Biostatistics and Epidemiology

Mekibib Altaye, PhD

Appointment

Research Assistant Professor

Email

mekibib.altaye@cchmc.org

Phone

513-636-5849

Fax

513-636-7509

Credentials

PhD: The University of Western Ontario, London, Canada; 1998; Biostatistics.
MSc: Oklahoma State University, Stillwater, OK; 1991; Statistics.
BSc: Addis Ababa Universtiy, Addis Ababa, Ethiopia; 1983; Statistics.

Awards and Honors

National Science Foundation (NSF) Travel Award, Statistical analysis of neuronal data workshop, Pittsburgh, PA, May 2006

National Science Foundation (NSF) Travel Award, ENAR Junior Investigator Workshop, Pittsburgh, PA, Mar 2004

Food and Agricultural Organization (FAO) Fellowship for graduate study, 1989-1991

Research

Analysis of correlated and longitudinal data, statistical methods for fMRI data, and inference procedures for reliablity data.

Research Grants and Contracts

NIH R01 HD038578: fMRI of Normal Language Development in Children, 08/01/06 – 06/30/11. Biostatistician.

NIH R01 MH074770: Response Variability in Children with ADHD, 06/01/06 – 3/21/10. Biostatistician.

NIH R40 MC06632: Increasing Retention in Home Visitation, 01/1/06 – 12/31/09. Biostatistician.

NIH R01 DC007186: fMRI, Genes And Outcome For Cochlear Implants In Infants, 12/1/04 – 11/30/09. Biostatistician.

NIH P01 HD 13021: Role of Human Milk in Infant Nutrition and Health, 06/1/03 – 03/31/08. Co-Investigator.

Presentations

Huang B, Altaye M, Sivaganisan S. Testing for Gene-Environment interaction: A bivariate binomial approach. Joint Statistical meeting, Denver, CO August 2-7 2008.

Jennifer V, Karunanayaka P, Altaye M, Schmithorst VJ, Plante E, Holland SK. (2008) Comparison between event-related and block-periodic fMRI data from a story processing task in Children. Pediatric Radiology 38 (Suppl 2) S337.

Fairbrother G, Broder K, Donauer S, Staat MA, Morrow AL, Tabangin ME, Altaye M, Holloway M, Hiratzka S, Schwartz B. Comparison of Pediatricians’ measured and reported immunizing behaviour for healthy children and measured immunizing behavior for high risk children during the national shortages of PCV7. 2008 PAS meeting. Honolulu, HI May2-6.

Wilke, M, Holland SK, Altaye M, Gaser C. Employing the general linear model for creating customized pediatric templates. Presented at the 14th Annual Meeting of the Organization for Human Brain Mapping, Melbourne, Australia, June 15-19 2008.

Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Wessel SD, Lanphear BP. Lead exposure during childhood disrupts adult brain metabolism. Presented at the 46th annual meeting of the American Society for Neuroradiology. New Orleans, LA May 31-June 5, 2008.

Yuan W, Air E, Altaye M, Holland SK, Jones B, Bierbrauer K, Mangano F. Abnormal fractional anisotropy in hydrocephalic children: a DTI study. Presented at the Society for Research into Hydrocephalus and Spina Bifida. 52nd Annual meeting. Brown University, Providence, RI June 10-14, 2008.

Holland SK, Kristen Smith, karunanayaka P, Altaye M, Care M, Egelhoff J, Choo D. MRI provides a window into central auditory processing in hearing impaired infants prior to cochlear implantation. Presented at the 10th International Conference on Cochlear Implants and other implantable auditory technologies. San Diego, CA April 10-12, 2008.

Cecil KM, Dietrich KN, Altaye M, Egelhoff JC, Brubaker CJ, Schmithorst VJ, Haynes EN, Wessel SD, Lanphear BP. (2008) Evaluating the effects of childhood lead exposure with proton MR spectroscopy and diffusion tensor imaging. Pediatric Radiology 38(Suppl 2): S311

Eaton KP, Ball AL, Altaye M, Holland SK, Szaflarski JP. (2008) Reliability of fMRI for studies of language recovery and development. Pediatric Radiology 38 (Suppl 2) S335.

Altaye M, Gaser C, Wilke M, Holland S. (2008) Probability templates for spatial normalization and segmentation of infant brain. Pediatric Radiology 38 (Suppl 2) S334.

