Ernest F. Zimmerman, PhD
Title
Professor Emeritus
Appointment
Professor Emeritus of Pediatrics
Email
ernest.zimmerman@chmcc.org
Phone
513-636-4545
Bio
Dr. Ernest Zimmerman's laboratory studies the role of oxygen free radicals produced by drugs or maternal factors to induce congenital malformations.
Current research is exploring whether oxidative stress is a causative factor in the pathogenesis of diabetic embryopathy. Employing the Splotch mutation in a mouse model, experiments are testing whether diabetes-induced oxidative stress decreases activity of the Pax-3 protein via a redox control mechanism. Thus, the function of the endogenous Pax-3 protein would be additively inhibited by the heterozygous Splotch genotype and oxidative decrease of Pax-3 activity by diabetes.
Research
Role of oxygen free radicals in teratogenesis; diabetic embryopathy and cocaine-induced birth defects.
Publications, Most Recent
E.F. Zimmerman; W.J. Scott; and M.D. Collins (1990):
Ethanol-induced limb defects in mice: effect of strain and Ro15-4513.Teratology 41: 453-462.
E.F. Zimmerman (1991): Substance abuse in pregnancy: Teratogenesis.Pediatr Ann
20: 541-547.
J.E. Fisher; R.B. Potturi, M. Collins; E Resnick; and E.F. Zimmerman (1994): Cocaine-induced embryonic cardiovascular disruption in mice.Teratology, 49: 182-191.
E.F. Zimmerman; R.B. Potturi; E. Resnick; and J.E. Fisher (1994): Role of oxygen free radicals in cocaine-induced vascular disruption in mice.Teratology, 49: 192-201.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
