William S. Ball, MD
Neuroradiologist, Division of Interventional Radiology
focuses on cerebrovascular complications in Sickle Cell Disease. He currently chairs a multidisciplinary group, working on clinical guidelines covering pediatric causes of cerebrovascular disease.
513-803-2209
william.ball@cchmc.org
William S. Ball, MD
Neuroradiologist, Division of Interventional Radiology
Academic Information
Professor, Division of Pediatric Radiology
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Specialties
Biography
William Ball, MD, received his undergraduate degree in biochemistry from Louisiana State University. He is a graduate of Tulane Medical School, and is board certified in both pediatrics and radiology with added certification in Neuroradiology. He joined the faculty in Radiology at Cincinnati Children's in 1984, and became chief of section in Pediatric Neuroradiology, a position he held from 1988 - 2001. In 1993, Dr. Ball developed and created the Imaging Research Center (IRC) at Cincinnati Children's, and served as its Director from April 1993 - 2002. As a researcher, Dr. Ball has contributed over 123 scientific contributions to literature, 11 book chapters and was the editor of a complete text Pediatric Neuroradiology that is still in publication today. He is currently a tenured professor in Biomedical Engineering, Radiology and Pediatrics. Dr. Ball became chair of the newly formed Department of Biomedical Engineering (UCBME) at UC. In 2003, a position he currently holds today. Under his direction, UCBME has grown to 13 full time faculty, over 200 undergraduate students and 45 graduate students. Undergraduate tracks include biomechanics and medical product design. Research programs in UCBME focus on medical imaging, reparative medicine, biomechanics, nanomedicine and bioinformatics. In 2008, Dr. Ball returned to Cincinnati Children’s Hospital as full-time attending staff neuroradiologist.
Education and Training
MD: Tulane University School of Medicine, New Orleans, LA, 1974.
Residency: Pediatrics, Charity Hospital, Tulane Service, New Orleans, LA, 1977; Pediatrics, Oschner Foundation Hospital, Division of Pediatrics, New Orleans, LA, 1977; Radiology, University of New Mexico School of Medicine, Albuquerque, NM.
Fellowships: Pediatric Radiology / Pediatric Neuroradiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1981; Neuroradiology, University of New Mexico Medical Center, Albuquerque, NM.
Certification: Certification of Added Qualifications Neuroradiology, American Board of Radiology 1999, American Board of Radiology, 1982; American Board of Pediatrics, 1982.
Grants
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Alan S. Brody, MD
Staff Radiologist
focuses on imaging of the chest in cystic fibrosis and in childhood diffuse lung disease. He directs the Center for Diagnostic Imaging of the Therapeutic Development Network of the Cystic Fibrosis Foundation.
513-636-8508
alan.brody@cchmc.org
Alan S. Brody, MD
Staff Radiologist
Chief, Thoracic Imaging
Academic Information
Professor, Division of Pediatric Radiology
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Specialties
Pediatric thoracic imaging; cystic fibrosis; diffuse lung disease
Biography
After receiving his degree from the Albert Einstein College of Medicine in New York, Alan S. Brody, MD, did his internship at San Francisco General Hospital. He then completed Pediatric and Radiology Residencies at the University of California in San Francisco. Dr. Brody is board-certified in both Pediatrics and Radiology. Dr. Brody completed his Pediatric Radiology Fellowship at Cincinnati Children's Hospital Medical Center in 1987. From 1987-1993, he worked at the Children's Hospital of Buffalo, where he was director of CT services. In 1993, Dr. Brody assumed the position of Chief of Pediatric Radiology at St. Joseph's Hospital in Phoenix, AZ. In 1995, Dr. Brody joined the Department of Radiology at Cincinnati Children's.
Education and Training
AB: Biology, Kenyon College, Gambier, OH, 1975. MD: Albert Einstein College of Medicine, Bronx, NY, 1980. Residency: Pediatrics, University of California San Francisco, San Francisco, CA, 1980-1983; Radiology, University of California San Francisco, San Francisco, CA, 1983-1986. Fellowship: Pediatric Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 1986-1987. Certification: Pediatrics, 1986; Radiology, 1986; Certificate of Additional Qualification in Pediatric Radiology, 1995.
Publications
View PubMed Publications
McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC; National Institutes of Health Rare Lung Diseases Consortium; MILES Trial Group. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med. 2011 Apr 28;364(17):1595-606. Donnelly LF, Gessner KE, Dickerson JM, Koch BL, Towbin AJ, Lehkamp TW, Moskovitz J, Brody AS, Dumoulin CL, Jones BV. Quality initiatives: department scorecard: a tool to help drive imaging care delivery performance. Radiographics. 2010 Nov;30(7):2029-38. Brody AS, Guillerman RP, Hay TC, Wagner BD, Young LR, Deutsch GH, Fan LL, Deterding RR. Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT. AJR Am J Roentgenol. 2010 Jan;194(1):238-44.
Rattan AS, Laor T, Ryckman FC, Brody AS. Pectus excavatum imaging: enough but not too much. Pediatr Radiol. 2010 Feb;40(2):168-72.
Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, Dardzinski BJ, Brody AS. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR Am J Roentgenol. 2009 Apr;192(4):1037-44.
Brody AS, Donnelly LF. Building a culture of research among clinical pediatric radiologists: a multifaceted, programmatic approach. Pediatr Radiol. 2009 Apr;39(4):367-70.
Brody AS. New perspectives in imaging interstitial lung disease in children. Pediatr Radiol. 2008 May;38 Suppl 2:S205-7. Review.
Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, Leonard JM, Schmithorst VJ, Laor T, Brody AS, Bean J, Salisbury S, Franz DN. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med. 2008 Jan 10;358(2):140-51.
Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD, Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston C; Pathology Cooperative Group, Albright EA, Askin FB, Baker P, Chou PM, Cool CM, Coventry SC, Cutz E, Davis MM, Dishop MK, Galambos C, Patterson K, Travis WD, Wert SE, White FV; ChILD Research Co-operative. Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med. 2007 Dec 1;176(11):1120-8. Epub 2007 Sep 20.
