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Charles Dumoulin, PhD Director, Imaging Research Center
is interested in the physics and engineering of magnetic resonance, MRI of neonates, and interventional MRI. His interests in interventional MR include: MR-guided focused ultrasound ablation for non-invasive "surgery" and MR-guided vascular interventions in which an MR scanner is used to guide catheters for procedures such as cardiac electrophysiology.
Director, Imaging Research Center
Professor, UC Department of Pediatrics
UC Department of Radiology
Medical imaging as it applies to radiology; cardiology; neonatology; neurology and pulmonary medicine
Charles Dumoulin, PhD, received his BS in chemistry from Florida State University in 1977 and his PhD degree in analytical chemistry in 1981. He then spent three years performing high-resolution NMR spectroscopy research at Syracuse University before moving to General Electric’s Research and Development Center in Niskayuna, NY, where he became part of the team that developed the first industrial prototype MR scanners.
Later, Dr. Dumoulin made major contributions to the fields of magnetic resonance angiography (MRA), dynamic MRI and interventional MRI (resulting in over 100 issued patents). In 2008 Dr. Dumoulin moved to Cincinnati and became the scientific director of the Imaging Research Center. His current research interests include MRI imaging of neonates, MR-guided focused ultrasound ablation, and interventional MR.
Donnelly LF, Gessner KE, Dickerson JM, Koch BL, Towbin AJ, Lehkamp TW, Moskovitz J, Brody AS, Dumoulin CL, Jones BV. Quality initiatives: department scorecard: a tool to help drive imaging care delivery performance. Radiographics. 2010 Nov;30(7):2029-38.
Dumoulin CL, Mallozzi RP, Darrow RD, Schmidt EJ. Phase-field dithering for active catheter tracking. Magn Reson Med. 2010 May;63(5):1398-403.
Schmidt EJ, Mallozzi RP, Thiagalingam A, Holmvang G, d’Avila A, Guhde R, et al. Electroanatomic Mapping and Radio-Frequency Ablation in Porcine Models of Atrial Fibrillation Using Magnetic Resonance Catheter Tracking. Circulation.
DeMan B, Pelc N, Dumoulin CL,Bernstein T. Propagation of quantum noise in multiplexed x-ray imaging. SPIE.
Schmidt EJ, Yoneyama R, Dumoulin CL, Darrow RD, Klein E, Hayase M. Detailed 3D Coronary Motion Tracking in Swine Models Using MR Tracking Catheters. Journal of Magnetic Resonance Imaging 2009;29:86-98.
Dukkipati SR, Mallozzi R, Schmidt EJ, d’Avila A, Holmvang G, Guhde R, et al. Electroanatomic Mapping of the Left Ventricle in a Porcine Model of Chronic Myocardial Infarction using Magnetic Resonance-Tracking. Circulation DOI: 10.1161/CIRCULATIONAHA.107.738229 (August 4, 2008).
Feng L, Dumoulin CL, Dashnaw S, Darrow RD, DeLaPaz R, Bishop PL, Pile-Spellman J. Feasibility of Stent Placement in Carotid Arteries with Real-time MR Imaging Guidance in Pigs. Radiology 2005;234:558-62.
Feng L, Dumoulin CL, Dashnaw S, Darrow RD, Guhde R, DeLaPaz R, Bishop PL, Pile-Spellman J. Transfemoral Catheterization of Carotid Arteries With Real-Time MR Imaging Guidance in Pigs. Radiology 2005;234:551-7.
Alan S. Brody, MD Radiologist, Department of Radiology and Medical Imaging
focuses on imaging of the chest in cystic fibrosis and in childhood diffuse lung disease. He directs the Center for Diagnostic Imaging of the Therapeutic Development Network of the Cystic Fibrosis Foundation.
Radiologist, Department of Radiology and Medical Imaging
Chief, Thoracic Imaging
Assistant Director of Clinical Research
Professor, UC Department of Radiology
Pediatric thoracic imaging; cystic fibrosis; diffuse lung disease
Dr. Brody completed his fellowship in pediatric radiology in 1987 and then returned to the Department of Radiology and Medical Imaging at Cincinnati Children’s Hospital Medical Center in 1995. Dr. Brody is active in the Department of Radiology of University of Cincinnati as well as Cincinnati Children’s Hospital Medical Center in clinical care, research, teaching and administration. The primary focus of his clinical duties is pediatric thoracic imaging.
Dr. Brody’s research efforts are focused on the use of CT scanning in the evaluation of cystic fibrosis and diffuse lung disease in children. He began and continues to direct the National Resource Center for Imaging of the Cystic Fibrosis Foundation Therapeutic Development Network. This center is currently funded by the Cystic Fibrosis Foundation and by industry sponsors to provide expertise in the use of imaging endpoints for clinical trials. Dr. Brody is a founding member and chair of the imaging committee of the childhood Interstitial Disease Consortium.
Dr. Brody is a fellow of the American Academy of Pediatrics and is board certified in pediatrics and radiology. He holds a certificate of special qualification in pediatric radiology from the American Board of Radiology. Dr. Brody is a member of multiple national and international medical societies including senior membership in the Society for Thoracic Radiology and membership in the Fleischner Society. Dr. Brody has been recognized as one of America’s top physicians since 2008.
AB: Biology, Kenyon College, Gambier, OH, 1975.
MD: Albert Einstein College of Medicine, Bronx, NY, 1980.
