M. Lindquist, PhD
is the director for the In Vivo Micro-imaging Laboratory within the Imaging Research Center. Her research focuses on the metabolic effects of various pharmaceutical agents as measured by proton, phosphorus and carbon magnetic resonance spectroscopy.
Associate Professor, UC Department of Pediatrics
Magnetic resonance spectroscopy of drug effects; magnetic resonance spectroscopy of metabolic disease; multinuclear magnetic resonance spectroscopy; pulse sequence design
Shereen A, Nemkul N, Yang D, Adhami F, Dunn RS, Hazen ML, Nakafuku M, Ning G, Lindquist DM, Kuan CY. Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke. J Cereb Blood Flow Metab. 2010 Dec 8.
Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.
Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Lindquist DM, Brubaker CJ, Lanphear BP. Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure. Environ Health Perspect. 2010 Oct 13.
Brubaker CJ, Schmithorst VJ, Haynes EN, Dietrich KN, Egelhoff JC, Lindquist DM, Lanphear BP, Cecil KM. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009 Nov;30(6):867-75.
Yang D, Nemkul N, Shereen A, Jone A, Dunn RS, Lawrence DA, Lindquist D, Kuan CY. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. J Neurosci. 2009 Jul 8;29(27):8669-74.
McNamara RK, Able J, Jandacek R, Rider T, Tso P, Lindquist DM. Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. J Lipid Res. 2009 Mar;50(3):405-11.
Lindquist D. Science to Practice: What can phosphorus MRS tell us about muscle disease? Radiology. 2008 247:1-2.
Lindquist D. What can 31P MR spectroscopy tell us about muscle disease? Radiology. 2008 Apr;247(1):1-2.
Lindquist D. Science to Practice: Is there a role for MR imaging in monitoring gene therapy response? Radiology. 2007 Jun;243(3):611-2.
John M. Racadio, MD Division Chief, Interventional Radiology, Department of Radiology and Medical Imaging
is the division chief of pediatric interventional radiology (IR) and the director of the IR research lab. Research interests include developing image guided minimally invasive techniques to treat a wide range of pediatric diseases. Additional interests include development of x-ray dose lowering IR protocols for pediatric patients. He is also interested in pediatric applications of MRI guided High Intensity Focused Ultrasound ablation (HIFU).
Division Chief, Interventional Radiology, Department of Radiology and Medical Imaging
Vascular access; gastrointestinal interventional radiology
John Racadio, MD, has been practicing interventional radiology (IR) for 14 years and has been the division chief of interventional radiology at Cincinnati Children’s Hospital Medical Center for the past 11 years. He has expertise in performing a wide range of vascular procedures including angiography, angioplasty, embolization, vascular access, and thrombolysis in patients ranging from 500g to 150kg.
He is also the director of the interventional radiology research lab, which is part of the Department of Radiology Imaging Research Center (IRC). This state-of-the-art IR lab, which is identical to our clinical IR labs, possesses cutting edge digital flat detector technology including 3-D rotational angiography (3DRA), 3-D Roadmapping, and C-arm cone beam CT. These features provide superior image quality for digital subtraction angiography, 3-D angiography reconstruction, and “CT-like” imaging. Lab support staff includes RT(R) licensed IR technologists, and an IR lab manager. The long term goal of the IR research lab is to develop new image guided interventional procedures and imaging techniques and protocols to improve clinical outcomes. Having an IR research lab identical to our IR clinical labs facilitates translation of lab results into clinical practice.
BS: Stanford University, Palo Alto, CA, 1987.
MD: University of Cincinnati, Cincinnati, OH, 1992.
Residency: University of Cincinnati, Cincinnati, OH, 1993-1997.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-1998.
Certification: Certificate of Added Qualifications, Pediatric Radiology, November 2001; Diagnostic Radiology, American Board of Radiology, 1997.
Hawkins CM, Racadio JM, McKinney DN, Racadio JM, Vu DN. Varicocele retrograde embolization with boiling contrast medium and gelatin sponges in adolescent subjects: a clinically effective therapeutic alternative. J Vasc Interv Radiol. 2012 Feb;23(2):206-10.
Patel MN, Racadio JM, Levitt MA, Bischoff A, Racadio JM, Peña A. Complex cloacal malformations: use of rotational fluoroscopy and 3-D reconstruction in diagnosis and surgical planning. Pediatr Radiol. 2012 Mar;42(3):355-63.
Sheyn DD, Racadio JM, Racadio JM, Patel MN, Kukreja K, Rampton JW, Johnson ND. Use of an Amplatz dilator to facilitate transrectal abscess drainage in children. J Vasc Interv Radiol. 2011 May;22(5):687-90.
