Cardiology

Bradley S. Marino, MD, MPP, MSCE

Title

Attending Physician

Appointment

Associate Professor of Pediatrics

Email

bradley.marino@cchmc.org

Phone

513-636-8254

Fax

513-636-3952

Credentials

BA: University of Virginia (History), 1989

MD: Harvard Medical School, Boston, MA, 1994.

MPP: Harvard University/John F. Kennedy School of Government (Masters in Public Policy - Health Care Policy), Boston, MA, 1994

MSCE: University of Pennsylvania/Center for Clinical Epidemiology and Biostatistics, (Master of Science in Clinical Epidemiology), Philadelphia, PA, 2005

Residency: Pediatrics, Johns Hopkins Hospital, Baltimore, MD, 1997.

Fellowships: Combined Pediatric Cardiology and Pediatric Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, 2002

Certification:
American Board of Pediatrics 1997, Recertification 2004;
Sub-Board of Pediatric Cardiology 2000;
Sub-Board of Pediatric Critical Care Medicine 2002

Awards and Honors

Best Doctors in America, 2008
Department of Anesthesiology and Critical Care Teaching Award, The Children's Hospital of Philadelphia, 2006
Department of Anesthesiology and Critical Care Teaching Award, The Children's Hospital of Philadelphia, 2005
Ann Newman Fellow in Pediatric Cardiology, The Children's Hospital of Philadelphia, 1999
John F. Kennedy School of Government, Knowles Fellowship, Harvard Medical School, 1992
Virginia Linnane Scholarship, Harvard Medical School, 1990
Raven Society, University of Virginia, 1989
Phi Alpha Theta History Honor Society, University of Virginia, 1989
Lawn Resident, University of Virginia, 1989
Phi Beta Kappa, University of Virginia, 1988
Omicron Delta Kappa, University of Virginia, 1988
Golden Key National Honor Society, University of Virginia, 1988
Golden Key-Peat Marwick Scholarship, University of Virginia, 1988
Alpha Epsilon Delta Pre-Medical Honor Society, University of Virginia, 1986
Echols Scholar, University of Virginia, 1985

Research

Intensive care outcomes; quality of life assesment in children and adolescents with congenital and acquired heart disease; aortic valve and mitral valve surgical outcomes; cardiopulmonary interaction (shock and cardiac arrest)

Research Grants and Contracts

National Institute of Health, K23-HD046837,
Testing the Pediatric Cardiac Quality of Life Instrument, 2/15/05 - 12/31/10, Principal Investigator.

Publications, Most Recent

Marino BS, Yannopoulos D, Sigurdsson G, Lai L, Cho C, Redington A, Nicolson S, Nadkarni V, Lurie K. Spontaneous breathing through an inspiratory impedance threshold device augments cardiac index and stroke volume index in a pediatric porcine model of hemorrhagic shock.Crit Care Med 2004; 32 (9): S398-S405.

Gaynor JW, Kuypers M, Rossem M, Wernovsky G, Marino BS, Tabbutt S, Nicolson SC, Spray TL. Hemodynamic Changes during Modified Ultrafiltration Immediately Following Stage 1 Reconstruction in 99 Neonates. Cardiol Young 2005: 15: 4-7.

Tabbutt S, Dominguez T, Ravishankar C, Marino BS, Gruber PJ, Wernovsky G, Gaynor JW, Nicolson SC, Spray TL. Outcomes After the Stage I Reconstruction Comparing the Right Ventricular to Pulmonary Artery Conduit With the Modified Blalock Taussig Shunt.Ann Thorac Surg 2005; 80:1 582–91

Srinivasan V, Nadkarni V, Yannopoulos D, Marino BS, Sigurdsson G, McKnite S, Zook M, Benditt DG, Lurie K. Rapid Induction of Cerebral Hypothermia Is Enhanced With Active Compression-Decompression Plus Inspiratory Impedance Threshold Device Cardiopulmonary Resuscitation in a Porcine Model of Cardiac Arrest.J Am Coll Cardiol 2006; 47: 835– 41.