Residency: Pediatrics, University of California San Francisco, San Francisco, CA, 1980-1983; Radiology, University of California San Francisco, San Francisco, CA, 1983-1986.
Fellowship: Pediatric Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986-1987.
Certification: Pediatrics, 1986; Radiology, 1986; Certificate of Additional Qualification in Pediatric Radiology, 1995.
Kim M. Cecil, PhD Spectroscopist, Imaging Research Center
focuses on the application of MR spectroscopy and imaging techniques to enhance how we characterize disease and injury; evaluating the neural effects of environmental neurotoxicants, and radiation; improving the diagnosis of inborn errors of metabolism; unraveling the etiology of neurodevelopmental disorders.
Spectroscopist, Imaging Research Center
UC Department of Pediatrics
Magnetic resonance spectroscopy; creatine deficiency syndromes
Kim M. Cecil, PhD, received her undergraduate and postgraduate training in chemistry. After a post-doctoral fellowship in magnetic resonance spectroscopy and imaging at the Hospital of the University of Pennsylvania, Dr. Cecil joined the Department of Radiology and the Imaging Research Center at Cincinnati Children’s Hospital Medical Center in 1998. She serves as an imaging research scientist and clinical MR spectroscopist.
In 2000, Kim M. Cecil, PhD, Antonius deGrauw, MD, PhD, and Gajja Salomons, PhD, discovered creatine transporter deficiency syndrome, a genetic disorder caused by mutations in the creatine transporter gene (SLC6A8). Male patients demonstrate a significant reduction or absence of creatine in the brain, as indicated by MR spectroscopy. This is an X-linked mental retardation disorder thought to be second only to fragile X in prevalence.
BS: Chemistry & Mathematics (magna cum laude), Kentucky Wesleyan College, 1988.
MS: Chemistry, Vanderbilt University, 1991.
PhD: Chemistry, Vanderbilt University, 1993.
Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA.
Clark JF, Cecil KM. Diagnostic methods and recommendations for the cerebral creatine deficiency syndromes. Pediatr Res. 2015;77:398-405.
Maugans TA, Farley C, Altaye M, Leach J, Cecil KM. Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics. 2012;129:28-37.
Cecil KM, Dietrich KN, Altaye M, et al. Proton magnetic resonance spectroscopy in adults with childhood lead exposure. Environ Health Perspect. 2011;119:403-8.
Brubaker CJ, Dietrich KN, Lanphear BP, Cecil KM. The influence of age of lead exposure on adult gray matter volume. Neurotoxicology. 2010;31:259-66.
Brubaker CJ, Schmithorst VJ, Haynes EN, et al. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009;30:867-75.
Yuan W, Holland SK, Cecil KM, et al. The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function. Pediatrics. 2006;118:971-7.
Salomons GS, van Dooren SJ, Verhoeven NM, et al. X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome. Am J Hum Genet. 2001;68:1497-500.
Cecil KM, Salomons GS, Ball WS Jr, et al. Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect? Ann Neurol. 2001;49:401-4.
Strakowski SM, DelBello MP, Adler C, Cecil KM, Sax KW. Neuroimaging in bipolar disorder. Bipolar Disord. 2000;2:148-64.
Roebuck JR, Cecil KM, Schnall MD, Lenkinski RE. Human breast lesions: characterization with proton MR spectroscopy. Radiology. 1998;209:269-75.
Impact of PBDE and PFC Exposures: Internalizing Behaviors and Neuroimaging Outcomes. Co-Principal Investigator. CHRF GAP Funding. Jan 2016-Dec 2016.
MRS of Creatine Transporter Deficiency Syndrome. Principal Investigator. Lumos Pharma. Sept 2015-Sept 2016.
Outcome of NASH in Adolescents after Bariatric Surgery vs. Lifestyle Intervention. Co-Investigator. National Institutes of Health. Sept 2013-Aug 2018. R01 DK100429.
Neurobehavioral and Neuroimaging Effects of Traffic Exposure in Children. Co-Investigator. National Institutes of Health. Jun 2012-May 2017. R01 ES019890.
Anomalous Motor Physiology in ADHD. Co-Investigator. National Institutes of Health. May 2012-Apr 2017. R01 MH095014.
Robert C. Coghill, PhD Director of Research, Division of Anesthesiology
is focused on delineating the neural mechanisms supporting individual differences in pain.
Director of Research, Division of Anesthesiology
Senior Scientist, Division of Anesthesiology
Professor, UC Department of Anesthesiology
Chronic pain; acute pain; brain imaging; sensory testing
Robert C. Coghill is focused on delineating the neural mechanisms supporting individual differences in pain. His research interleaves data obtained with functional MRI of brain activity with subjective reports of pain and psychological state. His work encompasses studies of the effects of expectations on pain, brain mechanisms supporting attention to pain, and processes associated with the cognitive modulation of pain. He is also highly interested in understanding how the nervous system evaluates and constructs an experience of sensory components of pain, including perceived intensity and location. Dr. Coghill also seeks to develop of better tools for the measurement of multiple dimensions of the pain experience.
Together, these pain assessments, psychological profiles, and neuroimaging endpoints can be used in combination to develop strategies to better predict, diagnose, and treat pain. More importantly, this research will be critically important for advancing personalized medicine, with the long-term goal of identifying the best treatment for each individual child.
PhD: Virginia Commonwealth University, Richmond, VA, 1991.
Post-doctoral Fellowship: University of Montreal, Montreal, Quebec.
