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Biomedical Informatics

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maroslo-keith

Keith Marsolo, PhD

Title

Director, Software Development and Data Warehouse

Appointment

Assistant Professor, University of Cincinnati College of Medicine

Email

keith.marsolo@cchmc.org

Phone

513-803-0333

Fax

513-636-2056

Bio

Dr. Marsolo is leading the development of a research data warehouse at Cincinnati Children's.  Based on a framework known as i2b2, the warehouse enables users to perform a hospital-wide search of a de-identified data set to determine the existence of a patient cohort.  The warehouse incorporates data from the hospital's new Epic electronic health record as well as from many other database systems used by hospital clinicians and researchers.  To protect the privacy of patients, Dr. Marsolo and his group also ensure that the appropriate regulatory and security safeguards are in place.  For more information, visit the i2b2 Research Data Warehouse web site:  http://i2b2.cchmc.org.

Credentials

PhD: Computer and Information Science, The Ohio State University, Columbus, OH, 2007

MS: Computer and Information Science, The Ohio State University, Columbus, OH, 2006

MS: Biomedical Engineering, The Ohio State University, Columbus, OH, 2005

BS: Computer Science and Engineering, The Ohio State University, Columbus, OH, 2002

Awards and Honors

  • Recipient – Outstanding Research Award. Department of Computer Science and Engineering, The Ohio State University (2007)
  • Participant - Summer Internship Program in Biomedical Research, National Institutes of Health (2006)
  • Nominee - Presidential Fellowship Award, The Ohio State University (2006)
  • Recipient - East Asia and Pacific Summer Institute Award, National Science Foundation (USA) and Australia Academy of Science (Australia) (2005)
  • Recipient - Student Travel Award - SIAM International Conference on Data Mining (2005)
  • Recipient - University Fellowship, The Ohio State University (2003)
  • Graduated Summa Cum Laude, B.S. in CSE, The Ohio State University (2002)
  • Recipient - The Ohio State University Computer and Information Science Department Undergraduate Scholarship (2001)
  • Recipient - The Ohio State University Tradition Scholarship, Engineering Dean's Award, Ohio Academic Scholarship, Robert C. Byrd Honors Scholarship (1998-2002)
  • Recipient - Hendrix Engineering Scholarship, Alumni Scholars Program Award, Walter H. Kidd Fund Award (1998)
  • Graduated Valedictorian, Westerville South High School (1998)

