Cincinnati Children's Hospital Medical Center Logo

Lang Lab

Lens Induction and Development Images

Endogenous lens (red arrow) and ectopic lenses (green arrows) in Xenopus tadpole derived from an embryo injected with RNA encoding Pax6.
Ectopic eyes (A, white arrow) form in Xenopus tadpoles from embryos misexpressing Pax6. Different markers for lens and retina can be identified in ectopic eyes (B) as in wild-type eyes(C). 
The expression activity of the Pax6 gene lens enhancer is restricted to the presumptive lens ectoderm (blue labeled area) at 9.5 days of gestation in the mouse.
Model describing the genetic regulation of lens induction in the mouse.