Hector R. Wong, MD
Title
Director
Appointment
Professor of Pediatrics
Email
hector.wong@cchmc.org
Phone
513-636-4259
Fax
513-636-4267
Credentials
MD: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, 1989.
Residency: Department of Pediatrics, George Washington University School of Medicine, Children's National Medical Center, Washington, DC, 1990 to 1992.
Fellowship: Clinical Fellow, Department of Anesthesiology, Division of Pediatric Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, 1992 to 1995; Research Fellow, Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1992 to 1995.
Certification: Diplomate, National Board of Medical Examiners, 1990; Diplomate, American Board of Pediatrics, 1993; Diplomate, American Board of Pediatrics: Sub-Board of Pediatric Critical Care Medicine, 1996.
Awards and Honors
- Best Doctors in America, 2008
- Awarded "2005 Best Doctors"
- Awarded "2004 Best Doctors"
- Phi Eta Sigma (Academic Honor Society), 1982
- Honorable Mention, Academic Collegiate All-America in Baseball, 1984
- Honorable Mention, Academic Collegiate All-America in Baseball, 1985
- Alpha Omega Alpha, 1988
- Society of Critical Care Medicine Educational Scholarship, 1994
- Society of Critical Care Medicine Educational Scholarship, 1995
- Society of Critical Care Medicine Specialty Award (Pediatrics), 1997
- Mentored Clinical Scientist Development Award, National Institutes of Health, 1997
- Presidential Citation, Society of Critical Care Medicine, 2000
- Presidential Citation, Society of Critical Care Medicine, 2001
- Research Citation, Society of Critical Care Medicine, 2001
- Presidential Citation, Society of Critical Care Medicine, 2002
- Best Doctors selection, 2002
- Presidential Citation, Society of Critical Care Medicine, 2003
- Best Doctors selection, 2003
Research
- Heat shock protein biology
- Heat shock response-mediated regulation of inflammation
- Heat shock protein-mediated cytoprotection
Research Grants and Contracts
National Institutes of Health
T32GM08478
Title: Host response to trauma research training program
Role: Co-investigator / Co-program Director; Principal Investigator: Joseph Solomkin
Dates of entire project period: July 2003 to June 2008
National Institutes of Health
Competitive Renewal of RO1GM061723
Title: The heat shock response and cytoprotection
Role: Principal Investigator
Dates of entire project period: June 2003 to May 2007
National Institutes of Health
RO1 GM064619-01A1
Title: Genomic analysis of pediatrics SIRS
Role: Principal Investigator
Dates of entire project period: July 2003 to June 2006
National Institutes of Health
RO1 DK56029
Title: Regulation of hepatic ischemia/reperfusion injury
Role: Co-Investigator; Principal Investigator: Alex Lentsch, PhD
Dates of entire project period: July 2004 to June 2009
Publications, Most Recent
Bridges JP, Xu Y, Na C-L, Wong HR, Weaver TE: Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C. J Cell Biol. 172:395-407, 2006.
Mortaz E, Redegeld FA, Nijkamp FP, Wong HR, Engels F: Acetylsalicylic acid-induced release of HSP70 from mast cells results in cell activation through the TLR pathway. Exp Hematol. 34:8-18, 2006.
Okaya T, Blanchard J, Schuster R, Kuboki S, Husted T, Caldwell CC, Zingarelli B, Wong HR, Solomkin JS, Lentsch AB: Age-dependent responses to hepatic ischemia/reperfusion injury. Shock. 24:421-427, 2005.
Wong HR, Dunsmore KE, Page K, Shanley TP: Heat shock-mediated regulation of MKP-1. Am J Physiol Cell Physiol. 289:C1152-C1158, 2005.
Mortaz E, Redegeld FA, van der Heijden MW, Wong HR, Nijkamp FP, Engels F: Mast cell activation is differentially affected by heat shock. Exp Hematol. 33:944-952, 2005.
Lai Y, Du L, Dunsmore KE, Jenkins LW, Wong HR, Clark RSB: Selectively increasing inducible heat shock protein 70 via tat-protein transduction protects neurons from nitrosative stress and exitotoxicity. J Neurochem. 94:360-366, 2005.
Wheeler DS, Fisher LE Jr, Catravas JD, Jacobs BR, Carcillo JA, Wong HR: Serum HSP70 levels in children with septic shock. Ped Crit Care Med. 6:308-311, 2005.
Nimah M, Zhao B, Denenberg AG, Bueno O, Molkentin J, Wong HR, Shanley TP: Contribution of MKP-1 regulation of p38 to endotoxin tolerance. Shock. 23:80-87, 2005.
