Biomedical Informatics

Long (Jason) Lu, PhD

Title

Assistant Professor

Appointment

Assistant Professor of Pediatrics

Email

long.lu@cchmc.org

Phone

513-636-8720

Fax

513-636-2056

Credentials

Postdoctoral Research Associate in Bioinformatics: Yale University, New Haven, CT, 2003-06.

PhD: Biochemistry, specialized in Computational Molecular Biology, Washington University School of Medicine, St. Louis, MO, 2003.

BS: Biotechnology/Bioengineering, Peking University, Beijing, China, 1998.

Research Grants and Contracts

Title: Probing the Robustness of a Developmental System
Sponsor: National Science Foundation (NSF)
Dates: 05/15/2009 - 05/14/2013
Role: Co-PI (PI: Jun Ma)

Title: Innovative Computational Strategy for Novel Drug Target Discovery in P. aeruginosa
Sponsor: Cincinnati Children's Board of Trustees (Trustee Award)
Dates: 07/01/2008 - 06/30/2010

Title: Breast Cancer Biomarker Discovery Using Protein Network
Sponsor: American Cancer Society
Dates: 01/01/2008 - 12/31/2008

Publications, Most Recent

He F, Wen Y, Deng J, Lin X, Lu LJ, Jiao R, et al. Probing intrinsic properties of a robust morphogen gradient in Drosophila. Dev Cell. 2008 Oct;15(4):558-67.

Huang YJ, Hang D, Lu LJ, Tong L, Gerstein MB, Montelione GT. Targeting the human cancer pathway protein interaction network by structural genomics. Mol Cell Proteomics. 2008 Oct;7(10):2048-60.

Wu L, Hwang SI, Rezaul K, Lu LJ, Mayya V, Gerstein M, et al. Global survey of human T leukemic cells by integrating proteomics and transcriptomics profiling. Mol Cell Proteomics. 2007 Aug;6(8):1343-53.

Lu LJ, Sboner A, Huang YJ, Lu HX, Gianoulis TA, Yip KY, et al. Comparing classical pathways and modern networks: towards the development of an edge ontology. Trends Biochem Sci. 2007 Jul;32(7):320-31.

Flores SC, Lu LJ, Yang J, Carriero N, Gerstein MB. Hinge Atlas: relating protein sequence to sites of structural flexibility. BMC Bioinformatics. 2007;8:167.

Kim PM, Lu LJ, Xia Y, Gerstein MB. Relating three-dimensional structures to protein networks provides evolutionary insights. Science. 2006 Dec 22;314(5807):1938-41.

Xia Y, Lu LJ, Gerstein M. Integrated prediction of the helical membrane protein interactome in yeast. J Mol Biol. 2006 Mar 17;357(1):339-49.

Flores S, Echols N, Milburn D, Hespenheide B, Keating K, Lu J, et al. The Database of Macromolecular Motions: new features added at the decade mark. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D296-301.

Lu LJ, Xia Y, Paccanaro A, Yu H, Gerstein M. Assessing the limits of genomic data integration for predicting protein networks. Genome Res. 2005 Jul;15(7):945-53.

Lu L, Xia Y, Yu H, Rives A, Lu H, Schubert F, et al. Protein interaction prediction by integrating genomic features and protein interaction network analysis. In: Azuaje F, Dopazo J, editors. Data Analysis and Visualization in Genomics and Proteomics. Hoboken: Wiley; 2005. p. 61-81.

Lu L, Arakaki AK, Lu H, Skolnick J. Multimeric threading-based prediction of protein-protein interactions on a genomic scale: application to the Saccharomyces cerevisiae proteome. Genome Res. 2003 Jun;13(6A):1146-54.

Lu H, Lu L, Skolnick J. Development of unified statistical potentials describing protein-protein interactions. Biophys J. 2003 Mar;84(3):1895-901.

Lu L, Lu H, Skolnick J. MULTIPROSPECTOR: an algorithm for the prediction of protein-protein interactions by multimeric threading. Proteins. 2002 Nov 15;49(3):350-64.