Recent Publications
Bu W., Mamedova A., Xia M., Tan M., Jiang J., Hegde R.S. (2008) “Structural basis for the receptor binding specificity of the Norwalk virus”, J. Virology 82(11):5340-7
Blakaj D.M., Fernandez-Fuentes N., Chen Z., Hegde R.S., Fiser A., Burk R.D., Brenowitz M. (2008)
“Evolutionary, structural and electrostatic relationships among the papillomavirus E2 protein DNA binding domains” Frontiers in Bioscience, (in press)
Hu S.H., Mamedova A., Hegde R.S. (2008)
“DNA binding and regulation mechanisms of the SIX family of retinal determination proteins”,
Biochemistry, 47:3586-3594
Liu, Y., Henry, G.D., Hegde, R.S., Baleja J.D. (2007) “
Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein”.
Biochemistry 46(38):10864-74
Hegde R.S. (2006)
“Papillomavirus proteins and their potential as drug design targets” Future Virology, 1(6):795-810
Rayapureddi J.P. and Hegde R.S. (2006)
“Branchio-oto-renal syndrome associated mutations in Eyes Absent 1 result in loss of phosphatase activity” FEBS Letters 580(16):3853-3859
Liou B., Kazmierczek A., Zhang M., Scott C.R., Hegde R.S., Grabowski G. (2006)
“Analyses of variant Acid ″-Glucosidases: Effects of Gaucher disease mutations” Journal of Biological Chemistry 281(7):4242-53
Blakaj D.M., Kattamuri C., Khrapunov S., Hegde R.S., Brenowitz M. (2006)
“Indirect readout of DNA sequence by papillomavirus E2 proteins depends upon cation uptake” Journal of Molecular Biology. 358(1):224-40
Seufert D.W., Hegde R.S., Nekkalapudi S., Kelly L.E., El-Hodiri H.M. (2005)
“Expression of a novel Ski-like gene in Xenopus Development”.
Gene Expression Patterns 6(1):22-8
Rayapureddi J.P., Kattamuri C., Chan F.H., Hegde R.S. (2005)
“Characterization of a plant, tyrosine-specific phosphatase of the aspartyl class”.
Biochemistry 44(2):751-8
Tan M., Hegde R.S., Jiang J. (2004)
"The P domain of norovirus capsid protein forms a dimer and binds to histo-blood group antigen receptor".
Journal of Virology 78(12):6233-42
Blakaj D.M., Khrapunov S., Kattamuri C., Hegde R.S., Brenowitz M. (2004)
“Assessing the contribution of DNA structure and flexibility to DNA sequence specific recognition by papillomavirus E2 proteins”. Biophysical Journal 86(1):590A-590A Part 2, Suppl. S
Wilson J., Malakhova M., Zhang R.G., Joachimiak A., Hegde R.S. (2004)
"Crystal structure of the Dachshund-homology domain of human SKI".
Structure 12(5):785-792
Zhang Y., Xi A., Hegde R.S., Shakked Z., Crothers D.M. (2004)
"Predicting indirect readout effects in protein-DNA interactions" Proceedings of the National Academy of Sciences 101(22):8337-41
Rayapureddi J.P., Kattamuri C., Steinmetz B.D., Frankfort B.J., Ostrin E.J., Mardon G., Hegde R.S. (2003)
"Eyes Absent represents a class of protein tyrosine phosphatases." Nature 426(6964):295-298 (News and Views, Nature (2003) 426(6964):238-9).
Kim S.S., Braunstein S.E., Zhang R.G., Joachimiak, A., Cvekl A., Hegde R.S., (2002)
"Structure of the retinal determination protein Dachshund reveals a DNA binding motif." Structure 10:787-795
Hegde R.S.,
"The papillomavirus E2 proteins: Structure, Function and Biology." (2002)
Annual Reviews of Biophysics and Biomolecular Structure 31:343-360
Kim S.S., Tam J.K., Wang A.F., and Hegde, R.S. (2000)
"The structural basis of DNA target discrimination by papillomavirus E2 proteins." Journal of Biological Chemistry 275:31245-31254