Brody AS. Computed tomography scanning in cystic fibrosis research trials: practical lessons from three clinical trials in the United States. Proc Am Thorac Soc. 2007 Aug 1;4(4):350-4.
Grants
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Kim M. Cecil, PhD
Spectroscopist
focuses on the application of MR spectroscopy and imaging in several populations by characterizing the features of inborn errors in metabolism and evaluating the effects of environmental neurotoxicants and radiation, respectively, on brain anatomy and function.
513-636-8559
kim.cecil@cchmc.org
Kim M. Cecil, PhD
Spectroscopist
Academic Information
Professor, Division of Pediatric Radiology
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Specialties
MR spectroscopy and imaging; evaluating the effects of environmental neurotoxicants and radiation
Biography
Kim M. Cecil, PhD, received her undergraduate and postgraduate training in chemistry. After a post-doctoral fellowship in magnetic resonance spectroscopy and imaging at the Hospital of the University of Pennsylvania, Dr. Cecil joined the Radiology Department and the Imaging Research Center at Cincinnati Children’s Hospital Medical Center in 1998. She serves as an imaging research scientist and clinical MR spectroscopist. In 2000, Kim M. Cecil, PhD, Antonius deGrauw, MD, PhD and Gajja Salomons, PhD, discovered creatine transporter deficiency syndrome, a genetic disorder caused by mutations in the creatine transporter gene (SLC6A8). Male patients demonstrate a significant reduction or absence of creatine in the brain, as indicated by MR spectroscopy. This is an X-linked mental retardation disorder thought to be second only to fragile X in prevalence.
Education and Training
BS: Chemistry & Mathematics (Magna Cum Laude), Kentucky Wesleyan College, 1988.
MS: Chemistry, Vanderbilt University, 1991.
PhD: Chemistry, Vanderbilt University, 1993.
Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA.
Publications
View PubMed Publications
Brubaker CJ, Dietrich KN, Lanphear BP, Cecil KM. The influence of age of lead exposure on adult gray matter volume. Neurotoxicology. 2010 Jun;31(3):259-66. Epub 2010 Mar 11.
Brubaker CJ, Schmithorst VJ, Haynes EN, Dietrich KN, Egelhoff JC, Lindquist DM, Lanphear BP, Cecil KM. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009 Nov;30(6):867-75. Epub 2009 Jul 18.
Miles L, DeGrauw TJ, Dinopoulos A, Cecil KM, van der Knaap MS, Bove KE. Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review. Pediatr Dev Pathol. 2009 May-Jun;12(3):180-6.
Cecil KM, Brubaker CJ, Adler CM, Dietrich KN, Altaye M, Egelhoff JC, Wessel S, Elangovan I, Hornung R, Jarvis K, Lanphear BP. Decreased brain volume in adults with childhood lead exposure. PLoS Med. 2008 May 27;5(5):e112.
Walz NC, Cecil KM, Wade SL, Michaud LJ. Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes. J Neurotrauma. 2008 Feb;25(2):94-103.
Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL. Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1919-25. Epub 2007 Sep 28.
Cecil KM, Kos RS. Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disorders. Top Magn Reson Imaging. 2006 Aug;17(4):275-93. Review.
Dinopoulos A, Gorospe JR, Egelhoff JC, Cecil KM, Nicolaidou P, Morehart P, DeGrauw T. Discrepancy between neuroimaging findings and clinical phenotype in Alexander disease. AJNR Am J Neuroradiol. 2006 Nov-Dec;27(10):2088-92. Review.
Patel NC, DelBello MP, Cecil KM, Adler CM, Bryan HS, Stanford KE, Strakowski SM. Lithium treatment effects on Myo-inositol in adolescents with bipolar depression. Biol Psychiatry. 2006 Nov 1;60(9):998-1004.
Grants
Neurobehavioral Late-Effects in Pediatric Brain Tumors. Co-investigator. National Institutes of Health. 2005-2011. #R01 CA112182. Effects of Lead, Manganese and Stress During Development. Co-investigator. National Institutes of Health. 2006-2011. #R01 ES015689. Bipolar Disorder Imaging & Treatment Research Center. Co-Investigator. National Institutes of Health. 2007-2012. #P50 MH077138. Neurofunctional and Neurochemical Markers of Treatment Response in Early Onset Bipolar Mania. Co-investigator. National Institutes of Health. 2007-2012. #R01 MH07043. Early Lead Exposure, ADHD and Persistent Criminality. Co-Principal Investigator. National Institutes of Health. 2007-2012. #R01 ES015559.
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Mark DiFrancesco, PhD
Assistant Director, Pediatric Neuroimaging Research Consortium
is interested in the use of concurrent EEG and fMRI to detect functional correlates of spontaneous brain activity, the study of the neurocognitive effects of Lupus using fMRI, applying functional imaging to investigate attentional deficits arising from sleep restriction in adolescents and assessing the impact of field strength on the quality of small animal brain imaging.
513-636-0436
Mark DiFrancesco, PhD
Assistant Director, Pediatric Neuroimaging Research Consortium
Academic Information
Assistant Professor, Division of Pediatric Radiology
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Biography
Education and Training
PhD: Physics, University of Pittsburgh, Pittsburgh, PA, 1989. MS: Physics, University of Pittsburgh, Pittsburgh, PA, 1985. BS: Physics, Carnegie-Mellon University, Pittsburgh, PA, 1981.
Grants
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Randy O. Giaquinto
is interested in RF coil design, CAD and fabrication. Mr. Giaquinto has designed RF coils and system hardware for over 30 years, and is an expert on the design and clinical application of multi-channel array RF coils for MRI of the torso, heart, head, prostate and breast.