Racadio JM, Kukreja K. Pediatric biliary interventions. Tech Vasc Interv Radiol. 2010 Dec;13(4):244-9.
Sidhu M, Strauss KJ, Connolly B, Yoshizumi TT, Racadio J, Coley BD, Utley T, Goske MJ. Radiation safety in pediatric interventional radiology. Tech Vasc Interv Radiol. 2010 Sep;13(3):158-66.
Racadio JM, Babic D, Homan R, Rampton JW, Patel MN, Racadio JM, Johnson ND. Live 3D guidance in the interventional radiology suite. AJR Am J Roentgenol. 2007 Dec;189(6):W357-64. Review.
Vo NJ, Hammelman BD, Racadio JM, Strife CF, Johnson ND, Racadio JM. Anatomic distribution of renal artery stenosis in children: implications for imaging. Pediatr Radiol. 2006 Oct;36(10):1032-6.
Williams JM, Racadio JM, Johnson ND, Donnelly LF, Bissler JJ. Embolization of renal angiomyolipomata in patients with tuberous sclerosis complex. Am J Kidney Dis. 2006 Jan;47(1):95-102.
Fricke BL, Racadio JM, Duckworth T, Donnelly LF, Tamer RM, Johnson ND. Placement of peripherally inserted central catheters without fluoroscopy in children: initial catheter tip position. Radiology. 2005 Mar;234(3):887-92.
Racadio JM, Doellman DA, Johnson ND, Bean JA, Jacobs BR. Pediatric peripherally inserted central catheters: complication rates related to catheter tip location. Pediatrics. 2001 Feb;107(2):E28.
Michael D. Taylor, MD Director, Advanced Imaging Innovation
is a non-invasive cardiologist interested in applications of imaging to problems of congenital and acquired heart disease. His primary research interest is cardiac MRI and its application in evaluating myocardial function and disease. He has a translational program that uses multi-modality imaging to characterize mouse models of inherited and acquired cardiomyopathies.
Director, Advanced Imaging Innovation
Cardiac MRI; cardiac CT; and echocardiography
Michael Taylor, MD, joined the Heart Institute in July, 2010 as the director of Advanced Imaging Innovation. He was previously the director of cardiac magnetic resonance at Texas Children’s Hospital in Houston.
Dr. Taylor has expertise in cardiac magnetic resonance imaging, positron emission tomography and computed tomography. He has a dual appointment in the Cincinnati Children's Hospital Medical Center Imaging Research Center, an interdisciplinary facility of advanced imaging faculty with dedicated clinical and pre-clinical imaging equipment.
Dr. Taylor's primary interests include myocardial metabolism in heart failure, animal models of cardiac pathology, and cardiac magnetic resonance imaging of congenital and acquired heart disease.
MD: University of Wisconsin, Madison, WI, 2001.PhD: Medical Physics, University of Wisconsin, Madison, WI, 2001.
Residency: Pediatrics, Baylor College of Medicine, Houston, TX, 2003.Fellowship: Pediatric Cardiology, Baylor College of Medicine, Houston, TX, 2006.Certification: Pediatrics, 2005.Certification: Pediatric Cardiology, 2006.
Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, Chung ES, Taylor MD, Jefferies JL, Woodrow Benson D, Gottliebson WM. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2011 Jan 8. Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502.
LP Browne, D Kearney, MD Taylor, T Chung, TC Slesnick, AC Nutting, R Krishnamurthy. ALCAPA: the role of myocardial viability studies in determining prognosis . Pediatr Radiol. 2010;40(2):163-167. JL Jefferies, MD Taylor, J Rossano, JW Belmont, WJ Craigen. Novel cardiac findings in periventricular nodular heterotopia . Am J Med Genet. 2009; 152A(1): 165-168. JW Rossano, MD Taylor, EO Smith, CD Fraser, ED McKenzie, JF Price, HA Dickerson, DP Nelson, AR Mott. Glycemic profile in infants who have undergone the arterial switch operation: hyperglycemia is not associated with adverse events . J Thorac Cardiovasc Surg. 2008; 135(4): 739-745.
Jean Tkach, PhD
is focused on neonatal MRI, functional MRI, MR angiography, magnetization transfer saturation MRI, MR spectroscopy and steady state MR techniques. Dr. Tkach's research focuses on neurological disease, including white matter disease, epilepsy, brain tumors and aneurysms. In addition, she has interests in MR safety testing of medical implants
Associate Professor, UC Department of Radiology
Neonatal MR acquisition technique development, optimization and application
BSE: Biomedical Engineering, Duke University, 1982.
MS: Biomedical Engineering, Case Western Reserve University, 1985.