Post-doctoral Fellowship: National Institutes of Health, Bethesda, MD.
Emerson NM, Zeidan F, Lobanov OV, Hadsel MS, Martucci KT, Quevedo AS, Starr CJ, Nahman-Averbuch H, Weissman-Fogel I, Granovsky Y, Yarnitsky D, Coghill RC. Pain sensitivity is inversely related to regional grey matter density in the brain. Pain. 2014;155(3):566-573.
Starr CJ, Sawaki L, Wittenberg GF, Burdette JH, Oshiro Y, Quevedo AS, McHaffie JG, Coghill RC. The contribution of the putamen to sensory aspects of pain: insights from structural connectivity and brain lesions. Brain. 2011;134(Pt7):1987-2004.
Quevedo AS, Coghill RC. Attentional modulation of spatial integration of pain: Evidence for dynamic spatial tuning. J Neurosci. 2007;27(43):11635-40.
Koyama T, McHaffie J, Laurienti P, Coghill RC. The subjective experience of pain: Where expectations become reality. Proc Natl Acad Sci. 2005;102:12950-12955.
Coghill RC, McHaffie JG, Yen Y-F. Neural correlates of inter-individual differences in the subjective experience of pain. Proc Natl Acad Sci. 2003;100:8538-8542.
Grill JD, Coghill RC. Transient analgesia evoked by noxious stimulus offset. J Neurophysiol. 2002 Apr;87(4):2205-8.
Coghill RC, Sang CN, Maisog JM, Iadarola MJ. Pain intensity processing within the human brain: A bilateral, distributed mechanism. J Neurophysiol. 1999;82:1934-1943.
Coghill RC, Talbot JD, Meyer E, Gjedde A, Evans AC, Bushnell MC, Duncan GH. Distributed processing of pain and vibration in the human brain. J Neurosci. 1994;14:4095-4108.
Mark DiFrancesco, PhD Assistant Director, Pediatric Neuroimaging Research Consortium
is interested in the use of concurrent EEG and fMRI to detect functional correlates of spontaneous brain activity, the study of the neurocognitive effects of lupus using fMRI, applying functional imaging to investigate attentional deficits arising from sleep restriction in adolescents and assessing the impact of field strength on the quality of small animal brain imaging.
Assistant Director, Pediatric Neuroimaging Research Consortium
Assistant Professor, UC Department of Radiology
PhD: Physics, University of Pittsburgh, Pittsburgh, PA, 1989.
MS: Physics, University of Pittsburgh, Pittsburgh, PA, 1985.
BS: Physics, Carnegie-Mellon University, Pittsburgh, PA, 1981.
Randy O. Giaquinto Senior Imaging Research Engineer, Imaging Research Center
is interested in RF coil design, CAD and fabrication. Mr. Giaquinto has designed RF coils and system hardware for over 30 years, and is an expert on the design and clinical application of multi-channel array RF coils for MRI of the torso, heart, head, prostate and breast.
Senior Imaging Research Engineer, Imaging Research Center
Instructor, UC Department of Radiology
High channel MRI imaging
Randy Giaquinto currently holds 16 patents and over 60 publications related to MRI Imaging. Prior to coming to Cincinnati Children's, he was a principle RF coil designer for GE Global Research Center for 30 years. Randy Giaquinto recently accepted a senior RF imaging engineering position at Cincinnati Children's Hospital Medical Center in July 2010.
Arunachalam A, Whitt D, Fish K, Giaquinto R, Piel J, Watkins R, Hancu I. Accelerated spectroscopic imaging of hyperpolarized C-13 pyruvate using SENSE parallel imaging. NMR Biomed. 2009 Oct;22(8):867-73.
Hardy CJ, Giaquinto RO, Piel JE, Rohling KW, Marinelli L, Blezek DJ, Fiveland EW, Darrow RD, Foo TK. 128-channel body MRI with a flexible high-density receiver-coil array. J Magn Reson Imaging. 2008 Nov;28(5):1219-25.
Niendorf T, Hardy CJ, Giaquinto RO, Gross P, Cline HE, Zhu Y, Kenwood G, Cohen S, Grant AK, Joshi S, Rofsky NM, Sodickson DK. Toward single breath-hold whole-heart coverage coronary MRA using highly accelerated parallel imaging with a 32-channel MR system. Magn Reson Med. 2006 Jul;56(1):167-76.
Hardy CJ, Cline HE, Giaquinto RO, Niendorf T, Grant AK, Sodickson DK. 32-element receiver-coil array for cardiac imaging. Magn Reson Med. 2006 May;55(5):1142-9.
Ohliger MA, Greenman RL, Giaquinto R, McKenzie CA, Wiggins G, Sodickson DK. Concentric coil arrays for parallel MRI. Magn Reson Med. 2005 Nov;54(5):1248-60.
Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications. Acad Radiol. 2005 May;12(5):626-35.
Lian J, Xing L, Hunjan S, Dumoulin C, Levin J, Lo A, Watkins R, Rohling K, Giaquinto R, Kim D, Spielman D, Daniel B. Mapping of the prostate in endorectal coil-based MRI/MRSI and CT: a deformable registration and validation study. Med Phys. 2004 Nov;31(11):3087-94.
Zhu Y, Hardy CJ, Sodickson DK, Giaquinto RO, Dumoulin CL, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Rofsky NM. Highly parallel volumetric imaging with a 32-element RF coil array. Magn Reson Med. 2004 Oct;52(4):869-77.