513-803-3186
randy.giaquinto@cchmc.org
Randy O. Giaquinto
Senior Imaging Research Engineer, Imaging Research Center
Academic Information
Instructor, Division of Pediatric Radiology
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Specialties
Clinical InterestsHigh channel MRI imaging Research InterestsDesign and clinical application of multi-channel array RF coils for MRI of the torso, heart, head, prostate and breast
Biography
Randy Giaquinto currently holds 16 patents, and over 60 publications related to MRI Imaging. Prior to coming to Cincinnati Children's, he was a Principle RF Coil designer for GE Global Research Center for 30 years. Randy Giaquinto recently accepted a Senior RF Imaging Engineering position at Cincinnati Children's Hospital Medical Center in July 2010.
Education and Training
Publications
View PubMed Publications
Arunachalam A, Whitt D, Fish K, Giaquinto R, Piel J, Watkins R, Hancu I. Accelerated spectroscopic imaging of hyperpolarized C-13 pyruvate using SENSE parallel imaging. NMR Biomed. 2009 Oct;22(8):867-73. Hardy CJ, Giaquinto RO, Piel JE, Rohling KW, Marinelli L, Blezek DJ, Fiveland EW, Darrow RD, Foo TK. 128-channel body MRI with a flexible high-density receiver-coil array. J Magn Reson Imaging. 2008 Nov;28(5):1219-25. Niendorf T, Hardy CJ, Giaquinto RO, Gross P, Cline HE, Zhu Y, Kenwood G, Cohen S, Grant AK, Joshi S, Rofsky NM, Sodickson DK. Toward single breath-hold whole-heart coverage coronary MRA using highly accelerated parallel imaging with a 32-channel MR system.Magn Reson Med. 2006 Jul;56(1):167-76. Hardy CJ, Cline HE, Giaquinto RO, Niendorf T, Grant AK, Sodickson DK. 32-element receiver-coil array for cardiac imaging. Magn Reson Med. 2006 May;55(5):1142-9. Ohliger MA, Greenman RL, Giaquinto R, McKenzie CA, Wiggins G, Sodickson DK. Concentric coil arrays for parallel MRI. Magn Reson Med. 2005 Nov;54(5):1248-60. Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications.Acad Radiol. 2005 May;12(5):626-35. Lian J, Xing L, Hunjan S, Dumoulin C, Levin J, Lo A, Watkins R, Rohling K, Giaquinto R, Kim D, Spielman D, Daniel B. Mapping of the prostate in endorectal coil-based MRI/MRSI and CT: a deformable registration and validation study.Med Phys. 2004 Nov;31(11):3087-94. Zhu Y, Hardy CJ, Sodickson DK, Giaquinto RO, Dumoulin CL, Kenwood G, Niendorf T, Lejay H, McKenzie CA, Ohliger MA, Rofsky NM. Highly parallel volumetric imaging with a 32-element RF coil array.Magn Reson Med. 2004 Oct;52(4):869-77. Hardy CJ, Darrow RD, Saranathan M, Giaquinto RO, Zhu Y, Dumoulin CL, Bottomley PA. Large field-of-view real-time MRI with a 32-channel system. Magn Reson Med. 2004 Oct;52(4):878-84. Lee RF, Giaquinto RO, Hardy CJ. Coupling and decoupling theory and its application to the MRI phased array.Magn Reson Med. 2002 Jul;48(1):203-13.
Grants
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Scott K. Holland, PhD
Director, Pediatric Neuroimaging Research Consortium
focuses on pediatric neuroimaging applications of MRI at high field, which includes perfusion MRI, functional MRI, micro-imaging of transgenic mice, and image processing methods.
513-636-7565
scott.holland@cchmc.org
Scott K. Holland, PhD
Director, Pediatric Neuroimaging Research Consortium
McLaurin Scholar
Academic Information
Professor, Division of Pediatric Radiology
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Specialties
Dr. Holland's research currently focuses on advanced neuroimaging applications of MRI in pediatrics. His major focus is on functional MRI of language, hearing and neuroplasticity following brain injury. His research in brain imaging extends to studies in small animals and the use of a 7 Tesla small animal MRI system for micro imaging in mouse and rat models brain development and brain injury.
Biography
Scott K. Holland, PhD, is the McLaurin Scholar in Pediatric Neurosurgery and Professor of Radiology, Pediatrics, Biomedical Engineering, Neuroscience and Physics at University of Cincinnati, and Director of the Pediatric Brain Imaging Research Center at Children’s Hospital Research Foundation. A physicist by training, he received his BS degree (1980) in physics from Muhlenberg College, Allentown, PA., MS (1982) and PhD (1985) degrees in applied physics from Yale University.
Education and Training
BS: Physics (Magna Cum Laude), Muhlenberg College, 1980.
MS: Engineering & Applied Science, Yale University,1982.
MPhil: Engineering & Applied Science, Yale University, 1983.
PhD: Engineering and Applied Science, Yale University, 1985.
Publications
View PubMed Publications
Tlustos SJ, Chiu CY, Walz NC, Holland SK, Bernard L, Wade SL. Neural correlates of interference control in adolescents with traumatic brain injury: functional magnetic resonance imaging study of the counting stroop task.J Int Neuropsychol Soc. 2011 Jan;17(1):181-9. Schmithorst VJ, Holland SK, Plante E. Diffusion Tensor Imaging Reveals White Matter Microstructure Correlations With Auditory Processing Ability.Ear Hear. 2010 Nov 8. Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus.Cerebrospinal Fluid Res. 2010 Nov 5;7:19. Smith KM, Mecoli MD, Altaye M, Komlos M, Maitra R, Eaton KP, Egelhoff JC, Holland SK. Morphometric Differences in the Heschl's Gyrus of Hearing Impaired and Normal Hearing Infants.Cereb Cortex. 2010 Sep 13. Kaimal V, Chu Z, Mahller YY, Papahadjopoulos-Sternberg B, Cripe TP, Holland SK, Qi X. Saposin C Coupled Lipid Nanovesicles Enable Cancer-Selective Optical and Magnetic Resonance Imaging.Mol Imaging Biol. 2010 Sep 14. Szaflarski JP, Eaton K, Ball AL, Banks C, Vannest J, Allendorfer JB, Page S, Holland SK. Poststroke Aphasia Recovery Assessed With Functional Magnetic Resonance Imaging and a Picture Identification Task.J Stroke Cerebrovasc Dis. 2010 Aug 17. Szaflarski JP, DiFrancesco M, Hirschauer T, Banks C, Privitera MD, Gotman J, Holland SK. Cortical and subcortical contributions to absence seizure onset examined with EEG/fMRI. Epilepsy Behav. 2010 Aug;18(4):404-13. Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study.Neuroimage. 2010 May 15;51(1):472-87. Leach JL, Holland SK. Functional MRI in children: clinical and research applications. Pediatr Radiol. 2010 Jan;40(1):31-49.
