Functional Brain Imaging
Functional neuroimaging in pediatrics continues to be a major focus of research in the Imaging Research Center at Cincinnati Children's Research Foundation. A dedicated 3T MRI scanner for research in pediatrics has been a key component in the development of this program.
New projects utilizing functional imaging have recently been funded by the NIH and private foundations this year for projects involving the use of fMRI for studies of language development, cognitive impairment associated with lead exposure, auditory representation in the brains of children with severe hearing impairment, bipolar disorder, perinatal stroke, and brain reorganization during rehabilitation in children with traumatic brain injury.
The fMRI studies are directed by IRC faculty (Drs. Holland and Schmithorst) and focus primarily on brain development and developmental disorders. Additionally, collaborations with researchers at CHMC and UCMC in psychiatry, psychology, neurology, and neurosurgery involve the use of fMRI in adult brain physiology and diseases.
Recent publications of Drs. Holland and Schmithorst: Wilke M, Schmithorst VJ, Holland SK. Assesment of spatial normalization in children. Human Brain Mapping, 17: 1-10, 2002.
Adler CM, Mcdonough-Ryan P, Sax KW, Holland SK, Arndt S, Strakowski SM. fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder. J Psychiatr Res, 34: 317-324, 2000.
- De Courten-Myers GM, Xi G, Hwang JH, Dunn RS, Mills AS, Holland SK, Wagner KR, Myers RE, Hypoglycemic brain injury: potentiation from respiratory depression and injury aggravation from hyperglycemic treatment overshoots. J Cereb Blood Flow Metab, 20: 82-92, 2000.
- Dardzinski BJ, Schmithorst VJ, Holland SK, Boivin GP, Imagawa T, Watanabe S, Lewis JM, Hirsch R. MR imaging of murine arthritis using ultrasmall superparamagnetic iron oxide particles. Magn Reson Imaging, 19: 1209-1216, 2001.
- Schmithorst VJ, Dardzinski BJ, Holland SK. Simultaneous correction of ghost and geometric distortion artifacts in EPI using a multiecho reference scan. IEEE Trans Med Imaging, 20: 535-539, 2001.
- Sze RW, Chan CB, Dardzinski BJ, Dunn S, Sanbe A, Schmithorst V, Robbins J, Holland SK, Strife JL. Three-dimensional MR microscopy of a transgenic mouse model of dilated cardiomyopathy. Pediatr Radiol, 31: 55-61, 2001.
- Adler CM, Sax KW, Holland SK, Schmithorst V, Rosenberg L, Strakowski SM. Changes in neuronal activation with increasing attention demand in healthy volunteers: an fMRI study. Synapse, 42: 266-272, 2001.
Holland SK, Plante E, Weber Byars A, Strawsburg RH, Schmithorst VJ, Ball WS Jr. Normal fMRI brain activation patterns in children performing a verb generation task. Neuroimage, 14: 837-843, 2001.
- Adler CM, Holland SK, Enseleit S, Strakowski SM. Age-related changes in regional activation during working memory in young adults: an fMRI study. Synapse, 42: 252-257, 2001.
- Ball WS Jr, Holland SK. Perfusion imaging in the pediatric patient. Magn Reson Imaging Clin N Am, 9: 207-230, ix, 2001.
Schmithorst VJ, Wilke M, Dardzinski BJ, Holland SK. Correlation of white matter diffusivity and anisotropy with age during childhood and adolescence: a cross-sectional diffusion-tensor MR imaging study. Radiology, 222: 212-218, 2002.
- D'errico F, Nath R, Holland S, Lamba M, Patz S, Rivard MJ. A Positive Sensitive Neutron Spectrometer/Dosimeter Based on Pressurized Superheated Drop (Bubble) Detectors. Nucl Instr Methods, A 476: 113-118, 2002.
- Schmithorst VJ, Wilke M. Differences in white matter architecture between musicians and non- musicians: a diffusion tensor imaging study. Neurosci Lett, 321: 57-60, 2002.