Hardy CJ, Darrow RD, Saranathan M, Giaquinto RO, Zhu Y, Dumoulin CL, Bottomley PA. Large field-of-view real-time MRI with a 32-channel system. Magn Reson Med. 2004 Oct;52(4):878-84.
Lee RF, Giaquinto RO, Hardy CJ. Coupling and decoupling theory and its application to the MRI phased array. Magn Reson Med. 2002 Jul;48(1):203-13.
Scott K. Holland, PhD Director, Research in Patient Services
focuses on pediatric neuroimaging applications of MRI at high field, which includes perfusion MRI, functional MRI, micro-imaging of transgenic mice, and image processing methods.
Director, Research in Patient Services
Director, Reading and Literacy Discovery Center
Advanced neuroimaging applications of MRI in pediatrics; functional MRI of language, hearing and neuroplasticity following brain injury; brain development.
Scott Holland is a physicist by training with a BS (1980) in physics from Muhlenberg College, Allentown, PA, and an MS (1982) and PhD (1985) in engineering and applied science from Yale University.
After a year (1985-86) as a research engineer with the Electromagnetic Sciences Laboratory at Stanford Research Institute (SRI International), Menlo Park, CA, Scott returned to the Yale School of Medicine as a post-doctoral fellow (1986-88) and later as an assistant professor (1988-94) of diagnostic radiology.
He joined the faculty of the University of Cincinnati College of Medicine in 1994 as associate professor of radiology and pediatrics and served as scientific director of the Imaging Research Center at Children's Hospital Medical Center until 2003.
In 2005 he founded the Pediatric Neuroimaging Research Consortium with the Department of Pediatric Radiology and the Divisions of Neurosurgery, Neurology, Psychiatry and Biostatistics at Cincinnati Children's. The PNRC continues to grow and currently consists of eight full-time faculty members engaged in research using a broad range of neuroimaging techniques to study the developing brain under the influence of diseases of childhood. From 2009 to 2013, Scott led the Communication Sciences Research Center as its founding director. Currently he is serving as director of the new Division of Research in Patient Services.
His research currently focuses on pediatric neuroimaging applications of MRI, MEG and EEG methods; including perfusion MRI, functional MRI, and image processing methods, to study development of the neural circuitry of hearing, language, speech and reading capabilities through childhood. His discoveries regarding changes in brain activity and connectivity during typical childhood development and under the influence of neurological disorders have been influential in our understanding of neuroplasticity and reorganization of the developing brain in response to injury.
BS: Physics (magna cum laude), Muhlenberg College, 1980.
MS: Engineering & Applied Science, Yale University,1982.
MPhil: Engineering & Applied Science, Yale University, 1983.
PhD: Engineering and Applied Science, Yale University, 1985.
Res Hafeman DM, Bebko G, Bertocci MA, Fournier JC, Bonar L, Holland SK, Phillips ML. Abnormal Deactivation of the Inferior Frontal Gyrus During Implicit Emotion Processing in Youth with Bipolar Disorder: Attenuated by Medication. J Psychiatr Res. 2014;58:129-136.
Horowitz-Kraus T, Cicchino N, Amiel M, Holland SK, Breznitz Z. Reading Improvement in English- and Hebrew-Speaking Children with Reading Difficulties after Reading Acceleration Training. Ann Dyslexia. 2014;64(3):183-201.
Jacola LM, Byars AW, Hickey F, Vannest J, Holland SK, Schapiro MB. Functional Magnetic Resonance Imaging of Story Listening in Adolescents and Young Adults with Down Syndrome: Evidence for Atypical Neurodevelopment. J Intellect Disabil. 2014;58(10):892-902.
Bertocci MA, Bebko G, Olino T, Fournier J, Hinze AK, Bonar L, Phillips ML. Behavioral and Emotional Dysregulation Trajectories Marked by Prefrontal-Amygdala Function in Symptomatic Youth. Psychol Med. 2014;44(12),:2603-2615.
Horowitz-Kraus T, Wang Y, Plante E, Holland SK. Involvement of the Right Hemisphere in Reading Comprehension: A Dti Study. Brain Res. 2014;1582:34-44.
Schmithorst VJ, Vannest J, Lee G, Hernandez-Garcia L, Plante E, Rajagopal A, The CMIND Authorship Consortium. Evidence That Neurovascular Coupling Underlying the Bold Effect Increases with Age During Childhood. Hum Brain Mapp. 2014.
Vannest J, Rajagopal A, Cicchino ND, Franks-Henry J, Simpson SM, Lee G, The CMIND Authorship Consortium. Factors Determining Success of Awake and Asleep Magnetic Resonance Imaging Scans in Nonsedated Children. Neuropediatrics. 2014.
*Farah R, Schmithorst VJ, Keith RW, Holland SK. Altered White Matter Microstructure Underlies Listening Difficulties in Children Suspected of Auditory Processing Disorders: A Dti Study. Brain and Behavior. 2014;4(4):531-543.
Rajagopal A, Byars A, Schapiro M, Lee GR, Holland SK. Success Rates for Functional MR Imaging in Children. AJNR Am J Neuroradiol. 2014.
Wilke M, Rose DF, Holland SK, Leach JL. Multidimensional Morphometric 3d MRI Analyses for Detecting Brain Abnormalities in Children: Impact of Control Population. Hum Brain Mapp. 2014;35(7):3199-3215.
Reading & Literacy Discovery Center Tier 3. Principal Investigator. Schroth Charitable Trust. Jan 2014-Dec 2016.