Grants
fMRI of Language Recovery Following Stroke in Adults. Principal Investigator. National Institute of Health. Dec 2008 - Nov 2013. #RO1 NS 048281-01. Improved Diagnostics & Advanced Magnetic Resonance Imaging for Pediatric NPSLE. National Institute of Health. Apr 2008 - Mar2013. P60-AR047784-06/ R01. The role of CD8+ T cells in the formation of T1 black holes in an animal model of MS. Consult. National Institute of Health. Apr 2008 - Mar 2012. #R01-NS05698.
Brain Mechanisms Linking Language, Attention and Memory. External Advisor. National Institute of Health. Apr 2007 - Mar 2012. #K01-DC008812.
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Yu Li, PhD
focuses on the technological development and clinical applications of high speed MR imaging and spectroscopy. Specifically, Dr. Li is interested in RF coil array for clinical MRI, parallel imaging, image reconstruction, microcoil array for NMR spectroscopy and clinical applications of parallel imaging.
513-803-3105
yu.li@cchmc.org
Yu Li, PhD
Academic Information
Assistant Professor, Division of Pediatric Radiology
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Specialties
Clinical applications of magnetic resonance imaging
Biography
Education and Training
PhD: University of Illinois at Urbana-Champaign, Urbana, IL, 2002.
Grants
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Diana M. Lindquist, PhD
is the director for the In Vivo Micro-imaging Laboratory within the Imaging Research Center. Her research focuses on the metabolic effects of various pharmaceutical agents as measured by proton, phosphorus and carbon magnetic resonance spectroscopy.
513-636-9268
diana.lindquist@cchmc.org
Diana M. Lindquist, PhD
Academic Information
Assistant Professor, Division of Pediatric Radiology
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Specialties
Magnetic resonance spectroscopy of drug effects; magnetic resonance spectroscopy of metabolic disease; multinuclear magnetic resonance spectroscopy; pulse sequence design
Biography
Education and Training
BS: University of New Mexico, Albuquerque, NM; May 1989.
MA: Brandeis University, Waltham, MA; December 1991.
PhD: University of Arkansas-Little Rock, Little Rock, AR; 1998.
Publications
View PubMed Publications
Shereen A, Nemkul N, Yang D, Adhami F, Dunn RS, Hazen ML, Nakafuku M, Ning G, Lindquist DM, Kuan CY. Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke. J Cereb Blood Flow Metab. 2010 Dec 8. Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus.Cerebrospinal Fluid Res. 2010 Nov 5;7:19. Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Lindquist DM, Brubaker CJ, Lanphear BP. Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure.Environ Health Perspect. 2010 Oct 13. Brubaker CJ, Schmithorst VJ, Haynes EN, Dietrich KN, Egelhoff JC, Lindquist DM, Lanphear BP, Cecil KM. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study.Neurotoxicology. 2009 Nov;30(6):867-75. Yang D, Nemkul N, Shereen A, Jone A, Dunn RS, Lawrence DA, Lindquist D, Kuan CY. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.J Neurosci. 2009 Jul 8;29(27):8669-74. McNamara RK, Able J, Jandacek R, Rider T, Tso P, Lindquist DM. Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study.J Lipid Res. 2009 Mar;50(3):405-11. Lindquist D. Science to Practice: What can phosphorus MRS tell us about muscle disease? Radiology. 2008 247:1-2. Lindquist D. What can 31P MR spectroscopy tell us about muscle disease?Radiology. 2008 Apr;247(1):1-2. Lindquist D. Science to Practice: Is there a role for MR imaging in monitoring gene therapy response?Radiology. 2007 Jun;243(3):611-2.
Grants
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Vincent J. Schmithorst, PhD
is interested in the investigation of central auditory processing deficits in children with unilateral sensorineural hearing loss, the development of language function in children, and white matter maturation in children's brains. Additionally, he is interested in new analysis techniques for fMRI data (Independent Component Analysis) and functional connectivity (structural equation modeling and multivariate autoregressive modeling).
513-636-3922
vince.schmithorst@cchmc.org
Vincent J. Schmithorst, PhD
Academic Information
Assistant Professor, Division of Pediatric Radiology
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Specialties
Cortical Reorganization in children with unilateral sensorineural hearing loss using functional magnetic resonance imaging (fMRI); the development of language function in children using fMRI; white matter maturation in children's brains using diffusion tensor imaging (DTI); analysis techniques for fMRI data and functional connectivity
Biography
Dr. Schmithorst is a physicist by training with BS, MS, and PhD degrees from the University of Cincinnati. Schmithorst's thesis was on utilizing an ionizing radiation detector in digital projection radiography to separate bone from soft-tissue components using information from the penetration depth of the x-ray beam. Dr. Schmithorst came to the Imaging research Center in the Fall of 1997. He is currently engaged in research projects involving the: - Development of language function and math processing in children using functional magnetic resonance imaging (fMRI)
- Investigation of the correlation of musical training with math ability on school-age children using fMRI, white matter maturation in children's brains using diffusion tensor imaging (DTI)
- Development of appropriate fMRI data acquisition and post-processing techniques in subjects with developmental or acquired communication disorders
- Use of information-theoretic methods, such as Independent Component Analysis (ICA), for analysis for fMRI data
As part of his research efforts, Schmithorst has authored Cincinnati Children's Hospital Image Processing Software (CCHIPS), an extensive software suite for MRI image reconstruction and post-processing in the Interactive Data Language (IDL) programming environment. CCHIPS is available free of charge for research purposes only to all interested parties.
