Lisa J. Martin, PhD
Appointment
Research Associate Professor, University of Cincinnati College of Medicine
Email
lisa.martin@cchmc.org
Phone
513-636-1244
Fax
513-636-7509
Bio
Dr. Martin is an internationally recognized genetic epidemiologist. She has performed genetic analysis of complex traits for over 10 years and has published over 60 peer-reviewed publications (nearly half of which she is first or senior author) in prestigious journals including Nature Genetics, PNAS, and Diabetes. During her post-doctoral training, she received the James V. Neel Young Investigator Award for work on obesity genetics. At Cincinnati Children's, she received the Charlotte R. Schmidlapp Award for being an outstanding female investigator. Her research skills are further reflected in her grant funding; she held a PI on American Diabetes Association Career Development Award and has worked as co-I on multiple grants focusing on the genetics of complex traits.
At Cincinnati Children's, Dr. Martin provides statistical support for human genetic studies. She has been involved in family and population based genetic analyses by collaborating with numerous investigators. As part of this support, Dr. Martin assists in project planning, writing the statistical section of grant proposals, and assists with writing research papers. Recently, Dr. Martin has studied methodological considerations of genome wide association (GWA), especially how to reduce the number of false positives in the context of a million statistical tests1, 2. This work served as a basis for performing GWA at Cincinnati Children's. Indeed, she has designed several GWA studies under consideration for funding.
Credentials
PhD: (with Honors) University of Kansas, Lawrence KS, 1999
Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002
Position History
2008-present Research Associate Professor, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center
2002- 2008 Research Assistant Professor, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center
Awards and Honors
- Who's Who in Medicine and Healthcare (4th edition, 2002-2003)
- IGES James V. Neel Young Investigator Award 2000
Research
The genetics of normal variation, obesity, reproduction, and asthma.
Research Grants and Contracts
PI: Hinton R
Source: NIH
Dates: 07/01/06 – 06/30/11
Title: The genetic and developmental basis of Pediatric Aortic Valve Disease Pathogenesis
Summary: The goal of this project is to identify the underlying etiology of hypo plastic left heart syndrome.
Role: Co-Investigator
PI: Benson W
Source: NIH
Dates: 06/01/06 – 05/31/08
Title: Genetic mechanisms of cardiac diseases in the young
Summary: The goal of this project is to clarify the genetic architecture of cardiac disease development in the young.
Role: Co-Investigator
PI: Benson W
Source: NIH/NHLBI
Dates: 1/01/04 – 12/31/09
Title: Molecular mechanisms of valve development and disease
Summary: This study is project 1 of a larger SCCOR grant designed to examine valvular heart disease. Project 1's goal is to identify genes responsible for the development of two types of valvular heart disease: bicusipid aortic valve (BAV) and Ebstein anomaly. This study will perform a genome screen on families ascertained for BAV and refine a previously identified linkage for Ebstein anomaly.
Role: Co-investigator Project 1
PI Molloy C
Autism Speaks #1984 07/01/07 – 06/30/10
Autism Speaks
Genome wide association study of autism characterized by developmental regression
The goal of this project is to identify autism susceptibility variants using genome wide association.
PI Woo D
R01 NS36695 07/01/08 – 06/30/13
NIH
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
The goal of this project is to use genome wide association to identify novel genetic variants associated with stroke.
Publications, Most Recent
Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG (2000) Quantitative trait loci on chromosomes 3 and 17 with epistatic interactions influence phenotypes of the metabolic syndrome. PNAS 97:14478-14483.
Martin LJ, Crawford MH, Koertvelyessy T, Keeping D, Collins M, Huntsman R. (2000) The population structure of ten Newfoundland outports. Human Biology 72:997-1014.
North KE , Martin LJ, Crawford MH (2000) The origins of the Irish Travellers and the genetic structure of Ireland. Annals of Hum. Biol. 27:453-465.
Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D, Kissebah A. (2001) The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. JCEM 86:4321-4325.
Comuzzie AG, Williams JT, Martin LJ, Blangero J (2001) Searching for genes underlying normal variation in human adiposity. J Molec Med 79:57-70.
Luke A, Guo X, Rotimi CN, Adeyemo A, Forrester T, Wilks R, Lowe WL, Comuzzie AG, Martin LJ, Cooper RS (2001) Heritability of anthropometric and body composition parameters among Nigerians, Jamaicans, and US Blacks. Intl J Obesity 25:1034-1041
Martin LJ, Blangero J, Rogers JA, Mahaney MC, Hixson JE, Carey KD, Comuzzie AG (2001) A major quantitative trait locus influencing activin-to-estrogen ratio in pedigreed baboons maps to a region homologous to human chromosome 19. Human Biol 73:787-800.
Martin LJ, Blangero J, Rogers JA, Mahaney MC, Hixson JE, Carey KD, Morin PA, Comuzzie AG (2001) A major quantitative trait locus influencing estrogen levels in pedigreed baboons maps to a region homologous to human chromosome 20. Physiol Genomics 5:75-80.
Martin LJ, Comuzzie AG, North KE, Blangero J (2001). The utility of the Bayesian model averaging approach for the detection of known oligogenic effects. Genet Epi 21(suppl 1):S789.
Rainwater DL, Martin LJ, Comuzzie AG (2001) Genetic control of coordinated changes in HDL and LDL size phenotypes. ATVB 21:1829-33.
Treuth MS, Butte NF, Ellis KJ, Martin LJ, Comuzzie AG (2001) Familial resemblance in body composition in prepubertal girls and their biological parents.AJCN 74:529-533
Williams JT, North KE, Martin LJ, Comuzzie AG, Blangero J (2001). Distribution of LOD scores in oligogenic linkage analysis.Genet Epi 21 (suppl 1):S805.
Broeckel U, Hengstenberg C, Mayer B, Holmer S, Martin LJ, Comuzzie AG, Blangero J, Riegger GAJ, Jacob HJ, Schunkert H (2002) A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 30:210-4.
Martin LJ, Cole SA, Hixson JE, Mahaney MC, Czerwinski SA, Almasy L, Blangero J, Comuzzie AG (2002) Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study. Genet Epi 22:105-115.
Martin LJ, Comuzzie AG, Dupont S, Vionnet N, Dina C, Gallina S, Houari M, Blangero J, Froguel P. (2002). A quantiative trait locus influencing type 2 diabetes-susceptibility maps to a region on 5q in an extended French family. Diabetes 51:3568-72.
Martin LJ, Mahaney MC, Almasy L, MacCluer JW, Blangero J, Jaquish CE, Comuzzie AG (2002) The sexual dimorphism in serum leptin levels is a result of genotype by sex interactions. Obesity Res 10:14-21.
Martin LJ, Mahaney MC, Almasy L, Hixson JE, Cole SA, MacCluer JW, Jaquish CE,Blangero J, Comuzzie AG. (2002) A QTL on Chromosome 22 for Serum Leptin Levels Adjusted for Serum Testosterone. Obesity Res 10:602-607.
Martin LJ, Mahaney MC, Bronikowski AM, Carey KD, Dyke B, Comuzzie AG. (2002). Lifespan in captive baboons is heritable. Mech Aging Devel 123:1461-7.
Cole SA, Martin LJ, Peebles KW, Leland MM, Rice K, VandeBerg JL, Blangero J, Comuzzie AG. (2003) Genetics of leptin expression in baboons. Int J Obes Relat Metab Disord. 27:778-83.
Comuzzie AG, Cole SA, Martin LJ, Carey KD, Mahaney MC, Blangero J, VandeBerg JL. (2003) The Baboon as a Non-Human Primate Model for the Study of the Genetics of Obesity. Obesity Res 11:75-80.