Publications, Most Recent

  1. Adaptive Postprocessing Techniques for Myocardial Tissue Tracking with Displacement-Encoded MRI.
    Keith Marsolo, Eric Bennett, Kwame Kutten, David Lipps, Jonathan Plehn, Neal Epstein, Pierre Croisille and Han Wen. Radiology. 2008. Pages 229-40.
  2. On the Use of Structure and Sequence-Based Features for Protein Classification and Retrieval.
    Keith Marsolo and Srinivasan Parthasarathy. Proceedings of the 6th IEEE International Conference on Data Mining (ICDM), IEEE. 2006. Pages 394-403. A.R. - 10% (Selected as a best paper for publication in a special issue of Knowledge and Information Systems (KAIS)).
  3. Structure-Based Querying of Proteins Using Wavelets.
    Keith Marsolo, Srinivasan Parthasarathy and Kotagiri Ramamohanarao. Proceedings of the ACM Conference on Information and Knowledge Management (CIKM). ACM Press. 2006. Pages 24-33. A.R. - 15%
  4. Spatial Modeling and Classification of Corneal Shape.
    Keith Marsolo*, Michael Twa*, Mark A. Bullimore and Srinivasan Parthasarathy. IEEE Transactions on Information Technology in Biomedicine. Vol. 11, Issue 2. March 2007. Pages 203-212. (* denotes joint first author)
  5. Alternate Representation of Distance Matrices for Characterization of Protein Structure.
    Keith Marsolo and Srinivasan Parthasarathy. Proceedings of the 5th IEEE International Conference on Data Mining (ICDM). IEEE. 2005. Pages 298-305. A.R. - 10.9%
  6. A Multi-Level Approach to SCOP Fold Recognition.
    Keith Marsolo, Srinivasan Parthasarathy, Chris Ding. Proceedings of the IEEE Symposium on BioInformatics and BioEngineering (BIBE). IEEE. 2005. Pages 57-64. A.R. - 18%
  7. Classification of Biomedical Data Through Model-Based Spatial Averaging.
    Keith Marsolo, Michael Twa, Srinivasan Parthasarathy, Mark Bullimore. Proceedings of the IEEE Symposium on BioInformatics and BioEngineering (BIBE). IEEE. 2005. Pages 49-56. A.R. - 18%
  8. A Model-Based Approach to Visualizing Classification Decisions for Patient Diagnosis.
    Keith Marsolo, Srinivasan Parthasarathy, Michael Twa, Mark Bullimore. Proceedings of the Conference on Artificial Intelligence in Medicine (AIME). Springer. 2005. Pages 473-483. A.R. - 22%
  9. Mining 3D-Motifs Using Physical-Chemical Constraints: Application to Cardiolipin-Binding Sites.
    Dmitrii Polshakov, Keith Marsolo, Srinivasan Parthasarathy. International Conference on Intelligent Systems for Molecular Biology (ISMB), June 2005 (Poster Paper).
  10. A New Approach to Protein Structure Mining and Alignment.
    Hongyuan Li, Keith Marsolo, Srinivasan Parthasarathy, Dmitrii Polshakov. Proceedings of the ACM SIGKDD Workshop on Data Mining and Bioinformatics (BIOKDD). ACM Press. 2004. Pages 1-10. A.R. - 23%
  11. Discovering Spatial Relations Between Approximately Equivalent Patterns in Contact Maps.
    Hui Yang, Keith Marsolo, Sameep Mehta. Proceedings of the ACM SIGKDD Workshop on Data Mining and Bioinformatics (BIOKDD). ACM Press. 2004. Pages 62-71. A.R. - 23%
  12. MotifMiner++: A High-Performance Data Mining Toolkit for Mining Biomolecular Structures.
    Keith Marsolo, Srinivasan Parthasarathy, Chao Wang, Hongyuan Li, Dmitrii Polshakov. International Conference on Intelligent Systems for Molecular Biology (ISMB), June 2004 (Poster Paper).

Selected Presentations

  • Structure-Based Querying of Proteins Using Wavelets
    ACM Fifteenth Conference on Information and Knowledge Management, Crystal City VA, USA – November 2006
  • Quantitative Analysis of Contractile Akinesia and Asynchrony in Myocardial Function
    NIH Summer Intern Poster Day, National Institutes of Health, Bethesda MD, USA - August 2006
  • Alternate Representation of Distance Matrices for Characterization of Protein Structure
    Fifth IEEE International Conference on Data Mining, Houston TX, USA - November 2005
  • A Multi-Level Approach to SCOP Fold Recognition
    Fifth IEEE International Symposium on BioInformatics and BioEngineering, Minneapolis, MN, USA - October 2005
  • Classification of Biomedical Data Through Model-Based Spatial Averaging
    Fifth IEEE International Symposium on BioInformatics and BioEngineering, Minneapolis, MN, USA - October 2005.
  • Alternative Representation of Distance Matrices for the Characterization of Protein Structure
    University of Sydney, Sydney, NSW, Australia - August 2005
    University of Melbourne, Melbourne, VIC, Australia - August 2005
  • Automated Classification of Corneal Shape
    Queensland University of Technology, Brisbane, QLD, Australia - August 2005
  • A New Approach to Protein Structure Mining and Alignment
    ACM SIGKDD Workshop on Data Mining and Bioinformatics, Seattle, WA, USA - August 2004
  • MotifMiner++: A High-Performance Data Mining Toolkit for Mining Biomolecular Structures
    International Conference on Intelligent Systems for Molecular Biology, Glasgow, Scotland - June 2004

Research Interests

  • Data Mining and Data Warehousing
  • Bioinformatics
  • Biomedical Data Modeling