Overview
One of the primary interests of the research lab directed by Bruce Aronow, PhD, and Anil Jegga, DVM, is the identification of constitutionally similar and/or conserved cis-element clusters in orthologous and non-orthologous genes. To that end, the lab has developed a web-based tool called TraFaC (Transcription Factor Comparison). TraFaC identifies the cis-elements in phylogenetic footprints, or non-coding DNA regions of six or more base pairs having almost 100 percent similarity and conserved across several species separated by several million years of evolution.
The lab also has developed CisMols Analyzer, which extends the scope of TraFaC to identify compositionally similar cis-regulatory element clusters that occur in groups of co-regulated genes. These computationally predicted cis-clusters, or cis-mols, could serve as valuable probes for genome-wide identification of regulatory regions.
Other current projects include:
- PolyDoms: A web-based application that maps synonymous and non-synonymous single nucleotide polymorphisms (SNPs and nSNPs) of proteins onto known functional domains.
- CMGCC (Cincinnati Comparative Mouse Genomics Centers Consortium): A collaborative initiative with the University of Cincinnati to develop transgenic and knockout mouse models based on human DNA sequence variants in environmentally responsive genes.
Contact Us
For more information about the Aronow/Jegga lab, contact Bruce Aronow, PhD, or Anil Jegga, DVM.