Comuzzie AG, Mitchell BD, Cole S, Martin LJ, Hsueh W-C, Rainwater DL, Almasy L, Stern MP, Hixson JE, MacCluer JW, Blangero J (2003) The genetics of obesity in Mexican Americans: An important risk factor in the development of type II diabetes.Human Biol 75(5):635-46.
Dick EJ Jr, Hubbard GB, Martin LJ, Leland MM. (2003). Record review of baboons with histologically confirmed endometriosis in a large established colony. J Med Primatol. 32:39-47.
Goldin LR, Camp NJ, Keen KJ, Martin LJ, Moslehi R, Ghosh S, North KE, Wyszynski DF, Blacker D. (2003) GAW13 Analyses of Obesity, Diabetes, and Lipid Phenotypes: Group 10 Summary Paper. Genet Epi 25 Suppl 1:S78-89
Martin LJ, North KE, Dyer T, Blangero J, Comuzzie AG, Williams JT. (2003) Phenotypic, Genetic, and Genome-Wide Structure in the Metabolic Syndrome. BMC Genetics 4 (Suppl 1): S95
Martin LJ, Kissebah AH, Sonnenberg GE, Blangero J, Comuzzie AG. (2003). Genotype by smoking interaction for leptin levels in the Metabolic Risk Complications of Obesity Genes Project. Intl J Obes 27:334-40.
Martin LJ, Carey KD, Comuzzie AG. (2003). Variation in menstrual cycle length and cessation of menstruation in captive raised baboons. Mech Aging Devel 124:865-71.
North KE, Martin LJ, Dyer T, Blangero J, Comuzzie AG, Williams JT. (2003) HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2q.BMC Genetics 4 (Suppl 1): S98
Cripe L, Andelfinger G, Martin LJ, Shooner K, Benson DW. (2004) Bicuspid Aortic Valve is Heritable.J Am Coll Cardio 44:138-143.
Fairbanks LA, Newman TK, Bailey JN, Jorgensen MJ, Breidenthal SE, Ophoff RA, Comuzzie AG, Martin LJ, Rogers J. 2004 Genetic contributions to social impulsivity and aggressiveness in vervet monkeys. Biol Psychiatry 55:642-7
Martin LJ, Cianflone K, Zakarian R, Nagrani G, Almasy L, Rainwater DL, Cole S, Hixson JE, MacCluer JW, Blangero J, Comuzzie AG. (2004) Bivariate linkage between acylation-stimulating protein, BMI & HDL on chromosomes 15 & 17. Obesity Research 12:669-678.
Martin LJ, Comuzzie AG, Sonnenberg GE, Myklebust J, James R, Marks J, Blangero J, Kissebah AH (2004). A major quantitative trait locus for resting heart rate maps to a region on chromosome 4. Hypertension 43:1146-51.
Rogers J, Martin LJ, Comuzzie AG, Mann JJ, Manuck SB, Leland M, Kaplan JR. (2004) Genetic analyses of monoamine metabolites in baboons: Overlapping sets of genes influence levels of 5-HIAA, MHPG and HVA. Biological Psychiatry 55:739-44
SonnenbergGE, Krakower GR, Olivier M, Martin LJ, Comuzzie AG, James RG, Marks JA, Weber JL, BlangeroJ, Kissebah AH. (2004) Genetic determinants of obesity-related lipid traits. J Lipid Res. 45:610-5.
North KE, Miller MB, Coon H, Martin LJ, Peacock JM, Arnett DK, Zhang B, Province M, Oberman A, Blangero J, Almasy L, Ellison RC, Heiss G (2005) Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q.Atherosclerosis 179:119-125.
Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan L(2005) The Relationships of Adiponectin with Insulin and Lipids Are Strengthened with Increasing Adiposity. JCEM 90:4255-9
MolloyCA, Keddache M, Martin LJ(2005) Evidence for linkage on 21q in autism subset with regression. Biol Psych 10:741-6
Avery C, Martin LJ, Williams JT, North KE (2005) Accuracy of haplotype estimation in a region of low linkage disequilibrium. BMC Genetics S6:80
Martin LJ, Avery CL, Williams JT, North KE (2005) QTL-Specific Genotype-by-Alcoholism Interaction on Linkage for Evoked EEG Oscillations. BMC Genetics S6:123
Woo JG, Dolan LM, Daniels SR, Goodman E, Martin LJ. (2005) Adolescent Sex Differences in Adiponectin are Conditional on Pubertal Development and Adiposity.Obesity Res.13:2095-2101.
Woo JG, Dolan LM, Deka R, Kaushal RD, Shen Y, Pal P, Daniels SR, Martin LJ. (2006) Interactions between non-contiguous haplotypes in ACDC are associated with plasma adiponectin. Diabetes 55:523-529.
Mosher MJ, Martin LJ, Cupples LA, Yang Q, Dyer TD, Williams JT, North KE. (2005) Genotype-by-sex interaction in the regulation of high-density lipoprotein (HDL): The Framingham Heart Study. Hum Biol 77:773-793.
Martin LJ, Woo JG, Geraghty SR, Altaye M, Davidson BS, Banach W, Dolan LM, Ruiz-Palacios GM, Morrow AL (2006) Adiponectin Is Present in Human Milk and Is Associated with Maternal Factors. AJCN 83:1106-11.
Broeckel U, Maresso K, Martin LJ (2006) Linkage analysis for complex diseases using variance component analysis: SOLAR. Methods Mol Med. 2006;128:91-100.
Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda S, Tremblay J, Holmer S, Erdmann J, Glöckner G, Harrison H, Martin LJ, Williams JT, Schmitz G, Riegger GAJ, Jacob HJ, Hamet P, Schunkert H. (2007). A Locus on Chromosome 10 Influences C-Reactive Protein Levels in Two Independent Populations. Human Genetics 122(1):95-102.
Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddache M, Benson DW (2007). Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and 13q for Bicuspid Aortic Valve and Associated Cardiovascular Malformations. Human Genetics 121(2):275-84.
Crimmins N, Martin LJ (2007) Polymorphisms in Adiponectin Receptor Genes ADIPOR1 and ADIPOR2 and Insulin Resistance. Obesity Reviews 8:419-23.
Crimmins NA, Woo JG, Kausha RD, Deka R, Dolan LM, Martin LJ (2007) Adiponectin Receptor 1 Gene (ADIPOR1) Variation is Associated with Decreased HOMA-IR Conditional on Adiposity in African-Americans. Obesity 15(8):1903-7.
Crimmins NA, Dolan LM, Martin LJ, Bean JA, Daniels SR, Lawson ML, Goodman E, Woo JG. (2007) Longitudinal Changes in Adolescent BMI During 3 Years of Follow-up.Journal of Pediatrics 151:383-7.
Saunders CL, ChiodiniBD, ShamP, LewisCM, CollierDA and the BMI-GSMA consortium (Abkevich V, AdeyemoAA, de AndradeM, AryaR, BerensonGS, BlangeroJ, BoreckiIB, ChagnonYC, ChenW, ComuzzieAG, DengH-W, DuggiralaR, FeitosaMF, FroguelP, HansonRL, HebebrandJ, Huezo-DiasP, KissebahAH, LiW, LukeA, Martin LJ,NashM, ÖhmanM, PalmerLJ, Peltonen L, Perola M, Price RA, Redline S, Srinivasan SR, Stern MP, StoneS, WijmengaC, Wu X. (2007) Meta-analysis of genome-wide linkage studies in body mass index and obesity. Obesity 15(9):2263-2275.