Sanlorenzo L, Zhao B, Spight D, Denenberg AG, Page K, Wong HR, Shanley TP: Heat shock inhibition of LPS-mediated TNF expression is associated with nuclear induction of MKP-1 and inhibition of MAP kinase. Crit Care Med. 32:2284-2292, 2004.
Aneja R, Hake PW, Burroughs TJ, Denenberg AG, Wong HR, Zingarelli B: Epigallocatechin (EGCG), a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. Mol Med. 10:55-62, 2004.
Aneja R, Odoms k, Denenberg AG, Wong HR: Theaflavin, a black tea extract, is a novel anti-inflammatory compound. Crit Care Med. 32:2097-2103, 2004.
Wheeler DS, Odoms K, Denenberg A, Malhotra V, Wong HR. Epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, inhibits IL-1B-dependent proinflammatory signal transduction. J Nutr, 2004.
Zingarelli B, Hake PW, O'Connor M, Denenberg A, Wong HR, Kong S, Aronow BJ. Differential regulation of activator protein-a and heat shock factor-1 in myocardial reperfusion: role of poly (ADP-ribose) polymerase-1.Am J Physiol, 2004.
Sheehan M, Hake PW, Wong HR, Zingarelli B. Sesquiterpene lactones improve colitis through inhibition of nuclear factor-kB in rats. Dig Dis Sci, 2004.
Odoms K, Shanley TP, Wong HR. Short term modulation of intereleukin-1b by hyperoxia: uncoupling of IκB kinase activation and NF-kB-dependent gene expression.Am J Physiol, 2004;286:L554-562.
Németh ZH, Wong HR, Odoms K, Deitch EA, Szabó C, Vizi S, Haskó G. Proteasome inhibition induces IκB kinase activation, IκB degradation, and nuclear factor-κB activation in HT-29 cells. Mol Pharmacol, 2004;65:342-349.
Sheehan M, Wong HR, Hake PW, Zingarelli B. Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis.Crit Care Med, 2003;31:2263-2270.
Wheeler DS, Dunsmore KD, Wong HR. Intracellular delivery of HSP70 using the HIV-1 tat protein transduction domain.Biochem Biophys Res Comm, 2003;301:54-59.
Bshesh K, Zhao B, Spight D, Biaggioni I, Feokistov I, Denenberg A, Wong HR, Shanley TP. The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells.J Leuko Biol, 2002;72:1027-1036.
Grossman BJ, Shanley TP, Denenberg AG, Zhao B, Wong HR. Phosphatase inhibition leads to activation of IkB kinase in murine macrophages.Biochem Biophys Res Comm, 2002;297:1264-1269.
Malhotra V, Kooy NW, Denenberg AG, Dunsmore KE, Wong HR. Genetic ablation of heat shock factor-1 increases susceptibility to hyperoxia-mediated cellular injury.Exp Lung Res, 2002;28:609-622.
Chen PC, Wheeler DS, Malhotra V, Odoms K, Denenberg AG, Wong HR. A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits Ik B kinase activation and IL-8 gene expression in respiratory epithelium. Inflammation, 2002;26:233-241.
Pritts TA, Wang Q, Sun X, Fischer DR, Hungness ES, Fischer JE, Wong HR, Hasselgren PO. The stress response decreases NF-kB activation in liver of endotoxemic mice.Shock, 2002;18:33-37.
Sheehan M, Wong HR, Hake PW, Zingarelli B. Protective effects of isohelenin, an inhibitor of nuclear factor kB, in endotoxic shock in rats. J Endotoxin Res, 2002;8:99-107.
Sheehan M, Wong HR, Hake PW, Zingarelli B. Parthenolide, an inhibitor of the nuclear factor-kB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Mol Pharmacol, 2002;61:953-963.
Pritts TA, Hungness ES, HershkoDD, Robb BW, Sun X, Lou GJ, Fischer JE, Wong HR, Hasselgren PO. Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.Am J Physiol, 2002;282:R1016-R1026.
Grossman BJ, Shanley TP, Odoms K, Dunsmore KE, Denenberg AG, Wong HR. Temporal and mechanistic effects of heat shock on LPS-mediated degradation of IkBa in macrophages.Inflammation, 2002;26:129-137.
Wong HR, Odoms KK, Denenberg AG, Allen GL, Shanley TP. Hyperoxia prolongs tumor necrosis factor-a-mediated activation of NF-kB: role of IkB kinase.Shock, 2002;17:274-27.
