Recent Publications
Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin αMβ2 binding motif. J. Clin. Invest., In Press.
Degen JL, Bugge TH, Goguen JD. Fibrin and fibrinolysis in infection and host defense. J. Thromb. Haemost. 5: 24-31, 2007.
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and -independent mechanisms. Blood 110: 133-141, 2007.
Adams RA, Bauer J, Flick MJ, Sikorskil S, Nuriell T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived γ377-395 peptide inhibits microglia activation and reverses relapsing paralysis in central nervous system autoimmune disease. J. Exp. Med. 204:571-582, 2007.
Zhang G, Kernan KA, Collins SJ, Cai X, Lopez-Guisa JM, Degen JL, Shvil Y, Eddy AA. Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition: Role of Plasmin-Activated Signals. J Am Soc Nephrol. 18: 846-859, 2007.
Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA. Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor. BMC Gastroenterology 6: 40-48 2006.
Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, Degen JL, Davis RJ, Mizushima N, Rakic P, Dardzinski BJ, Holland SK, Sharp FR, Kuan C-Y. Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am. J. Pathology 169: 566-583, 2006.
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jiroušková M, and Degen JL. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer-mediated elimination of tumor cells. Blood 105: 178-185, 2005.
Shanmukhappa K, Mourya R, Sabla GE, Degen JL, and Bezerra JA. Hepatic to pancreatic switch defines a novel role of hemostatic factors in cellular plasticity in mice. Proc. Natl. Acad. Sci. USA, 102: 10182-10187, 2005.
Degen JL, Massari JV, Talmage KE, La Jeunesse CM, Kombrinck KW, Flick MJ, and Palumbo PS. Hemostatic factors support metastasis by impeding NK cell-mediated elimination of embolic tumor cells. Haematological Reports 1:21-23, 2005.
Cho J, Degen JL, Coller BS, and Mosher DF. Fibrin but not absorbed fibrinogen supports fibronectin assembly by spread platelets: effects of the interaction of alpha IIbbeta 3 with the C-terminus of the fibrinogen gamma-chain. J. Biol. Chem., 280: 35490-35498, 2005.
Jirouskova M, Chereshnev I, Vaananen H, Degen JL and Coller BS. Antibody blockade or mutation of the fibrinogen chain C-terminus are more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen. Blood 103: 1995-2002, 2004.
Flick MJ, Du X, Witte DP, Jirouskova M, Soloviev DA, Busuttil SJ, Plow EF, and Degen JL. Leukocyte engagement of fibrinogen via the integrin receptor, αMß2/Mac-1, is critical for host inflammatory response in vivo. J. Clin. Invest. 113: 1596-1606, 2004.
Palumbo JS, Zogg M, Talmage KE, Degen JL, Weiler H, and Isermann BH. Role of fibrinogen- and platelet-mediated haemostasis in mouse embryogenesis and reproduction. J. Thromb. Haemst. 2: 1368-1379, 2004.
Flick MJ, Du X, and Degen JL. Fibrin(ogen)- αMß2 interactions regulate leukocyte function and innate immunity in vivo. Exp. Biol. & Med. 229: 1105-1110, 2004.
Tucker HM, Simpson J, Kihiko-Ehmann M, Younkin LH, McGillis JP, Younkin SG, Degen JL, and Estus S. Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neurosci Lett. 368: 285-289, 2004.
Currier AR, Sabla GE, Locaputo S, Melin-Aldana H, Degen JL, Bezerra JA. Plasminogen directs the pleiotropic effects of uPA in liver injury and repair. Am. J. Physiol. Gastrointest. Liver Physiol. 284: 508-515, 2003.
Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, and Weiler H. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat. Med. 9: 331-337, 2003.
Kufrin D, Eslin DE, Bdeir K, Murciano JC, Kuo A, Kowalska M A, Degen JL, Sachais BS, Cines DB, Poncz M. Anti-thrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets. Blood 102: 926-933, 2003.
Palumbo JS, Talmage KE, Liu H, La Jeunesse CM, Witte DP, and Degen JL. Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency. Blood 102: 2819-2827, 2003.
Ni H, Papalia JM, Degen JL, and Wagner DD. Control of thrombus embolization and fibronectin internalization by integrin αIIbβ3 engagement of the fibrinogen γ chain. Blood 102: 3609-3614, 2003.
Degen JL and Palumbo JS. Mechanisms linking hemostatic factors to tumor growth in mice. Pathophysiol Haemost Thromb. 33: 31-35, 2003.
View other representative publications.