Marino BS, Wernovsky G, Pasquali SK, Bockoven JR, McBride, M, Cho CJ, Spray TL, Paridon SM. Exercise Performance in Children and Adolescents After the Ross Procedure.Cardiol in the Young 2006; 16: 40-7.

Srinivasan V, Nadkarni V, Yannopoulos D, Marino BS, Sigurdsson G, McKnite S, Zook M, Benditt DG, Lurie K. Spontaneous Gasping Decreases Intracranial Pressure and Improves Cerebral Perfusion in a Pig model of Ventricular Fibrillation Resuscitation 2006; 69(2): 329-34.

Marino BS, Wernovsky G, Kreb DL, Mantel SF, van der Woerd WL, Visser D, Meijboom, EJ, McElhinney DB, Novella R, Cohen MS. Neo-aortic root dilation and regurgitation are progressive following the arterial switch procedure.Cardiol Young 2006; 16: 1-9.

Gillespie MJ, Marino BS, Cohen MS, Korteweg AE, Henket M, Gaynor JW, Spray TL, Tabbutt S, Wernovsky G. Risk factors for systemic atrioventricular valve surgery in the pediatric population. 2006 Cardiol Young; 16 (Suppl 3):35-42.

Marino BS, Wernovsky G, McElhinney DB, Jawad A., Kreb DL, Mantel SF,van der Woerd WL, Robbers-Visser D, Novello R, Gaynor JW, Cohen MS. Neo-aortic root dilation and valve regurgitation: Up to 16 years follow-up after the arterial switch operation. 2006 Cardiol Young; 16:481-489.

Ravishankar C, Dominguez T, Kreutzer J, Wernovsky G, Marino BS, Godinez RI, Priestley MA, Gruber PJ, Gaynor, JW, Nicolson SC, Spray TL, Tabbutt S. Extracorporeal membrane oxygenation after stage I reconstruction for hypoplastic left heart syndrome.Ped Crit Care Med 2006; 7(4): 319-23.

Pasquali SK, Shera D, Wernovsky G, Cohen MS, Tabbutt S, Nicolson SC, Spray TL, Marino BS. Mid-term outcomes and predictors of reintervention following the Ross procedure in infants, children, and young adults.J Thorac Cardiovasc Surg 2007; 133: 893-899.

Shillingford AJ, Marino BS, Ittenbach RF, Fedec A, Rychik J, Clancy RR, spray TL, Gaynor JW, Wernovsky G. Microcephaly is common in neonates with hypoplastic left heart syndrome.Cardiol Young 2007 (In Press)

Pasquali SK, Cohen MS, Shera D, Wernovsky G, Spray TL, Marino BS. The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in infants, children, and young adults.J Amer Coll Cardiol 2007 (In Press)

Ballweg JA, Dominguez TE, Ravishankar C, Kreutzer J, Marino BS, Bird GL, Gruber PJ, Wernovsky G, Gaynor JW, Nicholson SC, Spray TL, Tabbutt S. A Contemporary comparison of the impact of shunt type in hypoplastic left heart syndrome on the hemodynamics and outcome at the stage 2 reconstruction.J Thorac Cardiovasc Surg 2007 (In Press)

Pinto, NM, Marino, BS, Wernovsky G, DeFerranti, S, Walsh AZ, Laronde M, Hyland K, Cohen, MS. Obesity in Congenital and Acquired Heart Disease: A prevalent and significant comorbidity.Pediatrics 2007 (In Press)

Wernovsky G, Kuijpers M, Van Rossem MC, Marino BS, Ravishankar C, Dominguez T, Godinez RI, Dodds KM, Ittenbach RF, Nicolson SC, Bird GL, Gaynor JW, Spray TL, Tabbutt S. Postoperative course in the cardiac intensive care unit following stage I Norwood reconstruction.Cardiol Young 2007 (In Press)