Zingarelli B, Hake PW, Yang Z, O'Connor M, Denenberg A, Wong HR. Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-kB and AP-1 activation and enhances myocardial damage.FASEB J, 2002;16:327-42.
Malhotra V, Eaves-Pyles T, Odoms K, Quaid G, Shanley TP, Wong HR. Heat shock inhibits activation of NF-kB in the absence of heat shock factor-1.Biochem Biophys Res Comm, 2002;291:453-457.
Pearl JM, Nelson DP, Raake JL, Manning PB, Schwartz SM, Koons L, Shanley TP, Wong HR, Duffy JY. Inhaled nitric oxide increases endothelin-1 levels: a potential cause of rebound pulmonary hypertension.Crit Care Med, 2002;30:89-93.
Kohn G, Wong HR, Bshesh K, Zhao B, Vasi N, Denenberg A, Morris C, Stark J, Shanley TP. Heat shock inhibits TNF-induced ICAM-1 expression in human endothelial cells via Ik kinase (IKK) inhibition. Shock, 2002;17:91-97.
Zingarelli B, Hake PW, Denenberg A, Wong HR. Sesquiterpene lactone parthenolide, an inhibitor of IkB kinase complex and nuclear factor-kB, exerts beneficial effects in myocardial reperfusion injury.Shock, 2002;17:127-134.
Professional Organization Memberships
Special Interests
- Intensive care
- Respiratory failure
- Shock
- Multi-organ failure
- Sepsis
- Post-operative cardiac care
Presentations
Intracellular Signaling, Lecture, The Society of Critical Care Medicine 35th Congress, January 2006, San Francisco, CA.
Extracellular HSP70, Lecture, The Society of Critical Care Medicine 35th Congress, January 2006, San Francisco, CA.
The Importance of Genetics to Guide Critical Care Support, Lecture, 7th Pediatric Intensive Care Latin American Congress, October 2005, Cancun, Mexico.
Microarray Profiling in Pediatric Septic Shock, Lecture, 2nd International Congress of the German Sepsis Society, September 2005, Weimar, Germany.
Sepsis and Systemic Inflammatory Response Syndrome, Lecture, Society of Critical Care Medicine Pediatric Multiprofessional Critical Care Review Course, August 2005, Chicago, IL.
Immune System and Cytokine Basics in the Pediatric Intensive Care Unit, Lecture, Society of Critical Care Medicine Pediatric Multiprofessional Critical Care Review Course, August 2005, Chicago, IL.
Mechanisms of Tissue Injury in Sepsis/ARDS, Symposium Speaker, Pediatric Academic Societies Annual Meeting, May 2005, Washington, D.C.
Microarray Analysis in Pediatric Septic Shock, Plenary Speaker, 3rd Symposium on the Functional Genomics of Critical Illness and Injury, April 2005, National Institutes of Health, Bethesda, MD.
Signal Transduction in Critical Illness, Moderator, The Society of Critical Care Medicine 34th Congress, January 2005, Phoenix, AZ.
Cytoprotective Mechanisms Conferred by Heat Shock, Lecture, The Society of Critical Care Medicine 34th Congress, January 2005, Phoenix, AZ.
Functional Genomics: What is it?, Lecture, Postgraduate Review Course: Sepsis Pathophysiology for the Uninitiated, , The Society of Critical Care Medicine 34th Congress, January 2005, Phoenix, AZ.
3rd Annual Distinguished Alumnus Lecture, The Whole Blood Transcriptome of Pediatric Septic Shock, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, October 2004, Pittsburgh, PA.
Acute Lung Injury, Lecture, National Congress of Pediatric Intensive Care, October 2004, Viña Del Mar, Chile.
Evolution of New Therapies for Septic Shock, Lecture, National Congress of Pediatric Intensive Care, October 2004, Viña Del Mar, Chile.
Management of Increased Intracranial Pressure, Lecture, National Congress of Pediatric Intensive Care, October 2004, Viña Del Mar, Chile.
Genomic Applications in Pediatric Critical Care Medicine, Lecture, National Congress of Pediatric Intensive Care, October 2004, Viña Del Mar, Chile.
The Heat Shock Response, Department of Critical Care Medicine, Invited Seminar, University of Pittsburgh School of Medicine, October 2004, Pittsburgh, PA.
The Heat Shock Response, Invited Seminar, Department of Pediatrics, Yale University School of Medicine, May 2004, New Haven, CT.
Pediatric Grand Rounds, Pediatric Septic Shock: Fundamental Principles and One Future Direction, Department of Pediatrics, Yale University School of Medicine, May 2004, New Haven, CT.
Alphabet Soup and What Cytokines Mean to You, Lecture, Pediatric Critical Care Medicine 2004, April 2004, Washington, DC.
