Biosketch
Academic Appointments
Education, Training, and Research Experience
Honors and Awards
2008
Translational Research Award, Children’s Hospital Research Foundation
2004
Pilot and feasibility award from the Beta Cell Alliance and the Juvenile Diabetes Foundation
University of Cincinnati Cancer Programs Cancer Center Grant
2003
Career Development Award, Juvenile Diabetes Foundation
Junior Faculty Award, American Diabetes Foundation
2002
Trustee Award, Children's Hospital Research Foundation
2000
Postdoctoral Fellowship from the Juvenile Diabetes Foundation
1997
Postdoctoral Fellowship from the national American Cancer Society
1995
Traveling Fellowship for studies in mouse development from the journal Development
1994
Award for Excellence in Research from the Institute for Cell and Developmental Biology, SUNY at Stony Brook
1991-1992
Genetics program executive committee, SUNY at Stony Brook
1990-1992
Doctoral training fellowship in Genetics from the National Institutes of Health
Grants and Contracts
National Institutes of Health, NIDDK (AM Zorn P.I., JM Wells P.I. 15%)
NIH R01DK080823A1
Title: Role of Wnt signaling in foregut and liver development
Term: Start date TBD
National Institutes of Health, NIGMS (JM Wells, P.I. 20%)
NIH R01GM072915
Title: Mechanisms of endoderm specification along the A-P axis.
Term: April 1, 2006 - March 31, 2011
$190,000/year direct
Juvenile Diabetes Foundation, Career Development Award (JM Wells, P.I. 30%)
Title: Promoting endodermal and pancreatic differentiation of mouse ES cells
Term: November 1, 2003 - October 31, 2008
$100,000/year direct
CCHMC Translational Research Award (JM Wells, P.I.)
Title: Human Embryonic stem cell core
Term: June 1, 2008 - May 31, 2009
$50,000/year direct
Juvenile Diabetes Research Foundation (JM Wells, P.I. 20%)
JDRF 26-2008-894
Title: Role of Sox17 in beta cell homeostasis and regeneration
Term: September 1, 2008 - August 30, 2009
$100,000/year direct
Juvenile Diabetes Research Foundation
JDRF 3-2008-437
Trainee: JR Spence
Advisor: JM Wells
Title: Using Developmental Paradigms to Direct Human Endoderm into Beta Cells
Term: September 1, 2008 - August 30, 2010
Digestive Disease Research Center (MB Cohen, PI)
NIH P30 DK0789392
Term: August 1, 2007 - May 31, 2012
Cincinnati Center for Growth and Development
JM Wells – Full Member
Pending
National Institutes of Health (HE Heubi, J Tsevat)
NIH 1 U54 RR025216 01
Type of award: Clinical and Translational Science Award
University of Cincinnati/Cincinnati Children’s Hospital Medical Center
Section 11: MOLECULAR AND CELL THERAPY MATRIX PROGRAM AND TRANSLATIONAL CORES
Human Embryonic Stem Cell Core
Role: Director
Completed
National Institutes of Health (S Handwerger, PI)
NIH T32 HD07463 Training grant in Developmental and Perinatal Endocrinology
Trainee: JR Spence
Advisor: JM Wells
Title: Development of human endoderm and pancreas from ES cells
Term: November 1, 2006 - October 31, 2008
National Institutes of Health, NICHD (AM Zorn, P.I.)
NIH R01HD042572-03S1
Competing Supplement
Title: Molecular basis of endoderm development
Co-investigator: JM Wells
Term: July 1, 2004 - June 30, 2007
NIH beta cell consortium/JDRF (JM Wells, P.I.)
BCBC/JDRF 31148-R
Pilot and feasibility award
Title: Promoting the differentiation of human embryonic stem cells into endoderm and pancreas
Term: November 1, 2004 - October 31, 2006
$75,000/year direct
American Diabetes Association (JM Wells, P.I.)