Structural and Network-Function Correlates of Fragmented Early Life Across Species. Consultant. National Institutes of Health. June 2013-April 2018. 1P50MH096889-01.
Imaging the Effect of Centrotemporal Spikes and Seizures on Language in Children. Collaborator. National Institutes of Health. July 2011-June 2016. R01 NS065840-01A1.
Yu Li, PhD
focuses on the technological development and clinical applications of high speed MR imaging and spectroscopy. Specifically, Dr. Li is interested in RF coil array for clinical MRI, parallel imaging, image reconstruction, microcoil array for NMR spectroscopy and clinical applications of parallel imaging.
Clinical applications of magnetic resonance imaging
Diana M. Lindquist, PhD
is the director for the In Vivo Micro-imaging Laboratory within the Imaging Research Center. Her research focuses on the metabolic effects of various pharmaceutical agents as measured by proton, phosphorus and carbon magnetic resonance spectroscopy.
Associate Professor, UC Department of Pediatrics
Magnetic resonance spectroscopy of drug effects; magnetic resonance spectroscopy of metabolic disease; multinuclear magnetic resonance spectroscopy; pulse sequence design
BS: University of New Mexico, Albuquerque, NM, 1989.
MA: Brandeis University, Waltham, MA, 1991.
PhD: University of Arkansas-Little Rock, Little Rock, AR, 1998.
Shereen A, Nemkul N, Yang D, Adhami F, Dunn RS, Hazen ML, Nakafuku M, Ning G, Lindquist DM, Kuan CY. Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke. J Cereb Blood Flow Metab. 2010 Dec 8.
Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.
Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Lindquist DM, Brubaker CJ, Lanphear BP. Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure. Environ Health Perspect. 2010 Oct 13.
Brubaker CJ, Schmithorst VJ, Haynes EN, Dietrich KN, Egelhoff JC, Lindquist DM, Lanphear BP, Cecil KM. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009 Nov;30(6):867-75.
Yang D, Nemkul N, Shereen A, Jone A, Dunn RS, Lawrence DA, Lindquist D, Kuan CY. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. J Neurosci. 2009 Jul 8;29(27):8669-74.
McNamara RK, Able J, Jandacek R, Rider T, Tso P, Lindquist DM. Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. J Lipid Res. 2009 Mar;50(3):405-11.
Lindquist D. Science to Practice: What can phosphorus MRS tell us about muscle disease? Radiology. 2008 247:1-2.
Lindquist D. What can 31P MR spectroscopy tell us about muscle disease? Radiology. 2008 Apr;247(1):1-2.
Lindquist D. Science to Practice: Is there a role for MR imaging in monitoring gene therapy response? Radiology. 2007 Jun;243(3):611-2.
John M. Racadio, MD Division Chief, Interventional Radiology, Department of Radiology and Medical Imaging
is the division chief of pediatric interventional radiology (IR) and the director of the IR research lab. Research interests include developing image guided minimally invasive techniques to treat a wide range of pediatric diseases. Additional interests include development of x-ray dose lowering IR protocols for pediatric patients. He is also interested in pediatric applications of MRI guided high intensity focused ultrasound ablation (HIFU).
Division Chief, Interventional Radiology, Department of Radiology and Medical Imaging
Vascular access; gastrointestinal interventional radiology
John Racadio, MD, has been practicing interventional radiology (IR) for 14 years and has been the division chief of interventional radiology at Cincinnati Children’s Hospital Medical Center for the past 11 years. He has expertise in performing a wide range of vascular procedures including angiography, angioplasty, embolization, vascular access, and thrombolysis in patients ranging from 500g to 150kg.
He is also the director of the interventional radiology research lab, which is part of the Department of Radiology Imaging Research Center (IRC). This state-of-the-art IR lab, which is identical to our clinical IR labs, possesses cutting edge digital flat detector technology including 3-D rotational angiography (3DRA), 3-D Roadmapping, and C-arm cone beam CT. These features provide superior image quality for digital subtraction angiography, 3-D angiography reconstruction, and “CT-like” imaging. Lab support staff includes RT(R) licensed IR technologists, and an IR lab manager. The long term goal of the IR research lab is to develop new image guided interventional procedures and imaging techniques and protocols to improve clinical outcomes. Having an IR research lab identical to our IR clinical labs facilitates translation of lab results into clinical practice.
BS: Stanford University, Palo Alto, CA, 1987.
MD: University of Cincinnati, Cincinnati, OH, 1992.
Residency: University of Cincinnati, Cincinnati, OH, 1993-1997.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1997-1998.
Certification: Certificate of Added Qualifications, Pediatric Radiology, November 2001; Diagnostic Radiology, American Board of Radiology, 1997.
Hawkins CM, Racadio JM, McKinney DN, Racadio JM, Vu DN. Varicocele retrograde embolization with boiling contrast medium and gelatin sponges in adolescent subjects: a clinically effective therapeutic alternative. J Vasc Interv Radiol. 2012 Feb;23(2):206-10.
Patel MN, Racadio JM, Levitt MA, Bischoff A, Racadio JM, Peña A. Complex cloacal malformations: use of rotational fluoroscopy and 3-D reconstruction in diagnosis and surgical planning. Pediatr Radiol. 2012 Mar;42(3):355-63.
Sheyn DD, Racadio JM, Racadio JM, Patel MN, Kukreja K, Rampton JW, Johnson ND. Use of an Amplatz dilator to facilitate transrectal abscess drainage in children. J Vasc Interv Radiol. 2011 May;22(5):687-90.