Education and Training
PhD: University of Cincinnati, Cincinnati, OH, 1997.
Publications
View PubMed Publications.
Schmithorst VJ, Holland SK, Plante E. Diffusion tensor imaging reveals white matter microstructure correlations with auditory processing ability. Ear Hear. 2011 Mar-Apr;32(2):156-67. Propst EJ, Greinwald JH, Schmithorst V. Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging. Arch Otolaryngol Head Neck Surg. 2010 Jan;136(1):22-6. Vannest J, Rasmussen J, Eaton KP, Patel K, Schmithorst V, Karunanayaka P, Plante E, Byars A, Holland S. FMRI activation in language areas correlates with verb generation performance in children. Neuropediatrics. 2010 Oct;41(5):235-9. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study. Neuroimage. 2010 May 15;51(1):472-87. Schmithorst VJ, Yuan W. White matter development during adolescence as shown by diffusion MRI. Brain Cogn. 2010 Feb;72(1):16-25.
Brubaker CJ, Schmithorst VJ, Haynes EN, Dietrich KN, Egelhoff JC, Lindquist DM, Lanphear BP, Cecil KM. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009 Nov;30(6):867-75.
Vannest J, Karunanayaka PR, Schmithorst VJ, Szaflarski JP, Holland SK. Language networks in children: evidence from functional MRI studies. AJR Am J Roentgenol. 2009 May;192(5):1190-6. Vannest JJ, Karunanayaka PR, Altaye M, Schmithorst VJ, Plante EM, Eaton KJ, Rasmussen JM, Holland SK. Comparison of fMRI data from passive listening and active-response story processing tasks in children. J Magn Reson Imaging. 2009 Apr;29(4):971-6.
Schmithorst VJ, Altes TA, Young LR, Franz DN, Bissler JJ, McCormack FX, Dardzinski BJ, Brody AS. Automated algorithm for quantifying the extent of cystic change on volumetric chest CT: initial results in Lymphangioleiomyomatosis. AJR Am J Roentgenol. 2009 Apr;192(4):1037-44. Schmithorst VJ. Developmental sex differences in the relation of neuroanatomical connectivity to intelligence. Intelligence. 2009 Mar;37(2):164-173.
Grants
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Michael D. Taylor, MD
Director, Advanced Imaging Innovation
is a non-invasive cardiologist interested in applications of imaging to problems of congenital and acquired heart disease. His primary research interest is cardiac MRI and its application in evaluating myocardial function and disease. He has a translational program that uses multi-modality imaging to characterize mouse models of inherited and acquired cardiomyopathies.
513-803-0426
michael.taylor1@cchmc.org
Michael D. Taylor, MD
Director, Advanced Imaging Innovation
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsCardiac MRI; Cardiac CT; and echocardiography Research InterestsMyocardial metabolism; animal models of heart failure; positron emission tomography
Biography
Michael Taylor, MD joined the Heart Institute in July, 2010 as the director of Advanced Imaging Innovation. He was previously the director of cardiac magnetic resonance at Texas Children’s Hospital in Houston. Dr. Taylor has expertise in cardiac magnetic resonance imaging, positron emission tomography and computed tomography. He has a dual appointment in the Cincinnati Children's Hospital Medical Center Imaging Research Center, an interdisciplinary facility of advanced imaging faculty with dedicated clinical and pre-clinical imaging equipment. Dr Taylor's primary interests include myocardial metabolism in heart failure, animal models of cardiac pathology, and cardiac magnetic resonance imaging of congenital and acquired heart disease.
Education and Training
MD: University of Wisconsin, Madison, WI; 2001.
PhD: Medical Physics, University of Wisconsin, Madison, WI; 2001. Residency: Pediatrics, Baylor College of Medicine, Houston, TX; 2003.
Fellowship: Pediatric Cardiology, Baylor College of Medicine, Houston, TX; 2006.
Certification: Pediatrics; 2005.
Certification: Pediatric Cardiology; 2006.
Publications
View PubMed Publications
Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, Chung ES, Taylor MD, Jefferies JL, Woodrow Benson D, Gottliebson WM. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2011 Jan 8.
Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010 Oct 26;56(18):1493-502. LP Browne, D Kearney, MD Taylor, T Chung, TC Slesnick, AC Nutting, R Krishnamurthy. ALCAPA: the role of myocardial viability studies in determining prognosis . Pediatr Radiol. 2010;40(2):163-167.
JL Jefferies, MD Taylor, J Rossano, JW Belmont, WJ Craigen. Novel cardiac findings in periventricular nodular heterotopia . Am J Med Genet. 2009; 152A(1): 165-168.
JW Rossano, MD Taylor, EO Smith, CD Fraser, ED McKenzie, JF Price, HA Dickerson, DP Nelson, AR Mott. Glycemic profile in infants who have undergone the arterial switch operation: hyperglycemia is not associated with adverse events . J Thorac Cardiovasc Surg. 2008; 135(4): 739-745.
Grants
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Jean Tkach, PhD
is focused on neonatal MRI, functional MRI, MR angiography, magnetization transfer saturation MRI, MR spectroscopy and steady state MR techniques. Dr. Tkach research focuses on neurological disease, including white matter disease, epilepsy, brain tumors and aneurysms. In addition, she has interests in MR safety testing of medical implants
513-636-7166
jean.tkach@cchmc.org
Jean Tkach, PhD
Academic Information
Associate Professor, Division of Pediatric Radiology
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Specialties
Neonatal MR acquisition technique development, optimization and application
Biography
Jean Tkach, PhD, received her undergraduate and graduate training in biomedical engineering. She is an MRI physicist by training who has been involved in MRI research since 1985.
