Mario Medvedovic, PhD
Title
Associate Professor
Appointment
Associate Professor, University of Cincinnati College of Medicine
Email
mario.medvedovic@cchmc.org
Phone
513-636-7150
Fax
513-636-2056
Research
Dr. Medvedovic's research lab focuses on the development of Bayesian hierarchical models for unsupervised and semi-supervised learning from diverse data types, and the application of such methods through interdisciplinary biomedical efforts. For more information, visit Dr. Medvedovic's lab web site: http://eh3.uc.edu/.
Publications, Most Recent
Medvedovic M, Halbleib D, Miller ML, Ladow K, Sartor MA, Tomlinson CR. Gene expression profiling of blood to predict the onset of leukemia. Blood Cells Mol Dis. 2008 Oct 18.
Borchers MT, Wesselkamper SC, Eppert BL, Motz GT, Sartor MA, Tomlinson CR, et al. Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology. Toxicol Sci. 2008 Sep;105(1):188-99.
Tang WY, Newbold R, Mardilovich K, Jefferson W, Cheng RY, Medvedovic M, et al. Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein. Endocrinology. 2008 Jul 31.
Bakshi S, Zhang X, Godoy-Tundidor S, Cheng RY, Sartor MA, Medvedovic M, et al. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: oncogenic and immunomodulations involving the action of tumor necrosis factor. Environ Health Perspect. 2008 Jun;116(6):769-76.
Tam NN, Szeto CY, Sartor MA, Medvedovic M, Ho SM. Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17beta-estradiol- or diethylstilbestrol-induced prostate dysplasia in Noble rats. Neoplasia. 2008 Jan;10(1):20-40.
Ganguly K, Stoeger T, Wesselkamper SC, Reinhard C, Sartor MA, Medvedovic M, et al. Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure. Physiol Genomics. 2007 Nov 14;31(3):410-21.
Popa I, Zubkova I, Medvedovic M, Romantseva T, Mostowski H, Boyd R, et al. Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma. Int Immunol. 2007 Nov;19(11):1249-60.
Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, et al. Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007 Sep;37(3):309-21.
Liu X, Jessen WJ, Sivaganesan S, Aronow BJ, Medvedovic M. Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data. BMC bioinformatics. 2007;8:283.
Schwanekamp JA, Sartor MA, Karyala S, Halbleib D, Medvedovic M, Tomlinson CR. Genome-wide analyses show that nuclear and cytoplasmic RNA levels are differentially affected by dioxin. Biochimica et biophysica acta. 2006 Aug-Sep;1759(8-9):388-402.
Mesa C, Jr., Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, et al. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling. Cancer Res. 2006 Jul 1;66(13):6521-9.
Liu X, Sivaganesan S, Yeung KY, Guo J, Bumgarner RE, Medvedovic M. Context-specific infinite mixtures for clustering gene expression profiles across diverse microarray dataset. Bioinformatics. 2006 May 18.
Icenhour CR, Arnold J, Medvedovic M, Cushion MT. Competitive coexistence of two Pneumocystis species. Infect Genet Evol. 2006 May;6(3):177-86.
Gandhi M, Medvedovic M, Stringer JR, Nikiforov YE. Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements. Oncogene. 2006 Apr 13;25(16):2360-6.
Erwin CR, Jarboe MD, Sartor MA, Medvedovic M, Stringer KF, Warner BW, et al. Developmental characteristics of adapting mouse small intestine crypt cells. Gastroenterology. 2006 Apr;130(4):1324-32.
Wesselkamper SC, McDowell SA, Medvedovic M, Dalton TP, Deshmukh HS, Sartor MA, et al. The role of metallothionein in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol. 2006 Jan;34(1):73-82.
Medvedovic M, Tomlinson CR, Call MK, Grogg M, Tsonis PA. Gene expression and discovery during lens regeneration in mouse: regulation of epithelial to mesenchymal transition and lens differentiation. Mol Vis. 2006;12:422-40.
Sartor MA, Tomlinson CR, Wesselkamper SC, Sivaganesan S, Leikauf GD, Medvedovic M. Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments. BMC bioinformatics. 2006;7:538.
Sartor MA, Zorn AM, Schwanekamp JA, Halbleib D, Karyala S, Howell ML, et al. A new method to remove hybridization bias for interspecies comparison of global gene expression profiles uncovers an association between mRNA sequence divergence and differential gene expression in Xenopus. Nucleic Acids Res. 2006;34(1):185-200.
Wesselkamper SC, Case LM, Henning LN, Borchers MT, Tichelaar JW, Mason JM, et al. Gene expression changes during the development of acute lung injury: role of transforming growth factor beta. Am J Respir Crit Care Med. 2005 Dec 1;172(11):1399-411.
Puxeddu E, Knauf JA, Sartor MA, Mitsutake N, Smith EP, Medvedovic M, et al. RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response. Endocr Relat Cancer. 2005 Jun;12(2):319-34.
Puxeddu E, Zhao G, Stringer JR, Medvedovic M, Moretti S, Fagin JA. Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens. Mutat Res. 2005 Feb 15;570(1):17-32.
Stringer JR, Larson JS, Fischer JM, Medvedovic M, Hersh MN, Boivin GP, et al. Modeling variation in tumors in vivo. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2408-13.
Whitsett JA, Bachurski CJ, Barnes KC, Bunn PAJ, Case LM, Cook DN, et al. Functional genomics of lung disease. Second annual Pittsburgh International Lung Conference, October 2003. Am J Respir Cell Mol Biol. 2004 Aug;31(2 Suppl):S1-81.
Zhang J, Moseley A, Jegga AG, Gupta A, Witte DP, Sartor M, et al. Neural system-enriched gene expression: relationship to biological pathways and neurological diseases. Physiol Genomics. 2004 Jul 8;18(2):167-83.
Sonntag DM, de Boer J, Medvedovic M, Baxter CS, LeMasters G, Talaska G. Mutational biases associated with potential iron-binding DNA motifs in rodent lacI and human p53 mutational databases. Mutat Res. 2004 Jun 4;550(1-2):73-88.
Medvedovic M, Yeung KY, Bumgarner RE. Bayesian mixture model based clustering of replicated microarray data. Bioinformatics. 2004 May 22;20(8):1222-32.
Sartor M, Schwanekamp J, Halbleib D, Mohamed I, Karyala S, Medvedovic M, et al. Microarray results improve significantly as hybridization approaches equilibrium. Biotechniques. 2004 May;36(5):790-6.
Guo J, Sartor M, Karyala S, Medvedovic M, Kann S, Puga A, et al. Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicol Appl Pharmacol. 2004 Jan 1;194(1):79-89.
Bahassi el M, Karyala S, Tomlinson CR, Sartor MA, Medvedovic M, Hennigan RF. Critical regulation of genes for tumor cell migration by AP-1. Clin Exp Metastasis. 2004;21(4):293-304.
Karyala S, Guo J, Sartor M, Medvedovic M, Kann S, Puga A, et al. Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice. Cardiovasc Toxicol. 2004;4(1):47-73.
Yeung KY, Medvedovic M, Bumgarner RE. From co-expression to co-regulation: how many microarray experiments do we need?. Genome Biol. 2004;5(7):R48.
Puga A, Sartor MA, Huang MY, Kerzee JK, Wei YD, Tomlinson CR, et al. Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure. Cardiovasc Toxicol. 2004;4(4):385-404.
Vineis P, Schulte PA, Carreon T, Bailer AJ, Medvedovic M. Issues of design and analysis in studies of gene-environment interactions. IARC Sci Publ. 2004(157):417-35.