Racadio JM, Kukreja K. Pediatric biliary interventions. Tech Vasc Interv Radiol. 2010 Dec;13(4):244-9.
Sidhu M, Strauss KJ, Connolly B, Yoshizumi TT, Racadio J, Coley BD, Utley T, Goske MJ. Radiation safety in pediatric interventional radiology. Tech Vasc Interv Radiol. 2010 Sep;13(3):158-66.
Racadio JM, Babic D, Homan R, Rampton JW, Patel MN, Racadio JM, Johnson ND. Live 3D guidance in the interventional radiology suite. AJR Am J Roentgenol. 2007 Dec;189(6):W357-64. Review.
Vo NJ, Hammelman BD, Racadio JM, Strife CF, Johnson ND, Racadio JM. Anatomic distribution of renal artery stenosis in children: implications for imaging. Pediatr Radiol. 2006 Oct;36(10):1032-6.
Williams JM, Racadio JM, Johnson ND, Donnelly LF, Bissler JJ. Embolization of renal angiomyolipomata in patients with tuberous sclerosis complex. Am J Kidney Dis. 2006 Jan;47(1):95-102.
Fricke BL, Racadio JM, Duckworth T, Donnelly LF, Tamer RM, Johnson ND. Placement of peripherally inserted central catheters without fluoroscopy in children: initial catheter tip position. Radiology. 2005 Mar;234(3):887-92.
Racadio JM, Doellman DA, Johnson ND, Bean JA, Jacobs BR. Pediatric peripherally inserted central catheters: complication rates related to catheter tip location. Pediatrics. 2001 Feb;107(2):E28.
Michael D. Taylor, MD Director, Advanced Imaging Innovation
is a non-invasive cardiologist interested in applications of imaging to problems of congenital and acquired heart disease. His primary research interest is cardiac MRI and its application in evaluating myocardial function and disease. He has a translational program that uses multi-modality imaging to characterize mouse models of inherited and acquired cardiomyopathies.
Director, Advanced Imaging Innovation
Cardiac MRI; cardiac CT; and echocardiography; Cardiology Consult Service
Michael Taylor, MD, joined the Heart Institute in July, 2010 as the director of Advanced Imaging Innovation. He was previously the director of cardiac magnetic resonance at Texas Children’s Hospital in Houston.
Dr. Taylor has expertise in cardiac magnetic resonance imaging, positron emission tomography and computed tomography. He has a dual appointment in the Cincinnati Children's Hospital Medical Center Imaging Research Center, an interdisciplinary facility of advanced imaging faculty with dedicated clinical and pre-clinical imaging equipment.
Dr. Taylor's primary interests include myocardial metabolism in heart failure, animal models of cardiac pathology, and cardiac magnetic resonance imaging of congenital and acquired heart disease.
MD: University of Wisconsin, Madison, WI, 2001.
PhD: Medical Physics, University of Wisconsin, Madison, WI, 2001.
Residency: Pediatrics, Baylor College of Medicine, Houston, TX, 2003.
Fellowship: Pediatric Cardiology, Baylor College of Medicine, Houston, TX, 2006.
Certification: Pediatrics, 2005.
Certification: Pediatric Cardiology, 2006.
Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, Chung ES, Taylor MD, Jefferies JL, Woodrow Benson D, Gottliebson WM. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2011 Jan 8.
Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502.
LP Browne, D Kearney, MD Taylor, T Chung, TC Slesnick, AC Nutting, R Krishnamurthy. ALCAPA: the role of myocardial viability studies in determining prognosis. Pediatr Radiol. 2010;40(2):163-167.
JL Jefferies, MD Taylor, J Rossano, JW Belmont, WJ Craigen. Novel cardiac findings in periventricular nodular heterotopia. Am J Med Genet. 2009; 152A(1): 165-8.
JW Rossano, MD Taylor, EO Smith, CD Fraser, ED McKenzie, JF Price, HA Dickerson, DP Nelson, AR Mott. Glycemic profile in infants who have undergone the arterial switch operation: hyperglycemia is not associated with adverse events. J Thorac Cardiovasc Surg. 2008; 135(4): 739-745.
Jean Tkach, PhD
is focused on neonatal MRI, functional MRI, MR angiography, magnetization transfer saturation MRI, MR spectroscopy and steady state MR techniques. Dr. Tkach's research focuses on neurological disease, including white matter disease, epilepsy, brain tumors and aneurysms. In addition, she has interests in MR safety testing of medical implants.
Associate Professor, UC Department of Radiology
Neonatal MR acquisition technique development, optimization and application
Jean Tkach, PhD, received her undergraduate and graduate training in biomedical engineering. She is an MRI physicist by training who has been involved in MRI research since 1985.
Dr. Tkach joined the Cincinnati Children's faculty in the Fall of 2010. Throughout her career, the majority of her effort has been dedicated to the development, implementation, optimization and application of novel MRI acquisition techniques to address clinical as well as more fundamental research questions. The majority of these efforts have been dedicated toward neuroimaging. However, she has also been actively involved in research to advance the fields of cardiac, body and musculoskeletal MR imaging. Although most of Dr. Tkach's work has been directed toward human imaging, she also has been actively involved in multiple animal MR imaging studies.