Dr. Tkach joined the Cincinnati Children's faculty in the Fall of 2010. Throughout her career, the majority of her effort has been dedicated to the development, implementation, optimization and application of novel MRI acquisition techniques to address clinical as well as more fundamental research questions. The majority of these efforts have been dedicated toward neuroimaging. However, she has also been actively involved in research to advance the fields of cardiac, body and musculoskeletal MR imaging. Although most of Dr. Tkach's work has been directed toward human imaging, she also has been actively involved in multiple animal MR imaging studies.
Dr. Tkach’s research currently focuses on the development and implementation of state of the art MRI acquisition techniques optimized for (and to best address the most relevant clinical needs of) the neonate that exploit new technology being developed for this purpose. Most recently, Dr. Tkach received the Caffey Award for the Best Basic Science Research Paper at the 2011 Annual Meeting of the International Society for Pediatric Radiology.
Dr. Tkach is also is a consultant on the Circulatory System Devices Panel of the Medical Devices Advisory Committee, Center for Devices and Radiological Health, Food and Drug Administration (FDA)
Education and Training
BSE: Biomedical Engineering, Duke University, 1982. MS: Biomedical Engineering, Case Western Reserve University, 1985. PhD: Biomedical Engineering, Case Western Reserve University, 1988.
Publications
Grants
Functional MR Imaging Study of Speech Production in Childhood Apraxia of Speech. Principal Investigator. National Institutes of Health. Jul 2010 - Jul 2013. #1R21DC010188-01.
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Jennifer J. Vannest, PhD
is interested in the use of functional MRI and behavioral testing to examine how epilepsy and neurodevelopmental disorders affect language function and the brain circuitry that supports it. The goal of these studies is to provide better treatment and educational strategies for children with these disorders.
513-636-6959
jennifer.vannest@cchmc.org
Jennifer J. Vannest, PhD
Academic Information
Assistant Professor, UC Department of Pediatrics
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Specialties
Clinical InterestsCognitive neuroscience of language and memory (using functional MRI); cognitive effects of epilepsy and neurodevelopmental disorders Research InterestsNeurological disorders and language impairments
Biography
Jennifer Vannest, PhD, completed her undergraduate education at the Ohio State University and continued there for her graduate work. Her PhD is in Linguistics, and in addition, her graduate training included a number of courses in Cognitive Psychology, Neuropsychology and Speech and Hearing Sciences. As a postdoctoral fellow at University of Michigan and University of Rochester, Dr. Vannest was trained to use functional MRI to study the brain mechanisms underlying language skill. Dr. Vannest came to Cincinnati Children's Hospital Medical Center in 2006, and her current research makes use of functional MRI to examine how epilepsy and neurodevelopmental disorders affect language function, ultimately leading to better treatment and educational strategies for children with these disorders.
Education and Training
PhD: Ohio State University, Linguistics. Postdoctoral Training: University of Michigan (Psychology), University of Rochester (Brain and Cognitive Sciences).
Publications
View PubMed Publications
Vannest J, Newport EL, Newman AJ, Bavelier D. Interplay between morphology and frequency in lexical access: The case of the base frequency effect. Brain Res. 2011 Feb 10;1373:144-59.
Korostenskaja M, Pardos M, Fujiwara H, Kujala T, Horn P, Rose D, Byars A, Brown D, Seo JH, Wang Y, Vannest J, Xiang J, Degrauw T, Näätänen R, Lee KH. Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy. Epilepsy Res. 2010 Nov;92(1):63-73. Vannest J, Rasmussen J, Eaton KP, Patel K, Schmithorst V, Karunanayaka P, Plante E, Byars A, Holland S. FMRI activation in language areas correlates with verb generation performance in children. Neuropediatrics. 2010 Oct;41(5):235-9.
Szaflarski JP, Eaton K, Ball AL, Banks C, Vannest J, Allendorfer JB, Page S, Holland SK. Poststroke Aphasia Recovery Assessed With Functional Magnetic Resonance Imaging and a Picture Identification Task. J Stroke Cerebrovasc Dis. 2010 Aug 17.
Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study. Neuroimage. 2010 May 15;51(1):472-87.
Vannest J, Karunanayaka PR, Schmithorst VJ, Szaflarski JP, Holland SK. Language networks in children: evidence from functional MRI studies. AJR Am J Roentgenol. 2009 May;192(5):1190-6.
Vannest JJ, Karunanayaka PR, Altaye M, Schmithorst VJ, Plante EM, Eaton KJ, Rasmussen JM, Holland SK. Comparison of fMRI data from passive listening and active-response story processing tasks in children. J Magn Reson Imaging. 2009 Apr;29(4):971-6.
Wang Y, Xiang J, Kotecha R, Vannest J, Liu Y, Rose D, Schapiro M, Degrauw T. Spatial and frequency differences of neuromagnetic activities between the perception of open- and closed-class words. Brain Topogr. 2008 Dec;21(2):75-85. Liu Y, Xiang J, Wang Y, Vannest JJ, Byars AW, Rose DF. Spatial and frequency differences of neuromagnetic activities in processing concrete and abstract words. Brain Topogr. 2008 Spring;20(3):123-9. Vannest J, Szaflarski JP, Privitera MD, Schefft BK, Holland SK. Medial temporal fMRI activation reflects memory lateralization and memory performance in patients with epilepsy. Epilepsy Behav. 2008 Apr;12(3):410-8.
Grants
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Janaka P. Wansapura, PhD
is focused on MR of imaging of familial cardiomyopathy in human and in transgenic animal models using a range of MR methodologies including myocardial tagging, relaxation time mapping and delayed enhancement. Dr. Wansapura’s other research interests include vascular compliance, MR based thermometry and fat/water decomposition.