PhD: Biomedical Engineering, Case Western Reserve University, 1988.
Jennifer J. Vannest, PhD Assistant Director, Pediatric Neuroimaging Research Consortium
is interested in the use of functional MRI and behavioral testing to examine how epilepsy and neurodevelopmental disorders affect language function and the brain circuitry that supports it. The goal of these studies is to provide better treatment and educational strategies for children with these disorders.
Cognitive neuroscience of language and memory (using functional MRI); cognitive effects of epilepsy and neurodevelopmental disorders
Neurological disorders and language impairments
Jennifer Vannest, PhD, completed her undergraduate education at the Ohio State University and continued there for her graduate work. Her PhD is in linguistics, and in addition, her graduate training included a number of courses in cognitive psychology, neuropsychology and speech and hearing sciences. As a postdoctoral fellow at University of Michigan and University of Rochester, Dr. Vannest was trained to use functional MRI to study the brain mechanisms underlying language skill.
Dr. Vannest came to Cincinnati Children's Hospital Medical Center in 2006, and her current research makes use of functional MRI to examine how epilepsy and neurodevelopmental disorders affect language function, ultimately leading to better treatment and educational strategies for children with these disorders.
PhD: Ohio State University, Linguistics.
Postdoctoral Training: University of Michigan (Psychology), University of Rochester (Brain and Cognitive Sciences).
Vannest J, Newport EL, Newman AJ, Bavelier D. Interplay between morphology and frequency in lexical access: The case of the base frequency effect. Brain Res. 2011 Feb 10;1373:144-59. Korostenskaja M, Pardos M, Fujiwara H, Kujala T, Horn P, Rose D, Byars A, Brown D, Seo JH, Wang Y, Vannest J, Xiang J, Degrauw T, Näätänen R, Lee KH. Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy. Epilepsy Res. 2010 Nov;92(1):63-73.
Vannest J, Rasmussen J, Eaton KP, Patel K, Schmithorst V, Karunanayaka P, Plante E, Byars A, Holland S. FMRI activation in language areas correlates with verb generation performance in children. Neuropediatrics. 2010 Oct;41(5):235-9. Szaflarski JP, Eaton K, Ball AL, Banks C, Vannest J, Allendorfer JB, Page S, Holland SK. Poststroke Aphasia Recovery Assessed With Functional Magnetic Resonance Imaging and a Picture Identification Task. J Stroke Cerebrovasc Dis. 2010 Aug 17. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study. NeuroImage. 2010 May 15;51(1):472-87. Vannest J, Karunanayaka PR, Schmithorst VJ, Szaflarski JP, Holland SK. Language networks in children: evidence from functional MRI studies. AJR Am J Roentgenol. 2009 May;192(5):1190-6. Vannest JJ, Karunanayaka PR, Altaye M, Schmithorst VJ, Plante EM, Eaton KJ, Rasmussen JM, Holland SK. Comparison of fMRI data from passive listening and active-response story processing tasks in children. J Magn Reson Imaging. 2009 Apr;29(4):971-6. Wang Y, Xiang J, Kotecha R, Vannest J, Liu Y, Rose D, Schapiro M, Degrauw T. Spatial and frequency differences of neuromagnetic activities between the perception of open- and closed-class words. Brain Topogr. 2008 Dec;21(2):75-85.
Liu Y, Xiang J, Wang Y, Vannest JJ, Byars AW, Rose DF. Spatial and frequency differences of neuromagnetic activities in processing concrete and abstract words. Brain Topogr. 2008 Spring;20(3):123-9.
Vannest J, Szaflarski JP, Privitera MD, Schefft BK, Holland SK. Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy. Epilepsy Behav. 2008 Apr;12(3):410-8.
Janaka P. Wansapura, PhD
research is focused on the study of non-ischemic cardiomyopathy using advance MRI methodologies including arterial spin labeling, myocardial tagging, relaxation time mapping and delayed enhancement. His cardiac MRI research extends from mouse models to clinical studies. Dr. Wansapura’s other research interests include mathematical modeling, vascular compliance, MR based thermometry and fat/water decomposition.
Cardiovascular functional imaging; myocardial perfusion; imaging of non-ischemic cardiomyopathy; MRI of vascular function; MRI based fat quantification; MR thermometry
PhD: Physics, University of Cincinnati, OH, 1998.
MS: Physics, University of Cincinnati, OH, 1996.
BSc: Special Degree in Physics with first class honors. University of Colombo, Sri Lanka, 1991.
Cardiac Structure and Function in Early Familial Cardiomyopathy. Principal Investigator. National Institutes of Health. Jan 2010 - Mar 2015. #K25 HL102244-01.