Woo JG, Sun G, Haverbusch M, Indugula S, Martin LJ, Broderick JP, Deka R, Woo D. (2007). Quality Assessment of Buccal versus Blood Genomic DNA using the Affymetrix 500K GeneChip. BMC Genetics 8:79.
Martin LJ, Woo JG, Avery C, Chen HS, North KE. (2007) Multiple Testing in the Genomics Era: Findings from GAW 15. Genetic Epidemiology 31 (Suppl. 1): S124-S131.
Comuzzie AG, Tejero ME, Funahashi T, Martin LJ, Kisseban A, Takahashi M, Kihara S, Tanaka S, Rainwater DL, MatsuzawaY, MacCluer JW, and Blangero J (2007). The genes influencing adiponectin levels also influence risk factors for the metabolic syndrome and type 2 diabetes. Human Biology 79(2):191-200.
Tabangin ME, Woo JG, Liu C, Nick T, Martin LJ. (2007) Comparison of FDR for Genome-wide and Fine Mapping Regions. BMC Proceedings 1 Suppl 1:S148.
Hinton RB Jr, Martin LJ, Tabangin ME, Mazwi M, Cripe LH, Benson DW (2007) Hypoplastic Left Heart Syndrome is Heritable and a Severe Form of Valve Malformation. JAAC 50:1590-5.
Cordell HJ, de Andrade M, Babron M-C, Bartlett CW, Beyene J, Bickeböller H, Culverhouse R, Cupples A, Daw EW, Dupuis J, Falk CT, Ghosh S, Goddard KA, Goode EL, Hauser ER, Martin LJ, Martinez M, North KE, Saccone NL, Schmidt S, Tapper W, Thomas D, Tritchler D, Vieland VJ, Wijsman EM, Wilcox MA, Witte JS, Yang Q, Ziegler A, Almasy L, MacCluer JW. (2007). Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci. BMC Proceedings 1 Suppl 1:S1.
Comuzzie AG, Martin LJ, Cole S, Rogers J, Cox L, Mahaney MC, Blangero J, VandeBerg JL. (In press). A QTL for fat free mass in baboons localizes to a region homologous to human chromosome 6. Obes Res
North KE, Martin LJ (in press) The Importance of Gene-Environment Interaction: Implications for Social Scientists. Sociological Methods & Research.
Hinton RB, Martin LJ, Rame-Gowda S, Tabangin ME, Cripe LH, Benson DW (2009) Hypoplastic Left Heart Syndrome Links to Chromosomes 10q and 6q and isGenetically Related to Bicuspid Aortic Valve. JACC 53(12):1065-71.
Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeeding Medicine (In press)
Zhu H-Y, Wang S-W, Martin LJ, Liu L, Li Y-H, Chen R, Wang L, Zhang M-L, Benson DW. (In Press). The role of mitochondrial genome in essential hypertension in a Chinese Han population.European Journal of Human Genetics.
Tabangin ME, Woo JG, Martin LJ. (In Press). The effect of minor allele frequency (MAF) on likelihood of obtaining false positives. BMC Proceedings.
Professional Organization Memberships
Teaching
Guest lecturer, Cardiovascular Epidemiology, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45229, Spring 2003 & 2006
Responsibilities: Presentation of review of the genetics of obesity and cardiovascular disease.
Guest Lecturer, “Obesity, Cardiovascular Disease, Diabetes: The Adiponectin connection” 3rd Biennial genetics Program for Nursing Faculty’s Genetics Update Workshop, Multiple Perspectives on the Applications of Genetic Advances, Summer 2004
Guest Lecturer, Genetics of Complex Disease (26-BE-868), Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45229, Fall 2004, 2006, 2008:
Responsibilities: Presentation of mapping of complex traits.
Lecturer, Human Genetics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, Spring 2003 – 2006, Fall 2008
Responsibilities: Presentation of Mendelian inheritance, population genetics and linkage analysis, and writing examination questions.
Special Interests
Obesity, genetics, complex traits.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
