Anil Jegga, DVM, MRes
Title
Research Assistant Professor
Appointment
Assistant Professor of Pediatrics
Email
anil.jegga@cchmc.org
Phone
513-636-0261
Fax
513-636-2056
Bio
Anil Jegga, DVM, plays a key role in multiple collaborations at Cincinnati Children's and the University of Cincinnati. His work focuses on the elucidation of gene regulatory networks and the interaction between genotype and phenotype using a variety of bioinformatics approaches. Dr. Jegga is currently involved in application domains that include cardiovascular diseases, digestive disorders, genitourinary disorders and tumorigenesis in response to environmental challenges. To aid in the diffusion of genomics into biomedical research and education, Dr. Jegga works with Bruce Aronow, PhD, and their research lab on several approaches that integrate bioinformatics with clinical informatics. For more information about Dr. Jegga, visit his web site: http://anil.cchmc.org.
Credentials
Master of Research: Bioinformatics, University of York, England, UK
Master of Veterinary Science: Surgery, College of Veterinary Science, Hyderabad, India
Bachelor of Veterinary Science & Animal Husbandry: College of Veterinary Science, Hyderabad, India
Awards and Honors
- Adjudged as outstanding student in the state of Andhra Pradesh, India, in the faculties of Medical, Dental, Agricultural and Veterinary Sciences and awarded Gold Medal.
- Awarded Gold Medal for securing highest OGPA in Surgery (M.V.Sc)
- First rank in Bachelor of Veterinary Science & Animal Husbandry
Research Grants and Contracts
Title: Mouse Models of Gastrointestinal Cancer
Sponsor: National Institutes of Health
PI: Groden, J
Dates: 04/01/2004 - 03/31/2009
Title: Cincinnati DDRDC: Center for Growth and Development (CGD)
Sponsor: National Institutes of Health
PI: Cohen, M
Dates: 04/01/2003 - 03/31/2008
Title: Therapeutic Targets for Neurofibromas: Identification by Cross-species Gene Expression Analysis
Sponsor: Department of Defense
PI: Ratner, N
Dates: 10/01/2004 - 09/30/2007
Title: Murine Atlas of a Genitourinary Smooth Muscle Development
Sponsor: National Institutes of Health
PI: Lessard, J
Dates: 04/01/2005 - 03/31/2010
Publications, Most Recent
Markey MP, Bergseid J, Bosco EE, Stengel K, Xu H, Mayhew CN, et al. Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function. Oncogene. 2007 Apr 23.
Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, Spike BT, et al. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America. 2007 Apr 17;104(16):6794-9.
Liu C, Aronow BJ, Jegga AG, Wang N, Miethke A, Mourya R, et al. Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis. Gastroenterology. 2007 Jan;132(1):119-26.
Jegga AG, Chen J, Gowrisankar S, Deshmukh MA, Gudivada R, Kong S, et al. GenomeTrafac: a whole genome resource for the detection of transcription factor binding site clusters associated with conventional and microRNA encoding genes conserved between mouse and human gene orthologs. Nucleic Acids Res. 2007 Jan;35(Database issue):D116-21.
Jegga AG, Gowrisankar S, Chen J, Aronow BJ. PolyDoms: a whole genome database for the identification of non-synonymous coding SNPs with the potential to impact disease. Nucleic Acids Res. 2007 Jan;35(Database issue):D700-6.
Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG, et al. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res. 2006 Mar 1;66(5):2584-91.
Jegga AG, Kong S, Zhang J, Moseley A, Gupta A, Williams SS, et al. Comparative genomics of tissue specific gene expression in gene expression and regulation. In: Ma J, ed. Gene Expression and Regulation: Higher Education Press/Springer 2006.
Jegga AG, Gupta A, Gowrisankar S, Deshmukh MA, Connolly S, Finley K, et al. CisMols Analyzer: identification of compositionally similar cis-element clusters in ortholog conserved regions of coordinately expressed genes. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W408-11.
Vukkadapu SS, Belli JM, Ishii K, Jegga AG, Hutton JJ, Aronow BJ, et al. Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse. Physiol Genomics. 2005 Apr 14;21(2):201-11.
Gu Y, Alvares CJ, Jasti AC, Jansen M, Bean J, Jegga AG, et al. Alteration of RhoH expression is associated with human diffuse large b-cell lymphoma. Blood. 2004 Nov 16;104(11).
Takemoto CM, Shahlaee AH, Ye Y, Zeller KI, Zablocki D, Huynh J, et al. Transcriptional regulation of a distinct GATA-1 isoform during selection of the mast and erythroid lineages. Blood. 2004 Nov 16;104(11).
Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, et al. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. Embo J. 2004 Oct 27;23(21):4202-10.
Hutton JJ, Jegga AG, Kong S, Gupta A, Ebert C, Williams S, et al. Microarray and comparative genomics-based identification of genes and gene regulatory regions of the mouse immune system. BMC Genomics. 2004 Oct 25;5(1):82.
Livingston RJ, von Niederhausern A, Jegga AG, Crawford DC, Carlson CS, Rieder MJ, et al. Pattern of sequence variation across 213 environmental response genes. Genome Res. 2004 Oct;14(10A):1821-31.
Zhang J, Moseley A, Jegga AG, Gupta A, Witte DP, Sartor M, et al. Neural system-enriched gene expression: relationship to biological pathways and neurological diseases. Physiol Genomics. 2004 Jul 8;18(2):167-83.
Kim JW, Zeller KI, Wang Y, Jegga AG, Aronow BJ, O'Donnell KA, et al. Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol. 2004 Jul;24(13):5923-36.
Genter MB, Van Veldhoven PP, Jegga AG, Sakthivel B, Kong S, Stanley K, et al. Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system. Physiol Genomics. 2003 Dec 16;16(1):67-81.
Zeller KI, Jegga AG, Aronow BJ, O'Donnell KA, Dang CV. An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol. 2003;4(10):R69.
Jegga AG, Aronow BJ. Evolutionarily conserved noncoding DNA. In: Cooper DN, ed. Encyclopedia of the human genome. London: Nature Publishing Group 2003.
Jegga AG, Sherwood SP, Carman JW, Pinski AT, Phillips JL, Pestian JP, et al. Detection and visualization of compositionally similar cis-regulatory element clusters in orthologous and coordinately controlled genes. Genome Res. 2002 Sep;12(9):1408-17.
Warren MA, Koshoffer A, Aronow BJ, Jegga AG, Brackenbury R. Structure of the 5' portion of the human plakoglobin gene. J Invest Dermatol. 2002 Jul;119(1):196-7.
Bates MD, Erwin CR, Sanford LP, Wiginton D, Bezerra JA, Schatzman LC, et al. Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis. Gastroenterology. 2002 May;122(5):1467-82.
Presentations
Gudivada RC, Qu X, Jegga AG, Neumann EK, Aronow BJ. Relevance-ranking and inferencing of disease phenotype, etiology, pathophysiological mechanism and therapeutic opportunities using biomedical semantic web methodologies. Workshop for W3C Semantic Web Health Care and Life Sciences. 2006 Nov 6; Georgia Center, Athens, GA. [Abstract]
Jegga AG. Systems biology-based approaches to identify Alzheimer's disease-susceptibility genes. Hosted by Society for Neurochemistry (SNCI) & M.Tech. Bioinformatics Program, School of Life Sciences, University of Hyderabad. 2006 Oct 19; Hyderabad, India. [Presentation] | [Abstract]
Jegga AG, Gowrisankar S, Sychay G, Chen J, Gudivada RC, Kong S, Deshmukh MA, Muthukrishnan A, Aronow BJ. Systems biology approaches to integrative biomedical informatics. Genotype-To-Phenotype Correlation in Health and Disease, Welches. 2005 Dec 4-8; Oregon. [Poster] | [Abstract]
Chen J, Jegga AG, Aronow BJ. UMLS concept indexing of OMIM clinical synopsis and knowledge extraction. 13th Annual International Conference of Intelligent Systems for Molecular Biology (ISMB). 2005 Jun 25-9; Detroit, MI.
Gowrisankar S, Chen J, Jegga AG, Aronow BJ. Integrative bioinformatic approaches for functional analysis of non-synonymous single nucleotide polymorphisms. 13th Annual International Conference of Intelligent Systems for Molecular Biology (ISMB). 2005 Jun 25-9; Detroit, MI.
Gudivada RC, Jegga AG, Aronow BJ. Analysis of metastasis suppressor genes: comparative genomics and systems biology approaches. 13th Annual International Conference of Intelligent Systems for Molecular Biology (ISMB). 2005 Jun 25-9; Detroit, MI.
Inga A*, Menendez D*, Jegga AG*, Aronow BJ, Resnick MA. Evolutionary separation of the p53 regulatory network between mice and humans based on response element rules and pattern search. American Association of Cancer Research (AACR) 96th Annual Meeting. 2005 Apr 16-20; Anaheim/Orange County, CA. (* equal contribution)
Chen J, Gowrisankar S, Gudivada RC, Jegga AG, Aronow BJ. Integrative bioinformatics approaches for studying the impact of genomics and understanding the disease processes. University of Cincinnati Graduate Poster Forum. 2005 Mar; Cincinnati, OH.