Dr. Tkach’s research currently focuses on the development and implementation of state of the art MRI acquisition techniques optimized for (and to best address the most relevant clinical needs of) the neonate that exploit new technology being developed for this purpose. Most recently, Dr. Tkach received the Caffey Award for the Best Basic Science Research Paper at the 2011 Annual Meeting of the International Society for Pediatric Radiology.
Dr. Tkach is also is a consultant on the Circulatory System Devices Panel of the Medical Devices Advisory Committee, Center for Devices and Radiological Health, Food and Drug Administration (FDA).
BSE: Biomedical Engineering, Duke University, 1982.
MS: Biomedical Engineering, Case Western Reserve University, 1985.
PhD: Biomedical Engineering, Case Western Reserve University, 1988.
Jennifer J. Vannest, PhD Director, Pediatric Neuroimaging Research Consortium
is interested in the use of functional MRI and behavioral testing to examine how epilepsy and neurodevelopmental disorders affect language function and the brain circuitry that supports it. The goal of these studies is to provide better treatment and educational strategies for children with these disorders.
Director, Pediatric Neuroimaging Research Consortium
Cognitive neuroscience of language and memory (using functional MRI); cognitive effects of epilepsy and neurodevelopmental disorders
Jennifer Vannest, PhD, completed her undergraduate education at the Ohio State University and continued there for her graduate work. Her PhD is in linguistics, and in addition, her graduate training included a number of courses in cognitive psychology, neuropsychology and speech and hearing sciences. As a postdoctoral fellow at University of Michigan and University of Rochester, Dr. Vannest was trained to use functional MRI to study the brain mechanisms underlying language skill.
Dr. Vannest came to Cincinnati Children's Hospital Medical Center in 2006, and her current research makes use of functional MRI to examine how epilepsy and neurodevelopmental disorders affect language function, ultimately leading to better treatment and educational strategies for children with these disorders.
PhD: Linguistics, Ohio State University, Columbus, OH.
Postdoctoral Training: Psychology, University of Michigan, Ann Arbor, MI; Brain and Cognitive Sciences, University of Rochester, Rochester, NY.
Vannest J, Newport EL, Newman AJ, Bavelier D. Interplay between morphology and frequency in lexical access: The case of the base frequency effect. Brain Res. 2011 Feb 10;1373:144-59.
Korostenskaja M, Pardos M, Fujiwara H, Kujala T, Horn P, Rose D, Byars A, Brown D, Seo JH, Wang Y, Vannest J, Xiang J, Degrauw T, Näätänen R, Lee KH. Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy. Epilepsy Res. 2010 Nov;92(1):63-73.
Vannest J, Rasmussen J, Eaton KP, Patel K, Schmithorst V, Karunanayaka P, Plante E, Byars A, Holland S. FMRI activation in language areas correlates with verb generation performance in children. Neuropediatrics. 2010 Oct;41(5):235-9.
Szaflarski JP, Eaton K, Ball AL, Banks C, Vannest J, Allendorfer JB, Page S, Holland SK. Poststroke Aphasia Recovery Assessed With Functional Magnetic Resonance Imaging and a Picture Identification Task. J Stroke Cerebrovasc Dis. 2010 Aug 17.
Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study. NeuroImage. 2010 May 15;51(1):472-87.
Vannest J, Karunanayaka PR, Schmithorst VJ, Szaflarski JP, Holland SK. Language networks in children: evidence from functional MRI studies. AJR Am J Roentgenol. 2009 May;192(5):1190-6.
Vannest JJ, Karunanayaka PR, Altaye M, Schmithorst VJ, Plante EM, Eaton KJ, Rasmussen JM, Holland SK. Comparison of fMRI data from passive listening and active-response story processing tasks in children. J Magn Reson Imaging. 2009 Apr;29(4):971-6.
Wang Y, Xiang J, Kotecha R, Vannest J, Liu Y, Rose D, Schapiro M, Degrauw T. Spatial and frequency differences of neuromagnetic activities between the perception of open- and closed-class words. Brain Topogr. 2008 Dec;21(2):75-85.
Liu Y, Xiang J, Wang Y, Vannest JJ, Byars AW, Rose DF. Spatial and frequency differences of neuromagnetic activities in processing concrete and abstract words. Brain Topogr. 2008 Spring;20(3):123-9.
Vannest J, Szaflarski JP, Privitera MD, Schefft BK, Holland SK. Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy. Epilepsy Behav. 2008 Apr;12(3):410-8.
Jason C. Woods, PhD Director, Center for Pulmonary Imaging Research
is an imaging scientist who focuses on basic and translational pulmonary MRI and CT. His lab studies new methods for in-vivo assessment of regional pulmonary function, microstructure and physiology using hyperpolarized gases (3He and 129Xe) and 1H MRI, in addition to multi-volume CT. As new therapeutics for pulmonary diseases are developed, these new methods will be used for efficacy assessment and potential image guidance.
Director, Center for Pulmonary Imaging Research
Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions
Dr. Woods is one of the world’s experts on hyperpolarized-gas MRI and the use of such gas MRI to measure regional lung function, microstructure and physiology. He began his career in physics, radiology, and the dean's office at Washington University in St Louis, and moved to Cincinnati Children's in 2013 to apply new imaging techniques to pediatric translational research. He leads multiple team projects related to the multidisciplinary study of lung structure, function, biology and physiology. In particular, imaging applications to the study of cystic fibrosis, BPD, rare-lung diseases, and allograft rejection are all active areas of current research.
