Dr. Aronow received his BS in chemistry from Stanford University in 1976. From 1983 to 1985, he was a University Fellow at the University of Kentucky, and in 1984, Dr. Aronow was honored with the annual Sigma Xi Graduate Research Award from the University of Kentucky. In 1986, he completed his PhD in biochemistry at the University of Kentucky. From 1987 to 1989, Dr. Aronow received the National Research Service Award GM119828. He was a research fellow in the Division of Basic Science Research at the Cincinnati Children's Research Foundation from 1986 to 1989. In 1992, Dr. Aronow was honored with the prestigious Lotte Strauss Prize for Outstanding Basic Research Paper from the Pediatric Pathology Society. In 1997, Dr. Aronow was honored with two awards for separate works. He received the "Theodore Woodward Award" from the Society for Clinical and Climatologic Studies from the Mayo Foundation, and he was honored with the Leo Prize from the 3rd International Workshop on Clusterin, Villars-sur-Ollon, Switzerland.
Dr. Jegga plays a key role in multiple collaborations at Cincinnati Children's and the University of Cincinnati in the elucidation of gene regulatory networks and the interaction between genotype and phenotype using a variety of bioinformatics approaches. Dr. Jegga is currently involved in application domains that include cardiovascular diseases, digestive disorders, genitourinary disorders and tumorigenesis in response to environmental challenges. To aid in the diffusion of genomics into biomedical research and education, Dr. Jegga, together with Dr. Aronow, is working on several approaches that integrate bioinformatics with clinical informatics.
Dr. Jegga gradudated first rank with a bachelor's degree in veterinary science and animal husbandry from the College of Veterinary Science in Hyderabad, India, in 1993. Two years later, he received his DVM with a focus on surgery from the College of Veterinary Science in Hyderabad, India. In the same year, he was awarded a Gold Medal for securing the highest 0GPA in the surgery program. During 1994, he was adjudged as outstanding student in the state of Andhra Pradesh, India, in the faculties of medical, dental, agricultural and veterinary sciences and awarded Gold Medal. In 2000, he received his MRes in bioinformatics from the University of York. Additional details of his research and list of publications can be found at http://anil.cchmc.org.
Dr. Jessen received his bachelor's degree in physics from Purdue University. He then pursued a doctoral degree in biochemistry at Texas A&M University, where he graduated in 2004. The same year, he joined the Division of Biomedical Informatics as a research fellow. He is currently involved in several studies centered on gene expression analysis.
Bhuvana graduated with a master's degree in physics from Madurai Kamaraj University, India, in 1997. She later spent several years at Max-Plank Institute for Cardiology, Bad Nauheim, Germany, as a student and research assistant. In 2001, Bhuvana joined the Division of Biomedical Informatics as a research associate. Bhuvana's primary responsibilities include assisting researchers at Cincinnati Children's and the University of Cincinnati with DNA sequence and microarray data analysis. She also provides support and training for commercial and in-house developed bioinformatics applications including SeqWeb"/SeqLab", GeneSpringTM and TraFaC. Her other responsibilities include maintainenance and support of MySQL-based research databases.
Huan received her BS in zoology from Nanjing University in China in 2001. In 2005 she received her MS in molecular and developmental biology from the University of Cincinnati. She joined the Aronow/Jegga research lab in the Division of Biomedical Informatics in February, 2005, and is dedicated to the DDRDC Bioinformatics Core. Her primary responsibilities include all aspects of microarray analysis support for researchers at Cincinnati Children's and the University of Cincinnati.
Jing received the prestigious Singapore Ministry of Education Scholarship in 1998, which he used to complete his studies at the National University of Singapore, graduating in 2002 with a BE in computer engineering. Chen is currently enrolled in the University of Cincinnati's bioinformatics doctorate program and has been working with the Aronow/Jegga lab for nearly four years. His current research includes work on the GenomeTraFaC application. He also is working on PolyDoms, a component of the CMGCC project that is used to map non-synonymous SNPs onto known and functional protein domains and 3-D structures.
Johannes graduated from the Universität Leipzig with a MS in computer science with specialization in medical informatics, and minors in biomedicine and biostatistics. He is currently using the R programming language and GeneSpring software to analyze gene expression data as well as comparing data from various microarray platforms for the Aronow/Jegga lab. By comparing the data outputs of the various microarray platforms, Johannes has been able to discern which are the most accurate. He is experienced in programming with S-Plus/R, GeneSpring, C, Java", SPSS", PL/SQL, Oracle", Mathematica" and Lotus" Notes.
Siva graduated with a BE in electronics and communication engineering from Bharathidasan University in 2001. He received his MS in computer engineering from the University of Cincinnati and is currently enrolled in the bioinformatics doctorate program. Siva is working with the Aronow/Jegga lab on predicting the effects of regulatory SNPs on gene expression. He is also working on the annotation and patterning of mirror and inverted repeats. Earlier he worked on GenomeTraFaC, a project which deals with the identification of putative transcription regulatory regions. He has also worked on PolyDoms, a program that aids in the mapping of non-synonymous SNPs onto known functional protein domains and 3-D structures. Siva was awarded the University Research Council Summer Fellowship, 2006, for his ongoing work on predicting effects of regulatory indels on gene expression. Siva was also awarded the Scholar-in-training award at the third annual CMGCC symposium in Austin, Texas, for his work with the Aronow/Jegga lab and the CMGCC.
RangaChandra completed his BE in electronics and instrumentation engineering, graduating with distinction from Nagarjuna University in 2001. He is currently pursuing a PhD in bioinformatics at the University of Cincinnati. RangaChandra's primary interests center on adapting semantic web technologies and standards for life sciences data. Currently his work involves addressing non-trivial semantic integration of various complimentary genotype-to-phenotype data and knowledge to further enhance reasoning and inference utilizing OWL-DL knowledge representation standards. In addition, he is also working to conceptually map UMLS and OMIM clinical features using OWL and RDF standards and to explore subspace clustering techniques to form phenotype networks. His other interests include semantic mining, context-specific view of biological data using conceptual spaces, ranking relations on the semantic web, multi-agent systems and semantic grids.
Vivek graduated with a BE in computer engineering from the University of Pune in 2004. He is currently enrolled in the University of Cincinnati's bioinformatics doctorate program. He joined the Aronow/Jegga lab in June, 2006, and is working on comparative genomics-based analysis of human disease genes with an emphasis on Xenopus orthologs of human OMIM disease genes. Vivek is also working on comparative genomics of microRNAs.
For more information about the Aronow/Jegga lab, contact Bruce Aronow, PhD, or Anil Jegga, DVM.