Gowrisankar S, Gudivada RC, Chen J, Kong S, Gupta A, Deshmukh A, Deshmukh M, Jegga AG, Aronow BJ. Systems biology-based bioinformatics approaches to the analysis of genes and diseases of the digestive system: GenomeTrafac, Cismols, Polydoms, and Abstrainer. Digestive Disorder Research and Development Center (DDRDC) Scientific Retreat and External Advisory Board Meeting; 2005 Jan 22; Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Gu Y, Alvares CJ, Jasti AC, Jansen M, Bean J, Jegga AG, Aronow BJ, Williams DA. Alteration of RhoH expression is associated with human diffuse large B-Cell lymphoma. 46th ASH Annual meeting and exposition. Abstract in: Blood. 2004 Nov 16;104(11).
Takemoto CM, Shahlaee AH, Ye Y, Zeller KI, Zablocki D, Huynh J, Huang S, DeKoter RP, Jegga AG, Aronow BJ, Dang CV, McDevitt MA. Transcriptional regulation of a distinct GATA-1 isoform during selection of the mast and erythroid lineages. 46th ASH Annual meeting and exposition. Abstract in: Blood. 2004 Nov 16;104(11).
Jegga AG, Chen J. Detection and visualization of conserved cis-element structures and their annotation using NLP-based extraction and GFF3-formatting of biomedical literature-derived SO features. Sequence Ontology Meeting. 2004 Aug 19-20; University of California, Berkeley, CA.
Logan MA, Callahan E, Steele M, Jegga AG, Aronow BJ, Vetter. Identification of shared proneural bHLH transcriptional targets. FASEB Summer Conference: Transcriptional Regulation During Cell Growth, Differentiation, and Development. 2004 Aug 14-9; Saxtons River, VT.
Gowrisankar S, Deshmukh AS, Jegga AG, Aronow BJ. An integrative approach for the study of sequence variation impact on biological processes, diseases and environmental agents' risk. Third annual symposium of the Comparative Mouse Genomics Centers Consortium (CMGCC), Cell Cycle and DNA Repair Variants. 2004 Jun 1-4; M. D. Anderson Cancer Center, Science Park - Research Division, Austin, TX. [Poster | Abstract]
Chen J, Gowrisankar S, Jegga AG, Livingston R, Niederhausern AV, Crawford DC, Carlson CS, Rieder MJ, Weiss RB, Nickerson DA, Aronow BJ. PolyDoms: web resource for initial functional characterization of protein polymorphisms. Third annual symposium of the Comparative Mouse Genomics Centers Consortium (CMGCC), Cell Cycle and DNA Repair Variants. 2004 Jun 1-4; M. D. Anderson Cancer Center, Science Park - Research Division, Austin, TX. [Poster | Abstract]
Jegga AG, Gowrisankar S, Chen J, Adamczak R, Gupta A, Ramirez MA, Andra KSC, Carman JW, Aronow BJ. Cincinnati Comparative Mouse Genomics Centers Consortium: bioinformatics analysis tools for assessment of human gene polymorphisms. Genes, Environment and Disease. Second Annual CMGCC Symposium, Environmental Genome Project, NIEHS. 2003 Jun 7-9; Boston, MA. [Poster | Abstract]
Jegga AG. Identification of compositionally similar cis-element clusters in coordinately regulated genes. Systems Biology: Genomic Approaches to Transcription Regulation. 2003 Mar 6-9; Cold Spring Harbor Laboratory, NY. [Poster| Abstract]
Jegga AG. Comparative genomics approaches to the analysis of conserved cis-regulatory element clusters. 11th International Workshop BITS: Functional Expression and Evolutionary Analysis. 2001 Nov 9-12; DOE, VA.
Research Projects
- TraFaC/GenomeTraFaC: companion resources for identifying constitutionally similar and/or conserved cis-element clusters in orthologous and non-orthologous genes.
- CisMols Analyzer: an extension of TraFaC that identifies compositionally similar cis-regulatory element clusters that occur in groups of co-regulated genes.
- ConciseScanner: a web-based tool that enables you to select one or more transcription binding sites and search all genes in the GenomeTrafac database for clusters containing the selected site(s); within each cluster, you can view the exact position of each binding site.
- PolyDoms: a web-based application that maps synonymous and non-synonymous single nucleotide polymorphisms (SNPs) of proteins onto known functional domains.
- Abstrainer: a web-based tool that extracts protein-protein interactions and disease-gene associations from biomedical literature.
- CMGCC (Cincinnati Comparative Mouse Genomics Centers Consortium): a collaborative initiative with the University of Cincinnati to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive genes
