PolyDoms
PolyDoms was developed by the Aronow/Jegga lab to map synonymous and non-synonymous single nucleotide polymorphisms (SNPs and nsSNPs) of proteins onto known functional domains. The application uses only "pfam" for the protein domains. PolyDoms also gives a list of SNPs and their implications as predicted by two software programs, SIFT and PolyPhen, for each protein in the database.
Protein functions are determined by their three-dimensional structures, and PolyDoms takes advantage of this fact, mapping the SNPs onto three-dimensional structures wherever an equivalent protein structure is available.
As PolyDoms generates results, the latest relevant PubMed results are included along with the output. A POLYVIEW link is also given for each of the proteins in the database. The SNPs are highlighted in the Polyview image for easy inference of the results.
The interface to PolyDoms.
Contact Us
For more information, contact Bruce Aronow, PhD, or Anil Jegga, DVM.
