Other Representative Publications
Palumbo JS, Potter JM, Kaplan LS, Talmage KE, Jackson DG, and Degen JL. Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res. 62: 6966-6972, 2002.
Bezerra JA, Currier AR, Melin-Aldana H, Sabla G, Bugge TH, Kombrinck KW, and Degen JL. Plasminogen activators direct reorganization of the liver lobule after acute injury. Am. J. Pathol. 158: 921-929, 2001.
Drew AF, Tucker HL, Liu H, Witte DP, Degen JL, and Tipping PG. Crescentic glomerulnephritis is diminished in fibrinogen-deficient mice. Am. J. Physiol. 281: 1157-1163, 2001.
Drew AF, Liu H, Davidson JM, Daugherty CC, and Degen JL. Wound healing defects in mice lacking fibrinogen. Blood 97: 3691-3698, 2001.
Drew AF, Tucker HL, Liu H, Witte DP, Degen JL, and Tipping PG. Crescentic glomerulnephritis is diminished in fibrinogen-deficient mice. Am. J. Physiol. 281: 1157-1163, 2001.
Drew AF, Liu H, Davidson JM, Daugherty CC, and. Degen JL. Wound healing defects in mice lacking fibrinogen. Blood 97: 3691-3698, 2001.
Braun KM, Degen JL, and Sandgren EP. Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donors. Nature Med. 6: 320-326, 2000.
Wu YP, Siao C-J, Lu W, Sung T-C, Frohman MA, Milev P, Bugge TH, Degen JL, Levine JM, Margolis RU, and Tsirka SE. The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. J. Cell Biol. 148: 1295-1304, 2000.
Akassoglou K, Kombrinck KW, Degen JL, and Strickland S. Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury. J. Cell Biol. 149: 1157-1166, 2000.
Drew AF, Tucker HL, Kombrinck KW, Simon DI, Bugge TH, and Degen JL. Plasminogen is a critical determinant of vascular remodeling in mice. Circ. Res. 87: 133-139, 2000.
Heyu N, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO, and Wagner DD. Persistence of platelet thrombus formation in arterioles of mice lacking both van Willebrand factor and fibrinogen. J Clin Invest. 106: 385-392, 2000.
Palumbo JS, Kombrinck KW, Drew AF, Grimes TS, Kiser JH, Danton MJS, Degen JL, and Bugge TH. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 96: 3302-3309, 2000.
Hattori N, Degen JL, Sisson TH, Liu H, Moore BB, Pandrangi RG, Simon RH, and Drew AF. Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice. J. Clin. Invest. 106: 1341-1350, 2000.
Gebbia JA, Monco JCG, Degen JL, Bugge TH, and Benach JL. The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis. J. Clin. Invest. 103: 81-87, 1999.
Muraoka RS, Sun WY, Colbert MC, Waltz SE, Witte DP, Degen JL, and Degen SJF. The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse. J. Clin. Invest. 103: 1277-1285, 1999.
Lund LR, Romer J, Bugge TH, Nielsen BS, Frandsen TL, Degen JL, Stephens RW, Dano K. Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J. 18: 4645-4656, 1999.
Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, and Degen JL. Plasminogen deficiency leads to impaired remodeling following a toxic injury to the liver. Proc. Natl. Acad. Sci. USA 96: 15143-15148, 1999.
Xiao Q, Danton MJS, Witte DP, Kowala MC, Valentine MT, and Degen JL. Fibrinogen deficiency is compatible with the development of atherosclerosis in mice. J. Clin. Invest. 101: 1184-1194, 1998.
Drew AF, Kaufman AH, Kombrinck KW, Daughery CC, Danton MJS, Degen JL, and Bugge TH. Ligneous conjunctivitis in plasminogen-deficient mice. Blood 91: 1616-1624, 1998.
Bezerra JA, Carrick TL, Degen JL, Witte DP, and Degen SJF. Biological effects of the targeted inactivation of the hepatocyte growth factor-like protein in mice. J. Clin. Invest. 101: 1175-1183, 1998.
Bugge TH, Lund LR, Kombrinck KK, Nielsen BS, Holmbäck K, Drew AF, Flick MJ, Witte DP, Dano K, and Degen JL. Reduced metastasis of mammary cancer in plasminogen-deficient mice. Oncogene 16: 3097-3104, 1998.