Dr. Woods directs the Center for Pulmonary Imaging Research at Cincinnati Children’s Hospital Medical Center. The center is a multidisciplinary research and training program at the intersection of pulmonary medicine, radiology, and neonatology.
PhD: Washington University, St. Louis, MO, 2002.
Postdoctoral: Washington University, St. Louis, MO, 2004.
Walkup LL, Tkach JA, Higano NS, Thomen RP, Fain SB, Merhar SL, Fleck RJ, Amin RS, Woods JC. Quantitative magnetic resonance imaging of bronchopulmonary dysplasia in the NICU environment. Am J Respir Crit Care Med. 2015 Jul 17.
Walkup LL, Woods JC. Newer Imaging techniques for BPD. Clinics in Perinatology. 2015.
Young SM, Liu S, Rashika J, Batie M, Kofron M, Guo J, Woods JC, Varisco B. Localization and stretch-dependence of elastin remodeling in lung development and compensatory regrowth. J Appl Physiol. 2015;118:921-931.
Li Y, Wang H, Tkach J, Roach D, Woods J, Dumoulin C. Wavelet-space Correlation Imaging for High-speed MRI without Motion Monitoring or Data Segmentation. Magn Reson Med. 2015.
Guo J, Huang HJ, Wang X, Wang W, Ellison H, Thomen RP, Gelman AE, Woods JC. Imaging mouse lung allograft rejection with 1H MRI. Magn Reson Med. 2015;274:250-9.
Thomen RP, Sheshadri A, Quirk JD, Kozlowski J, Ellison HD, Castro M, Woods JC. Regional ventilation changes in severe asthma after bronchial thermoplasty by 3He MRI and CT. Radiology. 2015;573:1970-8.
Walkup L, Woods JC. Translational Applications of Hyperpolarized 3He and 129Xe. NMR Biomed. 2014;27:1429-38.
Pennati F, Salito C, Baroni G, Woods JC, Aliverti A. Comparison Between Multivolume CT-Based Surrogates of Regional Ventilation in Healthy Subjects. Acad Rad. 2014;21:1268-75.
Pennati F, Quirk JD, Yablonskiy DA, Castro M, Aliverti A, Woods JC. Assessment of regional lung function by multi-volume 1H-MRI in health and obstructive lung disease: comparison with 3He-MRI. Radiology. 2014;273:580-90.
Phillipot Q, Deslée G, Adair-Kirk T, Woods JC, Byers D, Dury S, Perotin Collard J-M, Lebargy F, Cassan C, Le Naour R, Holtzman MJ, Pierce RA. Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease. Plos One. 2014;9:e96285.
Salito C, Barazzetti L, Woods J, Aliverti A. Heterogeneity of Specific Gas Volume Changes: a New Tool to Plan Lung Volume Reduction in Emphysema. Chest. 2014;146:1554-65.
Chang YV, Quirk JD, Ruset IC, Atkinson JJ, Hersman FW, Woods JC. Quantification of human lung structure and physiology using hyperpolarized 129Xe. Magn Reson Med. 2014;71:339-344.
Weihong Yuan, PhD
is focused on diffusion tensor imaging in children with hydrocephalus. He is also interested in the application of functional MRI and diffusion tensor imaging in other pediatric patients, such as children with epilepsy, traumatic brain injury, supratentorial tumors and spina bifida.
Diffusion tensor study pediatric patient with hydrocephalus; diffusion tensor imaging study of pediatric supratentorial tumors; diffusion tensor imaging study of children with traumatic brain injury; functional MRI study of pediatric patients with spina bifida; fMRI/DTI study of epilepsy; intra-operative neuroimaging
Weihong Yuan, PhD, joined the faculty in 2005 and currently is the McLaurin fellow in pediatric neurosurgery and research assistant professor of radiology at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine. He is a biomedical engineer by training with BS degree (1991) from Zhejiang University, PRC, and MS (1997) and PhD degree (2000) from Rutgers, The State University of New Jersey, Piscataway, NJ.
BS: Zhejiang University, Hangzhou, PRC, 1991.
MS: Rutgers, The State University of New Jersey, Piscataway, NJ, 1997.
PhD: Rutgers, The State University of New Jersey, Piscataway, NJ, 2000.
Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010 Aug;16(8):872-9.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.
Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.
Schmithorst VJ, Yuan W. White matter development during adolescence as shown by diffusion MRI. Brain Cogn. 2010 Feb;72(1):16-25.
DiFrancesco MW, Rasmussen JM, Yuan W, Pratt R, Dunn S, Dardzinski BJ, Holland SK. Comparison of SNR and CNR for in vivo mouse brain imaging at 3 and 7 T using well matched scanner configurations. Med Phys. 2008 Sep;35(9):3972-8.
Yuan W, Altaye M, Ret J, Schmithorst V, Byars AW, Plante E, Holland SK. Quantification of head motion in children during various fMRI language tasks. Hum Brain Mapp. 2009 May;30(5):1481-9.
Kramer ME, Chiu CY, Walz NC, Holland SK, Yuan W, Karunanayaka P, Wade SL. Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes. J Int Neuropsychol Soc. 2008 May;14(3):424-35.
Yuan W, Holland SK, Jones BV, Crone K, Mangano FT. Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study. J Neurosurg Pediatr. 2008 Apr;1(4):263-9.
Karunanayaka PR, Holland SK, Yuan W, Altaye M, Jones BV, Michaud LJ, Walz NC, Wade SL. Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: a preliminary fMRI investigation. NeuroRehabilitation. 2007;22(5):355-69.
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