Wnt Signaling Image Detail
Pygopus is a nuclear protein essential for Wnt/beta-catenin signaling. Drosophila Pygopus Mutant embryo shows a wg-like cuticle defect (top). Depletion of Xenopus Pygo activity in embryos results in ventralized phenotype (Bottom left). Pygo-GFP protein is localized in nuclei when expressed in 293 cells.
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