Spence JR, Wells JM. Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev Dyn 2007;236:3218
Sinner D, Kordich JJ, Spence JR, Opoka R, Rankin, Lin SC, Jonatan D, Zorn AM, Wells JM. Sox17 and Sox4 differentially regulate beta-catenin/TCF activity and proliferation of colon carcinoma cells. Mol Cell Biol 2007;27:7802-15. | *This article is featured on the cover.
Moore-Scott BA, Opoka R, Kordich JJ, Lin S, Wells JM. Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation. Dev Dyn 2007;1997-2003.
Sinner D, Wells JM, Zorn AM. (2007). Principals of Developmental Genetics, Chapter 14: Endoderm Formation. 295-315. Edited by Sally A. Moody. Elsevier Press.
Moore-Scott B, Wells JM. (2007). Principals of Developmental Genetics, Chapter 40: Patterning the embryonic endoderm into presumptive organ domains. 909-931. Edited by Sally A. Moody. Elsevier Press.
Zorn AM, Wells JM. Molecular basis of vertebrate endoderm development. International Review of Cytology: a Survey of Cell Biology 2007;259:49-111.
Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM. Wnt/β-catenin is required for development of the exocrine pancreas. BMC Dev Biol 2007;7:4.
Park KS, Wells JM, Zorn AM, Wert SE, Whitsett JA. Sox17 Influences Differentiation of Respiratory Epithelial Cells. Dev Biol 2006;294(1):192-202.
Park KS, Wells JM, Zorn AM, Wert SE, Laubach VE, Fernandez LG, Whitsett JA. Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol 2006;34(2):151-7.
Dessimoz J, Kordich JJ, Opoka R, Grapin-Botton A, Wells JM. FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Mech Dev 2006;123(1):42-55.
Bates MD, Wells JM, Venkatesh B. Comparative Genomics of the Hlx Homeobox Gene and Protein. Gene 2005;6;352:45-56.
Serls AE, Doherty S, Parvatiyar P, Wells JM, Deutsch GH. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 2005;132:35-47.
*Gu G, *Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. Global analysis of gene regulatory pathways that function during development of the endocrine pancreas. Development 2004;131:165-79. | *These authors contributed equally and are listed alphabetically.
Wells JM. Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes research. Diabetes Metab Res Rev 2003;19:191-201.
Zhang J, Dong M, Li L, Pathre P, Fan Y, Dong J, Lou D, Wells JM, Olivares-Villagom D, Van Kaer L, Wang X, Xu M. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci USA 2003;100:15782-7.
Wells JM, Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 2000;127:1563-72. | *for more information, this manuscript was reviewed in BioEssays, 22.7:599-602.
Wells JM, Melton DA. Vertebrate endoderm development. Annu Rev Cell Dev Biol 1999;15:393-410.
Wells JM, Strickland S. Regulated cellular localization confers multiple functions of the protease urokinase plasminogen activator during skeletal muscle differentiation. J Cell Physiol 1997;171:217-25.
Duffy JB, Wells JM, Gergen JP. Screening for maternal modifiers of the segmentation gene runt. Genetics 1995;142, 670-7.
Wells JM, Strickland S. Aprotinin, a Kunitz-type protease inhibitor, stimulates skeletal muscle differentiation. Development 1994;120: 3639-47.
Carroll PM, Richards WG, Darrow AL, Wells JM, Strickland S. Cell-surface binding of tissue-type plasminogen activator in murine preimplantation embryos. Development 1993;119:191-8.
Kozak LP, Kozak UC, Jerry JJ, Wells JM. (1989). The glycerol phosphate dehydrogenase gene: Analysis of a complex structural domain and a null mutant. UCLA symposium: Obesity, towards a molecular approach. p. 263-272.
Kozak LP, Britton JH, Kozak UC, Wells JM. The mitochondrial uncoupling protein gene: Correlation of exon structure to transmembrane domains. J Biol Chem. 1988;263:12274-7.
Manuscripts submitted
Stefania Gimelli, Gianluca Caridi, Silvana Beri, Monica Dagnino, Luisa Murer, Elisa Benetti, Roberto Giorda, Orsetta Zuffardi, Kyle McCracken, James M. Wells, Giorgio Gimelli, Gian Marco Ghiggeri. (2008). Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract. Submitted to Nature.
Manuscripts in preparation
Spence JR, Wells JM. (2008). Identification of molecular pathways that control migration and patterning of human embryonic endoderm cells derived from ES cells. In Preparation.
Spence JR, Lin SC, Wells JM. (2008). Ventral pancreas, common bile duct and gall bladder derive from a common progenitor. In Preparation.
Lin S-C,Wells JM. (2008). Factors that are required for preimplantation development and that regulate pluripotency of ES cells. In Preparation.
How to Reach Us
The Wells Laboratory is part of the Division of Developmental Biology at Cincinnati Children's Hospital Medical Center. The lab is located in Location R (Research Foundation Building), Room 3469. For more information, contact Jim Wells, 513-636-8767 (james.wells@chmcc.org).