Szaflarski JP, Eaton K, Ball A, Holland SK, Altaye M, Kissela B, Banks C. (2007) Reliability Estimates of fMRI Language Localization at 4T in Healthy and Left Middle Cerebral Artery (LMCA) Stroke Subjects. Presented at the 59th Annual Meeting of the American Academy of Neurology, Boston MA April 28-May5, 2007.

Vannest J, Karunanayaka P, Altaye M, Schmithorst V, Plante E, Eaton K, Holland SK. (2007) Comparison between event-related and block-periodic fMRI data from a story processing task in children. NeuroImage 36 (Suppl 1) S51.

Karunanayaka PR, Holland SK, Yuan WH, Altaye M, Egelhoff JC, Michaud L, Walz NC, Wade SL. (2007) "Abnormal language processing following brain injury in young children as measured by fMRI." NeuroImage 36 (Suppl 1) S88.

Karunanayaka PR, Holland SK, Yuan W, Altaye M, Jones BV, Michaud LJ, Walz NC, Wade SL: Abnormalities in language circuitry in children with traumatic brain injury: a Functional magnetic resonance imaging study. American Academy of Physical Medicine and Rehabilitation 68th Annual Assembly, Boston, Massachusetts, September 27-30, 2007.

Ammerman RT, Donovan EF, Besl J, Atherton H, Khoury JC, Altaye M, Putnam FW, Van Ginkel JB. (2007, May) Intensive home visiting is associated with decreased risk of infant death. Presented at the annual conference of the Pediatric Academic Society, Toronto May 5-8, 2007.

Karunanayaka P, Holland S, Mecoli M, Egelhoff J, Schmithorst V, Altaye M, Brown D, Choo D. fMRI shows differences in auditory activation between infants with normal hearing and bilateral sensorineural deafness. Accepted for Poster presentation at the 11th International Conference on Cochlear Implants in Children in Charlotte, North Carolina, April 11-14, 2007.

Mecoli M, Holland S, Karunanayaka P, Egelhoff J, Schmithorst V, Altaye M, Cahill L, Brown D, Choo D. Correlations of fmri activation in auditory cortex and hearing levels in infants with congenital hearing impairment prior to cochlear implantation. Presented at the 11th International Conference on Cochlear Implants in Children in Charlotte, North Carolina, April 11-14, 2007.

Szaflarski JP, Eaton K, Ball A, Altaye M, Kissela B, Banks C, Holland SK. (2007) Reliability Estimates of fMRI Language Localization at 4T in Control and Left Middle Cerebral Artery (LMCA) Stroke Subjects. NeuroImage 36 (Suppl 1) S52.

Mecoli M, Karunanayaka P, Altaye M, Huei T, Choo D, Arjmand E, Egelhoff J, Schmithorst V, Holland S. fMRI of Deaf Infants Under Sedation Prior to Cochlear Implantation. Presented at ASNR 45th Annual Meeting June 9 - 14, 2007 Chicago IL.

Eaton K, Ball A, Altaye M, Kissela B, Banks C, Holland SK, Szaflarski JP. (2007) Comparison of Reliability Estimates of fMRI Language Localization for Verb Generation and Semantic/Tone Decision Tasks at 4T in Control and Left Middle Cerebral Artery (LMCA) Stroke Subjects. NeuroImage 36 (Suppl 1) S40.

Gaser C, Altaye M, Wilke M, Holland SK. (2007) Unified Segmentation Without Tissue Priors. NeuroImage 36 (Suppl 1) S68.

Altaye M, Gaser C, Mecoli M, Huie T, Egelhoff J, Wilke M, Holland SK. (2007) Infant brain probability templates for segmentation and normalization. NeuroImage 36 (Suppl 1) S45.

Publications, Most Recent

Altaye M, Holland SK, Wilke M, Gaser C. Infant brain probability templates for MRI segmentation and normalization.NeuroImage 2008;43(4):721-30.

Szilagyi PG, G Fairbrother, MR Griffin, M Staat, RW Hornung, S Sexton, C Albertin A Morrow, M Altaye, Y Zhu, S Ambrose, KA Poehling, KM Edwards, G Lofthus, M Holloway, Marika Iwane. Influenza vaccine effectiveness among children 6to 59 months of age during two influenza seasons: A case-cohort study.Archive of Pediatrics and Adolescent medicine (2008) 162(10): 943-51.