Davis JA, Davis, McBride MG, Seliem MA, Marino BS, Tomlinson RS, Pampaloni MH,
Gaynor JW, Spray TL, Paridon SM. Evaluation of myocardial ischemia following surgical repair of anomalous aortic origin of a coronary artery in a series of pediatric patients.J Amer Coll Cardiol 2007 (In Press)

Pasquali SK, Marino BS, McBride MG, Wernovsky G, Paridon SM. Coronary artery pattern and age impact exercise performance late after the arterial switch operation.J Thorac Cardiovasc Surg 2007 (In Press)

Dorfman AT, Marino BS, Wernovsky G, Dominguez T, Ravishankar C, Godinez RI, Priestley M, Dodds KM, Rychik J, Gruber PS, Gaynor JW, Levy R, Nicolson SC, Montenegro LM, Spray TL, Tabbutt S. Critical heart disease in the neonate: presentation and outcome at a tertiary care pediatric cardiac intensive care unit.Peds Crit Care Med 2007 (In Press)

Editorials, Reviews, Chapters:

Conran A, Marino BS. Congenital Heart Disease. In: Litman RS. Pediatric Anesthesia: The Requisites in Anesthesiology. Philadelphia: Elsevier Press 2004; 19-35

Fisher MJ, Marino BS, Litman RS. Oncologic Diseases. In: Litman RS. Pediatric Anesthesia: The Requisites in Anesthesia. Philadelphia: Elsevier Press, 2004; 60-67.

Marino BS, Wernovsky G. Stabilization and transport of the neonate with congenital heart disease. In: Taeusch HW, Ballard RA, Gleason CA. Avery's Diseases of the Newborn, 8th Ed. Philadelphia, W.B. Saunders, 2005; 812-815.

Marino BS. Transposition of the great arteries. In: Schwartz MW, 4th ed. 5-Minute Pediatric Consult. Philadelphia: Lippincott, Williams, and Wilkins 2005; 864-865.

Marino BS, Ostrow A, Cohen MS. Surgery for Congenital Heart Disease. In: Vetter VL. Pediatric Cardiology: The Requisites in Pediatrics. Philadelphia: Mosby, 2005; 277-320.

Marino BS. Health related quality of life assessment after intensive care therapy: Pre-existing disease matters Crit Care Medicine, 2005; 33:1658-9

Marino BS, Wernovsky G, Greeley WJ. Single Ventricle Lesions. In Nichols DG, Ungerleider RM, Spevak PJ, Greeley WJ, Cameron DE, Lappe DG, Wetzel RC, 2nd ed. Critical Heart Disease in Infants and Children. St. Louis, Mosby-Year Book, Inc. 2006; 789-797.

Marino BS, Greeley WJ, Spray TL. Separating the Circulations – Cavopulmonary Connections and the Modified Fontan Operation. In Nichols DG, Ungerleider RM, Spevak PJ, Greeley WJ, Cameron DE, Lappe DG, Wetzel RC, 2nd ed. Critical Heart Disease in Infants and Children. St. Louis, Mosby-Year Book, Inc. 2006; 845-867.

Steven JM, Marino BS, Jobes DR. Hypoplastic left heart syndrome. In Nichols DG, Ungerleider RM, Spevak PJ, Greeley WJ, Cameron DE, Lappe DG, Wetzel RC, 2nd ed. Critical Heart Disease in Infants and Children. St. Louis, Mosby-Year Book, Inc. 2006; 823-844.

Marino BS, Pasquali S, Spray TL, Wernovsky G. Is the Ross Procedure as Good as We Thought it Would Be? Cardiol Young 2006; 16 (Suppl. 3): 125–130.