513-636-9384
janaka.wansapura@cchmc.org
Janaka P. Wansapura, PhD
Academic Information
Assistant Professor, Division of Pediatric Radiology
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Specialties
Cardiovascular function; vascular compliance; MR of imaging of familial cardiomyopathy; MR thermometry and fat/water decomposition; fat quantification; MR image guided thermal therapy; diffusion tensor imaging; modeling of MR phenomena
Biography
Education and Training
PhD: Physics, University of Cincinnati, OH, 1998. MS: Physics, University of Cincinnati, OH, 1996. BSc: Special Degree in Physics with first class honors. University of Colombo, Sri Lanka, 1991.
Publications
View PubMed Publications
Mazur W, Hor KN, Germann JT, Fleck RJ, Al-Khalidi HR, Wansapura JP, Chung ES, Taylor MD, Jefferies JL, Woodrow Benson D, Gottliebson WM. Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain. Int J Cardiovasc Imaging. 2011 Jan 8.
Acehan D, Vaz F, Houtkooper RH, James J, Moore V, Tokunaga C, Kulik W, Wansapura J, Toth MJ, Strauss A, Khuchua Z. Cardiac and skeletal muscle defects in a mouse model of human barth syndrome. J Biol Chem. 2011 Jan 14;286(2):899-908.
Wansapura JP, Millay DP, Dunn RS, Molkentin JD, Benson DW. Magnetic resonance imaging assessment of cardiac dysfunction in δ-sarcoglycan null mice. Neuromuscul Disord. 2011 Jan;21(1):68-73.
Dasgupta S, Wansapura J, Hariharan P, Pratt R, Witte D, Myers MR, Banerjee RK. HIFU lesion volume as a function of sonication time, as determined by MRI, histology, and computations. J Biomech Eng. 2010 Aug;132(8):081005.
Hagenbuch SC, Gottliebson WM, Wansapura J, Mazur W, Fleck R, Benson DW, Hor KN. Detection of progressive cardiac dysfunction by serial evaluation of circumferential strain in patients with Duchenne muscular dystrophy. Am J Cardiol. 2010 May 15;105(10):1451-5.
Sundaram N, Tailor A, Mendelsohn L, Wansapura J, Wang X, Higashimoto T, Pauciulo MW, Gottliebson W, Kalra VK, Nichols WC, Kato GJ, Malik P. High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood. 2010 Jul 8;116(1):109-12.
Wansapura JP, Hor KN, Mazur W, Fleck R, Hagenbuch S, Benson DW, Gottliebson WM. Left ventricular T2 distribution in Duchenne muscular dystrophy. J Cardiovasc Magn Reson. 2010 Mar 18;12:14.
Hor KN, Gottliebson WM, Carson C, Wash E, Cnota J, Fleck R, Wansapura J, Klimeczek P, Al-Khalidi HR, Chung ES, Benson DW, Mazur W. Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging. 2010 Feb;3(2):144-51.
Zhao X, Pratt R, Wansapura J. Quantification of aortic compliance in mice using radial phase contrast MRI. J Magn Reson Imaging. 2009 Aug;30(2):286-91.
Hor KN, Wansapura J, Markham LW, Mazur W, Cripe LH, Fleck R, Benson DW, Gottliebson WM. Circumferential strain analysis identifies strata of cardiomyopathy in Duchenne muscular dystrophy: a cardiac magnetic resonance tagging study. J Am Coll Cardiol. 2009 Apr 7;53(14):1204-10.
Grants
Cardiac Structure and Function in Early Familial Cardiomyopathy. Principal Investigator. National Institutes of Health. Jan 2010 - Mar 2015. #K25 HL102244-01.
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Patrick Winter, PhD
is interested in targeted MRI contrast agents, multi-nuclear imaging and spectroscopy, activatable MRI contrast agents and automated image processing routines. His research focuses on biomarkers of cardiovascular disease and cancer, including angiogenesis and tracking anti-angiogenic therapies.
513-803-3104
Patrick Winter, PhD
Academic Information
Assistant Professor, Division of Pediatric Radiology
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Biography
Patrick Winter, PhD received his undergraduate degree in Electrical Engineering from Washington University in St. Louis, Missouri and his PhD in Biomedical Engineering from The University of Texas Southwestern Medical School in Dallas. Patrick returned to Washington University as a post-doc in 2000 and subsequently became an Assistant Professor of Medicine in 2005. He took a one-year leave of absence from his faculty position in 2008 to initiate clinical trials of an investigational MRI contrast agent with a small bio-technology company in St. Louis named Kereos. In 2010, he joined the Imaging Research Center at Cincinnati Children’s Hospital.
Dr. Winter has more than 15 years of experience in MRI research, with a strong record of publications (51 peer-reviewed journal papers, 13 book chapters and 79 scientific abstracts) and grant funding from the NIH and private sources (4 grants as principal investigator and 5 grants as co-investigator). In addition, Dr. Winter is involved in reviewing journal articles, teaching at university and professional levels, organizing courses and scientific sessions, consulting for pharmaceutical companies and participating in professional societies. His current research interests include molecular imaging of cancer and cardiovascular disease, multi-nuclear imaging and spectroscopy, activatable MRI contrast agents, and automated image processing routines.
Education and Training
PhD: Biomedical Engineering, University of Texas Southwestern Medical School, Dallas, TX, 2000. BS: Electrical Engineering, Washington University, St. Louis, MO, 1994.
Publications
View PubMed Publications
Winter PM, Caruthers SD, Lanza GM, Wickline SA. Quantitative cardiovascular magnetic resonance for molecular imaging. J Cardiovasc Magn Reson. 2010 Nov 3;12:62.
Cai K, Caruthers SD, Huang W, Williams TA, Zhang H, Wickline SA, Lanza GM, Winter PM. MR molecular imaging of aortic angiogenesis. JACC Cardiovasc Imaging. 2010 Aug;3(8):824-32.