Langberg, JM., Epstein, JN., Altaye M., Molina, B., Arnold, E., Vitiello, B. The transition to middle school is associated with changes in the developmental trajectory of ADHD symptomatology in young adolescents with ADHD.Journal of Clinical Child and Adolescent Psychology (2008) 37(3): 651-63.

Yuan W, Altaye M, Ret J, Schmithorst VJ Byars AW, Plante E, Holland SK. Quantification of children’s head motion in various fMRI language tasks.Human Brain Mapping (2008): Jul 17 [Epub ahead of print]

Eaton KP, Szaflarski JP, Altaye M, Ball AL, Kissela BM, Banks C, Holland SK. Reliability of fMRI for studies of language in post-stroke aphasia subjects.NeuroImage (2008) 41(2): 311-22.

Wilke M, Holland SK, Altaye M, Gaser C. Template-o-matic: a toolbox for creating customized pediatric templates.NeuroImage (2008) 41(3): 903-13.

Cecil KM, Brubaker CJ, Adler CM, Dietrich KN, Altaye M, Egelhoff JC, Wessel S, Elangovan I, Hornung R, Jarvis K, Lanphear B. Decrease brain volume in adults with childhood lead exposure.PLoS medicine (2008) 27: 5(5): e112.

Difrancesco MW, Holland SK, Ris MD, Adler CM, Nelson S, DelBello MP, Altaye M, Brunner HI. Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus: A pilot study.Arthritis and Rheumatism (2007): 56: 4151-4163.

Karunanayaka PR, Holland SK,Yuan W, Altaye M, Jones BV, Michaud LJ, Walz NC, Wade SL. Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: A preliminary fMRI investigation.NeuroRehabilitation (2007) 22: 355-369.

Donovan EF, Ammerman, RT, Besl J, Atherton, H, Khoury JC, Altaye M, Putnam FW, Van Ginkel, JB. Intensive home visiting is associated with decreased risk of infant death.Pediatrics 2007 119(6):1145-51.

Eghtesdy P, Michelfelder E, Altaye M, Ballard E, Hirsh R, Beekman RH. Revisiting animal models of aortic stenosis in the early gestation fetus.Annals of Thoracic Surgery (2007) 83(2):631-639.

Yuan W, Holland SK, Cecil KM, Dietrich KN, Wessel SD, Altaye M, Hornung RW, Ris MD, Egelhoff JC, Lanphear BP. The impact of early childhood lead exposure of brain organization: a functional magnetic resonance imaging study of language function.Pediatrics 2006 Sep;118(3):971-977.

Ammerman RT, Stevens J, Putnam FW, Altaye M, Hulsmann JE, Lehmkuhl HD, Monroe JC, Gannon TA, Van Ginkle JB. Predictors of early disengagement in home visitation.Journal of Family Violence (2006) 21(2) 105-115.

Szaflarski JP, Schmithorst VJ, Altaye M, Byars AW, Rett J, Plante E, Holland SK. A longitudinal fMRI study of language development in children age 5-11.Annals of Neurology (2006) 59(5): 796-807.

Malloy CA, Morrow AL, Meinzen-Derr J. Schleifer K, Dienger K. Manning-Courtney P, Altaye M, Wills-Karp M. Elevated cytokine levels in children with autism spectrum disorder.Journal of Neuroimmunology (2006) 172(1-2): 198-205.

Meinzen-Derr JK, Guerrero ML, Altaye M, Oretega-Gallegos H, Ruiz-Palacios GM, Morrow AL. Duration of exclusive breastfeeding and increased risk of anemia at 9 months in a cohort of Mexican infants.Journal of Nutrition (2006) 136(2) 452-458.

Martin LJ, Woo JG, Geraghty SR, Altaye M, Davidson BS, Banach W, Dolan LM, Ruiz-Palacios GM, Morrow AL. Adiponectin is in human milk and is associated with maternal factors.American Journal of Clinical Nutrition (2006) 83(5) 1106-11.

Mari G, Abuhamad AZ, Cosmi E, Segata M, Altaye M, Akiyama M. Middle cerebral artery peak systolic velocity: Technique and variability.The Journal of Ultrasound in Medicine (2005) 24(4) 425-430