Kaltman J, Marino BS, Tanel RE. Cardiac Arrhythmias in the Pediatric Intensive Care Unit. In: Davis D, Helfaer MA. Pediatric Critical Care Medicine: The Requisites. Philadelphia: Mosby, 2007 (In Press)

Marino BS, Ravishankar C, Dominguez T, Greeley WJ. Congenital Heart Disease. In: Davis D, Helfaer MA. Pediatric Critical Care: The Requisites. Philadelphia: Mosby, 2007 (In Press)

Marino BS, Kaltman J, Tanel RE. Cardiac Conduction, Dysrhythmias, and Pacing. In Nichols DG, 4th ed. Rogers Textbook of Pediatric Intensive Care Medicine. Philadelphia, Lippincott Williams & Wilkins 2007 (In Press)

Marino BS. Transposition of the great arteries. In: Schwartz MW, 5th ed. 5-Minute Pediatric Consult. Philadelphia: Lippincott, Williams, and Wilkins 2007 (In Press).

Marino BS. Myocarditis. In: Schwartz MW, 5th ed. 5-Minute Pediatric Consult. Philadelphia: Lippincott, Williams, and Wilkins 2007 (In Press).

Books:

Marino BS, Snead K. 4th ed. Blueprints in Pediatrics. Baltimore, Lippincott Williams & Wilkins, 2007.

Presentations, Most Recent:

Lurie KG, McKnite S, Nadkarni V, Yannopoulos D, Sigurdsson G , Srinivasan V, Marino BS, Frascon RJ, Dries D, Idris A. Cardio-cranial interactions: reduction of elevated intracranial pressure with an inspiratory impedance threshold device in spontaneously breathing pigs after resuscitation from cardiac arrest.Crit Care Med 2003; 31: (suppl) A10. (Presented at the 33rd Critical Care Congress, Orlando, FL, 2004)

Dorfman A, Marino BS, Tabbutt S, Dominguez T, Ravishankar C, Godinez RI, Schultz S, Priestley M, Dodds KM, Rychik J, Gruber P, Gaynor JW, Nicolson SC, Montenegro LM, Spray TL, Wernovsky G. Heart disease in the neonate: presentation and outcome at a tertiary care center in the current era. (Presented at Cardiology 2004: Annual Update on Pediatric Cardiovascular Disease, Orlando, FL, 2004)

Wray J, Franklin R, Blyth J, Stumper O, Elliott M, Sanchez M, Lunnon-Wood T, Rees P, Wernovsky G , Marino BS. The development of a disease specific measure to assess quality of life in children and adolescents with heart disease – an international study. (Presented at the Working Group on Psychosocial Problems in Congenital Heart Disease, Vienna, Austria 2004)

Srinivasan V, Nadkarni V, Yannopoulos D, McKnite S, Marino BS, Sigurdsson G, Benditt D, Helfaer M, Lurie K. Active compression-decompression plus inspiratory impedance threshold device CPR results in more efficient cold transfer between blood and brain than standard CPR during cardiac arrest. Pediatr Crit Care Med 2005; 6(1) 106. (Presented at the 15th Annual Pediatric Critical Care Colloquium, New York, 2004)

Shillingford AJ, Marino BS, Ittenbach RF, Fedec A, Rychik J, Clancy RR, spray TL, Gaynor JW, Wernovsky G, Microcephaly is common in neonates with hypoplastic left heart syndrome. Pediatr Cardiol 2005; 25: 581A. (Presented at the American Academy of Pediatrics, San Francisco CA, 2004)

Yannopoulos, D, Benditt D, Srinivasan V, Marino BS, Nadkarni V, McKnite S, Lurie KG. Atrial contraction during ventricular fibrillation. Crit Care Med 2004; 32(12): A55. (Presented at 34th Critical Care Congress, Phoenix, Arizona, 2005)

Ravishankar C, Dominguez T, Wernovsky G, Marino BS, Godinez RI, Gruber PJ, Gaynor, JW, Spray TL, Tabbutt S. Outcome of extracorporeal membrane oxygenation after the Norwood operation. Crit Care Med 2004; 32(12): A50. (Presented at 34th Critical Care Congress, Phoenix, Arizona, 2005)