Winter PM, Caruthers SD, Allen JS, Cai K, Williams TA, Lanza GM, Wickline SA. Molecular imaging of angiogenic therapy in peripheral vascular disease with alphanubeta3-integrin-targeted nanoparticles. Magn Reson Med. 2010 Aug;64(2):369-76.
Winter PM, Caruthers SD, Zhang H, Williams TA, Wickline SA, Lanza GM. Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis. JACC Cardiovasc Imaging. 2008 Sep;1(5):624-34.
Winter PM, Schmieder AH, Caruthers SD, Keene JL, Zhang H, Wickline SA, Lanza GM. Minute dosages of alpha(nu)beta3-targeted fumagillin nanoparticles impair Vx-2 tumor angiogenesis and development in rabbits. FASEB J. 2008 Aug;22(8):2758-67.
Winter PM, Cai K, Caruthers SD, Wickline SA, Lanza GM. Emerging nanomedicine opportunities with perfluorocarbon nanoparticles. Expert Rev Med Devices. 2007 Mar;4(2):137-45.
Winter PM, Cai K, Chen J, Adair CR, Kiefer GE, Athey PS, Gaffney PJ, Buff CE, Robertson JD, Caruthers SD, Wickline SA, Lanza GM. Targeted PARACEST nanoparticle contrast agent for the detection of fibrin. Magn Reson Med. 2006 Dec;56(6):1384-8.
Winter PM, Neubauer AM, Caruthers SD, Harris TD, Robertson JD, Williams TA, Schmieder AH, Hu G, Allen JS, Lacy EK, Zhang H, Wickline SA, Lanza GM. Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2103-9.
Winter PM, Morawski AM, Caruthers SD, Fuhrhop RW, Zhang H, Williams TA, Allen JS, Lacy EK, Robertson JD, Lanza GM, Wickline SA. Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles. Circulation. 2003 Nov 4;108(18):2270-4.
Winter PM, Caruthers SD, Kassner A, Harris TD, Chinen LK, Allen JS, Lacy EK, Zhang H, Robertson JD, Wickline SA, Lanza GM. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer Res. 2003 Sep 15;63(18):5838-43.
Grants
Monitoring Tissue Oxygenation and Angiogenic Therapy in PAD with Perfluorocarbon Nanoparticles. Principal Investigator. American Heart Association. Jul 2010 - Jun 2012.
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Weihong Yuan, PhD
is focused on diffusion tensor imaging in children with hydrocephalus. He is also interested in the application of functional MRI and diffusion tensor imaging in other pediatric patients, such as children with epilepsy, traumatic brain injury, supratentorial tumors and spina bifida.
513-636-2862
Weihong.Yuan@cchmc.org
Weihong Yuan, PhD
Academic Information
Assistant Professor, Division of Pediatric Radiology
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Specialties
Diffusion tensor study pediatric patient with hydrocephalus; diffusion tensor imaging study of pediatric supratentorial tumors; diffusion tensor imaging study of children with traumatic brain injury; functional MRI study of pediatric patients with spina bifida; fMRI/DTI study of epilepsy; intra-operative neuroimaging
Biography
Weihong Yuan, PhD, joined the faculty in 2005 and currently is the McLaurin fellow in Pediatric Neurosurgery and research assistant professor of Radiology at Cincinnati Children's Hospital Medical Center and the University of Cincinnati. He is a biomedical engineer by training with BS degree (1991) from Zhejiang University, PRC, and MS (1997) and PhD degree (2000) from Rutgers, The State University of New Jersey, Piscataway, NJ.
Education and Training
BS: Zhejiang University, Hangzhou, PRC, 1991.
MS: Rutgers, The State University of New Jersey, Piscataway, NJ, 1997.
PhD: Rutgers, The State University of New Jersey, Piscataway, NJ, 2000.
Publications
View PubMed Publications
Yuan W, Deren KE, McAllister JP 2nd, Holland SK, Lindquist DM, Cancelliere A, Mason M, Shereen A, Hertzler DA, Altaye M, Mangano FT. Diffusion tensor imaging correlates with cytopathology in a rat model of neonatal hydrocephalus. Cerebrospinal Fluid Res. 2010 Nov 5;7:19.
Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010 Aug;16(8):872-9.
Air EL, Yuan W, Holland SK, Jones BV, Bierbrauer K, Altaye M, Mangano FT. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010 Apr;5(4):385-91.
Yuan W, Mangano FT, Air EL, Holland SK, Jones BV, Altaye M, Bierbrauer K. Anisotropic diffusion properties in infants with hydrocephalus: a diffusion tensor imaging study. AJNR Am J Neuroradiol. 2009 Oct;30(9):1792-8.
Schmithorst VJ, Yuan W. White matter development during adolescence as shown by diffusion MRI. Brain Cogn. 2010 Feb;72(1):16-25.
DiFrancesco MW, Rasmussen JM, Yuan W, Pratt R, Dunn S, Dardzinski BJ, Holland SK. Comparison of SNR and CNR for in vivo mouse brain imaging at 3 and 7 T using well matched scanner configurations. Med Phys. 2008 Sep;35(9):3972-8.
Yuan W, Altaye M, Ret J, Schmithorst V, Byars AW, Plante E, Holland SK. Quantification of head motion in children during various fMRI language tasks. Hum Brain Mapp. 2009 May;30(5):1481-9.
Kramer ME, Chiu CY, Walz NC, Holland SK, Yuan W, Karunanayaka P, Wade SL. Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes. J Int Neuropsychol Soc. 2008 May;14(3):424-35.
Yuan W, Holland SK, Jones BV, Crone K, Mangano FT. Characterization of abnormal diffusion properties of supratentorial brain tumors: a preliminary diffusion tensor imaging study. J Neurosurg Pediatr. 2008 Apr;1(4):263-9
Karunanayaka PR, Holland SK, Yuan W, Altaye M, Jones BV, Michaud LJ, Walz NC, Wade SL. Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: a preliminary fMRI investigation. NeuroRehabilitation. 2007;22(5):355-69.
Grants
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