Sun WY, Witte DP, Degen JL, Colbert MC, Burkart M, Holmbäck K, Xiao Q, Bugge TH, and Degen SJF. Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proc. Nat. Acad. Sci. USA 95: 7597-7602, 1998.
Busso N, Peclat V, van Ness K, Kolodziesczyk, E, Degen JL, Bugge TH, and So A. Excerbation of antigen-induced arthritis in urokinase-deficient mice. J. Clin. Invest. 102:41-50, 1998.
Coleman JL, Gebbia JA, Piesman J, Degen JL, Bugge TH, and Benach JL. Plasminogen is required for efficient dissemination of Borrelia burgorderi in ticks and for enhancement of spirochetemia in the vertebrate host. Cell 89: 1111-1119, 1997.
Tsirka SE, Rosgove AD, Bugge TH, Degen JL, and Strickland S. Neuronal death in the CNS demonstrates a non-fibrin substrate for plasmin. Proc. Natl. Acad. Sci. USA 94: 9779-9781, 1997.
Xiao Q, Danton MJS, Witte DP, Kowala MC, Valentine MT, Bugge TH, and Degen JL. Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis. Proc. Nat. Acad. Sci. USA 94: 10335-10340, 1997.
Bugge TH, Kombrinck KW, Xiao Q, Holmbäck K, Daugherty CC, Witte DP, and Degen JL. Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. Blood 90: 4522-4531, 1997.
Tsirka SE, Rosgove AD, Bugge TH, Degen JL, and Strickland S. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J. Neurosci. 17: 543-552, 1997.
Rømer J, Bugge TH, Pyke C, Flick MJ, Degen JL, and Danø K. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Medicine. 2: 287-292, 1996.
Bugge TH, Flick MJ, Danton MJS, Daugherty CC, Rømer J, Danø K, Carmeliet P, Collen D, and Degen JL. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proc. Natl. Acad. Sci. USA 93: 5899-5904, 1996.
Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmbäck K, Danton MJS, Colbert MC, Witte DP, Fujikawa K, Davie EW, and Degen JL. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc. Natl. Acad. Sci. USA 93: 6258-6263, 1996.
Holmbäck K, Danton MJS, Suh TT, Daugherty CC, and Degen JL. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin αIIbβ3. EMBO J. 15: 5760-5771, 1996.
Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJ, and Degen JL. Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. Cell 87: 709-719, 1996.
Bugge TH, Flick MJ, Daugherty CC, and Degen JL. Plasminogen-deficiency causes severe thrombosis but is compatible with development and reproduction. Genes & Development 9: 794-807, 1995.
Bugge TH, Suh TT, Flick MJ, Daugherty CC, Rømer J, Solberg H, Ellis V, Danø K, and Degen JL. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J. Biol. Chem. 270: 16886-16894, 1995.
Suh TT, Holmbäck K, Jensen NJ, Daugherty CC, Small K, Simon DI, Potter SS, and Degen JL. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes & Development. 9: 2020-2033, 1995.
Rhim JA, Sandgren EP, Degen JL, Palmiter RD, and Brinster RL. Replacement of diseased mouse liver by hepatic cell transplantation. Science 263: 1149-1152, 1994.
Carmeliet P, Schoojans L, Kieckens L, Ream B, Degen JL, Bronson R, De Vos R, Van den Oord JJ, Collen D, and Mulligan RC. Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368: 419-424, 1994.
Suh TT, Jensen N, Nerlov C, Danø K , and Degen JL. The murine urokinase-type plasminogen receptor gene. J. Biol. Chem. 269: 25992-25998, 1994.
Sandgren EP, Heckel JL, Palmiter RD, Brinster RL and Degen JL. DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice. Proc. Natl. Acad. Sci. USA 69: 11523-11527, 1992.
Sandgren EP, Palmiter RD, Heckel JL, Daugherty CC, Brinster RL, and Degen JL. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell 66: 245-256, 1991.
Heckel JL, Sandgren EP, Degen JL, Palmiter RD, and Brinster RL. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell 62: 447-456, 1990.