Marino BS, Nathan A, Lee A, Ravishankar C, Tabbutt S, Bird GL, Tomlinson RS, Sheikh F, Ahearn LK, Godinez RI, Nicholson SC, Gaynor JW, Spray TL, Wetmore R, Dominguez TE. Tracheostomies in 100 pediatric patients with congenital and acquired heart disease. Ped Crit Care Med 2005:6(3) 395. (Presented at Pediatric Cardiac Intensive Care Symposium, Miami, Florida, February 2005)

Marino BS, Shera D, Shea J, Gallagher M, Lee A, Stern W, Cho C, Davis L, Aguirre A, Tong E, Teitel D, Mussatto K, Ghanayem N, Gleason M, Helfaer M, Wernovsky G. The Pediatric Cardiac Quality of Life Inventory: A quality of life measure for children and adolescents with heart disease. J Am Coll Cardiol 2005:45 Suppl A: 328A. (Presented at the 54th Scientific Session of the American College of Cardiology, Orlando, Florida, 2005)

Tabbutt S, Dominguez T, Ravishankar C, Marino BS, Gruber PJ, Nicolson SC, Gaynor JW, Spray TL. Contemporary comparison of outcomes following use of the right ventricular to pulmonary artery conduit vs. the modified Blalock Taussig shunt as part of the modified Norwood procedure. Circulation 2005; 112 (suppl): 4441. (Presented at 41st Annual Meeting of The Society of Thoracic Surgeons, Tampa, FL, 2005)

Kuijpers M, Van Rossem MC, Marino BS, Dodds KM, Godinez RI, Ravishankar C, Dominguez T, Ittenbach R, Nicolson SC, Gaynor JW, Spray TL, Wernovsky G, Tabbutt S. Postoperative course in the cardiac intensive care unit following stage I Norwood reconstruction. (Presented at Cardiology 2005, Orlando, FL)

Medoff-Cooper B, Marino BS, Wernovsky G, Stallings V, Verger J, Irving SY. Growth and feeding patterns of infants with congenital heart defects from birth to 3 months (Presented at Cardiology 2005, Orlando, FL, Winner, Outstanding Nursing Research Award)

Pasquali SK, Wernovsky G, Cohen MS, Tabbutt S, Montenegro L, Spray TL, Marino BS. Mid-term outcomes of the Ross procedure in children and young adults. Pediatr Cardiol 2005; 26: 500. (Presented at the Section on Cardiology and Cardiac Surgery of the American Academy of Pediatrics National Conference and Exhibition, Washington, DC, 2005)

Pasquali SK, Cohen MS, Wernovsky G, Shera D, Spray TL, Marino BS. The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in children and young adults. Circulation 2005; 112: U424. (Presented at the 78th Scientific Sessions of the American Heart Association, Dallas, TX 2005)

Pasquali SK, Marino BS, McBride MG, Wernovsky G, Paridon S. Variant coronary artery pattern and ventricular septal defect are associated with chronotropic impairment late after the arterial switch operation. J Am Coll Cardiol 2006; 47: 248A. (Presented at the 55th Scientific Session of the American College of Cardiology, Atlanta, GA 2006)

Pinto NM, Marino BS, Wernovsky G, DeFerrenti S, Walsh AZ, Armsby L, Hyland K, Cohen MS Obesity is prevalent, and is a significant additional comorbidity in children with congenital and acquired heart disease. J Am Coll Cardiol 2006; 47: 246A. (Presented at the 55th Scientific Session of the American College of Cardiology, Atlanta, GA, 2006)

