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Zebrafish Movies

These movies show a normal and a mutant zebrafish embryo at 48 hours after fertilization. Click on each thumbnail to see a full-size QuickTime movie. (Each movie requires Apple's QuickTime player. Download the QuickTime player for PC or Macintosh from Apple.)

Normal Zebrafish Embryo.Movie 1. Normal zebrafish embryo. The heart can easily be seen beating, and circulation of individual blood cells through the blood vessels is observed.
Mutant embryo without endocardial cushion development.Movie 2. Mutant embryo without endocardial cushion development (cardiofunk). This embryo lacks endocardial cushions; thus when the ventricle contracts blood moves backward into the atrium instead of forward into the higher-resistance aorta. Despite the lack of circulation, the embryo otherwise develops normally for 4-5 days, allowing ample time for analysis of heart morphogenesis before embryonic lethality.