The Cellular Response to Shock, Lecture, Pediatric Critical Care Medicine 2004. April 2004, Washington, DC.
Genetic Factors. Moderator, 24th International Symposium on Intensive Care and Emergency Medicine, Mar. 2004, Brussels, Belgium.
The Heat Shock Response. Speaker, 24th International Symposium on Intensive Care and Emergency Medicine, Mar. 2004, Brussels, Belgium.
Gene Expression Profiles in Pediatric Septic Shock. Opening Session Speaker, 24th International Symposium on Intensive Care and Emergency Medicine, Mar. 2004, Brussels, Belgium.
Heat Shock Protein-70 and Protection Against Oxidant Injury. Speaker, The Society of Critical Care Medicine 33rd Congress. Feb. 2004, Orlando, FL.
Heat Shock Factor-1 and Susceptibility to Cellular Injury. Speaker, The Society of Critical Care Medicine 33rd Congress. Feb. 2004, Orlando, FL.
The Vascular System: When Vessels Go Bad in Patients. Lecture, Children's Hospital Research Foundation Lecture Series on Development and Disease; Oct. 2003, Cincinnati, OH
The Heat Shock Response: Links to the NF-kB Pathway and Developing Links to the Bedside. Seminar, Children's Hospital of Oakland Research Institute; July 2003, Oakland, CA.
Septic Shock: Fundamentals and Genome-Level Analysis. Pediatric Grand Rounds, Oakland Children's Hospital; July 2003, Oakland, CA.
Molecular Basis of Shock and Sepsis. Moderator, 4th World Congress on Pediatric Intensive Care, June 2003, Boston, MA.
Studying Gene Expression in Critical Illness: Will It Take Us in New Directions? Speaker, 4th World Congress on Pediatric Intensive Care; June 2003, Boston, MA.
Molecular and Genetic Advances in Acute Lung Injury. Speaker, 4th World Congress on Pediatric Intensive Care; June 2003, Boston, MA.
Septic Shock: Basic Principles and One Future Direction. Pediatric Grand Rounds, University of Montreal, St. Justine's Hospital; Mar. 2003, Montreal, Canada.
Septic Shock: Basic Principles and One Future Direction. Pediatric Grand Rounds, McGill University Health Centre, Montreal Children's Hospital; Mar. 2003, Montreal, Canada.
Sepsis: Signal Transduction. Moderator, The Society of Critical Care Medicine 32nd Congress; Feb. 2003, San Antonio, TX.
Gene Expression Profiles in Pediatric Septic Shock. Speaker, The Society of Critical Care Medicine 32nd Congress; Feb. 2003, San Antonio, TX.
Future Role for Genomics and Molecular Biology in ARDS. Speaker, The Toronto Critical Care Medicine Symposium; Nov. 2002, Toronto, Canada.
Genetics of Sepsis: Future Directions in Genomic Research. Speaker, The Toronto Critical Care Medicine Symposium; Nov. 2002, Toronto, Canada.
Septic Shock. Pediatric Grand Rounds, Cincinnati Children's Hospital Medical Center; Aug. 2002, Cincinnati, OH.
Impact of Sequential Stimuli on Signal Transduction Mechanisms. Speaker, American Thoracic Society International Conference; May 2002, Atlanta, GA.
Pediatric Septic Shock. Seminar, National Institute of Child Health and Human Development, Research Planning Conference for Pediatric Critical Care and Rehabilitation; May 2002, Bethesda, MD.
Alphabet Soup and What Cytokines Mean to You. Lecture, Pediatric Critical Care Medicine 2002; Apr. 2002, Washington, DC.
The Cellular Response to Shock. Lecture, Pediatric Critical Care Medicine 2002; Apr. 2002, Washington, DC.
Basic Cardiovascular Physiology. Lecture, 2002 Neofest. Cincinnati Children's Hospital Medical Center; Mar. 2002, Cincinnati, OH.
Sepsis: Inflammatory Mechanisms and Genetic Predisposition. Lecture, Current Concepts in Pediatric Critical Care; Feb. 2002, San Diego, CA.
Endogenous Cytoprotective Mechanisms. Moderator, The Society of Critical Care Medicine 31st Congress; Feb. 2002, San Diego, CA.
Cell Signaling: NF-kB. Moderator, The Society of Critical Care Medicine 31st Congress; Feb. 2002, San Diego, CA.
Redox Sensitive Transcription Factors. Speaker, The Society of Critical Care Medicine 31st Congress; Feb. 2002, San Diego, CA.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
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