Marino BS, Shera D, Shea JA, Ahearn L, Tomlinson R, Welkom J, Schissler A, Dunn S,
Cohen MI, Hill M, Wray J, Kazak AE, Wernovsky G. The Pediatric Cardiac Quality of Life Inventory testing trial: reliability and validity Data. (Presented at the Association of European Pediatric Cardiology Psychosocial Working Group, Belfast, Ireland (UK), 2006)

Marino BS, Shera DM, Shea JA, Kimmel S, Kazak AE, Wernovsky G. Testing the Pediatric Cardiac Quality of Life Inventory (Presented at the NIH Medical Rehabilitation Research Training Workshop, Rockville, MD, 2006)

Hehir DA, Dominguez TE, Ballweg JA, Ravishankar C, Marino BS, Bird GL, Nicolson SC, Spray TL, Gaynor JW, Tabbutt S. Risk factors for interstage death in infants with single ventricle following hospital discharge after Stage 1 reconstruction. Crit Care Med 2005; 33(12): A64. (Presented at the 35th Critical Care Congress, San Francisco, CA, 2006)

Davis JA, McBride M, Seliem MA, Marino BS, Tomlinson RS, Pampaloni, MH, Gaynor JW,
Spray TL, Paridon SM. Evaluation of myocardial ischemia following surgical repair of anomalous aortic origin of a coronary artery from the opposite sinus of valsalva in a series of pediatric patients. Circulation 2006; 114(18): II-387. (Presented at the 79th Scientific Sessions of the American Heart Association 2006, Chicago, IL)

Sumpter D, Irving S, Wernovsky G, Marino BS, Stallings V, Bird G, Ravishankar C, Felipe Garcia-Espana J, Medoff-Cooper B. Impact of growth, cardiac physiology and parental stress on development at 6 months of age. (Presented at Cardiology 2007, Orlando, Florida)

Irving S, Wernovsky G, Marino BS, Stallings V, Bird G, Ravishankar C, Medoff-Cooper B. Impact of growth, cardiac physiology and parental stress on development at 6 months of age. Ped Crit Care Med 2007 (In Press) (Accepted for Presentation at the 5th World Congress on Pediatric Critical Care Medicine, Geneva, Switzerland 2007)

Nguyen NVT, Marino BS, Tabbutt S, Wernovsky G, Ballweg JA, Ravishankar C, Bird GL, Lee A, Tomlinson RS, Nathan A, Godinez RI, Nicolson SC, Gruber PJ, Gaynor JW, Spray TL, Wetmore R, Dominguez TE. Tracheostomy in single ventricle patients: early and midterm outcomes. Ped Crit Care Med 2007 (In Press) (Accepted for Presentation at the 5th World Congress on Pediatric Critical Care Medicine, Geneva, Switzerland 2007)

Kaltmann JR, Tomlinson R, Hurd L, Tanel, RE, Shah MJ, Vetter VL, Shera D, Kazak A, Wernovsky G, Marino BS. Quality of Life in pediatric patients with the long QT syndrome. Heart Rhythm Journal 2007 (In Press). (Presented at Heart Rhythm, Denver, CO 2007)

Pasquali SK, Marino BS, Kaltman JR, Schissler AJ, Wernovsky G, Spray TL, Tanel RE. Rhythm and Conduction Disturbances at Midterm Follow-up after the Ross Procedure in Infants, Children, and Young Adults. (Accepted for Presentation at the Section on Cardiology and Cardiac Surgery of the American Academy of Pediatrics National Conference and Exhibition, San Francisco, CA 2007)

Davis JA, McBride MG, Marino BS, Tomlinson RS, Seliem MA, Pampaloni MH, Gaynor JW, Spray TL, Paridon SM. Exercise Performance and Quality of Life Following Surgical Repair of Anomalous Aortic Origin of a Coronary Artery From the Opposite Sinus of Valsalva in a Series of Pediatric Patients (Accepted for Presentation at the Section on Cardiology and Cardiac Surgery of the American Academy of Pediatrics National Conference and Exhibition, San Francisco, CA 2007)