Wells Lab

Overview

About the Wells Lab

Jim Wells
Jim Wells, PhD
Phone 513-636-8767
Email james.wells@cchmc.org

Meet the people doing research in the Wells lab.

In our lab, we study the molecular mechanisms underlying endoderm organ development in mouse and chick. Why study endoderm development? The genes and signaling mechanisms that we identify in our embryonic studies are being used to promote the differentiation of embryonic and adult stem cells into therapeutically important cell types such as insulin producing beta cells. Stem cells are a promising renewable source of cells for transplantation to treat human diseases like Type 1 diabetes.

Research in the Wells Lab:

1. Endoderm organogenesis. We investigate the molecular mechanisms that determine where endoderm organs will develop along anterior-posterior (A-P) axis of the embryo.
2. Adult stem cells of the endoderm. We are interested in how embryological pathways are utilized to regulate proliferation and differentiation of stem cells in adult endoderm organs.
3. Embryonic stem cells. The goal of this research is to translate information from embryonic studies to promote the differentiation of pluripotent embryonic stem cells into therapeutically important cell types.