Cardiovascular Disease in Children with Chronic Kidney Disease. Co-Investigator. Jul 2011 - Jun 2016.
Jason C. Woods, PhD Director, Center for Pulmonary Imaging Research
is an imaging scientist who focuses on basic and translational pulmonary MRI and CT. His lab studies new methods for in-vivo assessment of regional pulmonary function, microstructure and physiology using hyperpolarized gases (3He and 129Xe) and 1H MRI, in addition to multi-volume CT. As new therapeutics for pulmonary diseases are developed, these new methods will be used for efficacy assessment and potential image guidance.
Director, Center for Pulmonary Imaging Research
Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions
Dr. Woods is one of the world’s leading experts on hyperpolarized-gas MRI and the use of such gas MRI to measure regional lung function, microstructure and physiology. He began his career at Washington University, where he helped lead multiple team projects related to lung imaging, biology and physiology. Interests in both world-class science and higher education led him to pursue simultaneous roles as a professor and academic dean, when he became program director for Washington University’s MARC (T34) training program.
Currently Dr. Woods directs the Center for Pulmonary Imaging Research at Cincinnati Children’s Hospital Medical Center. The center is a multidisciplinary research and training program at the intersection of pulmonary medicine and radiology.
PhD: Washington University, St. Louis, MO, 2002.
Postdoctoral: Washington University, St. Louis, MO, 2004.
DA Yablonskiy, AL Sukstanskii, JD Quirk, JC Woods, MS Conradi. Probing Lung Microstructure in Health and Disease with Hyperpolarized Noble Gases Diffusion MRI: Theoretical Models and Experimental Results. Magn Reson Med. 2013 Apr 2.
M Castro, JC Woods. Insights into pediatric asthma with hyperpolarized MRI of the Lung. J Allergy Clin Immunol. 2013;131:377-378.
AJ Hajari, DA Yablonskiy, AL Sukstanskii, JD Quirk, MS Conradi, JC Woods. Morphometric changes in the human pulmonary acinus during inflation. J Appl Physiol. 2012;112:937-43.
A Aliverti, F Pennati, C Salito, JC Woods. Regional lung function and heterogeneity of specific gas volume in health and emphysema. Eur Resp J2012. 2012 Aug 9.
W Wang, NM Nguyen, E Agapov, DA Yablonskiy, MJ Holtzman, JC Woods. Monitoring in-vivo changes in lung microstructure with 3He MRI in Sendai-virus infected mice. J Appl Physiol. 2012;112:1593-1599.
W Wang, NM Nguyen, DA Yablonskiy, AL Sukstanskii, E Osmanagic, JJ Atkinson, MS Conradi, JC Woods. Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI. Mag Reson Med. 2011;65:620-626.
JD Quirk, BA Lutey, DS Gierada, JC Woods, RM Senior, SS Lefrak, AL Sukstanskii, MS Conradi, DA Yablonskiy. Detection of Acinar Microstructural Changes in Early Emphysema by in vivo Lung Morphometry with Hyperpolarized 3He MRI. Radiology. 2011;260:866-874.
JE McDonough, R Yuan, M Suzuki, N Seyednejad, WM Elliott, PG Sanchez, AC Wright, WB Gefter, L Litzky, HO Coxson, PD Paré, DD Sin, RA Pierce, JC Woods, JD Cooper, JC Hogg. The relationship between small airway obstruction and emphysematous destruction in chronic obstructive pulmonary disease. New Engl J Med. 2011;365:1567-1575.
C Salito, JC Woods, A Aliverti. 3-D airway tree reconstruction in healthy subjects and emphysema patients. Lung. 2011;189:287-293.
AH Hajari, DA Yablonskiy, JD Quirk, AL Sukstanskii, RA Pierce, G Deslée, MS Conradi, JC Woods. Alveolar-duct geometry during expiration via 3He lung morphometry. J Appl Physiol. 2011;110:1448-54.
Single-session bronchial thermoplasty for severe asthmatics guided by HXe MRI. Co-Principal Investigator. NHLBI. Sep 2012 – Aug 2015.
Severe Asthma Research Program (SARP). Investigator. NHLBI. Aug 2011 – Jul 2017.
Weihong Yuan, PhD
Weihong Yuan, PhD, joined the faculty in 2005 and currently is the McLaurin fellow in pediatric neurosurgery and research assistant professor of radiology at Cincinnati Children's Hospital Medical Center and the University of Cincinnati. He is a biomedical engineer by training with BS degree (1991) from Zhejiang University, PRC, and MS (1997) and PhD degree (2000) from Rutgers, The State University of New Jersey, Piscataway, NJ.
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