Brown Lab Research Interests
The long-term research goals of our lab are to understand the molecular mechanisms regulating the development of the mammalian lens and retina. We use mouse models to investigate the genetic pathways underlying lens and retinal tissue formation during embryogenesis. This research will contribute to a better understanding of congenital eye diseases and ultimately inform stem cell therapies to correct vision loss.
Currently our work is focused on understanding how lens progenitor cells differentiate into fiber cells; and retinal progenitor cells select a particular neuronal fate.
We are members of the Division of Developmental Biology and the Department of Ophthalmology at Cincinnati Children's Research Foundation and the University of Cincinnati School of Medicine. Our lab is located in Location R (Research Foundation Building), Room 3001.
Lens Development
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Retina Development
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| We are investigating how the Notch signaling pathway controls lens progenitor cell growth and differentiation. |
Focusing on retinal ganglion neuron formation, we are examining how bHLH transcription factors and Notch signaling regulate neurogenesis. |
