Allergy and Immunology

Yui-Hsi Wang, PhD

Title

Assistant Professor of Pediatrics

Appointment

Assistant Professor of Pediatrics, University of Cincinnati College of Medicine

Email

yui_hsi.wang@cchmc.org

Phone

513-803-2193

Fax

513-636-3310

Credentials

University of Alabama, Birmingham, AL, 35205, 2001

Position History

Postdoctoral fellow, 2002-2006
Instructor, 2006-2008
Assistant professor, 2008-present

Awards and Honors

Gail H. Cassell Scholarship Endowment Award, 1999
Tanox Inc. Fellowship Award, 2003-2006
Vivan L. Smith CCIR Award for Outstanding Young Immunologist, 2005
ST*AR Awardee in American Academy of Allergy Asthma & Immunology Society, 2006
CTSA KL2 Research Scholars career development award, 2009

Research

Asthma; food allergy; T cell biology

Research Grants and Contracts

CTSA KL2 Research Scholars career development award Exploring the novel allergen-specific TH2 memory cell subsets in asthmatic patients, 2009, Primary Investigator

Publications, Most Recent

K. S. Voo, Y.-H. Wang, F. R. Santor i, C. Boggiano, K. Arima, L. Bover, S. Hanabuchi, J. Khalili, E. Marinova, B. Zheng, D. R. Littman, Y.-J. Liu. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. 2009, Proc. Natl. Acad. Sci. USA, 106(12):4793-8.

C. J. Corrigan, A. Jayaratnam1, Y.-H. Wang, Y.-J. Liu, R. W. Malefyt, Q. Meng, A.B. Kay, S. Phipps, T. H. Lee, and Sun Ying. Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen-induced late phase cutaneous responses in atopic subjects. 2009, Allergy. 64(7):1014-1022.

E. Esashi, Y.-H. Wang, O. A. Perng, X. F. Qin, L. Hennighausen, Y.-J. Liu and S. S. Watowich. Differential regulation of plasmacytoid and conventional dendritic cell development by GM-CSF through STAT5. 2008., Immunity. 28:1-12.

Y.-H Wang and Y.-J. Liu. The IL-17 cytokine family and their role in allergic inflammation. 2008, Curr. Opin. Immunol. 20(6):697-702.

Y.-J. Liu, V. Soumelis, N. Watanabe, T. Ito, Y.-H. Wang, R. W. Malefyt, M. Omori, B. Zhou, and S. F. Ziegler. TSLP: An Epithelial Cell-Cytokine Regulates Central and Peripheral T Cell Development by Conditioning Dendritic Cell Maturation. 2007, Ann. Rev. Immunol. Vol. 25:193-220.

T. Ito, Yang M, Y.-H. Wang, R. Lande, J Gregorio, O. A. Perng, X. F. Qin, Y.-J. Liu, and M. Gilliet. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. 2007, J. Exp. Med. 204(1): 105-115.

S. Ebner, V.A. Nguyen, M. Forstner, Y.-H. Wang, D.M. Wolfram, Y.-J. Liu, N. Romani. Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen presenting cells that induce pro-allergic T cells. 2007, J. Allergy Clin. Immunol. 119(4): 982-90.

P. Angkasekwinai, H. Park, Y.-H. Wang, B. Sun, D. B. Corry, Y.-J. Liu, Z. Zhu, and C. Dong IL-25 promotes the initiation of proallergic type 2 immune response. 2007, J. Exp. Med. 204(7): 1509-1517.

Y.-H. Wang, P. Angkasekwinai, Q. Meng, N. Lu, K. S. Voo, K. Arima, S. Hanabuchi, C. J. Corrigan, T. Lee, C. Dong, D. P. Huston, Z. Yao, S. Ying, and Y.-J. Liu. IL-25 mediated cross talk between eosinophils and TSLP-DC-activated TH2 memory cells augments allergic immune responses. 2007, J. Exp. Med. 204(8): 1837-1847.

R. Lande, J. Gregorio, V. Facchinetti, B. Chatterjee, Y. Wang, B. Homey , W. Cao, Y.-H. Wang, B. Su, F. O. Nestle, T. Zal, I. Mellman, J.-M. Schro¨der, Y.-J. Liu and M. Gilliet Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. 2007, Nature, 449 (7162):564-9.

R. Bagheri-Yarmand, S. Balasenthil, A.E. Gururaj, A.H. Talukder, Y.-H. Wang, J.H. Lee, Y.S. Kim, X. Zhang, D.M. Jones, L. J. Medeiros, L.C. Stephens, Y.-J. Liu, N. Lee, I. Kim, and R. Kumar Metastasis Associated Protein-1 (MTA1) Transgenic Mice: A New Model of Spontaneous B Cell Lymphomas. 2007, Cancer Research. 67(15):7062-7.

Y.-H. Wang and Yong-Jun Liu. OX40/OX40L: A promising therapeutic target for allergic diseases? 2007, J. Clin Invest, 117(12):3655-7.

M. Chen, Y.-H. Wang, Y. Wang, H. Sandoval, Y-J. Liu, and J. Wang. Apoptosis deficiency in dendritic cells induces systemic autoimmunity. 2006, Science, 311, (5764): 1160-4.

Hanabuchi S, N. Watanabe, Y.-H. Wang, Y. Wang, T. Ito, Shaw J, W Cao, FX Qin, and Y.-J. Liu. Human plasmacytoid pre-dendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). 2006, Blood. 107(9):3617-3623.

Y.-H. Wang, T. Ito, Y. Wang, B. Homey, N. Watanabe, R. Martin, C. J. Barnes, M. Gilliet, R. Kumar, Z. Yao, and Y.-J. Liu. Maintenance and polarization of human T helper type 2 central memory T cells by thymic stromal lymphopoietin activated dendritic cells. 2006, Immunity Vol.24, No.6:827-838.

T. Ito, Y.-H. Wang, T. Hori, G. J. Delespesse, W. Cao1, X.-F. Qin, Yong-Jun Liu. OX40 ligand shuts down IL-10-producing regulatory T cells. 2006, Proc. Natl. Acad. Sci. USA, 103(35):13138-43.

Y.-J. Liu, H. Kanzler, Y.-H. Wang, Y. Wang, M. Gilliet, W. Cao and T. Ito. pDC: From Plasmacytoid Dendritic Cell Precursors to Professional Type 1 Interferon-Producing Cells.DC Book, 2005.

Y.-H Wang and Y.-J. Liu. TSLP, OX40L, and IL-25 in Allergic Responses. 2009, Clin. Exp. Aller. 39(6):798-806.

Presentations, Most Recent

American Academy of Allergy, Asthma, and Immunology, A Novel Subset of TH2 memory/Effector Cells That Produce Inflammatory Cytokine IL-17 and Promote the Exacerbation of Allergic Asthma, Washington DC, 3/2009

6th Biennial International Symposium Eosinophils 2009 of the International Eosinophil Society, "TSLP, IL-25, and OX40L", Bruges, Belgium 7/2009