Kristen Page, PhD
Title
Research Assistant Professor
Appointment
Research Assistant Professor of Pediatrics
Email
kristen.page@cchmc.org
Phone
513-636-3079
Fax
513-636-4267
Credentials
BS Biology: Northern Illinois University, DeKalb, IL: 1988.
PhD Biochemistry: Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL: 1997.
Postdoctoral Fellow: University of Chicago, Chicago, IL: 1997-1999.
Research
Asthma, inflammation, regulation of cytokine expression, cockroach-induced inflammatory responses in airway epithelium, protease-activated receptors.
Publications, Most Recent
Page K, Strunk VS, Hershenson MB. Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR-2) and ERK.J Allergy Clin Immunol. 2003;112:1112-1118.
Shimotake TK, Izhar FM, Rumilla K, Li J, Tan A, Page K, Braiser AR, Schreiber MD, Hershenson MB. Interleukin (IL) - 1B in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kB dependent pathway.Ped Res. 2003.
Page K, Li J, Zhou L, Iazvovskaia S, Corbit KC, Soh J-W, Weinstein IB, Brasier AR, Lin A, Hershenson MB. Regulation of airway epithelial cell NF-kB dependent gene expression by protein kinase Cdelta.J Immunol. 2003;170:5681-5689.
Bhat RK*, Page K*, Tan A, Hershenson MB. German cockroach (Blattela germanica) extract increases human bronchial epithelial cell interleukin-8 expression in a serine protease-dependent manner.Clinical and Experimental Allergy. 2003;33:35-42.
Li J, Kartha S, Iasvovskaia S, Tan A, Bhat RK, Manaligod JM, Page K, Brasier AR, and Hershenson MB. Regulation of human airway epithelial cell interleukin-8 expression by mitogen-activated protein kinases.American Journal of Physiology. 2002;283: L690-L699.
Page K, Li J, Bauerfeld CP, Rumilla KM, Corbit KC, Soh J-W, Weinstein IB, Pestell RG, Rosner MR, and Hershenson MB. Protein kinase C delta regulates cyclin D1 transcription in primary airway smooth muscle cells via multiple cis-acting elements.American Journal of Respiratory Cell and Molecular Biology. 2002;27:204-213.
Bauerfeld CP, Hershenson MB, and Page K. Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal smooth muscle cells.American Journal of Physiology. 2001;280:L974-L982.
Page K, Li J, Hershenson MB. p38 mitogen-activated protein kinase negatively regulates cyclin D1 expression in airway smooth muscle cells.American Journal of Physiology. 2001 ;280:L955-L964.
Page K, Hershenson, MB. Mitogen-activated signaling and cell cycle regulation in airway smooth muscle.Frontiers in Bioscience. 2000;5:d258-267.
Page K, Li J, Wang Y, Kartha S, Pestell RG, Hershenson MB. Regulation of cyclin D1 expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells.American Journal of Respiratory Cell and Molecular Biology. 2000;23:436-443.
Page K, Li J, Hodge JA, Liu PT, Vanden Hoek TL, Becker LB, Pestell RG, Rosner MR, Hershenson MB. Characterization of a Rac1 signaling pathway to cyclin D1 expression in airway smooth muscle growth.Journal of Biological Chemistry. 1999;274:22065-22071.
Page K, Li J, Hershenson MB. PDGF stimulation of mitogen-activated protein kinases and cyclin D1 promoter activity in cultured airway smooth muscle cells: Role of Ras.American Journal of Respiratory Cell and Molecular Biology. 1999;20:1294-1302.
Page K, Lange Y. Integrin binding regulated 5'AMP-activated protein kinase in fibroblasts.Journal of Biological Chemistry. 1997;272:19339-19342.
*these authors contributed equally to this work
Grants
Principal Investigator, July 2003 - June 2005: Cincinnati Children's Hospital Medical Center
Trustee Grant "Cockroach serine proteases induce a direct inflammatory effect in human airway epithelium."
Principal Investigator, July 1, 2002 - June 30, 2004: American Lung Association Research Grant "Cockroach-induced pro-inflammatory responses in human airway epithelium."
Principal Investigator, December 2002- December 2003: University of Cincinnati Research Council Grant "Determination of cockroach-induced pro-inflammatory mediators by gene array analysis."
Special Interests
Asthma, airway inflammation, proteases, signaling
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