Junior Faculty Award
Title: Promoting endodermal and pancreatic differentiation of ES cells
Term: June 1, 2003 - June 31, 2006
Total Awarded: $409,000
JDRF Postdoctoral Fellowship
Trainee: BA Moore-Scott (relocated to GA in 2007)
Advisor: JM Wells
Title: The role of FGFbp1 in endoderm patterning
Term: September 1, 2006 - August 31, 2008
JDRF Postdoctoral Fellowship
Trainee: SC Lin
Advisor: JM Wells
Title: The role of Klf5 in endoderm development
Term: November 1, 2004 - October 31, 2006
University of Cincinnati Cancer Programs (JM Wells, P.I.)
Pilot award from the UC Cancer Center
Title: Sox17-mediated repression of beta-catenin activity in colon carcinoma cells
Term: August 1, 2004 - July 31, 2005
$25,000/year direct
CCHMC Research Foundation (JM Wells, P.I.)
Award from the Board of Trustees, CCHMC
Title: Characterization of genes that promote differentiation of embryonic stem cells into endoderm
Term: January 1, 2003 - December 31, 2004
$50,000/year direct
National / International Distinguished Activities
2008
Invited speaker at the Transatlantic Airway Conference, Lucern Switzerland, January 22-25.
2007
Invited speaker at the American Diabetes Association’s 67th Scientific Sessions, June 13.
2006
Speaker at the FEBS-EMBO workshop “Programming Pancreatic Beta Cells”, El Perello, Spain, October 19.
Invited by graduate students as the Keynote speaker at the annual graduate students symposium, Department of Molecular and Cellular Pharmacology Graduate program, SUNY Stony Brook, NY, June 19.
2005
Keynote speaker at the annual meeting of the Juvenile Diabetes Research Foundation, Connecticut, June 22.
Invited speaker at the American Diabetes Association’s 65th Scientific Sessions, June 13
2004
Invited speaker at the 14th annual workshop of the Center for the Study of Inflammatory Bowel Disease, “Inventing and Re-inventing the GI Tract – Stem Cells, Development and Differentiation”. Boston, MA, November 14-15.
Invited speaker at the workshop at the Barbara Davis Center for Childhood Diabetes, “Pancreatic Development and Regeneration”. Denver, CO, October 18-19.
Keynote speaker at the annual meeting of the Juvenile Diabetes Research Foundation, Southwest chapter, Phoenix, AZ, June 14.
Session chair and invited speaker at the annual Meeting of the Society for Developmental Biology, Mid-Atlantic Region. Pittsburgh, PA. May 21-22.
2002
Speaker, EMBO Meeting "Endoderm Development, Differentiation and Cancer, August 19-23.
1999
Speaker, 35th Annual Meeting European Association for the study of Diabetes, Brussels, September 28th-October 2nd, 1999
Invited Seminars
- Miami University, March 2008
- University of Pennsylvania/Children’s Hospital of Philadelphia, Division of Developmental Biology, February 5, 2008
- CCHMC Board of trustees annual retreat, January 26, 2008
- Nebraska Medical Center, Genetics, Cell Biology and Anatomy, February 28, 2007
- SUNY Stony Brook, Department of Molecular Pharmacology, NY, November 28, 2006
- Stem cell institute, Munich Germany, March 2006
- ISREC, Lausanne Switzerland, March 2006
- Vanderbilt University, Diabetes Center Grand Rounds, October 2005
- Miami University, April 2005
- University of Iowa, December 2004
- CyThera Inc., San Diego, CA, November, 2004
- University of California San Francisco, CA, February 2004
- Ohio State University, February 2004
- Miami University, Ohio, September, 2003
- ISREC, Lausanne Switzerland, September, 2003
- Department of Pathology, UC, March, 2003
- ISREC, Lausanne Switzerland, August, 2002
- Department of Cell Biology, Vontz Center, UC, October 2002
- Department of Biomedical Sciences, Cornell University, April 2001
- Department of Biology, Penn State University, March 2001
- University of Colorado Medical Center, Barbara Davis Center for Childhood Diabetes, March 2001
- Department of Molecular Biology and Genetics, Cornell University, March 2001
- Department of Biology, University of Rochester, February 2001
- Department of Anesthesiology, University of Massachusetts Medical School, January 2001
How to Reach Us
The Wells Laboratory is part of the Division of Developmental Biology at Cincinnati Children's Hospital Medical Center. The lab is located in Location R (Research Foundation Building), Room 3469. For more information, contact Jim Wells, 513-636-8767 (james.wells@chmcc.org).
