Nives Zimmermann, MD
Title
Associate Professor of Pediatrics
Appointment
Associate Professor
Email
zimmn0@cchmc.org
Phone
513-636-3887
Fax
513-636-3310
Credentials
MD: School of Medicine, University of Zagreb; Zagreb, Croatia, 1995.
Position History
- 1990-93 Teaching Assistant, Department of Biology, School of Medicine, Zagreb, Croatia
- 1991-92 Researcher, Dept of Physiology & Immunology, School of Medicine, Zagreb, Croatia
- 1992 Researcher, Department of Biology, School of Medicine, Zagreb, Croatia
- 1992 Fellow, Institute for Molecular Biology, Salzburg, Austria
- 1993-94 Researcher, Laboratory of Molecular Neuropharmacology, Department of Pharmacology, School of Medicine, Zagreb, Croatia
- 1994 Karyn Kupcinet International Science School, Summer Program. Weizmann Institute of Science, Rehovot, Israel
- 1995-96 Research Scholar, Dept of Otolaryngology-Head and Neck Surgery, U.Cincinnati College of Medicine, Cincinnati, Ohio
- 1997-99 Research Associate, Division of Pulmonary Medicine, Allergy and Clinical Immunology, Children's Hospital Medical Center, Cincinnati, Ohio
- 1999-2002 Instructor in Pediatrics, Children's Hospital Medical Center, U. Cincinnati College of Medicine, Cincinnati, Ohio
- 2002-2008 Assistant Professor of Pediatrics, University of Cincinnati College of Medicine, Children’s Hospital Medical Center
- 2005-present Member, Immunobiology Graduate Program, University of Cincinnati College of Medicine, Children’s Hospital Medical Center
- 2008-present Associate Professor of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children’s Hospital Medical Center
Awards and Honors
- 1991-92 Dean's Award, School of Medicine, University of Zagreb, Zagreb, Croatia
- 1991-94 University of Zagreb scholarship (awarded twice)
- 1992 Scholarship awarded by the Republic of Austria; Institute of Molecular Biology, Salzburg, Austria
- 1994 Summer student program of the Karyn Kupcinet International Science School, Rehovot, Israel
- 1999 Symposia Funded Scholarship, Keystone Symposia
- 1999 Travel Grant Recipient, American Academy of Allergy, Asthma & Immunology
- 2004 Woman physician in allergy junior faculty development award (special recognition), AAAAI/Aventis
Research
Asthma; eosinophils; lung inflammation
Research Grants and Contracts
National Institutes of Health R01, "The role of arginase in allergic airway inflammation" December 15, 2002 - November 30, 2007, Co-Investigator.
March of Dimes Birth Defects Foundation, "The role of arginine transport in the development of inflammatory homeostasis in the lung" June 1, 2006 – May 31, 2009, Principal Investigator.
Cincinnati Children's Hospital Medical Center (translational research initiative), "Targeting eosinophils by anti-Siglec treatment" July 1, 2007 - June 30, 2008, Principal Investigator.
Dana Foundation (Bochner, Bruce), "Novel genetic and therapeutic approaches focusing on Siglec-8 for the diagnosis and treatment of human idiopathic eosinophilic disorders" October 1, 2007- September 30, 2010, Co-Investigator.
The role of GPR65/TDAG8 in airway inflammation, January 1, 2008 - December 31, 2008, Co-Principal Investigator.
Publications, Most Recent
Pope SM, Fulkerson PC, Blanchard C, Saito Akei H, Nikolaidis NM, Zimmermann N, Molkentin JD and Rothenberg ME. Identification of a cooperative mechanism involving IL-13 and eotaxin-2 in experimental allergic lung disease.J Biol Chem. 2005; 280(14):13952-61.
Zimmermann N, Doepker, MP, Witte DP, Stringer KF, Fulkerson PC, Pope SM, Brandt EB, Mishra A, King NE, Nikolaidis NM, Wills-Karp M, Finkelman FD, and Rothenberg ME. Expression and regulation of small proline rich protein (SPRR)2 in allergic inflammation.J Respir Cell Mol Biol 2005; 32(5):428-35.
Zimmermann N, Colyer JL, Koch L and Rothenberg ME. Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1.BMC Immunol 2005; 6:7.
Pope SM, Zimmermann N, Stringer KF, Karow ML, Rothenberg ME. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia.J Immunol. 2005; 175(8):5341-50.
Fulkerson PC, Zhu H, Williams DA, Zimmermann N, Rothenberg ME. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.Blood. 2005; 106(2):436-43.
Brandt EB, Zimmermann N, Muntel EE, Yamada Y, Pope SM, Mishra A, Hogan SP, Rothenberg ME. The alpha4beta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine.Clin Exp Allergy. 2006; 36(4):543-53.
Zimmermann N, Rothenberg ME. The arginine-arginase balance in asthma and lung inflammation.Eur J Pharmacol. 2006; 533(1-3):253-62
Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG and Zimmermann N. The cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.Proc Natl Acad Sci USA 2006; 103:14895
Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmermann N, Mahalingam S, Webb DC, Tremethick DJ, Thompson PJ, Hogan SP, Rothenberg ME, Cowden WB, Foster PS. Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.J Immunol. 2006;177:5595-603.
Bergeron C, Boulet LP, Page N, Laviolette M, Zimmermann N, Rothenberg ME, Hamid Q. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.J Allergy Clin Immunol 2007;119:391-7.
Guo JP, Nutku E, Yokoi H, Schnaar RL, Zimmermann N, Bochner BS. Siglec-8 and Siglec-F: inhibitory receptors on eosinophils, basophils and mast cells.Allergy Clin Immunol Inter – J World Allergy Org 2007;19:54-59.
Zimmermann N. McBride M.L. Yamada Y. Hudson S.A. Jones C. Cromie K.D. Crocker P.R. Rothenberg M.E. Bochner B.S. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy 2008;63:1156-63.
Professional Organization Memberships
- Member, American Academy of Allergy, Asthma and Immunology
- Member, American Association of Immunologists
Special Interests
Asthma; allergy
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
